Indoleamine-sensitive adenylate cyclase in rabbit retina: characterization and distribution.

abstract：:Endogenous norepinephrine (NE) release in cerebral cortex slices taken from normal and morphine-tolerant guinea pigs was measured by HPLC. In normal slices, a linear relationship was found between electrically evoked NE release and the log of the frequency of stimulation in the range of 1-20 Hz. The efficiency of the ...

journal_title：Journal of neurochemistry

authors： Tomasini C,Guidorzi R,Bianchi C,Beani L

更新日期：1992-04-01 00:00:00

abstract：:Exosomes are small extracellular vesicles released by almost all cell types in physiological and pathological conditions. The exosomal potential to unravel disease mechanisms, or to be used as a source of biomarkers, is being explored, in particularly in the field of neurodegenerative diseases. Alzheimer's disease (AD...

journal_title：Journal of neurochemistry

authors： Soares Martins T,Trindade D,Vaz M,Campelo I,Almeida M,Trigo G,da Cruz E Silva OAB,Henriques AG

更新日期：2020-07-03 00:00:00

abstract：:We have previously shown that Regulator of Calcineurin 1 (RCAN1) regulates multiple stages of vesicle exocytosis. However, the mechanisms by which RCAN1 affects secretory vesicle exocytosis and quantal release kinetics remain unknown. Here, we use carbon fibre amperometry to detect exocytosis from chromaffin cells and...

journal_title：Journal of neurochemistry

authors： Zanin MP,Mackenzie KD,Peiris H,Pritchard MA,Keating DJ

更新日期：2013-02-01 00:00:00

abstract：:Previously used methods of comparing amperometric spike characteristics from two separate groups of cells have entailed pooling all the values for a spike characteristic from each group of cells and then statistically comparing the two samples. Although this approach has indicated that there are significant difference...

journal_title：Journal of neurochemistry

authors： Colliver TL,Hess EJ,Pothos EN,Sulzer D,Ewing AG

更新日期：2000-03-01 00:00:00

abstract：:Primary dopaminergic neuronal cultures with increased superoxide dismutase (SOD) activity were established for studying the role of superoxide anion (O2-) in 1-methyl-4-phenylpyridinium (MPP+)-induced degeneration of dopamine (DA) neurons. Mean SOD activity in cultures prepared from transgenic (human) Cu/Zn SOD (hSOD1...

journal_title：Journal of neurochemistry

authors： Sanchez-Ramos JR,Song S,Facca A,Basit A,Epstein CJ

更新日期：1997-01-01 00:00:00

abstract：:Five muscarinic receptor genes (m1-m5) that encode distinct muscarinic receptor subtypes have been cloned. Because of their structural homology and pharmacological similarity, ligand binding probes currently available do not clearly distinguish among the subtypes. To obtain a clear distribution within the CNS of molec...

journal_title：Journal of neurochemistry

authors： Wei J,Walton EA,Milici A,Buccafusco JJ

更新日期：1994-09-01 00:00:00

abstract：:Microglia are the main players of the brain immune response. They act as active sensors that rapidly respond to injurious insults by shifting into different activated states. Elevated levels of unconjugated bilirubin (UCB) induce cell death, immunostimulation and oxidative stress in both neurons and astrocytes. We rec...

journal_title：Journal of neurochemistry

authors： Silva SL,Osório C,Vaz AR,Barateiro A,Falcão AS,Silva RF,Brites D

更新日期：2011-05-01 00:00:00

abstract：:Sphingosine 1-phosphate (S1P) is accumulated in lipoproteins, especially high-density lipoprotein (HDL), in plasma. However, it remains uncharacterized how extracellular S1P is produced in the CNS. The treatment of rat astrocytes with retinoic acid and dibutyryl cAMP, which induce apolipoprotein E (apoE) synthesis and...

journal_title：Journal of neurochemistry

authors： Sato K,Malchinkhuu E,Horiuchi Y,Mogi C,Tomura H,Tosaka M,Yoshimoto Y,Kuwabara A,Okajima F

更新日期：2007-12-01 00:00:00

abstract：:Therapy of malignant glioma relies on treatment with the O6 -methylating agent temozolomide (TMZ) concomitant with ionizing radiation followed by adjuvant TMZ. For the treatment of recurrences, DNA chloroethylating drugs are also used. The main killing lesion induced by these drugs is O6 -alkylguanine. Since this dama...

journal_title：Journal of neurochemistry

authors： Aasland D,Reich TR,Tomicic MT,Switzeny OJ,Kaina B,Christmann M

更新日期：2018-01-01 00:00:00

abstract：:Semaphorins are a family of secreted and membrane-associated proteins involved in growth cone guidance during development. Here, we describe the interaction of Semaphorin4F (Sema4F) with the post-synaptic density protein SAP90/PSD-95. Using the yeast two-hybrid system and coprecipitation assays we were able to show an...

