Tryptophan metabolism and oxidative stress in patients with Huntington's disease.

abstract：:Effective drugs are not available to protect against beta-amyloid peptide (A beta)-induced neurotoxicity. Cortical neurons from rat embryos were treated with the toxic fragment A beta25-35 at 1 microM in the presence or absence of flupirtine, a triaminopyridine, successfully applied clinically as a nonopiate analgesic...

journal_title：Journal of neurochemistry

authors： Müller WE,Romero FJ,Perovic S,Pergande G,Pialoglou P

更新日期：1997-06-01 00:00:00

abstract：:N-Copine is a novel protein with two C2 domains. Its expression is brain specific and up-regulated by neuronal activity such as kainate stimulation and tetanus stimulation evoking hippocampal CA1 long-term potentiation. We examined the localization and subcellular distribution of N-copine in mouse brain. In situ hybri...

journal_title：Journal of neurochemistry

authors： Nakayama T,Yaoi T,Kuwajima G

更新日期：1999-01-01 00:00:00

abstract：:We recently reported an abnormal production of interleukin-1 (IL-1) in peripheral macrophages of several neurological mutant mice that exhibit patterns of neuronal degeneration, especially in the cerebellum. After in vitro activation by lipopolysaccharide acid (LPS), these macrophages hyperexpress IL-1 beta mRNA and h...

journal_title：Journal of neurochemistry

authors： Kopmels B,Mariani J,Delhaye-Bouchaud N,Audibert F,Fradelizi D,Wollman EE

更新日期：1992-01-01 00:00:00

abstract：:Neuroactive steroid family includes molecules synthesized in peripheral glands (i.e., hormonal steroids) and directly in the nervous system (i.e., neurosteroids) which are key regulators of the nervous function. As already reported in clinical and experimental studies, neurodegenerative diseases affect the levels of n...

journal_title：Journal of neurochemistry

authors： Caruso D,Melis M,Fenu G,Giatti S,Romano S,Grimoldi M,Crippa D,Marrosu MG,Cavaletti G,Melcangi RC

更新日期：2014-08-01 00:00:00

abstract：:45Ca2+ uptake measurements were performed on intact and osmotically lysed synaptosomes from rat brain to study the possible influence of prostaglandins (PGs) on Ca2+ movements into and within the nerve endings. The K+-induced 45Ca2+ uptake of intact synaptosomes was not influenced by several inhibitors of PG synthesis...

journal_title：Journal of neurochemistry

authors： Denzlinger C,Hertting G,Jackisch R

更新日期：1982-08-01 00:00:00

abstract：:PC12D cells, a new subline of conventional PC12 cells, respond not only to nerve growth factor but also to cyclic AMP by extending their neurites. These cells are flat in shape and are similar in appearance to PC12 cells that have been treated with nerve growth factor for a few days. In both cell lines, we have charac...

journal_title：Journal of neurochemistry

authors： Katoh-Semba R,Oohira A,Sano M,Watanabe K,Kitajima S,Kashiwamata S

更新日期：1989-03-01 00:00:00

abstract：:The isolated neurointermediate lobe (NIL) of the rat hypophysis accumulates [3H]dopamine from the incubation medium. Column chromatographic analysis showed that 92% of the tissue radioactivity was contained in the catecholamine fraction. [3H]Dopamine represented 70% and [3H]noradrenaline 30% of the [3H]catecholamines....

journal_title：Journal of neurochemistry

authors： Racké K,Muscholl E

更新日期：1983-11-01 00:00:00

abstract：:The developing central nervous system is a primary target of ethanol toxicity. The teratogenic effect of ethanol may result from its action on prostaglandins. Prostaglandins are generated through the release of arachidonic acid (AA) by the action of cytosolic phospholipase A(2) (cPLA(2)) on membrane-bound phospholipid...

journal_title：Journal of neurochemistry

authors： Luo J,Lindström CL,Donahue A,Miller MW

更新日期：2001-03-01 00:00:00

abstract：:This study investigates the functioning of synaptosomal ouabain-sensitive Na+ -K+ -ATPase in cold-induced edema. During vasogenic brain edema development, the enzyme affinities for Na+ and K+ are progressively decreased paralleling the increase in the tissue water content, whereas maximal velocity of the reaction is n...

journal_title：Journal of neurochemistry

authors： Averet N,Rigoulet M,Cohadon F

更新日期：1984-01-01 00:00:00

abstract：:Genomic and cDNA clones encoding the rat D1 receptor were isolated and sequenced. Comparison of the D1 receptor cDNA and genomic sequences revealed that the rat D1 receptor gene is organized into two exons separated by a small intron in the 5' untranslated region of its mRNA. The transcription start site is located 86...

