Solubilization of brain benzodiazepine receptors with a zwitterionic detergent: optimal preservation of their functional interaction with the GABA receptors.

abstract：:The effects of a potent adenosine deaminase inhibitor, deoxycoformycin, on purine and amino acid neuro-transmitter release from the ischemic rat cerebral cortex were studied with the cortical cup technique. Cerebral ischemia (20 min) was elicited by four-vessel occlusion. Purine and amino acid releases were compared f...

journal_title：Journal of neurochemistry

authors： Phillis JW,Walter GA,Simpson RE

更新日期：1991-02-01 00:00:00

abstract：:Lipocalin-type prostaglandin (PG) D synthase (L-PGDS) is responsible for the production of PGD(2), the main PG in the CNS. PGD(2) is an endogenous sleep inducer, and it is involved in the control of odor and pain responses and body temperature. In addition, PGD synthase transports lipophilic molecules in the subarachn...

journal_title：Journal of neurochemistry

authors： García-Fernández LF,Iñiguez MA,Eguchi N,Fresno M,Urade Y,Muñoz A

更新日期：2000-08-01 00:00:00

abstract：:Chronic exposure to the pesticide rotenone induces a selective degeneration of nigrostriatal dopaminergic neurons and reproduces the features of Parkinson's disease in experimental animals. This action is thought to be relevant to its inhibition of the mitochondrial complex I, but the precise mechanism of this suppres...

journal_title：Journal of neurochemistry

authors： Moon Y,Lee KH,Park JH,Geum D,Kim K

更新日期：2005-06-01 00:00:00

abstract：:In this report we demonstrate that a defective herpes simplex virus type one (HSV-1) vector can express enzymatically active tyrosine hydroxylase in cultured striatal cells that are thereby converted into L-DOPA-producing cells. A human tyrosine hydroxylase cDNA (form II) was inserted into an HSV-1 vector (pHSVth) and...

journal_title：Journal of neurochemistry

authors： Geller AI,During MJ,Oh YJ,Freese A,O'Malley K

更新日期：1995-02-01 00:00:00

abstract：:cAMP is known to regulate neurotransmitter release via protein kinase A (PKA)-dependent and/or PKA-independent signal transduction pathways at a variety of central synapses. Here we report the cAMP-mediated long-lasting enhancement of glycinergic transmission in developing rat spinal substantia gelatinosa neurons. For...

journal_title：Journal of neurochemistry

authors： Choi IS,Nakamura M,Cho JH,Park HM,Kim SJ,Kim J,Lee JJ,Choi BJ,Jang IS

更新日期：2009-09-01 00:00:00

abstract：:The rat pheochromocytoma PC12 cell line has been an invaluable model system for studying neuritogenesis. Nerve growth factor (NGF) elicits multiple aspects of neurite outgrowth in PC12 cells. It is therefore difficult to dissect and assign an individual signaling pathway to each stage of neuritogenesis. We have recent...

journal_title：Journal of neurochemistry

authors： Xiao J,Liu Y

更新日期：2003-09-01 00:00:00

abstract：:Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis, catalyzes the conversion of tyrosine to DOPA, Cyclic AMP-dependent protein phosphorylation conditions alter tyrosine hydroxylase activity in rat striatal homogenates. In agreement with other laboratories, we find that short-term pre-incubati...

journal_title：Journal of neurochemistry

authors： Vrana KE,Allhiser CL,Roskoski R Jr

更新日期：1981-01-01 00:00:00

abstract：:It is well established that chronic nicotine treatment produces a dose-dependent increase in high-affinity L-[3H]nicotine binding. This increase may be due to chronic desensitization of the receptor. Sophisticated kinetic analyses of high-affinity nicotine binding to rat brain have demonstrated that the association ra...

journal_title：Journal of neurochemistry

authors： Bhat RV,Marks MJ,Collins AC

更新日期：1994-02-01 00:00:00

abstract：:Primary neuronal cultures from 8-day-old rat cerebellum were incubated in the presence of exogenously added 16 nM [gamma-32P]ATP. Phosphorylation of a 45-kDa endogenous protein was detected within 1 min and increased linearly for approximately 20 min. Unlike what was seen with [gamma-32P]ATP, in the presence of [32P]o...

journal_title：Journal of neurochemistry

authors： Volonté C,Merlo D,Ciotti MT,Calissano P

更新日期：1994-12-01 00:00:00

abstract：:Rat brain succinyl-CoA:3-oxo-acid CoA-transferase (3-oxo-acid CoA-transferase, EC 2.8.3.5), the first committed enzyme in the oxidation of ketone bodies in mitochondria, was purified to apparent homogeneity as judged by polyacrylamide gel electrophoresis. The enzyme has an apparent molecular weight of 90,000 as determ...

