The malleable brain - An educational review from students to students.

abstract：:Brain-derived neurotrophic factor (BDNF) activates a variety of signaling molecules to exert various functions in the nervous system, including neuronal differentiation, survival, and regulation of synaptic plasticity. Previously, we have suggested that BIT/SHPS-1 (brain immunoglobulin-like molecule with tyrosine-base...

journal_title：Journal of neurochemistry

authors： Araki T,Yamada M,Ohnishi H,Sano SI,Hatanaka H

更新日期：2000-10-01 00:00:00

abstract：:Endogenous norepinephrine (NE) release in cerebral cortex slices taken from normal and morphine-tolerant guinea pigs was measured by HPLC. In normal slices, a linear relationship was found between electrically evoked NE release and the log of the frequency of stimulation in the range of 1-20 Hz. The efficiency of the ...

journal_title：Journal of neurochemistry

authors： Tomasini C,Guidorzi R,Bianchi C,Beani L

更新日期：1992-04-01 00:00:00

abstract：:We recently reported an abnormal production of interleukin-1 (IL-1) in peripheral macrophages of several neurological mutant mice that exhibit patterns of neuronal degeneration, especially in the cerebellum. After in vitro activation by lipopolysaccharide acid (LPS), these macrophages hyperexpress IL-1 beta mRNA and h...

journal_title：Journal of neurochemistry

authors： Kopmels B,Mariani J,Delhaye-Bouchaud N,Audibert F,Fradelizi D,Wollman EE

更新日期：1992-01-01 00:00:00

abstract：:Preincubation of D384 cells, derived from the human astrocytoma cell line G-CCM, with dopamine resulted in a time-dependent attenuation of cyclic AMP responsiveness to subsequent dopamine stimulation. This effect was agonist specific because the prostaglandin E1 (PGE1) stimulation of cyclic AMP of similarly treated ce...

journal_title：Journal of neurochemistry

authors： Balmforth AJ,Warburton P,Ball SG

更新日期：1990-12-01 00:00:00

abstract：:Adenosine A2A receptors (A2A R) play a key role in modulating dopamine-dependent locomotor activity, as heralded by the sensitization of locomotor activity upon chronic A2A R blockade, which is associated with elevated dopamine levels and altered corticostriatal synaptic plasticity. Since the orphan receptor GPR37 has...

journal_title：Journal of neurochemistry

authors： Morató X,Gonçalves FQ,Lopes JP,Jauregui O,Soler C,Fernández-Dueñas V,Cunha RA,Ciruela F

更新日期：2019-03-01 00:00:00

abstract：:Abnormalities in the kynurenine pathway may play a role in Huntington's disease (HD). In this study, tryptophan depletion and loading were used to investigate changes in blood kynurenine pathway metabolites, as well as markers of inflammation and oxidative stress in HD patients and healthy controls. Results showed tha...

journal_title：Journal of neurochemistry

authors： Stoy N,Mackay GM,Forrest CM,Christofides J,Egerton M,Stone TW,Darlington LG

更新日期：2005-05-01 00:00:00

abstract：:In Aplysia, serotonin mediates behavioral sensitization by increasing the strength of the synapse between sensory and motor neurons, a process known as facilitation. The retention of long-term facilitation is blocked by rapamycin, an inhibitor of a specific translational pathway. One possible rapamycin-sensitive targe...

journal_title：Journal of neurochemistry

authors： Carroll M,Warren O,Fan X,Sossin WS

更新日期：2004-09-01 00:00:00

abstract：:Abstract Dorfin is a RING-finger type ubiquitin ligase for mutant superoxide dismutase 1 (SOD1) that enhances its degradation. Mutant SOD1s cause familial amyotrophic lateral sclerosis (FALS) through the gain of unelucidated toxic properties. We previously showed that the accumulation of mutant SOD1 in the mitochondri...

journal_title：Journal of neurochemistry

authors： Takeuchi H,Niwa J,Hishikawa N,Ishigaki S,Tanaka F,Doyu M,Sobue G

更新日期：2004-04-01 00:00:00

abstract：:Some data on the concentration range of response and the concentration for half-response (EC50) of gamma-aminobutyric acid (GABA) for the GABAA receptor are reviewed and compared. An analysis of the 36Cl- flux assay demonstrates that both the EC50 and the slope of a Hill plot depend on the ion influx or efflux assay t...

journal_title：Journal of neurochemistry

authors： Kardos J,Cash DJ

更新日期：1990-10-01 00:00:00

abstract：:Immunoaffinity chromatography with a monoclonal antibody produced against bovine tau protein was used to purify tau proteins from human brain. Fifty grams of brain tissue yielded approximately 2 mg of pure tau proteins. The affinity-purified human tau was used to produce a high-titered rabbit anti-human tau serum. The...

