Abstract：
:The normal cellular prion protein (PrP(C)) is a glycoprotein with two highly conserved potential N-linked glycosylation sites. All prion diseases, whether inherited, infectious or sporadic, are believed to share the same pathogenic mechanism that is based on the conversion of the normal cellular prion protein (PrP(C)) to the pathogenic scrapie prion protein (PrP(Sc)). However, the clinical and histopathological presentations of prion diseases are heterogeneous, depending not only on the strains of PrP(Sc) but also on the mechanism of diseases, such as age-related sporadic vs. infectious prion diseases. Accumulated evidence suggests that N-linked glycans on PrP(C) are important in disease phenotype. A better understanding of the nature of the N-linked glycans on PrP(C) during the normal aging process may provide new insights into the roles that N-linked glycans play in the pathogenesis of prion diseases. By using a panel of 19 lectins in an antibody-lectin enzyme-linked immunosorbent assay (ELISA), we found that the lectin binding profiles of PrP(C) alter significantly during aging. There is an increasing prevalence of complex oligosaccharides on the aging PrP(C), which are features of PrP(Sc). Taken together, this study suggests a link between the glycosylation patterns on PrP(C) during aging and PrP(Sc).
journal_name
J Neurochemjournal_title
Journal of neurochemistryauthors
Goh AX,Li C,Sy MS,Wong BSdoi
10.1111/j.1471-4159.2006.04268.xsubject
Has Abstractpub_date
2007-02-01 00:00:00pages
841-54issue
3eissn
0022-3042issn
1471-4159pii
JNC4268journal_volume
100pub_type
杂志文章abstract：:The antisense strategy was used to unravel the functional contribution of the mRNAs encoding dopamine (DA) receptors to the multiple transduction mechanisms operated by DA in rat pituitary cells. An antisense oligonucleotide was designed to recognize seven nucleotides upstream and 11 nucleotides downstream from the in...
journal_title：Journal of neurochemistry
pub_type： 杂志文章
doi：10.1046/j.1471-4159.1994.62041260.x
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abstract：:Blood-based tests for the differential diagnosis of Alzheimer's disease (AD) are under intensive investigation and have shown promising results with regard to Abeta40 and Abeta42 peptide species in incipient AD. Moreover, plasma Abeta40 was suggested as an independent cerebrovascular risk factor candidate. These consi...
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journal_title：Journal of neurochemistry
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doi：10.1111/j.1471-4159.1982.tb08011.x
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doi：10.1111/j.1471-4159.1984.tb06109.x
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journal_title：Journal of neurochemistry
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doi：10.1111/j.1471-4159.1981.tb02401.x
更新日期：1981-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1046/j.1471-4159.1994.63051941.x
更新日期：1994-11-01 00:00:00
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