GluA and GluN receptors regulate the surface density of GluN receptor subunits in cultured neocortical interneurons.

abstract：:We are very sad that the ISN lost its President Kazuhiro Ikenaka, Professor and Chairman at National Institute for Physiological Sciences (NIPS), Director of Okazaki Institute of Integrative Biology. JNeurochem published an Obituary to value his outstanding achievements: Akio Wanaka et al. (2019) OBITUARY Kazuhiro Ike...

journal_title：Journal of neurochemistry

authors：

更新日期：2019-06-01 00:00:00

abstract：:We examined changes in biosynthetic capacity of sciatic nerve during the early stages of Wallerian degeneration, utilizing a model that permits exclusion of nonresident cells from degenerating nerve. Sciatic nerve segments were placed in either 5-microns pore (allowing infiltration of nonresident cells) or 0.22-micron...

journal_title：Journal of neurochemistry

authors： White FV,Toews AD,Goodrum JF,Novicki DL,Bouldin TW,Morell P

更新日期：1989-04-01 00:00:00

abstract：:To gain insight into the mechanism through which the neurotransmitter glutamate causally participates in several neurological diseases, in vitro cultured cerebellar granule cells were exposed to glutamate and oxygen radical production was investigated. To this aim, a novel procedure was developed to detect oxygen radi...

journal_title：Journal of neurochemistry

authors： Atlante A,Gagliardi S,Minervini GM,Ciotti MT,Marra E,Calissano P

更新日期：1997-05-01 00:00:00

abstract：:Dual-probe microdialysis was used to study interstitial diffusion in the rat brain. A radiolabelled tracer, (3H]mannitol, was continuously infused at different concentrations via a probe acutely implanted into the striatum of an anaesthetized male rat or into a dilute agar gel. Samples were collected by a second probe...

journal_title：Journal of neurochemistry

authors： Höistad M,Chen KC,Nicholson C,Fuxe K,Kehr J

更新日期：2002-04-01 00:00:00

abstract：:We examined the effects of wild-type and mutant atlastin-1 on vesicle transport in the endoplasmic reticulum (ER)-Golgi interface and vesicle budding from ER-derived microsomes using the temperature-sensitive reporter vesicular stomatitis virus glycoprotein (VSV-G), and the ability of purified atlastin-1 to form tubul...

journal_title：Journal of neurochemistry

authors： Muriel MP,Dauphin A,Namekawa M,Gervais A,Brice A,Ruberg M

更新日期：2009-09-01 00:00:00

abstract：:1-Methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) is known to cause a destruction of the dopaminergic nigrostriatal pathway in certain animal species including mice. MPTP and some structurally related analogs were tested in vitro for their capacity to inhibit the uptake of [3H]3,4-dihydroxyphenylethylamine-([3H]DA),...

journal_title：Journal of neurochemistry

authors： Heikkila RE,Youngster SK,Manzino L,Cabbat FS,Duvoisin RC

更新日期：1985-01-01 00:00:00

abstract：:Metallothionein (MT) protein and mRNA levels were monitored following exposure of rat neonatal primary astrocyte cultures to methylmercury (MeHg). MT-I and MT-II mRNAs were probed on northern blots with an [alpha-32P]dCTP-labeled synthetic cDNA probe specific for rat MT mRNA. MT-I and MT-II mRNAs were detected in untr...

journal_title：Journal of neurochemistry

authors： Rising L,Vitarella D,Kimelberg HK,Aschner M

更新日期：1995-10-01 00:00:00

abstract：:The normal developmental profile of preprotachykinin (PPT) gene expression was determined in rat striatum from embryonic day 20 to adulthood (greater than 45 days of age). At embryonic day 20, the amount of striatal PPT mRNA was approximately 8% of adult levels, and this specific mRNA approached adult levels by postna...

journal_title：Journal of neurochemistry

authors： Haverstick DM,Jeziorski M,Bannon MJ

更新日期：1990-09-01 00:00:00

abstract：:Exogenously administered estrogens can enhance the rate of increase of glucose 6-phosphate dehydrogenase activity in rat extensor digitorum longus muscles following denervation. In this communication, we report that the effect of denervation on glucose 6-phosphate dehydrogenase activity is modified by variations in en...

journal_title：Journal of neurochemistry

authors： Schaerf FW,Patz T,Max SR

更新日期：1982-06-01 00:00:00

abstract：:Postsynaptic interactions between dopamine and glutamate receptors in the nucleus accumbens are critical for acute responses to drugs of abuse and for neuroadaptations resulting from their chronic administration. We tested the hypothesis that D(1) dopamine receptor stimulation increases phosphorylation of the AMPA rec...

journal_title：Journal of neurochemistry

authors： Chao SZ,Lu W,Lee HK,Huganir RL,Wolf ME

更新日期：2002-06-01 00:00:00

abstract：:Myelin P2 protein is a small (14,800 Da) protein found in peripheral and central nervous system myelin. To investigate the regulation of expression of this myelin protein, a mouse genomic library was screened with a rabbit P2 cDNA (pSN2.2-2), and a single positive phage clone containing a 20-kb insert was obtained. Th...

