An HSV-1 vector expressing tyrosine hydroxylase causes production and release of L-dopa from cultured rat striatal cells.

abstract：:Transforming growth factor-beta1 (TGF-beta1) has central functions in development, tissue maintenance, and repair and has been implicated in major diseases. We discovered that TGF-beta1 contains several amphipathic helices and hydrophobic domains similar to apolipoprotein E (apoE), a protein involved in lipoprotein me...

journal_title：Journal of neurochemistry

authors： Tesseur I,Zhang H,Brecht W,Corn J,Gong JS,Yanagisawa K,Michikawa M,Weisgraber K,Huang Y,Wyss-Coray T

更新日期：2009-08-01 00:00:00

abstract：:The Ret receptor tyrosine kinase is the common signaling receptor for the glial cell line-derived neurotrophic factor (GDNF) family ligands. The Met918Thr mutation leads to constitutive activation of Ret and is responsible for dominantly inherited cancer syndrome MEN2B. Previously, we found that the mice carrying the ...

journal_title：Journal of neurochemistry

authors： Mijatovic J,Patrikainen O,Yavich L,Airavaara M,Ahtee L,Saarma M,Piepponen TP

更新日期：2008-06-01 00:00:00

abstract：:The present study demonstrates that [3H]imipramine binds to both high- and low-affinity imipramine binding components on membranes prepared from rat cerebral cortex. Scatchard and computer analyses of saturation experiments using a wide range of [3H]imipramine concentrations (0.5 nM-50 nM) revealed the presence of two...

journal_title：Journal of neurochemistry

authors： Conway PG,Brunswick DJ

更新日期：1985-07-01 00:00:00

abstract：:Rats with unilateral lesions of the locus coeruleus were used to study the role of norepinephrine (NE) signal input in the down-regulation by antidepressants of the noradrenergic cyclic AMP-generating system in the cortex. Chronic administration of both desipramine (blockade of NE reuptake) and iprindole (no blockade ...

journal_title：Journal of neurochemistry

authors： Janowsky A,Steranka LR,Gillespie DD,Sulser F

更新日期：1982-07-01 00:00:00

abstract：:Hypoxic preconditioning (HP) 24 h before hypoxic-ischemic (HI) injury confers significant neuroprotection in neonatal rat brain. Recent studies have shown that the mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K) intracellular signaling pathways play a role in the induction of tolerance...

journal_title：Journal of neurochemistry

authors： Jones NM,Bergeron M

更新日期：2004-04-01 00:00:00

abstract：:Metabotropic glutamate receptor (type 1; mGluR1) is expressed predominantly in the hippocampus and the cerebellum. Using cultured cerebellar granule cells, we investigated the regulation of the mGluR1 mRNA expression. Levels of mGluR1 mRNA were decreased to less than half by high potassium stimulation and by glutamate...

journal_title：Journal of neurochemistry

authors： Bessho Y,Nawa H,Nakanishi S

更新日期：1993-01-01 00:00:00

abstract：:PC12D cells, a new subline of conventional PC12 cells, respond not only to nerve growth factor but also to cyclic AMP by extending their neurites. These cells are flat in shape and are similar in appearance to PC12 cells that have been treated with nerve growth factor for a few days. In both cell lines, we have charac...

journal_title：Journal of neurochemistry

authors： Katoh-Semba R,Oohira A,Sano M,Watanabe K,Kitajima S,Kashiwamata S

更新日期：1989-03-01 00:00:00

abstract：:Aminoguanidine inhibits the development of retinopathy in diabetic animals, but the mechanism remains unclear. Inasmuch as aminoguanidine is a relatively selective inhibitor of the inducible isoform of nitric oxide synthase (iNOS), we have investigated the effects of hyperglycemia on the retinal nitric oxide (NO) path...

journal_title：Journal of neurochemistry

authors： Du Y,Smith MA,Miller CM,Kern TS

更新日期：2002-03-01 00:00:00

abstract：:Intracellular protein inclusions in Alzheimer's disease and progressive supranuclear palsy contain UBB+1, a variant ubiquitin. UBB+1 is able block the 26S proteasome in cell lines. Proteasome inhibition by drug action has previously been shown to induce a heat-shock response and render protection against stress. We in...

journal_title：Journal of neurochemistry

authors： Hope AD,de Silva R,Fischer DF,Hol EM,van Leeuwen FW,Lees AJ

更新日期：2003-07-01 00:00:00

abstract：:Arg0-Met5-enkephalin (Arg0-MEK) was isolated from bovine striatum and purified to homogeneity. The peptide was extracted with trichloroacetic acid, followed by column chromatography successively on Bio-Sil C8, semipreparative HPLC Radial-Pak C18, fast protein liquid chromatography (FPLC) Mono S, HPLC Ultrasphere-ODS, ...

