Dietary n-6 polyunsaturated fatty acid deprivation increases docosahexaenoic acid metabolism in rat brain.

abstract：:An important step in the cascade leading to neuronal cell death is degradation of laminin and other components of the brain extracellular matrix by microglia-derived proteases. Excitotoxic cell death of murine hippocampal neurones in vivo can be prevented by inhibitors of tissue plasminogen activator (tPA) or by inhib...

journal_title：Journal of neurochemistry

authors： Campbell SJ,Finlay M,Clements JM,Wells G,Miller KM,Perry VH,Anthony DC

更新日期：2004-06-01 00:00:00

abstract：:Precise cellular targeting of macromolecular cargos has important biotechnological and medical implications. Using a recently established 'protein stapling' method, we linked the proteolytic domain of botulinum neurotoxin type A (BoNT/A) to a selection of ligands to target neuroendocrine tumor cells. The botulinum pro...

journal_title：Journal of neurochemistry

authors： Arsenault J,Ferrari E,Niranjan D,Cuijpers SA,Gu C,Vallis Y,O'Brien J,Davletov B

更新日期：2013-07-01 00:00:00

abstract：:In the adult mammalian brain, neural stem cells (NSCs) reside in two neurogenic regions, the walls of the lateral ventricles, and the subgranular zone of the hippocampus, which generate new neurons for the olfactory bulb and dentate gyrus, respectively. These adult NSCs retain their self-renewal ability and capacity t...

journal_title：Journal of neurochemistry

authors： Hayashi Y,Jinnou H,Sawamoto K,Hitoshi S

更新日期：2018-12-01 00:00:00

abstract：:Differential assembly of N-methyl-D-aspartate (NMDA) receptor subunits determines their functional characteristics. Using in situ hybridization, we found a selective increase of the subunits NR1 and NR2A mRNA at 24 h in ventral motor neurons (VMN) caudal to a standardized spinal cord contusion injury (SCI). Other neur...

journal_title：Journal of neurochemistry

authors： Grossman SD,Wolfe BB,Yasuda RP,Wrathall JR

更新日期：2000-07-01 00:00:00

abstract：:Malonaldehyde formation by cortical brain slices from rat brain was determined as a function of incubation time and of oxygen pressure. This substance, a byproduce of lipid peroxidation, was detected by the thiobarbituric acid test. Significant amounts of malonaldehyde were formed by brain slices during incubation in ...

journal_title：Journal of neurochemistry

authors： Kovachich GB,Mishra OP

更新日期：1980-12-01 00:00:00

abstract：:Nerve growth factor (NGF) serves a critical survival-promoting function for developing sympathetic neurons. Following removal of NGF, sympathetic neurons undergo apoptosis characterized by the activation of c-Jun N-terminal kinases (JNKs), up-regulation of BH3-only proteins including BcL-2-interacting mediator of cell...

journal_title：Journal of neurochemistry

authors： Lomb DJ,Straub JA,Freeman RS

更新日期：2007-12-01 00:00:00

abstract：:It is now clearly established that the brain has the capability of synthesizing various biologically active steroids including 17-hydroxypregnenolone (17OH-Delta(5)P), 17-hydroxyprogesterone (17OH-P), dehydroepiandrosterone (DHEA) and androstenedione (Delta(4)). However, the presence, distribution and activity of cyto...

journal_title：Journal of neurochemistry

authors： Do Rego JL,Tremblay Y,Luu-The V,Repetto E,Castel H,Vallarino M,Bélanger A,Pelletier G,Vaudry H

更新日期：2007-01-01 00:00:00

abstract：:gamma-Aminobutyric acidB (GABAB) receptor recognition sites that inhibit cyclic AMP formation, open potassium channels, and close calcium channels are coupled to these effector systems by guanine nucleotide binding proteins (G proteins). These G proteins are ADP-ribosylated by islet-activating protein (IAP), also know...

journal_title：Journal of neurochemistry

authors： Wojcik WJ,Ulivi M,Paez X,Costa E

更新日期：1989-09-01 00:00:00

abstract：:Genetic factors and nerve injury-induced changes of gene expression in sensory neurons are potential contributors to tactile allodynia, a neuropathic pain state manifested as hypersensitivity to innocuous mechanical stimulation. To uncover genes relevant to neuropathic allodynia, we analyzed gene expression profiles i...

journal_title：Journal of neurochemistry

authors： Valder CR,Liu JJ,Song YH,Luo ZD

更新日期：2003-11-01 00:00:00

abstract：:Parkinson's disease is a progressive neurological disorder that is characterized by the formation of intracellular protein inclusion bodies composed primarily of a misfolded and aggregated form of the protein α-synuclein. There is growing evidence that supports the prion-like hypothesis of α-synuclein progression. Thi...