journal_title：Journal of neurochemistry

authors： Mercken M,Vandermeeren M,Lübke U,Six J,Boons J,Vanmechelen E,Van de Voorde A,Gheuens J

更新日期：1992-02-01 00:00:00

abstract：:Perineuronal nets (PNNs) are presumed to limit plasticity in adult animals. Ischaemic stroke results in the massive breakdown of PNNs resulting in rejuvenating states of neuronal plasticity, but the mechanisms of this phenomenon are largely unknown. As hyaluronic acid (HA) is the structural backbone of PNNs, we hypoth...

journal_title：Journal of neurochemistry

authors： Katarzyna Greda A,Nowicka D

更新日期：2020-12-20 00:00:00

abstract：:The murine neuroblastoma N1E-115 cell line possesses a high density of angiotensin II (AngII) receptors that can be solubilized with the zwitterionic detergent 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate. These solubilized binding sites exhibited high affinity for CGP-42112A and not Losartan, indicating ...

journal_title：Journal of neurochemistry

authors： Siemens IR,Reagan LP,Yee DK,Fluharty SJ

更新日期：1994-06-01 00:00:00

abstract：:Reactive oxygen species are believed to play a crucial role in situations where dopamine neurons die, such as in Parkinson's disease or during intracerebral transplantation of embryonic mesencephalic tissue. The present study was designed to address the question whether, and to what extent, the glutathione redox syste...

journal_title：Journal of neurochemistry

authors： Grasbon-Frodl EM,Andersson A,Brundin P

更新日期：1996-10-01 00:00:00

abstract：:In rats rendered hyperthyroid by chronic treatment with L-triiodothyronine (T3) hormone there was a 21 and 27% decrease, respectively, in the number of binding sites for [3H]flunitrazepam ([3H]FNZ) and [3H]ethyl-beta-carboline-3-carboxylate ([3H]beta-CCE) without changes in affinity for the two ligands. Two weeks afte...

journal_title：Journal of neurochemistry

authors： Medina JH,De Robertis E

更新日期：1985-05-01 00:00:00

abstract：:Depletion of glutathione in the substantia nigra is one of the earliest changes observed in Parkinson's disease (PD) and could initiate dopaminergic neuronal degeneration. Nevertheless, experimental glutathione depletion does not result in preferential toxicity to dopaminergic neurons either in vivo or in vitro. Moreo...

journal_title：Journal of neurochemistry

authors： Nakamura K,Wright DA,Wiatr T,Kowlessur D,Milstien S,Lei XG,Kang UJ

更新日期：2000-06-01 00:00:00

abstract：:This study examines the proteolysis of the carboxy terminal domain of the full-length (alpha 1(212)) and truncated (alpha 1(190)) forms of the rabbit skeletal muscle L-type calcium channel alpha 1 subunit by calpain I and calpain II. Although both forms of the alpha 1 subunit show little sensitivity to proteolysis by ...

journal_title：Journal of neurochemistry

authors： De Jongh KS,Colvin AA,Wang KK,Catterall WA

更新日期：1994-10-01 00:00:00

abstract：:Rat glioma X mouse neuroblastoma hybrid neurotumor cells (NG108-15), synchronized by amino acid deprivation, showed a cell-cycle-dependent peak of activity of a ganglioside N-acetylgalactosaminyl transferase 14-24 h following release from the cell cycle block (S/G2 phase). Maximal expression of two typical lysosomal h...

journal_title：Journal of neurochemistry

authors： Scheideler MA,Lockney MW,Dawson G

更新日期：1984-04-01 00:00:00

abstract：:Phosphoinositide hydrolysis was studied in neurohybrid NCB-20 cells prelabeled with myo-[3H]inositol. Among nearly 20 neurotransmitters and neuromodulators examined, only bradykinin, carbachol, and histamine significantly increased the accumulation of [3H]inositol monophosphate (IP1) in the presence of lithium. The EC...

journal_title：Journal of neurochemistry

authors： Chuang DM,Dillon-Carter O

更新日期：1988-08-01 00:00:00

abstract：:The neuropathological and immune changes induced in the brain by 'binge drinking' have been investigated in a rat model. Evidence of neuro-inflammation was identified in the 'binge drinking' rat model of alcohol abuse after 3 weeks of administration of 2 or 3 g/kg ethanol (EtOH), three times per day for two consecutiv...

journal_title：Journal of neurochemistry

authors： Ward RJ,Colivicchi MA,Allen R,Schol F,Lallemand F,de Witte P,Ballini C,Corte LD,Dexter D

更新日期：2009-12-01 00:00:00

abstract：:Huntington's disease and six other neurodegenerative diseases are associated with abnormal gene products containing expanded polyglutamine (poly-Q; Qn) domains (n > or = 40). In the present work, we show that glutathione S-transferase (GST) fusion proteins containing a small, physiological-length poly-Q domain (GSTQ10...

