Glycosylation of proteins in developing human brain.

abstract：:A sustained increase in the brain concentrations of neuroactive steroids was previously shown to induce Y1 receptor gene expression in the amygdala of Y1R/LacZ transgenic mice which harbour a construct comprising the murine Y1 receptor gene promoter and the lacZ reporter gene. We now investigated the effects of restra...

journal_title：Journal of neurochemistry

authors： Mele P,Oberto A,Serra M,Pisu MG,Floris I,Biggio G,Eva C

更新日期：2004-06-01 00:00:00

abstract：:Rat brain benzodiazepine receptors have been solubilized by means of the zwitterionic detergent CHAPS under conditions in which the GABA stimulation of [3H]flunitrazepam binding to the benzodiazepine receptors is maintained intact. This stimulation is partially or totally abolished when using other conventional deterg...

journal_title：Journal of neurochemistry

authors： Mernoff ST,Cherwinski HM,Becker JW,de Blas AL

更新日期：1983-09-01 00:00:00

abstract：:We have analyzed brain coated vesicles and synaptic plasma membrane for the presence of the plasma membrane proteolipid protein. Coated vesicles were isolated from calf brain gray matter with a final purification on Sephacryl S-1000 and reisolated twice by chromatography to ensure homogeneity. Fractions were analyzed ...

journal_title：Journal of neurochemistry

authors： Sapirstein VS,Nolan C,Stern R,Ciocci M,Masur SK

更新日期：1988-09-01 00:00:00

abstract：:2,4,5-Trihydroxyphenylalanine (TOPA) oxidizes in solution to form a quinone derivative that is a non-N-methyl-D-aspartate agonist and neurotoxin. Although pathways have been postulated for the formation of both TOPA and TOPA quinone from closely related catecholamines, the generation of these compounds has not been co...

journal_title：Journal of neurochemistry

authors： Newcomer TA,Palmer AM,Rosenberg PA,Aizenman E

更新日期：1993-09-01 00:00:00

abstract：:Dietary n-6 polyunsaturated fatty acid (PUFA) deprivation in rodents reduces brain arachidonic acid (20:4n-6) concentration and 20:4n-6-preferring cytosolic phospholipase A(2) (cPLA(2) -IVA) and cyclooxygenase (COX)-2 expression, while increasing brain docosahexaenoic acid (DHA, 22:6n-3) concentration and DHA-selectiv...

journal_title：Journal of neurochemistry

authors： Igarashi M,Kim HW,Chang L,Ma K,Rapoport SI

更新日期：2012-03-01 00:00:00

abstract：:α-Synuclein causes Parkinson's disease if mutated or aberrantly produced in neurons. α-Synuclein-lipid interactions are important for the normal function of the protein, but can also contribute to pathogenesis. We previously reported that deletion of the first 10 N-terminal amino acids dramatically reduced lipid bindi...

journal_title：Journal of neurochemistry

authors： Vamvaca K,Lansbury PT Jr,Stefanis L

更新日期：2011-10-01 00:00:00

abstract：:Previous studies have indicated that the brains of DBA/2J (D2) mice have a more heavily myelinated CNS than those of C57BL/6J (B6) at postnatal days 17-21. However, the amount of myelin in the brains of F1 (B6 X D2) hybrids is even higher than in their parental strains. To investigate further factors involved in regul...

journal_title：Journal of neurochemistry

authors： Sato C,Yu RK

更新日期：1987-10-01 00:00:00

abstract：:In the present study we have used perfused hippocampal slices to examine the hypothesis that nitric oxide (NO) can evoke the release of adenosine from nervous tissue. ATP stores were labeled by incubation with [3H]adenine. Electrical field stimulation at 5 Hz for 5 min evoked the release of 3H-purines, and this was en...

journal_title：Journal of neurochemistry

authors： Fallahi N,Broad RM,Jin S,Fredholm BB

更新日期：1996-07-01 00:00:00

abstract：:JNK/SAPK has been implicated in the pathogenesis of Alzheimer's disease, but the upstream cascade leading to JNK/SAPK activation has not been elucidated in the disease. In this study, we focused on one of the physiological activators of JNK/SAPK, JNK kinase 1 (JKK1). Although there was no significant difference in the...

journal_title：Journal of neurochemistry

authors： Zhu X,Ogawa O,Wang Y,Perry G,Smith MA

更新日期：2003-04-01 00:00:00

abstract：:It has been reported that caffeine (1.5-30 mg/kg i.p.) as well as specific A1 (DPCPX, 8-cyclopentyl-1,3-dipropylxanthine) receptor antagonists fail to increase extracellular dopamine (DA) in the shell of the nucleus accumbens (NAc). However, it has also been reported that caffeine (10 and 30 mg/kg i.p.) and the A1 ant...