journal_title：Journal of neurochemistry

authors： Narayanan V,Kaestner KH,Tennekoon GI

更新日期：1991-07-01 00:00:00

abstract：:Converging lines of evidence implicate the beta-amyloid peptide (Ass) as causative in Alzheimer's disease. We describe a novel class of compounds that reduce A beta production by functionally inhibiting gamma-secretase, the activity responsible for the carboxy-terminal cleavage required for A beta production. These mo...

journal_title：Journal of neurochemistry

authors： Dovey HF,John V,Anderson JP,Chen LZ,de Saint Andrieu P,Fang LY,Freedman SB,Folmer B,Goldbach E,Holsztynska EJ,Hu KL,Johnson-Wood KL,Kennedy SL,Kholodenko D,Knops JE,Latimer LH,Lee M,Liao Z,Lieberburg IM,Motter RN,

更新日期：2001-01-01 00:00:00

abstract：:The effect of phorbol esters was investigated on the down-regulation of protein kinase C (PKC) and on the release of [3H]norepinephrine (NE) in synaptosomes from the rat cerebrum. Treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) promoted the translocation of PKC activity in a P2 fraction from the cytosol to t...

journal_title：Journal of neurochemistry

authors： Oda T,Shearman MS,Nishizuka Y

更新日期：1991-04-01 00:00:00

abstract：:This study was undertaken to explore the metabolic fate of acetyl-L-carnitine in rat brain. To measure the flux of carbon atoms into anabolic processes occurring at regional levels, we have injected [1-(14)C]acetyl-L-carnitine into the lateral brain ventricle of conscious rats. After injection of [1-(14)C]acetyl-L-car...

journal_title：Journal of neurochemistry

authors： Ricciolini R,Scalibastri M,Kelleher JK,Carminati P,Calvani M,Arduini A

更新日期：1998-12-01 00:00:00

abstract：:Mitochondrial respiratory function, assessed from the rate of oxygen uptake by homogenates of rat brain subregions, was examined after 30 min of forebrain ischemia and at recirculation periods of up to 48 h. Ischemia-sensitive regions which develop extensive neuronal loss during the recirculation period (dorsal-latera...

journal_title：Journal of neurochemistry

authors： Sims NR,Pulsinelli WA

更新日期：1987-11-01 00:00:00

abstract：:Ras-GAP SH3-domain-binding protein, G3BP, is an important component in the assembly of stress granules (SGs), which are cytoplasmic aggregates assembled following translational stress. To assess the physiological function of G3BP, we generated viable G3bp1-knockout (KO) mice, which demonstrated behavioral defects link...

journal_title：Journal of neurochemistry

authors： Martin S,Zekri L,Metz A,Maurice T,Chebli K,Vignes M,Tazi J

更新日期：2013-04-01 00:00:00

abstract：:The putative neuroprotective properties of various flavonoids have long been reported. Among this class of chemicals, quercetin, a major flavone/flavonol naturally occurring in plants, deserves focused attention because of the myriad of beneficial effects observed in various in vitro and in vivo models of central nerv...

journal_title：Journal of neurochemistry

authors： Lee YJ,Bernstock JD,Nagaraja N,Ko B,Hallenbeck JM

更新日期：2016-07-01 00:00:00

abstract：:Glutaminyl cyclases (QC) catalyze the formation of neurotoxic pGlu-modified amyloid-β peptides found in the brains of people with Alzheimer's disease (AD). Reports of several-fold increases in soluble QC (sQC) expression in the brain and peripheral circulation of AD individuals has prompted the development of QC inhib...

journal_title：Journal of neurochemistry

authors： Gunn AP,Wong BX,McLean C,Fowler C,Barnard PJ,Duce JA,Roberts BR,AIBL Research Group.

更新日期：2020-07-02 00:00:00

abstract：:Differential assembly of N-methyl-D-aspartate (NMDA) receptor subunits determines their functional characteristics. Using in situ hybridization, we found a selective increase of the subunits NR1 and NR2A mRNA at 24 h in ventral motor neurons (VMN) caudal to a standardized spinal cord contusion injury (SCI). Other neur...

journal_title：Journal of neurochemistry

authors： Grossman SD,Wolfe BB,Yasuda RP,Wrathall JR

更新日期：2000-07-01 00:00:00

abstract：:Previous histological, electrophysiological, and biochemical reports have addressed the hypothesis that serotonin functions as a neurotransmitter in mammalian retinas. We have tested the effect on the levels of cyclic AMP of the application of exogenous serotonin, 5-methoxytryptamine, melatonin, and 5-methoxydimethyl-...

