Protection of flupirtine on beta-amyloid-induced apoptosis in neuronal cells in vitro: prevention of amyloid-induced glutathione depletion.

abstract：:Aging was associated with an increase in the density of specific binding sites for [3H]imipramine in postmortem specimens of human hypothalamus, frontal cortex, and parietal cortex. In general, [3H]imipramine binding was not affected by factors considered difficult to control in postmortem studies, i.e., time from dea...

journal_title：Journal of neurochemistry

authors： Severson JA,Marcusson JO,Osterburg HH,Finch CE,Winblad B

更新日期：1985-11-01 00:00:00

abstract：:The membrane-bound or solubilized melatonin receptors were treated with protein-modifying agents under specific conditions and then assayed for 125I-melatonin binding in order to obtain information on amino acids present in the ligand binding domain. The reagents specific for sulfhydryl (N-ethylmaleimide and p-chlorom...

journal_title：Journal of neurochemistry

authors： Kosar E,Teisinger J,Vyskocil F,Vanĕcek J

更新日期：1994-08-01 00:00:00

abstract：:In the PNS, ciliary neurotrophic factor (CNTF) is found in significant amounts in the adult sciatic nerve, localized to myelin-related Schwann cells (SCs). Levels are undetectable in newborn but high in adult animals. After crush injury, CNTF production is reduced, recovering only as the nerve regenerates; if regenera...

journal_title：Journal of neurochemistry

authors： Lee DA,Zurawel RH,Windebank AJ

更新日期：1995-08-01 00:00:00

abstract：:The accumulation of apolipoprotein B100 lipoproteins in Bruch membrane is an early event thought to promote age-related macular degeneration (AMD). Immunohistochemistry using an anti-oxidized low density lipoprotein antibody on 10 AMD specimens showed staining in Bruch membrane including basal deposits, a marker of AM...

journal_title：Journal of neurochemistry

authors： Yamada Y,Tian J,Yang Y,Cutler RG,Wu T,Telljohann RS,Mattson MP,Handa JT

更新日期：2008-05-01 00:00:00

abstract：:After traumatic brain injury, progesterone has important neuroprotective effects in the nervous system. There is better functional outcome and less oedema formation in pseudopregnant rat females (high levels of endogenous progesterone) than in males. In addition to intracellular progesterone receptors, membrane bindin...

journal_title：Journal of neurochemistry

authors： Meffre D,Delespierre B,Gouézou M,Leclerc P,Vinson GP,Schumacher M,Stein DG,Guennoun R

更新日期：2005-06-01 00:00:00

abstract：:alpha-Conotoxins interact with nicotinic acetylcholine receptors (nAChRs) and acetylcholine-binding proteins (AChBPs) at the sites for agonists/competitive antagonists. alpha-Conotoxins blocking muscle-type or alpha7 nAChRs compete with alpha-bungarotoxin. However, alpha-conotoxin ImII, a close homolog of the alpha7 n...

journal_title：Journal of neurochemistry

authors： Kasheverov IE,Zhmak MN,Fish A,Rucktooa P,Khruschov AY,Osipov AV,Ziganshin RH,D'hoedt D,Bertrand D,Sixma TK,Smit AB,Tsetlin VI

更新日期：2009-11-01 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) has central functions in development, tissue maintenance, and repair and has been implicated in major diseases. We discovered that TGF-beta1 contains several amphipathic helices and hydrophobic domains similar to apolipoprotein E (apoE), a protein involved in lipoprotein me...

journal_title：Journal of neurochemistry

authors： Tesseur I,Zhang H,Brecht W,Corn J,Gong JS,Yanagisawa K,Michikawa M,Weisgraber K,Huang Y,Wyss-Coray T

更新日期：2009-08-01 00:00:00

abstract：:The kinetic properties of soluble tyrosine hydroxylase from rat striatum and the activation of the enzyme by the polyanion heparin were assessed as a function of the monovalent cations K+, Na+, tetramethylammonium (TMA+), and Tris. Substitution of K+ or Na+ for TMA+ or Tris can alter the kinetic properties of tyrosine...

journal_title：Journal of neurochemistry

authors： Kuczenski R

更新日期：1981-09-01 00:00:00

abstract：:Microtubule-associated proteins (MAPs) were phosphorylated by a Ca2+- and calmodulin-dependent protein kinase from rat brain cytosol. The maximal amount of phosphate incorporated into MAPs was 25 nmol of phosphate/mg protein. A Ka value of the enzyme for calmodulin was 57.0 nM, with MAPs as substrates. Among MAPs, MAP...

journal_title：Journal of neurochemistry

authors： Yamamoto H,Fukunaga K,Tanaka E,Miyamoto E

更新日期：1983-10-01 00:00:00

abstract：:Fingolimod, a sphingosine-1-phosphate receptor (S1PR) agonist, is clinically available to treat multiple sclerosis and is showing promise in treating stroke. We investigated if fingolimod provides long-term protection from experimental neonatal germinal matrix hemorrhage (GMH), aiming to support a potential mechanism ...