journal_title：Journal of neurochemistry

authors： De Luca MA,Bassareo V,Bauer A,Di Chiara G

更新日期：2007-10-01 00:00:00

abstract：:Cysteine-string protein (Csp) is a major synaptic vesicle and secretory granule protein first discovered in Drosophila and Torpedo. Csps were subsequently identified from Xenopus, Caenorhabditis elegans, and mammalian species. It is clear from the study of a null mutant in Drosophila that Csp is required for viability...

journal_title：Journal of neurochemistry

authors： Chamberlain LH,Burgoyne RD

更新日期：2000-05-01 00:00:00

abstract：:We investigated the role of mitogen-activated protein kinase (MAPK) pathways in hypoxic neuronal injury using primary cultures from murine cerebral cortex. Hypoxia caused the death of approximately 50% of neurons at 16 h and approximately 65% of neurons at 24 h. This was associated with phospho-activation of the MAPK/...

journal_title：Journal of neurochemistry

authors： Jin K,Mao XO,Zhu Y,Greenberg DA

更新日期：2002-01-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating peptide (PACAP) receptor (PAC1R) is a class B Gprotein-coupled receptor (GPCR) that is widely expressed in the human body and is involved in neuronal differentiation. As class B GPCRs are known to form heterocomplexes with family members, we hypothesized that PAC1R mediates neuro...

journal_title：Journal of neurochemistry

authors： Ke R,Lok SIS,Singh K,Chow BKC,Lee LTO

更新日期：2020-10-20 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) receptor complex as defined by the binding of [3H]MK-801 has been solubilized from membranes prepared from both rat and porcine brain using the anionic detergent deoxycholate (DOC). Of the detergents tested DOC extracted the most receptors (21% for rat, 34% for pig), and the soluble com...

journal_title：Journal of neurochemistry

authors： McKernan RM,Castro S,Poat JA,Wong EH

更新日期：1989-03-01 00:00:00

abstract：:The concentration of dopamine (DA) in the synaptic cleft in the mouse striatum in vivo was estimated from the competition between the synaptic DA and the 3H-labelled DA D2 receptor agonists N-n-propylnorapomorphine (NPA) or N,N-diethyl-N'-[(3 alpha, 4a alpha, 10 beta)-1,2,3,4,4a,5,10,10a-octahydro- 7-hydroxyl-1-propyl...

journal_title：Journal of neurochemistry

authors： Ross SB

更新日期：1991-01-01 00:00:00

abstract：:Free radicals have been implicated in the etiology of many neurodegenerative conditions. Yet, because these species are highly reactive and thus short-lived it has been difficult to test these hypotheses. We adapted a method in which hydroxyl radicals are trapped by salicylate in vivo, resulting in the stable and quan...

journal_title：Journal of neurochemistry

authors： Giovanni A,Liang LP,Hastings TG,Zigmond MJ

更新日期：1995-04-01 00:00:00

abstract：:Mitochondrial dysfunction represents a critical event during the pathogenesis of Parkinson's disease (PD) and expanding evidences demonstrate that an altered balance in mitochondrial fission/fusion is likely an important mechanism leading to mitochondrial and neuronal dysfunction/degeneration. In this study, we invest...

journal_title：Journal of neurochemistry

authors： Wang X,Petrie TG,Liu Y,Liu J,Fujioka H,Zhu X

更新日期：2012-06-01 00:00:00

abstract：:In this report we demonstrate that a defective herpes simplex virus type one (HSV-1) vector can express enzymatically active tyrosine hydroxylase in cultured striatal cells that are thereby converted into L-DOPA-producing cells. A human tyrosine hydroxylase cDNA (form II) was inserted into an HSV-1 vector (pHSVth) and...

journal_title：Journal of neurochemistry

authors： Geller AI,During MJ,Oh YJ,Freese A,O'Malley K

更新日期：1995-02-01 00:00:00

abstract：:Abnormal tau accumulations were observed and documented in post-mortem brains of patients affected by Alzheimer's disease (AD) long before the identification of mutations in the Microtubule-associated protein tau (MAPT) gene, encoding the tau protein, in a different neurodegenerative disease called Frontotemporal deme...

journal_title：Journal of neurochemistry

authors： Hannan SB,Dräger NM,Rasse TM,Voigt A,Jahn TR

更新日期：2016-04-01 00:00:00

abstract：:Aromatic L-amino acid decarboxylase (AAAD) activity of the rat retina increases when animals are placed in a lighted environment from the dark. The rise of activity can be inhibited by administering alpha 2 adrenoceptor agonists. In the dark, the enzyme activity can be made to increase by administering alpha 2 adrenoc...