journal_title：Journal of neurochemistry

authors： Schultze W,Eulenburg V,Lessmann V,Herrmann L,Dittmar T,Gundelfinger ED,Heumann R,Erdmann KS

更新日期：2001-08-01 00:00:00

abstract：UNLABELLED:J. Neurochem. (2012) 121, 597-606. ABSTRACT:In cultured rat neocortical interneurons, we have studied the effect of long-term application of NMDA or AMPA on the surface density of the NMDA (GluN) receptor subunits GluN1 and GluN2B. Stimulation of Ca(2+) -permeable AMPA (GluA) receptors located on the intern...

journal_title：Journal of neurochemistry

authors： Meyer DK,Lindemeyer AK,Wilmes T,Sobottka H,Nörenberg W

更新日期：2012-05-01 00:00:00

abstract：:Abnormalities of alpha-synuclein (alpha-Syn) are mechanistically linked to Parkinson's disease (PD) and other alpha-synucleinopathies. To gain additional insights into the relationships between alpha-Syn expression and cell death, we examined the effects of expressing human alpha-Syn (Hualpha-Syn) variants on the cell...

journal_title：Journal of neurochemistry

authors： Li W,Lee MK

更新日期：2005-06-01 00:00:00

abstract：:Schwannoma-derived growth factor (SDGF) is a potent mitogen and neuronal differentiation factor. Because of its relationship to epidermal growth factor (EGF) and the heregulins, it was asked if SDGF interacts with the EGF receptor or HER2/neu. SDGF binds to and causes the phosphorylation on tyrosine of the EGF recepto...

journal_title：Journal of neurochemistry

authors： Maher PA,Schubert D

更新日期：1995-10-01 00:00:00

abstract：:Microelectrophoretic methods were used to study the effects on cat spinal neurones of a number of compounds structurally related to the gamma-aminobutyric acid (GABA) agonists muscimol, THIP, and isoguvacine. While N-methylmuscimol was an agonist at bicuculline methochloride-sensitive GABA receptors, somewhat weaker t...

journal_title：Journal of neurochemistry

authors： Krogsgaard-Larsen P,Hjeds H,Curtis DR,Leah JD,Peet MJ

更新日期：1982-11-01 00:00:00

abstract：:The intracerebroventricular injection of pyridoxal phosphate (PLP, 0.125-1.25 mumol/rat) causes epileptic seizures (4 min leads to 1 min) that are preventable or reversible by GABA (1 mumol/rat), by muscimol (0.025 mumol/rat), or by diazepam (1.75 mumol/rat). At the peak of PLP-induced convulsions, the activities of G...

journal_title：Journal of neurochemistry

authors： Kouyoumdjian JC,Ebadi M

更新日期：1981-01-01 00:00:00

abstract：:Multiple lines of evidence implicate lysosomes in a variety of pathogenic events that produce neurodegeneration. Genetic mutations that cause specific enzyme deficiencies account for more than 40 lysosomal storage disorders. These mostly pre-adult diseases are associated with abnormal brain development and mental reta...

journal_title：Journal of neurochemistry

authors： Bahr BA,Bendiske J

更新日期：2002-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common neurodegenerative disorder and is, on a histopathological level, characterized by the presence of extracellular amyloid plaques composed of the protein fragment Aβ, and intracellular neurofibrillary tangles, which contain the microtubule-associated protein tau in a hyperphos...

journal_title：Journal of neurochemistry

authors： Brandt R,Bakota L

更新日期：2017-11-01 00:00:00

abstract：:Ras-GAP SH3-domain-binding protein, G3BP, is an important component in the assembly of stress granules (SGs), which are cytoplasmic aggregates assembled following translational stress. To assess the physiological function of G3BP, we generated viable G3bp1-knockout (KO) mice, which demonstrated behavioral defects link...

journal_title：Journal of neurochemistry

authors： Martin S,Zekri L,Metz A,Maurice T,Chebli K,Vignes M,Tazi J

更新日期：2013-04-01 00:00:00

abstract：:Increase in oxidative stress has been postulated to play an important role in the pathogenesis of a number of neurodegenerative diseases including Alzheimer's disease. There is evidence for involvement of amyloid-beta peptide (Abeta) in mediating the oxidative damage to neurons. Despite yet unknown mechanism, Abeta ap...

journal_title：Journal of neurochemistry

authors： Shelat PB,Chalimoniuk M,Wang JH,Strosznajder JB,Lee JC,Sun AY,Simonyi A,Sun GY

更新日期：2008-07-01 00:00:00

abstract：:In recent years, there has been increasing evidence that serotonergic neurotransmission modulates a wide variety of experimentally induced seizures. Generally, agents that elevate extracellular serotonin (5-HT) levels, such as 5-hydroxytryptophan and serotonin reuptake blockers, inhibit both focal and generalized seiz...