journal_title：Journal of neurochemistry

authors： Rolland WB,Krafft PR,Lekic T,Klebe D,LeGrand J,Weldon AJ,Xu L,Zhang JH

更新日期：2017-03-01 00:00:00

abstract：:In cerebellar granule cells, the mitogen-activated protein kinase (MAPK) or extracellular signal-regulated kinase (ERK) cascade mediates multiple functions, including proliferation, differentiation, and survival. In these cells, ERKs are activated by diverse stimuli, including cyclic adenosine monophosphate (cAMP), pi...

journal_title：Journal of neurochemistry

authors： Obara Y,Horgan AM,Stork PJ

更新日期：2007-04-01 00:00:00

abstract：:We investigated the role of Ca(2+)-dependent protein kinases in the regulation of astrocytic cell volume. Calmodulin (CaM) antagonists were used to inhibit CaM and thus Ca2+/CaM-dependent protein kinase. The effect of these inhibitors as well as activators and inhibitors of protein kinase C (PKC) on astrocytic volume ...

journal_title：Journal of neurochemistry

authors： Bender AS,Neary JT,Blicharska J,Norenberg LO,Norenberg MD

更新日期：1992-05-01 00:00:00

abstract：:Angiopoietin-1, an angiogenic factor, stabilizes brain microvessels through Tie-2 receptor tyrosine kinase. In traumatic brain injury, blood-brain barrier (BBB) disruption is an aggravating factor that induces brain edema and neuroinflammation. We previously showed that BQ788, an endothelin ETB receptor antagonist, pr...

journal_title：Journal of neurochemistry

authors： Michinaga S,Tanabe A,Nakaya R,Fukutome C,Inoue A,Iwane A,Minato Y,Tujiuchi Y,Miyake D,Mizuguchi H,Koyama Y

更新日期：2020-08-01 00:00:00

abstract：:The protein tyrosine kinase Src is known to regulate NMDA receptors in native neurons. While NR2A, NR2B and NR2D are known to be phosphorylated on tyrosine residues, the exact sites have remained unidentified. Immunoprecipitation of NMDA receptor subunits followed by western blotting was used to analyze the state of t...

journal_title：Journal of neurochemistry

authors： Yang M,Leonard JP

更新日期：2001-04-01 00:00:00

abstract：:The pivotal role for voltage-sensitive calcium channels in initiating synaptic transmitter release is undisputed, but it is only partly known to what extent the different subtypes contribute in vivo. Their importance for the dendritic release of dopamine has not been investigated in vivo previously. To evaluate compre...

journal_title：Journal of neurochemistry

authors： Bergquist F,Jonason J,Pileblad E,Nissbrandt H

更新日期：1998-04-01 00:00:00

abstract：:The short and long forms of the D2 dopamine receptor have been expressed at similar levels in fibroblast Ltk- cells, and the long form of the receptor has also been expressed in Chinese hamster ovary cells. The ligand binding properties of the two forms of receptor expressed in different systems have been compared in ...

journal_title：Journal of neurochemistry

authors： Castro SW,Strange PG

更新日期：1993-01-01 00:00:00

abstract：:Endogenous cannabinoid receptor ligands (endocannabinoids) may rescue neurons from glutamate excitotoxicity. As these substances also accumulate in cultured immature neurons following neuronal damage, elevated endocannabinoid concentrations may be interpreted as a putative neuroprotective response. However, it is not ...

journal_title：Journal of neurochemistry

authors： Hansen HH,Schmid PC,Bittigau P,Lastres-Becker I,Berrendero F,Manzanares J,Ikonomidou C,Schmid HH,Fernández-Ruiz JJ,Hansen HS

更新日期：2001-09-01 00:00:00

abstract：:This study examined the respective influences of cannabinoid type-1 (CB1) receptors expressed either in forebrain GABAergic neurons, in cortical glutamatergic neurons, or in astrocytes on the turnover rates of the endocannabinoids N-arachidonoylethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), and the non-cannabin...

journal_title：Journal of neurochemistry

authors： Belluomo I,Matias I,Pernègre C,Marsicano G,Chaouloff F

更新日期：2015-04-01 00:00:00

abstract：:The nuclear factor 1 (NF-1) motifs, NF-1 II/III, In the two 98-bp repeats of the transcription-regulatory region of JC virus (JCV), have a critical role in brain-specific transcription from the JCV early promoter-enhancer. In this study, the role of these motifs in transactivation of the JCV late promoter-enhancer (JC...

journal_title：Journal of neurochemistry

authors： Kumar KU,Devireddy LR,Tang SC,Pater A,Pater MM

更新日期：1996-08-01 00:00:00

abstract：:Both increased gamma-aminobutyric acid (GABA)-ergic and decreased glutamatergic neurotransmission have been suggested relative to the pathophysiology of hepatic encephalopathy. This proposed disturbance in neurotransmitter balance, however, is based mainly on brain tissue analysis. Because the approach of whole tissue...

