Developmental profile of striatal preprotachykinin gene expression.

abstract：:From immunizations of mice with a glutathione S-transferase fusion protein containing residues 724-781 of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluR1-flop, two monoclonal antibodies (mAbs) were developed that differed widely in their ranges of specificity. In immunocytochemical ...

journal_title：Journal of neurochemistry

authors： Tönnes J,Stierli B,Cerletti C,Behrmann JT,Molnár E,Streit P

更新日期：1999-11-01 00:00:00

abstract：:Sprague-Dawley rats were fed one of three purified diets--10% corn oil, 10% hydrogenated coconut oil, or 10% linseed oil--through two generations. At 60-80 days of age the animals were sacrificed. The fatty acyl composition of phosphatidylcholine, phosphatidylethanolamine, plasmalogen phosphatidylethanolamine, and com...

journal_title：Journal of neurochemistry

authors： Brown ML,Marshall LA,Johnston PV

更新日期：1984-11-01 00:00:00

abstract：:The effect of tumor necrosis factor-alpha (TNF-alpha) on neuronal viability has been investigated in the SK-N-BE neuroblastoma cell line. These cells undergo differentiation upon chronic treatment with retinoic acid. Exposure of SK-N-BE cells to TNF-alpha produced a proliferative response in undifferentiated cells, wh...

journal_title：Journal of neurochemistry

authors： Condorelli F,Sortino MA,Stella AM,Canonico PL

更新日期：2000-09-01 00:00:00

abstract：:Iron deficiency (ID) anemia during infancy results in long-term neurological consequences, yet the mediating mechanisms remain unclear. Infant monkeys often become naturally anemic during the first 6 months of life, presenting an opportunity to determine the effect of developmental iron deficiency. After weaning, anim...

journal_title：Journal of neurochemistry

authors： Geguchadze RN,Coe CL,Lubach GR,Clardy TW,Beard JL,Connor JR

更新日期：2008-04-01 00:00:00

abstract：UNLABELLED:J. Neurochem. (2012) 121, 597-606. ABSTRACT:In cultured rat neocortical interneurons, we have studied the effect of long-term application of NMDA or AMPA on the surface density of the NMDA (GluN) receptor subunits GluN1 and GluN2B. Stimulation of Ca(2+) -permeable AMPA (GluA) receptors located on the intern...

journal_title：Journal of neurochemistry

authors： Meyer DK,Lindemeyer AK,Wilmes T,Sobottka H,Nörenberg W

更新日期：2012-05-01 00:00:00

abstract：:The Review "The malleable brain: plasticity of neural circuits and behavior - A review from students to students" has been written by a group of students following the International Society for Neurochemistry and Journal of Neurochemistry Flagship School. Comprehensively written by students for students, it provides b...

journal_title：Journal of neurochemistry

authors： Schulz JB,Hausmann L

更新日期：2017-09-01 00:00:00

abstract：:Recent evidence indicates that tyrosine phosphorylation may play important roles in retinal photoreceptor rod outer segments (ROS). We investigated the tyrosine phosphorylation of endogenous proteins in isolated bovine ROS. Several proteins with apparent molecular masses of 31, 39, 60, 83, 90, 97, 120, 140, and 180 kD...

journal_title：Journal of neurochemistry

authors： Bell MW,Desai N,Guo XX,Ghalayini AJ

更新日期：2000-11-01 00:00:00

abstract：:Amino acid neurotransmitters in the nucleus tractus solitarius (NTS) are thought to play a key role in the mediation of visceral reflexes and glutamate has been proposed as the neurotransmitter of visceral afferent nerves projecting to this region. The present studies sought to characterize the use of in vivo microdia...

journal_title：Journal of neurochemistry

authors： Sved AF,Curtis JT

更新日期：1993-12-01 00:00:00

abstract：:Adenosine transport by rat and guinea pig synaptosomes was studied to establish the basis for the marked differences in the potency of some transport inhibitors in these species. An analysis of transport kinetics in the presence and absence of nitrobenzylthioinosine (NBTI) using synaptosomes derived from several areas...

journal_title：Journal of neurochemistry

authors： Shank RP,Baldy WJ

更新日期：1990-08-01 00:00:00

abstract：:Environmental stress can interact with genetic predisposition to increase the risk of developing psychopathology. In this work, we tested the hypothesis that social isolation stress interacts with impaired glutathione synthesis and have cumulative effects on the neurochemical profile of the frontal cortex. A mouse mod...

journal_title：Journal of neurochemistry

authors： Corcoba A,Gruetter R,Do KQ,Duarte JMN

更新日期：2017-09-01 00:00:00

abstract：:Altered aquaporin-4 (AQP4) expression has been reported in brain edema, tumors, muscular dystrophy, and neuromyelitis optica. However, the plasma membrane organization of AQP4 and its interaction with proteins such as the dystrophin-associated protein complex are not well understood. In this study, we used sucrose den...