journal_title：Journal of neurochemistry

authors： Russell JJ,Patel MS

更新日期：1982-05-01 00:00:00

abstract：:In the rat parotid gland, substance P has been shown to induce a phosphatidylinositol bisphosphate breakdown resulting in an inositol trisphosphate production. These data suggested that substance P activated a phospholipase C and thus mediated its effects through the calcium-phospholipid pathway. To determine which ne...

journal_title：Journal of neurochemistry

authors： Guillemain I,Rollandy I,Imhoff V,Rossignol B

更新日期：1992-06-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disorder characterized pathologically by motor neuron degeneration and associated with aggregation of RNA-binding proteins. TATA-binding protein-associated factor 15 (TAF15) accumulates as cytoplasmic aggregates in neuronal cells, and clearance of these...

journal_title：Journal of neurochemistry

authors： Choi HJ,Joo Cha S,Do HA,Kim HJ,Lee JW,Kim K

更新日期：2020-09-11 00:00:00

abstract：:Microdialysis in the awake, freely moving rat was used to determine the effect of pyrithiamine-induced thiamine deficiency on the levels of amino acids in the brain. Studies were carried out on (a) presymptomatic animals immediately before the development of behavioral changes and (b) acute symptomatic animals within ...

journal_title：Journal of neurochemistry

authors： Hazell AS,Butterworth RF,Hakim AM

更新日期：1993-09-01 00:00:00

abstract：:A monoclonal antibody (8-18C5) directed against myelin/oligodendrocyte glycoprotein (MOG) induced demyelination in aggregating brain cell cultures. With increasing doses of anti-MOG antibody in the presence of complement, myelin basic protein (MBP) concentration decreased in a dose-related manner. A similar, albeit le...

journal_title：Journal of neurochemistry

authors： Kerlero de Rosbo N,Honegger P,Lassmann H,Matthieu JM

更新日期：1990-08-01 00:00:00

abstract：:Astrogliosis occurs after brain ischemia, and excessive astrogliosis can devastate the neuronal recovery. Previous reports show that galectin-1 (Gal-1) regulates proliferation of several cell types and plays an important role after nervous system injuries. Here, we found that expression of Gal-1 was remarkably up-regu...

journal_title：Journal of neurochemistry

authors： Qu WS,Wang YH,Ma JF,Tian DS,Zhang Q,Pan DJ,Yu ZY,Xie MJ,Wang JP,Wang W

更新日期：2011-01-01 00:00:00

abstract：:Nanomolar β-amyloid peptide (Aβ) can induce neuronal loss in culture by activating microglia to phagocytose neurons. We report here that this neuronal loss is mediated by the bridging protein lactadherin/milk-fat globule epidermal growth factor-like factor 8 (MFG-E8), which is released by Aβ-activated microglia, binds...

journal_title：Journal of neurochemistry

authors： Neniskyte U,Brown GC

更新日期：2013-08-01 00:00:00

abstract：:Stroke is the third leading cause of death as dementia is a main symptom of Alzheimer's disease. One of the important mechanisms in the pathogeny of stroke is free radical production during the reperfusion period, therefore the effects of a type of natural antioxidant, i.e. Crataegus flavonoids (CF), on brain ischemic...

journal_title：Journal of neurochemistry

authors： Zhang DL,Zhang YT,Yin JJ,Zhao BL

更新日期：2004-07-01 00:00:00

abstract：:Functional activation of NMDA receptors requires co-activation of glutamate- and glycine-binding sites. D-serine is considered to be an endogenous ligand for the glycine site of NMDA receptors. Using a combination of a rat formalin-induced conditioned place avoidance (F-CPA) behavioral model and whole-cell patch-clamp...

journal_title：Journal of neurochemistry

authors： Ren WH,Guo JD,Cao H,Wang H,Wang PF,Sha H,Ji RR,Zhao ZQ,Zhang YQ

更新日期：2006-03-01 00:00:00

abstract：:Unilateral ligation of the left common carotid artery in anesthetized Mongolian gerbils resulted in a steep rise in extracellular dopamine in the ipsilateral striatum in 9 out of 19 animals. Extracellular dopamine was measured by cerebral dialysis in vivo and reached a peak of 0.19 mM at 40 min. At the same time, the ...

journal_title：Journal of neurochemistry

authors： Slivka A,Brannan TS,Weinberger J,Knott PJ,Cohen G

更新日期：1988-06-01 00:00:00

abstract：:In the PNS, ciliary neurotrophic factor (CNTF) is found in significant amounts in the adult sciatic nerve, localized to myelin-related Schwann cells (SCs). Levels are undetectable in newborn but high in adult animals. After crush injury, CNTF production is reduced, recovering only as the nerve regenerates; if regenera...