journal_title：Journal of neurochemistry

authors： Cooper AJ,Sheu KF,Burke JR,Onodera O,Strittmatter WJ,Roses AD,Blass JP

更新日期：1997-07-01 00:00:00

abstract：:The effect of selective inhibition of monoamine oxidase (MAO) subtypes A and B on striatal metabolism of DOPA to dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), and 4-hydroxy-3-methoxyphenylacetic acid (homovanillic acid; HVA) was studied in halothane-anesthetized rats 3 weeks after unilateral 6-hydroxydopamine...

journal_title：Journal of neurochemistry

authors： Finberg JP,Wang J,Goldstein DS,Kopin IJ,Bankiewicz KS

更新日期：1995-09-01 00:00:00

abstract：:Late Infantile Neuronal Ceroid Lipofuscinosis (LINCL) is a rare neurodegenerative disease caused by mutations in the Cln2 gene that leads to deficiency or loss of function of the tripeptidyl peptidase 1 (TPP1) enzyme. TPP1 deficiency is known to cause the accumulation of autofluoroscent lipid-protein pigments in brain...

journal_title：Journal of neurochemistry

authors： Ghosh A,Rangasamy SB,Modi KK,Pahan K

更新日期：2017-05-01 00:00:00

abstract：:Different forms of acetylcholinesterase (AChE), EC 3.1.1.7, were demonstrated in human brain caudate nucleus. One form was solubilized at high ionic strength, the other with Triton X-100. The detergent-extractable form was purified to homogeneity by affinity chromatography. This form of AChE is amphiphile-dependent; i...

journal_title：Journal of neurochemistry

authors： Sørensen K,Gentinetta R,Brodbeck U

更新日期：1982-10-01 00:00:00

abstract：:Cerebral microvessels isolated from perfused, adult murine brain produce a compound with the chromatographic properties of a monohydroxyeicosatetraenoic acid when incubated with arachidonic acid or stimulated with calcium ionophore A23187. The formation of this arachidonic acid metabolite is not reduced in the presenc...

journal_title：Journal of neurochemistry

authors： Moore SA,Figard PH,Spector AA,Hart MN

更新日期：1989-08-01 00:00:00

abstract：:The autoradiographic method with L-[35S]methionine was used to determine the effects of an n-3 fatty acid deficiency on brain protein synthesis. Brain protein synthesis was significantly increased (from 50 to 150%) in 45 of the 52 brain structures studied in n-3 fatty acid-deficient rats as compared with control anima...

journal_title：Journal of neurochemistry

authors： Giaume M,Gay N,Baubet V,Gharib A,Durand G,Bobillier P,Sarda N

更新日期：1994-11-01 00:00:00

abstract：:The glycine receptor is a member of the Cys-loop, ligand-gated ion channel family and is responsible for inhibition in the CNS. We examined the orientation of amino acids I229 in transmembrane 1 (TM1) and A288 in TM3, which are both critical for alcohol and volatile anesthetic action. We mutated these two amino acids ...

journal_title：Journal of neurochemistry

authors： Lobo IA,Harris RA,Trudell JR

更新日期：2008-03-01 00:00:00

abstract：:Previous work has demonstrated that there is a selective increase in extracellular taurine in the brain during acute water intoxication. One aim of the present study was to investigate whether plasma taurine contributes to this increase. To this end, the concentrations of taurine, other amino acids, and ethanolamine (...

journal_title：Journal of neurochemistry

authors： Lehmann A,Carlström C,Nagelhus EA,Ottersen OP

更新日期：1991-02-01 00:00:00

abstract：:Cultures of chromaffin cells isolated from the bovine adrenal medulla have been extremely useful for investigating secretory mechanisms, but such cultures used up to the present time represent mixed populations of adrenergic and noradrenergic cells. This report describes how, with slight modifications to standard proc...

journal_title：Journal of neurochemistry

authors： Moro MA,Garcia AG,Langley OK

更新日期：1991-08-01 00:00:00

abstract：:The Kölliker-Fuse nucleus (KF) is a functionally distinct component of the parabrachial complex, located in the dorsolateral pons of mammals. The KF has a major role in respiration and upper airway control. A comprehensive understanding of the KF and its contributions to respiratory function and dysfunction requires a...

journal_title：Journal of neurochemistry

authors： Varga AG,Maletz SN,Bateman JT,Reid BT,Levitt ES

更新日期：2021-01-01 00:00:00

abstract：:The present investigation examined the effect of in vivo antagonism of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor by 2,3-dihydro-6-nitro-7-sulfamoyl-benzo(f)quinoxaline (NBQX) on local cerebral glucose utilization (LCGU) using the quantitative autoradiographic 2-deoxy[14C]-glucose met...

journal_title：Journal of neurochemistry

authors： Suzdak PD,Sheardown MJ

更新日期：1993-10-01 00:00:00