journal_title：Journal of neurochemistry

authors： Nicchia GP,Cogotzi L,Rossi A,Basco D,Brancaccio A,Svelto M,Frigeri A

更新日期：2008-06-01 00:00:00

abstract：:Using a chemical-induced model of dentate granule (DG) cell death, cDNA microarray analysis was used to identify gene profiles from the laser-captured microdissected (LCM) hippocampal DG cell region versus the CA pyramidal cell layer (CA) from 21-day-old male CD1 mice injected with trimethyltin hydroxide (TMT; 3.0 mg/...

journal_title：Journal of neurochemistry

authors： Lefebvre d'Hellencourt C,Harry GJ

更新日期：2005-04-01 00:00:00

abstract：:This study investigates the functioning of synaptosomal ouabain-sensitive Na+ -K+ -ATPase in cold-induced edema. During vasogenic brain edema development, the enzyme affinities for Na+ and K+ are progressively decreased paralleling the increase in the tissue water content, whereas maximal velocity of the reaction is n...

journal_title：Journal of neurochemistry

authors： Averet N,Rigoulet M,Cohadon F

更新日期：1984-01-01 00:00:00

abstract：:Recent studies have suggested important roles for certain proteases and protease inhibitors in the growth and development of the CNS. In the present studies, inhibitors of urokinase or thrombin in cultured neural cells and serum-free medium from the cells were identified by screening for components that formed sodium ...

journal_title：Journal of neurochemistry

authors： Wagner SL,Lau AL,Nguyen A,Mimuro J,Loskutoff DJ,Isackson PJ,Cunningham DD

更新日期：1991-01-01 00:00:00

abstract：:Peptidyl-glycine alpha-amidation enzyme activity has been measured in 36 nuclei or areas in the rat CNS and pituitary using D-Tyr-Phe-Gly as the substrate. The distribution of this enzyme is highly uneven, with highest activity levels (greater than 30 pmol/mg of protein/h) in hypothalamic nuclei, substantia grisea cen...

journal_title：Journal of neurochemistry

authors： Meng F,Tsou K

更新日期：1988-05-01 00:00:00

abstract：:Rat cerebral cortex synaptosomes were exposed in superfusion to various depolarizing stimuli and the release of somatostatin-like immunoreactivity (SRIF-LI) was measured by means of a radioimmunoassay procedure. High KCl (9-50 mM) concentration dependently evoked SRIF-LI release; the evoked overflow reached a plateau ...

journal_title：Journal of neurochemistry

authors： Bonanno G,Parodi B,Cafaggi S,Raiteri M

更新日期：1991-10-01 00:00:00

abstract：:The neurotoxin 1-methyl-4-phenylpyridinium ion (MPP+) in the brain striatum has recently been shown to bind at a putatively vesicular site labeled by [3H]tyramine ([3H]TY). Whereas in the rat and mouse striatum MPP+ antagonized TY binding competitively, in the cerebellum there was a mixed-type antagonism, which sugges...

journal_title：Journal of neurochemistry

authors： Vaccari A,Saba PL,Gessa GL,Del Zompo M

更新日期：1993-02-01 00:00:00

abstract：:Here, we examined whether amyloid-beta (Abeta) protein participates in cell death and retinal function using three types of transgenic (Tg) mice in vivo [human mutant amyloid precursor protein (APP) Tg (Tg 2576) mice, mutant presenilin-1 (PS-1) knock-in mice, and APP/PS-1 double Tg mice]. ELISA revealed that the insol...

journal_title：Journal of neurochemistry

authors： Shimazawa M,Inokuchi Y,Okuno T,Nakajima Y,Sakaguchi G,Kato A,Oku H,Sugiyama T,Kudo T,Ikeda T,Takeda M,Hara H

更新日期：2008-10-01 00:00:00

abstract：:Many models of Parkinson's disease (PD) have succeeded in replicating dopaminergic neuron loss or alpha-synuclein aggregation but not the formation of classical Lewy bodies, the pathological hallmark of PD. Our cybrid model of sporadic PD was created by introducing the mitochondrial genes from PD patients into neurobl...

journal_title：Journal of neurochemistry

authors： Trimmer PA,Borland MK,Keeney PM,Bennett JP Jr,Parker WD Jr

更新日期：2004-02-01 00:00:00

abstract：:Prodynorphin, a multifunctional precursor of several important opioid peptides, is expressed widely in the CNS. It is processed at specific single and paired basic sites to generate various biologically active products. Among the prohormone convertases (PCs), PC1 and PC2 are expressed widely in neuroendocrine tissues ...