journal_title：Journal of neurochemistry

authors： Hui KS,Lo ES,Hui MP

更新日期：1994-11-01 00:00:00

abstract：:This Editorial highlights a study by Xia and coworkers in the current issue of the Journal of Neurochemistry, in which the authors reveal a possible mechanistic link between DISC1 (disrupted-in-schizophrenia-1), a genetic risk factor for schizophrenia, and N-methyl-d-aspartate receptor (NMDAR) that is also linked with...

journal_title：Journal of neurochemistry

authors： Wu S,Barger SW

更新日期：2016-08-01 00:00:00

abstract：:The exact molecular mechanism of ischemic neuronal death still remains unclear from rodents to primates. A number of studies using lower species animals have suggested implication of apoptosis cascade, while using monkeys the authors recently claimed necrosis cascade by calpain-induced leakage of lysosomal cathepsins ...

journal_title：Journal of neurochemistry

authors： Tsukada T,Watanabe M,Yamashima T

更新日期：2001-12-01 00:00:00

abstract：:Glial uptake of neurotransmitter glutamate (GLU) from the extracellular fluid was studied in vivo in rat brain by (13)C NMR and microdialysis combined with gas-chromatography/mass-spectrometry. Brain GLU C5 was (13)C enriched by intravenous [2,5-(13)C]glucose infusion, followed by [(12)C]glucose infusion to chase (13)...

journal_title：Journal of neurochemistry

authors： Kanamori K,Ross BD,Kondrat RW

更新日期：2002-11-01 00:00:00

abstract：:Depletion of glutathione in the substantia nigra is one of the earliest changes observed in Parkinson's disease (PD) and could initiate dopaminergic neuronal degeneration. Nevertheless, experimental glutathione depletion does not result in preferential toxicity to dopaminergic neurons either in vivo or in vitro. Moreo...

journal_title：Journal of neurochemistry

authors： Nakamura K,Wright DA,Wiatr T,Kowlessur D,Milstien S,Lei XG,Kang UJ

更新日期：2000-06-01 00:00:00

abstract：:One of the most striking features of neurons in the mature peripheral nervous system is their ability to survive and to regenerate their axons following axonal injury. To perform a comprehensive survey of the molecular mechanisms that underlie peripheral nerve regeneration, we analyzed a cDNA library derived from the ...

journal_title：Journal of neurochemistry

authors： Kubo T,Yamashita T,Yamaguchi A,Hosokawa K,Tohyama M

更新日期：2002-09-01 00:00:00

abstract：:The effect of depolarizing concentrations of potassium (56 mM) on the release of [3H]taurine was examined in two types of cultured neurons from mouse brain: cerebral cortex neurons, which are largely GABAergic, and cerebellar neurons, which after treatment with kainate consist almost entirely of glutamatergic granule ...

journal_title：Journal of neurochemistry

authors： Schousboe A,Pasantes-Morales H

更新日期：1989-10-01 00:00:00

abstract：:Trichloroethylene, a chlorinated solvent widely used as a degreasing agent, is a common environmental contaminant. Emerging evidence suggests that chronic exposure to trichloroethylene may contribute to the development of Parkinson's disease. The purpose of this study was to determine if selective loss of nigrostriata...

journal_title：Journal of neurochemistry

authors： Liu M,Choi DY,Hunter RL,Pandya JD,Cass WA,Sullivan PG,Kim HC,Gash DM,Bing G

更新日期：2010-02-01 00:00:00

abstract：:Tryptophan hydroxylase (TPH) is the initial and rate-limiting enzyme in serotonin biosynthesis. The enzyme activity is dependent on molecular oxygen, a tetrahydropterin cosubstrate, and ferrous iron. The present study demonstrates that TPH is inhibited by a novel compound, p-ethynylphenylalanine (pEPA), produced by th...

journal_title：Journal of neurochemistry

authors： Stokes AH,Xu Y,Daunais JA,Tamir H,Gershon MD,Butkerait P,Kayser B,Altman J,Beck W,Vrana KE

更新日期：2000-05-01 00:00:00

abstract：:Each of the known classes of mammalian glycosaminoglycans, with the exception of keratan sulphate, was found in cerebral cortex samples from patients with Alzheimer-type dementia and age-matched controls. These molecules were quantitated, after electrophoresis and staining with Alcian Blue dye, by scanning densitometr...

journal_title：Journal of neurochemistry

authors： Jenkins HG,Bachelard HS

更新日期：1988-11-01 00:00:00

abstract：:Neuromelanin is a dark brown pigment present at high concentrations in dopaminergic neurones of the human substantia nigra (SN). Early electron microscopic examinations of neuromelanin fine structure revealed a significant neutral lipid component; however, the identity of this lipid has remained unknown. Here we show ...

journal_title：Journal of neurochemistry

authors： Fedorow H,Pickford R,Hook JM,Double KL,Halliday GM,Gerlach M,Riederer P,Garner B