journal_title：Journal of neurochemistry

authors： Tyson T,Steiner JA,Brundin P

更新日期：2016-10-01 00:00:00

abstract：:The metabolic pathway of inositol phospholipids represents a series of synthetic and hydrolytic reactions with inositol as a by-product. Hence, the rate of [3H]inositol release from prelabeled phospholipids can be used as a reflection of activity of this pathway. In the frog sympathetic ganglion prelabeled with [3H]in...

journal_title：Journal of neurochemistry

authors： Rubio R,Bencherif M,Berne RM

更新日期：1989-03-01 00:00:00

abstract：:Ammonium (NH(4) (+) ) is required to maintain pathways involved in shuttling metabolic precursors between astrocytes and neurones. Under hyperammonaemic conditions, increases in the cellular influx of NH(4) (+) , and accompanying changes in ion concentrations, may contribute to disruptions in metabolism and neurotrans...

journal_title：Journal of neurochemistry

authors： Kelly T,Rose CR

更新日期：2010-12-01 00:00:00

abstract：:Increasing evidence suggests that proteasome inhibition plays a causal role in promoting the neurodegeneration and neuron death observed in multiple disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD). The ability of severe and acute inhibition of proteasome function to induce neuron death and n...

journal_title：Journal of neurochemistry

authors： Ding Q,Dimayuga E,Martin S,Bruce-Keller AJ,Nukala V,Cuervo AM,Keller JN

更新日期：2003-07-01 00:00:00

abstract：:The blood-brain barrier (BBB) is important physiologically. Pathologically, BBB disruption has been implicated in a wide spectrum of neurological disorders including Parkinson's disease (PD). Recent studies indicate that caffeine is protective against PD, but by poorly understood mechanisms. Using a MPTP neurotoxin mo...

journal_title：Journal of neurochemistry

authors： Chen X,Lan X,Roche I,Liu R,Geiger JD

更新日期：2008-11-01 00:00:00

abstract：UNLABELLED:J. Neurochem. (2012) 121, 597-606. ABSTRACT:In cultured rat neocortical interneurons, we have studied the effect of long-term application of NMDA or AMPA on the surface density of the NMDA (GluN) receptor subunits GluN1 and GluN2B. Stimulation of Ca(2+) -permeable AMPA (GluA) receptors located on the intern...

journal_title：Journal of neurochemistry

authors： Meyer DK,Lindemeyer AK,Wilmes T,Sobottka H,Nörenberg W

更新日期：2012-05-01 00:00:00

abstract：:Gs alpha, the GTP-binding protein that mediates receptor stimulation of adenylyl cyclase, exists in small (Gs alpha-S) and large (Gs alpha-L) molecular forms. Previous work has established that these Gs alpha isoforms are products of alternatively spliced Gs alpha pre-mRNA. The present work examined the splicing patte...

journal_title：Journal of neurochemistry

authors： Granneman JG,Bannon MJ

更新日期：1991-09-01 00:00:00

abstract：:Microtubule-associated protein (MAP) 1B is a high-molecular-weight cytoskeletal protein that is abundant in developing neuronal processes and appears to be necessary for axonal growth. Various biochemical and immunocytochemical results are reported, indicating that a significant fraction of MAP1B is expressed as an in...

journal_title：Journal of neurochemistry

authors： Tanner SL,Franzen R,Jaffe H,Quarles RH

更新日期：2000-08-01 00:00:00

abstract：:The cochleo-vestibular ganglion contains neural crest-derived glial cells and sensory neurons that are derived from the neurogenic otic placode. Little is known about the molecular mechanisms that regulate the tightly orchestrated development of this structure. Here, we report that Sox10, a high-mobility group DNA-bin...

journal_title：Journal of neurochemistry

authors： Breuskin I,Bodson M,Thelen N,Thiry M,Borgs L,Nguyen L,Stolt C,Wegner M,Lefebvre PP,Malgrange B

更新日期：2010-09-01 00:00:00

abstract：:Signaling by muscarinic agonists is thought to result from the activation of cell surface acetylcholine receptors (mAChRs) that transmit extracellular signals to intracellular systems. In N1E-115 neuroblastoma cells, we detected both plasma membrane and intracellular M(1) -mAChRs using both biochemical and pharmacolog...

journal_title：Journal of neurochemistry

authors： Uwada J,Anisuzzaman AS,Nishimune A,Yoshiki H,Muramatsu I

更新日期：2011-09-01 00:00:00

abstract：:Alzheimer's disease (AD) is a typical progressive, chronic neurodegenerative disorder with worldwide prevalence. Its clinical manifestation involves the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs). NFTs occur in brain tissues as a result of both Aβ agglomeration and Tau phosphory...