journal_title：Journal of neurochemistry

authors： Rossetti Z,Krajnc D,Neff NH,Hadjiconstantinou M

更新日期：1989-02-01 00:00:00

abstract：:The photic regulation of heme oxygenase (HO) activity was examined in the golden hamster retina. This enzymatic activity was significantly higher at midday than at midnight. When the hamsters were placed under constant darkness for 48 h and killed at subjective day or at subjective night, the differences in HO activit...

journal_title：Journal of neurochemistry

authors： Sacca GB,Sáenz DA,Jaliffa CO,Minces L,Keller Sarmiento MI,Rosenstein RE

更新日期：2003-04-01 00:00:00

abstract：:A recent study has linked the butyrylcholinesterase (BChE) K-variant and the apolipoprotein epsilon4 isoform to late-onset Alzheimer's disease. These findings have been controversial and have led us to examine the differences between wild-type and K-variant BChE in enzyme activity, protein stability, and quaternary st...

journal_title：Journal of neurochemistry

authors： Altamirano CV,Bartels CF,Lockridge O

更新日期：2000-02-01 00:00:00

abstract：:Increasing reports support that air pollution causes neuroinflammation and is linked to central nervous system (CNS) disease/damage. Diesel exhaust particles (DEP) are a major component of urban air pollution, which has been linked to microglial activation and Parkinson's disease-like pathology. To begin to address ho...

journal_title：Journal of neurochemistry

authors： Levesque S,Taetzsch T,Lull ME,Johnson JA,McGraw C,Block ML

更新日期：2013-06-01 00:00:00

abstract：:We addressed the balance between thrombin and its serpin protease nexin I (PNI) after sciatic nerve injury in the mouse. Prothrombin levels increased twofold 24 h after nerve crush, as measured by a specific chromogenic assay, and peaked at day 3. Thrombin activity also increased 2-4 days after injury in distal sciati...

journal_title：Journal of neurochemistry

authors： Smirnova IV,Ma JY,Citron BA,Ratzlaff KT,Gregory EJ,Akaaboune M,Festoff BW

更新日期：1996-11-01 00:00:00

abstract：:rho(1) GABA(C) receptor antagonists inhibit myopia in chick but the site of this effect is not known. The sclera ultimately determines the shape and size of the globe and thus an untested possibility is that GABA agents have a scleral mechanism. Whether rho(1) GABA(C) receptors are expressed and located in chick scler...

journal_title：Journal of neurochemistry

authors： Cheng ZY,Chebib M,Schmid KL

更新日期：2011-07-01 00:00:00

abstract：:We applied our in vivo fatty acid method to examine concentrations, incorporation, and turnover rates of docosahexaenoic acid (22:6 n-3) in brains of rats subject to a dietary deficiency of alpha-linolenic acid (18:3 n-3) for three generations. Adult deficient and adequate rats of the F3 generation were infused intrav...

journal_title：Journal of neurochemistry

authors： Contreras MA,Greiner RS,Chang MC,Myers CS,Salem N Jr,Rapoport SI

更新日期：2000-12-01 00:00:00

abstract：:G protein-coupled receptors are important regulators of cellular signaling processes. Within the large family of rhodopsin-like receptors, those binding to biogenic amines form a discrete subgroup. Activation of biogenic amine receptors leads to transient changes of intracellular Ca²⁺-([Ca²⁺](i)) or 3',5'-cyclic adeno...

journal_title：Journal of neurochemistry

authors： Balfanz S,Jordan N,Langenstück T,Breuer J,Bergmeier V,Baumann A

更新日期：2014-04-01 00:00:00

abstract：:Increased awareness for a role of oxidative stress in the pathogenesis of Alzheimer's disease has highlighted the issue of whether oxidative damage is a fundamental step in the pathogenesis or instead results from disease-associated pathology. In vitro experiments support both possibilities: Oxidative stress increases...

journal_title：Journal of neurochemistry

authors： Smith MA,Hirai K,Hsiao K,Pappolla MA,Harris PL,Siedlak SL,Tabaton M,Perry G

更新日期：1998-05-01 00:00:00

abstract：:The current study used an ethanol antagonist, increased atmospheric pressure, to test the hypothesis that ethanol acts on multiple sites in glycine receptors (GlyRs). The effects of 12 times normal atmospheric pressure of helium-oxygen gas (pressure) on ethanol-induced potentiation of GlyR function in Xenopus oocytes ...

journal_title：Journal of neurochemistry

authors： Davies DL,Crawford DK,Trudell JR,Mihic SJ,Alkana RL

更新日期：2004-06-01 00:00:00

abstract：:The biophysical properties of NMDA receptors are thought to be critical determinants involved in the regulation of long-term synaptic plasticity during neocortical development. NMDA receptor channel properties are strongly dependent on the subunit composition of heteromeric NMDA receptors. During neocortical developme...

journal_title：Journal of neurochemistry

authors： Hoffmann H,Gremme T,Hatt H,Gottmann K

更新日期：2000-10-01 00:00:00