更新日期：2005-02-01 00:00:00

abstract：:Rats fasted overnight were allowed to consume single meals containing 0, 18, or 40% protein or continued to fast; after 2 h, brains and sera were taken and assayed for various amino acids. In general, serum levels of most amino acids were reduced by the 0% protein meal and elevated by the high-protein meal when compar...

journal_title：Journal of neurochemistry

authors： Glaeser BS,Maher TJ,Wurtman RJ

更新日期：1983-10-01 00:00:00

abstract：:Because of the relative impermeability of the blood-brain barrier (BBB), many drugs are unable to reach the CNS in therapeutically relevant concentration. One method to deliver drugs to the CNS is the osmotic opening of the BBB using mannitol. Hyperosmotic mannitol induces a strong phosphorylation on tyrosine residues...

journal_title：Journal of neurochemistry

authors： Wilhelm I,Nagyoszi P,Farkas AE,Couraud PO,Romero IA,Weksler B,Fazakas C,Dung NT,Bottka S,Bauer H,Bauer HC,Krizbai IA

更新日期：2008-10-01 00:00:00

abstract：:Summary During hypoxia, ATP was released from type I (glomus) cells in the carotid bodies. We studied the action of ATP on the intracellular Ca(2+) concentration ([Ca(2+)](i)) of type I cells dissociated from rat carotid bodies using a Ca(2+) imaging technique. ATP did not affect the resting [Ca(2+)](i) but strongly s...

journal_title：Journal of neurochemistry

authors： Xu J,Xu F,Tse FW,Tse A

更新日期：2005-03-01 00:00:00

abstract：:Microinfarcts are small, but strikingly common, ischemic brain lesions in the aging human brain. There is mounting evidence that microinfarcts contribute to vascular cognitive impairment and dementia, but the origins of microinfarcts are unclear. Understanding the vascular pathologies that cause microinfarcts may yiel...

journal_title：Journal of neurochemistry

authors： Hartmann DA,Hyacinth HI,Liao FF,Shih AY

更新日期：2018-03-01 00:00:00

abstract：:We examined the effects of chronic (2 weeks) treatment with a typical neuroleptic, haloperidol (1 mg/kg, s.c.), and an atypical neuroleptic, clozapine (20 mg/kg, s.c.), on neurotensin receptor (NTR) mRNA levels by in situ hybridization histochemistry. Quantitative OD analysis showed haloperidol-induced NTR mRNA levels...

journal_title：Journal of neurochemistry

authors： Bolden-Watson C,Watson MA,Murray KD,Isackson PJ,Richelson E

更新日期：1993-09-01 00:00:00

abstract：:Gamma-Aminobutyric acid (GABA) was taken up by a MgATP-dependent mechanism into synaptic vesicles isolated by hypoosmotic shock and density gradient centrifugation. The properties of the vesicular uptake differed clearly from those of synaptosomal and glial uptake, both with respect to Na+, Mg2+, and ATP dependence an...

journal_title：Journal of neurochemistry

authors： Fykse EM,Fonnum F

更新日期：1988-04-01 00:00:00

abstract：:Clearance rates for serotonin (5-HT) in heterozygote (+/-) and homozygote (-/-) serotonin transporter (5-HTT) knockout (KO) mice have not been determined in vivo. Moreover, the effect of selective serotonin reuptake inhibitors (SSRIs) on 5-HT clearance in these mice has not been examined. In this study, the rate of cl...

journal_title：Journal of neurochemistry

authors： Montañez S,Owens WA,Gould GG,Murphy DL,Daws LC

更新日期：2003-07-01 00:00:00

abstract：:Melatonin is neuroprotective because of its antioxidative action, but it also can modify neuronal vulnerability by altering gene expression. 5-Lipoxygenase (5-LO) gene expression is suppressed by the binding of melatonin to its high-affinity nuclear receptors. Recently, we reported that in rats the melatonin deficienc...

journal_title：Journal of neurochemistry

authors： Uz T,Longone P,Manev H

更新日期：1997-11-01 00:00:00

abstract：:GTP binding regulatory protein (G protein)-coupled receptors can activate MAPK pathways via G protein-dependent and -independent mechanisms. However, the physiological outcomes correlated with the cellular signaling events are not as well characterized. In this study, we examine the involvement of G protein and beta-a...

journal_title：Journal of neurochemistry

authors： McLennan GP,Kiss A,Miyatake M,Belcheva MM,Chambers KT,Pozek JJ,Mohabbat Y,Moyer RA,Bohn LM,Coscia CJ

更新日期：2008-12-01 00:00:00

abstract：:Monoclonal antibodies were raised against the synaptosomal plasma membranes (SPMs) purified from the electric organ of the Torpedo. One antibody that reacts preferentially with SPMs rather than with other membrane fractions isolated from this tissue was previously found to inhibit hydrophilic and amphiphilic choline-O...

journal_title：Journal of neurochemistry

authors： Eder-Colli L,Briand PA,Pellegrinelli N,Dunant Y

更新日期：1989-11-01 00:00:00