journal_title：Journal of neurochemistry

authors： Bosman DK,Deutz NE,Maas MA,van Eijk HM,Smit JJ,de Haan JG,Chamuleau RA

更新日期：1992-08-01 00:00:00

abstract：:The accumulation of choline, homocholine, and 4-hydroxybutyltrimethylammonium by rat brain synaptosomes was measured; the choline uptake mechanism transported homocholine but not hydroxybutyltrimethylammonium, which, in addition, did not block choline accumulation. In cats' superior cervical ganglia, preganglionic ner...

journal_title：Journal of neurochemistry

authors： Collier B

更新日期：1981-03-01 00:00:00

abstract：:Neural progenitor cells isolated from the embryonic cerebral cortex are well known to differentiate into neurons and glial cells, but recent reports have demonstrated differentiation into smooth muscle cells (SMCs) under the influence of fetal bovine serum. In this study, we report that agonists for G protein-coupled ...

journal_title：Journal of neurochemistry

authors： Morishita R,Nagata K,Ito H,Ueda H,Asano M,Shinohara H,Kato K,Asano T

更新日期：2007-05-01 00:00:00

abstract：:In an established rat model of penetrating ballistic-like brain injury (PBBI), arylsulfatase B (ARSB; N-acetylgalactosamine 4-sulfatase) activity was significantly reduced at the ipsilateral site of injury, but unaffected at the contralateral site or in sham controls. In addition, the ARSB substrate chondroitin 4-sulf...

journal_title：Journal of neurochemistry

authors： Bhattacharyya S,Zhang X,Feferman L,Johnson D,Tortella FC,Guizzetti M,Tobacman JK

更新日期：2015-08-01 00:00:00

abstract：:Previous studies on central 5-hydroxytryptamine1A (5-HT1A) receptors have consistently shown the existence of a GTP-insensitive component of agonist binding, i.e., binding of [3H]8-hydroxy-2-(di-n-propylamino)tetralin ([3H]8-OH-DPAT) that persists in the presence of 0.1 mM GTP or guanylylimidodiphosphate (GppNHp). The...

journal_title：Journal of neurochemistry

authors： Emerit MB,Miquel MC,Gozlan H,Hamon M

更新日期：1991-05-01 00:00:00

abstract：:Dietary n-6 polyunsaturated fatty acid (PUFA) deprivation in rodents reduces brain arachidonic acid (20:4n-6) concentration and 20:4n-6-preferring cytosolic phospholipase A(2) (cPLA(2) -IVA) and cyclooxygenase (COX)-2 expression, while increasing brain docosahexaenoic acid (DHA, 22:6n-3) concentration and DHA-selectiv...

journal_title：Journal of neurochemistry

authors： Igarashi M,Kim HW,Chang L,Ma K,Rapoport SI

更新日期：2012-03-01 00:00:00

abstract：:The uptake of radioactive biotin has been studied in glial cell cultures from dissociated cerebral hemispheres of newborn rats. We describe saturable kinetics for the biotin uptake at biotin concentrations of less than 60 nM and linear at greater than 60 nM. The uptake appeared temperature sensitive, Na+ independent, ...

journal_title：Journal of neurochemistry

authors： Rodriguez-Pombo P,Ugarte M

更新日期：1992-04-01 00:00:00

abstract：:In a previous study, interleukin-1beta (IL-1beta) has been shown to induce matrix metalloproteinases (MMPs) expression through mitogen-activated protein kinases and nuclear factor-kappaB pathways in rat brain astrocytes. Moreover, transactivation of growth factor receptors and phosphatidylinositol 3-kinase (PI3K)/Akt ...

journal_title：Journal of neurochemistry

authors： Wu CY,Hsieh HL,Sun CC,Tseng CP,Yang CM

更新日期：2008-05-01 00:00:00

abstract：:We have demonstrated previously that D1 dopamine receptors are coupled to both Gs alpha and Go alpha. We examine here the coupling between human D5 dopamine receptors and G proteins in transfected rat pituitary GH4C1 cells. Similar to D1 receptors, cholera toxin treatment of cells reduced, but did not abolish, D5 agon...

journal_title：Journal of neurochemistry

authors： Sidhu A,Kimura K,Uh M,White BH,Patel S

更新日期：1998-06-01 00:00:00

abstract：:We have correlated myelin membrane structure with biochemical composition in the CNS and PNS of a phylogenetic series of animals, including elasmobranchs, teleosts, amphibians, and mammals. X-ray diffraction patterns were recorded from freshly dissected, unfixed tissue and used to determine the thicknesses of the liqu...

journal_title：Journal of neurochemistry

authors： Kirschner DA,Inouye H,Ganser AL,Mann V

更新日期：1989-11-01 00:00:00

abstract：:Syntaxin, a protein required for the docking of synaptic vesicles, may be involved in the manifestation of synaptic plasticity. The possible involvement of syntaxin in epileptogenesis was investigated by assessing the expression levels of syntaxin1B/GR33 mRNA by in situ hybridization at different stages of hippocampal...

journal_title：Journal of neurochemistry

authors： Kamphuis W,Smirnova T,Hicks A,Hendriksen H,Mallet J,Lopes da Silva FH

更新日期：1995-11-01 00:00:00