journal_title：Journal of neurochemistry

authors： Blazynski C,Ferrendelli JA,Cohen AI

更新日期：1985-08-01 00:00:00

abstract：:We looked at the possible interactions between astrocytes and neurones during reperfusion using an in vitro model of ischaemia-reperfusion injury, as a controlled environment that lends itself easily to manipulation of the numerous variables involved in such an insult. We constructed a chamber in which O2 can be lower...

journal_title：Journal of neurochemistry

authors： Griffin S,Clark JB,Canevari L

更新日期：2005-11-01 00:00:00

abstract：:We have recently isolated from bovine adrenal medulla a novel C-terminally amidated opioid peptide, amidorphin, which derives from proenkephalin A. Amidorphin revealed a widespread distribution in bovine, ovine, and porcine tissue. Particularly high concentrations of amidorphin immunoreactivity were detected in adrena...

journal_title：Journal of neurochemistry

authors： Liebisch DC,Seizinger BR,Michael G,Herz A

更新日期：1985-11-01 00:00:00

abstract：:Incretin-related therapy was found to be beneficial for experimental diabetic neuropathy, but its mechanism is obscure. The purpose of this study is to explore the mechanism through which dipeptidyl peptidase IV inhibitor, vildagliptin (VG), influences neuropathy in diabetic rodents. To this end, non-obese type 2 diab...

journal_title：Journal of neurochemistry

authors： Tsuboi K,Mizukami H,Inaba W,Baba M,Yagihashi S

更新日期：2016-02-01 00:00:00

abstract：:The accumulation of apolipoprotein B100 lipoproteins in Bruch membrane is an early event thought to promote age-related macular degeneration (AMD). Immunohistochemistry using an anti-oxidized low density lipoprotein antibody on 10 AMD specimens showed staining in Bruch membrane including basal deposits, a marker of AM...

journal_title：Journal of neurochemistry

authors： Yamada Y,Tian J,Yang Y,Cutler RG,Wu T,Telljohann RS,Mattson MP,Handa JT

更新日期：2008-05-01 00:00:00

abstract：:Previous studies have purified from brain a Ca2+/calmodulin-dependent protein kinase II (designated CaM-kinase II) that phosphorylates synapsin I, a synaptic vesicle-associated phosphoprotein. CaM-kinase II is composed of a major Mr 50K polypeptide and a minor Mr 60K polypeptide; both bind calmodulin and are phosphory...

journal_title：Journal of neurochemistry

authors： Shields SM,Vernon PJ,Kelly PT

更新日期：1984-12-01 00:00:00

abstract：:Iron, a transition metal and essential nutrient, is a typical pro-oxidant forming free radicals, lipid peroxides and causing cell damage when added at high (> or = 50 microM) concentrations to oligodendroglia-like OLN-93 cells that have been enriched for 3 days with 10 microM docosahexaenoic acid (DHA, 22 : 6 n-3). At...

journal_title：Journal of neurochemistry

authors： Brand A,Schonfeld E,Isharel I,Yavin E

更新日期：2008-05-01 00:00:00

abstract：:A rat kidney epithelial cell line expressing the rat neurokinin-1 receptor (NK-1 R) was used to investigate the relationship between receptor phosphorylation and desensitization. Substance P (SP) maximally stimulated cellular inositol 1,4,5-trisphosphate (IP3) production 14-fold within 3 s, after which cellular IP3 le...

journal_title：Journal of neurochemistry

authors： Vigna SR

更新日期：1999-11-01 00:00:00

abstract：:cDNAs encoding four isoforms of the human NMDA receptor (NMDAR) NMDAR2C (hNR2C-1, -2, -3, and -4) have been isolated and characterized. The overall identity of the deduced amino acid sequences of human and rat NR2C-1 is 89.0%. The sequences of the rat and human carboxyl termini (Gly925-Val1,236) are encoded by differe...

journal_title：Journal of neurochemistry

authors： Daggett LP,Johnson EC,Varney MA,Lin FF,Hess SD,Deal CR,Jachec C,Lu CC,Kerner JA,Landwehrmeyer GB,Standaert DG,Young AB,Harpold MM,Veliçelebi G

更新日期：1998-11-01 00:00:00

abstract：:Intracellular calcium ions regulate the structure and functions of cytoskeletal proteins. On the other hand, recent studies have shown that the cytoskeleton, and actin filaments in particular, can modulate calcium influx through plasma membrane ligand- and voltage-gated channels. We now report that calcium release fro...

journal_title：Journal of neurochemistry

authors： Wang Y,Mattson MP,Furukawa K

更新日期：2002-08-01 00:00:00

abstract：:In a previous study we showed that in vivo treatment with pertussis toxin could inhibit some, but not all, effects of adenosine in the rat hippocampus. In this study we investigated the effect of pertussis toxin on the binding of adenosine analogues to A1 receptors in rat brain. Intraventricular injection of pertussis...

journal_title：Journal of neurochemistry

authors： van der Ploeg I,Parkinson FE,Fredholm BB

更新日期：1992-04-01 00:00:00