journal_title：Journal of neurochemistry

authors： Lee DA,Zurawel RH,Windebank AJ

更新日期：1995-08-01 00:00:00

abstract：:Dopamine- and cAMP-regulated phosphoprotein (Mr 32 kDa, DARPP-32) is an integrator of multiple neuronal signals and plays a crucial role particularly in mediating the dopaminergic component of the systems involved in the evaluation of stimuli and the ensuing elaboration of complex behavioral responses (e.g., responses...

journal_title：Journal of neurochemistry

authors： Scheggi S,De Montis MG,Gambarana C

更新日期：2018-11-01 00:00:00

abstract：:Myelin was isolated from the brains of 16-day-old rabbits that had received intracerebral injections of [32P]orthophosphate 24 h earlier. The basic protein was extracted and examined by polyacrylamide gel electrophoresis both at low and at high pH. At low pH a single band corresponding to the basic protein contained a...

journal_title：Journal of neurochemistry

authors： Agrawal HC,Martenson RE,Agrawal D

更新日期：1982-12-01 00:00:00

abstract：:Previous histological, electrophysiological, and biochemical reports have addressed the hypothesis that serotonin functions as a neurotransmitter in mammalian retinas. We have tested the effect on the levels of cyclic AMP of the application of exogenous serotonin, 5-methoxytryptamine, melatonin, and 5-methoxydimethyl-...

journal_title：Journal of neurochemistry

authors： Blazynski C,Ferrendelli JA,Cohen AI

更新日期：1985-08-01 00:00:00

abstract：:The loss of ATP, which is needed for ionic homeostasis, is an early event in the neurotoxicity of glutamate and beta-amyloid (A(beta)). We hypothesize that cells supplemented with the precursor creatine make more phosphocreatine (PCr) and create larger energy reserves with consequent neuroprotection against stressors....

journal_title：Journal of neurochemistry

authors： Brewer GJ,Wallimann TW

更新日期：2000-05-01 00:00:00

abstract：:We previously reported that pretreatment of murine cortico-hippocampal neuronal cultures with the complement-derived anaphylatoxin C5a, protects against glutamate neurotoxicity. In this study we explored the potential mechanisms involved in C5a-mediated neuroprotection. We found that C5a neuroprotects in vitro through...

journal_title：Journal of neurochemistry

authors： Mukherjee P,Pasinetti GM

更新日期：2001-04-01 00:00:00

abstract：:Sodium-dependent, high-affinity glutamate transport is generally assumed to limit the toxicity of glutamate in vivo and in vitro, but there is very little direct evidence to support this hypothesis. In the present study, the effects of the specific uptake inhibitor L-trans-pyrrolidine-2,4-dicarboxylate on the toxicity...

journal_title：Journal of neurochemistry

authors： Robinson MB,Djali S,Buchhalter JR

更新日期：1993-12-01 00:00:00

abstract：:The possibilities of interference by glycerophosphoryl ethanolamine (GPE) in the estimation of taurine levels in cerebral cortex, midbrain, cerebellum, medullapons, and spinal cord of developing human fetal brain regions were eliminated by hydrolyzing tissue extracts with 6 M HCl. Cysteic acid thus produced was separa...

journal_title：Journal of neurochemistry

authors： Datta SC

更新日期：1988-04-01 00:00:00

abstract：:Neolactoglycolipids are derived from neolactotetraosylceramide (nLcOse4Cer). They are found during the embryonic and neonatal developmental periods in the rat cerebral cortex and disappear shortly after birth. These glycolipids are, however, abundant in the adult cerebellum. Lactotriosylceramide (LcOse3Cer):galactosyl...

journal_title：Journal of neurochemistry

authors： Chou DK,Jungalwala FB

更新日期：1994-01-01 00:00:00

abstract：:Studies on glial cultures have demonstrated that fetal bovine serum contains a factor that induces bipotential glial precursors known as oligodendrocyte-type 2 astrocyte (O-2A) progenitors to become type 2 astroglia rather than oligodendroglia. The goal of this research project was to characterize and purify this fact...

journal_title：Journal of neurochemistry

authors： Levison SW,McCarthy KD

更新日期：1991-09-01 00:00:00

abstract：:Calcium-activated neutral proteases (calpains) are regulated by specific endogenous protein inhibitors, the calpastatins, which are widely distributed in mammalian tissues. Calpastatins from different species or in various tissues from the same species exhibit considerable size heterogeneity on sodium dodecyl sulfate ...

journal_title：Journal of neurochemistry

authors： Mohan PS,Nixon RA

更新日期：1995-02-01 00:00:00