journal_title：Journal of neurochemistry

authors： Zhou QY,Li C,Civelli O

更新日期：1992-11-01 00:00:00

abstract：:In continuing studies on smooth microsomal and synaptic membranes from rat forebrain, we compared the binding properties of opiate receptors in these two discrete subcellular populations. Receptors in both preparations were saturable and stereospecific. Scatchard and Hill plots of [3H]naloxone binding to microsomes an...

journal_title：Journal of neurochemistry

authors： Roth BL,Coscia CJ

更新日期：1984-06-01 00:00:00

abstract：:We investigated changes in the extracellular levels of acetylcholine (ACh) following local application of serotonergic agents to the dorsal hippocampus of freely moving rats by means of perfusion using a microdialysis technique. Perfusion of serotonin (5-HT; 10 microM, for 30 min at a rate of 3 microliters/min), disso...

journal_title：Journal of neurochemistry

authors： Izumi J,Washizuka M,Miura N,Hiraga Y,Ikeda Y

更新日期：1994-05-01 00:00:00

abstract：:125I-Porcine brain natriuretic peptide (125I-pBNP) bound to mouse astrocytes in primary culture in a time-dependent manner (t1/2 = 4.5 min), similar to 125I-human atrial natriuretic peptide (125I-hANP) (t1/2 = 5 min). Binding was saturable and reached equilibrium after 90 min at 22 degrees C for both radioligands. Sca...

journal_title：Journal of neurochemistry

authors： Yeung VT,Lai CK,Cockram CS,Young JD,Nicholls MG

更新日期：1991-05-01 00:00:00

abstract：:In the immune system, T- and B-cell proliferation, as well as B-cell immunoglobulin secretion, is induced by interleukin-2 (IL-2), a T-cell-derived lymphokine. IL-2 also influences the growth of glial cells, specifically, the proliferation and maturation of oligodendrocytes. Studies were conducted to investigate furth...

journal_title：Journal of neurochemistry

authors： Benveniste EN,Herman PK,Whitaker JN

更新日期：1987-10-01 00:00:00

abstract：:Three forms of acetylcholinesterase (AChE) have been reported: the 4S, 10S, and 16S forms. It was suggested previously that 16S AChE is characteristic of the end-plate region; subsequently its presence has also been demonstrated in sciatic nerve, vagus nerve, several nerve trunks, cardiac atria, and distal ileum of ra...

journal_title：Journal of neurochemistry

authors： Kása P,Rakonczay Z

更新日期：1982-01-01 00:00:00

abstract：:The binding of L-2-[3H]amino-4-phosphonobutyrate ([3H]L-AP4) was examined in brain sections of wild-type mice and mice lacking the mGluR4 subtype of metabotropic glutamate receptors (mGluRs). Very high relative densities of [3H]L-AP4 binding were observed in the molecular layer of the cerebellar cortex, the nucleus ba...

journal_title：Journal of neurochemistry

authors： Thomsen C,Hampson DR

更新日期：1999-02-01 00:00:00

abstract：:An adrenomedullary protease capable of generating Met5-enkephalin from endogenous precursor(s) has been purified 1,000-fold using affinity chromatography in combination with gel filtration. This trypsin-like enzyme has an apparent molecular weight of 20,000 daltons by gel filtration. The reactivity of the enzyme towar...

journal_title：Journal of neurochemistry

authors： Lindberg I,Yang HY,Costa E

更新日期：1984-05-01 00:00:00

abstract：:The membrane-bound or solubilized melatonin receptors were treated with protein-modifying agents under specific conditions and then assayed for 125I-melatonin binding in order to obtain information on amino acids present in the ligand binding domain. The reagents specific for sulfhydryl (N-ethylmaleimide and p-chlorom...

journal_title：Journal of neurochemistry

authors： Kosar E,Teisinger J,Vyskocil F,Vanĕcek J

更新日期：1994-08-01 00:00:00

abstract：:Synaptic scaffolding molecule (S-SCAM) is a synaptic protein that consists of PDZ domains, a guanylate kinase domain, and WW domains. It interacts with N-methyl-d-aspartate receptor subunits, neuroligin, and beta-catenin. Here, we identified Axin as a novel binding partner of S-SCAM. Axin was co-immunoprecipitated wit...

journal_title：Journal of neurochemistry

authors： Hirabayashi S,Nishimura W,Iida J,Kansaku A,Kishida S,Kikuchi A,Tanaka N,Hata Y

更新日期：2004-07-01 00:00:00

abstract：:Despite the wealth of information on the functional and pharmacological properties of the M2 muscarinic receptor, we know relatively little of structure and regulation of the M2 receptor gene. Here, we describe the organisation of the human M2 gene and its promoters. Four exons are present in the 5' untranslated regio...