journal_title：Journal of neurochemistry

authors： Berman Y,Mzhavia N,Polonskaia A,Furuta M,Steiner DF,Pintar JE,Devi LA

更新日期：2000-10-01 00:00:00

abstract：:This study examines the proteolysis of the carboxy terminal domain of the full-length (alpha 1(212)) and truncated (alpha 1(190)) forms of the rabbit skeletal muscle L-type calcium channel alpha 1 subunit by calpain I and calpain II. Although both forms of the alpha 1 subunit show little sensitivity to proteolysis by ...

journal_title：Journal of neurochemistry

authors： De Jongh KS,Colvin AA,Wang KK,Catterall WA

更新日期：1994-10-01 00:00:00

abstract：:Both phosphointermediate- and vacuolar-type (P- and V-type, respectively) ATPase activities found in cholinergic synaptic vesicles isolated from electric organ are immunoprecipitated by a monoclonal antibody to the SV2 epitope characteristic of synaptic vesicles. The two activities can be distinguished by assay in the...

journal_title：Journal of neurochemistry

authors： Hicks BW,Parsons SM

更新日期：1992-04-01 00:00:00

abstract：:5-HT(3) (serotonin type 3) receptors are targets of antiemetics, antipsychotics, and antidepressants and are believed to play a role in cognition. Nevertheless, contrasting results have been obtained with respect to their functions in the CNS and in the control of transmitter release. We used rat hippocampal neurons i...

journal_title：Journal of neurochemistry

authors： Dorostkar MM,Boehm S

更新日期：2007-01-01 00:00:00

abstract：:In vitro studies indicate that p42/p44MAPK phosphorylate both nuclear and cytoplasmic proteins. However, the functional targets of p42/p44MAPK activation in vivo remain unclear. To address this question, we localized activated p42/p44MAPK in hippocampus and cortex and determined their signaling effects after electroco...

journal_title：Journal of neurochemistry

authors： Bhat RV,Engber TM,Finn JP,Koury EJ,Contreras PC,Miller MS,Dionne CA,Walton KM

更新日期：1998-02-01 00:00:00

abstract：:Neural stem cells (NSCs) are self-renewing multipotent cells that undergo symmetric and asymmetric cell division during development of the nervous system. The behavior of NSCs is tightly regulated by intrinsic processes such as transcriptional and post-transcriptional control, as well as the stem cell niche factors th...

journal_title：Journal of neurochemistry

authors： Gan HT,Tham M,Hariharan S,Ramasamy S,Yu YH,Ahmed S

更新日期：2011-05-01 00:00:00

abstract：:The angiotensin II competitive antagonist [125I]-Sar1, Ile8-angiotensin II was not transported from the vascular space to the cerebroventricular space in either intact or nephrectomized rats. In addition [125I]Sar1, Ile8-angiotensin II lacked the capacity to move in the opposite direction over a 20-min collection peri...

journal_title：Journal of neurochemistry

authors： Harding JW,Sullivan MJ,Hanesworth JM,Cushing LL,Wright JW

更新日期：1988-02-01 00:00:00

abstract：:There is extensive experimental evidence indicating a crucial role for glutamate in epileptogenesis and epileptic activity. The glial glutamate transporters GLT1 and GLAST are proposed to account for the majority of extracellular glutamate re-uptake. In the present study, polyclonal antibodies specific to GLT1 and GLA...

journal_title：Journal of neurochemistry

authors： Ingram EM,Wiseman JW,Tessler S,Emson PC

更新日期：2001-11-01 00:00:00

abstract：:Enzymes considered to be markers for neurons (angiotensin converting enzyme, thermolysin-like metalloendopeptidase, alanine aminopeptidase, and glutamate-oxaloacetate transaminase), glia (glutamine synthetase, pyruvate carboxylase, and beta-glucuronidase), and endothelial cells (alkaline phosphatase and plasminogen ac...

journal_title：Journal of neurochemistry

authors： Butterworth J

更新日期：1986-08-01 00:00:00

abstract：:The loss of ATP, which is needed for ionic homeostasis, is an early event in the neurotoxicity of glutamate and beta-amyloid (A(beta)). We hypothesize that cells supplemented with the precursor creatine make more phosphocreatine (PCr) and create larger energy reserves with consequent neuroprotection against stressors....

journal_title：Journal of neurochemistry

authors： Brewer GJ,Wallimann TW

更新日期：2000-05-01 00:00:00

abstract：:The regulatory role of ascorbic acid in norepinephrine biosynthesis was studied using digitonin-permeabilized chromaffin cells. When permeabilized chromaffin cells were incubated with [3H]3,4-dihydroxyphenylethylamine ([3H]dopamine) in calcium-free medium, the amounts of radioactive dopamine and norepinephrine measure...

journal_title：Journal of neurochemistry

authors： Morita K,Levine M,Pollard HB

更新日期：1986-03-01 00:00:00