journal_title：Journal of neurochemistry

authors： Bagdy G,Kecskemeti V,Riba P,Jakus R

更新日期：2007-02-01 00:00:00

abstract：:A non-invasive (13)C magnetic resonance spectroscopy (MRS) technique is described for the determination of the N-acetyl-L-aspartate (NAA) synthesis rate, V(NAA), in the human brain in vivo. In controls, the mean V(NAA) was 9.2 +/- 3.9 nmol/min/g. In Canavan disease, where [NAA] is increased (p < 0.001) and [aspartate]...

journal_title：Journal of neurochemistry

authors： Moreno A,Ross BD,Blüml S

更新日期：2001-04-01 00:00:00

abstract：:To study potential biochemical correlates of dopamine (DA) and serotonin receptor supersensitivity, rats were lesioned at 3 days after birth with 6-hydroxydopamine (6-OHDA; 67 micrograms in each lateral ventricle; desipramine pretreatment, 20 mg/kg i.p., 1 h) and then sensitized with the DA D1 agonist, SKF 38393 HCl (...

journal_title：Journal of neurochemistry

authors： Gong L,Kostrzewa RM,Li C

更新日期：1994-10-01 00:00:00

abstract：:By using a 125I-calmodulin overlay assay, three major high-affinity calmodulin-binding proteins, showing apparent molecular masses of 135, 60, and 50 kDa, have been detected in purified nuclear fractions isolated from rat neurons. It has been shown that after extraction of the nuclei with nucleases and high salt, all ...

journal_title：Journal of neurochemistry

authors： Pujol MJ,Bosser R,Vendrell M,Serratosa J,Bachs O

更新日期：1993-04-01 00:00:00

abstract：:P-glycoprotein (P-gp), an adenosine triphosphate (ATP)-binding cassette transporter which acts as a drug efflux pump, is highly expressed at the blood-brain barrier (BBB) where it plays an important role in brain protection. Recently, P-gp has been reported to be located in the caveolae of multidrug-resistant cells. I...

journal_title：Journal of neurochemistry

authors： Jodoin J,Demeule M,Fenart L,Cecchelli R,Farmer S,Linton KJ,Higgins CF,Béliveau R

更新日期：2003-11-01 00:00:00

abstract：:The lipid compositions of 10 different brain regions from patients affected by Alzheimer's disease/senile dementia of Alzheimer's type were analyzed. The total phospholipid amount decreased somewhat in nucleus caudatus and in white matter. The cortical areas that are morphologically affected by Alzheimer's disease, i....

journal_title：Journal of neurochemistry

authors： Söderberg M,Edlund C,Alafuzoff I,Kristensson K,Dallner G

更新日期：1992-11-01 00:00:00

abstract：:During development, dynamic changes in the axonal growth cone and dendrite are necessary for exploratory movements underlying initial axo-dendritic contact and ultimately the formation of a functional synapse. In the adult central nervous system, an impressive degree of plasticity is retained through morphological and...

journal_title：Journal of neurochemistry

authors： Gordon-Weeks PR,Fournier AE

更新日期：2014-04-01 00:00:00

abstract：:Acetylcholinesterase (AChE) is found both in motor end-plate (MEP)-free and MEP-rich regions of rat or mouse muscle. We studied the developmental aspects of the localization of asymmetric 16S AChE in both regions of the sternocleidomastoid muscle, which has a well-defined zone of motor innervation. In the rat, the pro...

journal_title：Journal of neurochemistry

authors： Rieger F,Goudou D,Tran LH

更新日期：1984-03-01 00:00:00

abstract：:U-78518F, a 21-aminosteroid from the novel family of lipid peroxidation inhibitors (lazaroids), increased survival of dopamine (DA) neurons in mesencephalic cell cultures incubated with the neurotoxin 1-methyl-4-phenylpyridinium (MPP+). Protection against DA neuron death occurred with increasing concentrations of U-78...

journal_title：Journal of neurochemistry

authors： Sanchez-Ramos JR,Song S,Mash DC,Weiner WJ

更新日期：1992-01-01 00:00:00

abstract：:Melanocortin-4 receptors (MC4 R) are unique among G-protein-coupled receptors (GPCRs) as they have endogenous ligands that can exhibit inverse agonistic properties in the case of elevated basal activity. It is known that the constitutive activity of GPCRs strongly affects the ligand-dependent physiological responses, ...

journal_title：Journal of neurochemistry

authors： Link R,Veiksina S,Tahk MJ,Laasfeld T,Paiste P,Kopanchuk S,Rinken A

更新日期：2020-05-01 00:00:00

abstract：:Current evidence indicates that glutamate acting via the N-methyl-D-aspartate (NMDA) receptor/ion channel complex plays a major role in the neuronal degeneration associated with a variety of neurological disorders. In this report the role of glycine in NMDA neurotoxicity was examined. We demonstrate that NMDA-mediated...

journal_title：Journal of neurochemistry

authors： Patel J,Zinkand WC,Thompson C,Keith R,Salama A

更新日期：1990-03-01 00:00:00