journal_title：Journal of neurochemistry

authors： Krejci A,Bruce AW,Dolezal V,Tucek S,Buckley NJ

更新日期：2004-10-01 00:00:00

abstract：:The photic regulation of heme oxygenase (HO) activity was examined in the golden hamster retina. This enzymatic activity was significantly higher at midday than at midnight. When the hamsters were placed under constant darkness for 48 h and killed at subjective day or at subjective night, the differences in HO activit...

journal_title：Journal of neurochemistry

authors： Sacca GB,Sáenz DA,Jaliffa CO,Minces L,Keller Sarmiento MI,Rosenstein RE

更新日期：2003-04-01 00:00:00

abstract：:The role of gamma-aminobutyric acid (GABA) modulation of septohippocampal cholinergic neurons in kindling was investigated. Hippocampal acetylcholine release was evaluated with the microdialysis technique in freely moving rats either after acute administration of isoniazid (an inhibitor of GABA synthesis) or pentylene...

journal_title：Journal of neurochemistry

authors： Serra M,Dazzi L,Cagetti E,Chessa MF,Pisu MG,Sanna A,Biggio G

更新日期：1997-01-01 00:00:00

abstract：:At 1, 2, and 4 weeks after unilateral premotor and motor cortex ablation in rats, a significant and lasting decrease in glutamate levels in the ipsilateral versus contralateral striatum was observed. A significant corresponding fall in aspartate was seen only after 1 week. In contrast, there was a large increase in th...

journal_title：Journal of neurochemistry

authors： Hassler R,Haug P,Nitsch C,Kim JS,Paik K

更新日期：1982-04-01 00:00:00

abstract：:Rat glioma X mouse neuroblastoma hybrid neurotumor cells (NG108-15), synchronized by amino acid deprivation, showed a cell-cycle-dependent peak of activity of a ganglioside N-acetylgalactosaminyl transferase 14-24 h following release from the cell cycle block (S/G2 phase). Maximal expression of two typical lysosomal h...

journal_title：Journal of neurochemistry

authors： Scheideler MA,Lockney MW,Dawson G

更新日期：1984-04-01 00:00:00

abstract：:The contribution of neuromelanin (NM) to the pathogenesis of Parkinson's disease (PD) has long been suspected. In particular, a correlation has been reported between the estimated cell loss in the mesencephalic dopaminergic cell groups and the percentage of NM-pigmented neurons in these cell groups. To test whether th...

journal_title：Journal of neurochemistry

authors： Kastner A,Hirsch EC,Lejeune O,Javoy-Agid F,Rascol O,Agid Y

更新日期：1992-09-01 00:00:00

abstract：:We are very sad that the ISN lost its President Kazuhiro Ikenaka, Professor and Chairman at National Institute for Physiological Sciences (NIPS), Director of Okazaki Institute of Integrative Biology. JNeurochem published an Obituary to value his outstanding achievements: Akio Wanaka et al. (2019) OBITUARY Kazuhiro Ike...

journal_title：Journal of neurochemistry

authors：

更新日期：2019-06-01 00:00:00

abstract：:Mouse monoclonal B-50 antibodies (Mabs) were screened to select a Mab that may interfere with suggested functions of B-50 (GAP-43), such as involvement in neurotransmitter release. Because the Mab NM2 reacted with peptide fragments of rat B-50 containing the unique protein kinase C (PKC) phosphorylation site at serine...

journal_title：Journal of neurochemistry

authors： Oestreicher AB,Hens JJ,Marquart A,Mercken M,De Graan PN,Zwiers H,Gipsen WH

更新日期：1994-03-01 00:00:00

abstract：:Parkinson's disease is a progressive neurological disorder that is characterized by the formation of intracellular protein inclusion bodies composed primarily of a misfolded and aggregated form of the protein α-synuclein. There is growing evidence that supports the prion-like hypothesis of α-synuclein progression. Thi...

journal_title：Journal of neurochemistry

authors： Tyson T,Steiner JA,Brundin P

更新日期：2016-10-01 00:00:00

abstract：:Cultures of neonatal rat superior cervical ganglia (SCG) were used to test the hypothesis that the cytokines leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) control GTP cyclohydrolase I (GTPCH) gene expression and 5,6,7,8-tetrahydrobiopterin (BH4) content as traits of the noradrenergic phenotyp...

journal_title：Journal of neurochemistry

authors： Stegenga SL,Hirayama K,Kapatos G

更新日期：1996-06-01 00:00:00

abstract：:We investigated the role of Ca(2+)-dependent protein kinases in the regulation of astrocytic cell volume. Calmodulin (CaM) antagonists were used to inhibit CaM and thus Ca2+/CaM-dependent protein kinase. The effect of these inhibitors as well as activators and inhibitors of protein kinase C (PKC) on astrocytic volume ...

journal_title：Journal of neurochemistry

authors： Bender AS,Neary JT,Blicharska J,Norenberg LO,Norenberg MD

更新日期：1992-05-01 00:00:00