journal_title：Journal of neurochemistry

authors： Jha NK,Jha SK,Kar R,Nand P,Swati K,Goswami VK

更新日期：2019-07-01 00:00:00

abstract：:The binding of a series of glycosylated beta-galactosidases to a fraction rich in synaptic membrane of bovine brain was examined. beta-galactosidase modified with p-aminophenyl beta-D-galactopyranoside (beta-D-Gal beta-gal) was found the most effective in binding to synaptic membrane, followed by that modified with be...

journal_title：Journal of neurochemistry

authors： Naoi M,Nagatsu T

更新日期：1986-02-01 00:00:00

abstract：:This study investigated the temporal expression and cell subtype distribution of activated caspase-3 following cortical impact-induced traumatic brain injury in rats. The animals were killed and examined for protein expression of the proteolytically active subunit of caspase-3, p18, at intervals from 6 h to 14 days af...

journal_title：Journal of neurochemistry

authors： Beer R,Franz G,Srinivasan A,Hayes RL,Pike BR,Newcomb JK,Zhao X,Schmutzhard E,Poewe W,Kampfl A

更新日期：2000-09-01 00:00:00

abstract：:Microglial activation by blood-borne factors following blood-brain barrier damage may play a significant role in subsequent neuropathogenesis of several neurodegenerative diseases. Exposure of primary cultured rat brain microglia to pure, fatty acid- and lipid-deficient rat serum albumin or fraction V, (fatty acid and...

journal_title：Journal of neurochemistry

authors： Hooper C,Pinteaux-Jones F,Fry VA,Sevastou IG,Baker D,Heales SJ,Pocock JM

更新日期：2009-05-01 00:00:00

abstract：:Epilepsy is a serious neurological condition exhibiting complex pathology and deserving of more serious attention. More than 30% of people with epilepsy are not responsive to more than 20 anti-epileptic drugs currently available, reflecting an unmet clinical need for novel therapeutic strategies. Not much is known abo...

journal_title：Journal of neurochemistry

authors： Paudel YN,Semple BD,Jones NC,Othman I,Shaikh MF

更新日期：2019-12-01 00:00:00

abstract：:Previously, we identified protein kinase FA/glycogen synthase kinase-3 (GSK-3) as a microtubule-associated protein tau kinase that can incorporate 4 mol of phosphates into 1 mol of tau protein and cause its electrophoretic mobility shift in sodium dodecyl sulfate gels, a unique property characteristic of paired helica...

journal_title：Journal of neurochemistry

authors： Yang SD,Song JS,Yu JS,Shiah SG

更新日期：1993-11-01 00:00:00

abstract：:Oxidation of ketone bodies (KBs) generates acetyl coenzyme A (AcCoA), which can be further incorporated into fatty acid. We have determined the rates of lipogenesis from ketone bodies in developing rats and their relation to the activities of enzymes involved in the production of cytoplasmic AcCoA via different pathwa...

journal_title：Journal of neurochemistry

authors： Yeh YY,Ginsburg JR,Tso TB

更新日期：1983-01-01 00:00:00

abstract：:The RGS proteins are a recently discovered family of G protein regulators that have been shown to act as GTPase-activating proteins (GAPs) on the G(alpha i) and G(alpha q) subfamilies of the heterotrimeric G proteins. Here, we demonstrate that RGS7 is a potent GAP in vitro on G(alpha i1), and G(alpha o) heterotrimeric...

journal_title：Journal of neurochemistry

authors： Shuey DJ,Betty M,Jones PG,Khawaja XZ,Cockett MI

更新日期：1998-05-01 00:00:00

abstract：:The effects of hypoxia and hypoglycaemia on the redox state in vitro have been studied. NADH and NAD+ were extracted simultaneously from superfused cerebral cortex slices and assayed by bioluminescence. The results show a nonsignificant increase in NADH and the redox ratio in "mild hypoxia," whereas "severe hypoxia" p...

journal_title：Journal of neurochemistry

authors： Garofalo O,Cox DW,Bachelard HS

更新日期：1988-07-01 00:00:00

abstract：:The endogenous neuropeptide N-acetyl-L-aspartyl-L-glutamate (NAAG) fulfills several criteria required to be accepted as a neurotransmitter. NAAG inactivation may proceed through enzymatic hydrolysis into N-acetyl-L-aspartate and glutamate by an N-acetylated-alpha-linked acidic dipeptidase (NAALADase). Therefore, some ...

journal_title：Journal of neurochemistry

authors： Serval V,Barbeito L,Pittaluga A,Cheramy A,Lavielle S,Glowinski J

更新日期：1990-07-01 00:00:00

abstract：:Autoimmune optic neuritis (AON), a model of multiple sclerosis-associated optic neuritis, is accompanied by degeneration of retinal ganglion cells (RGCs) and optic nerve demyelination and axonal loss. In order to investigate the role of N-methyl-d-aspartate (NMDA) receptors in mediating RGC degeneration, upstream chan...

journal_title：Journal of neurochemistry

authors： Bojcevski J,Stojic A,Hoffmann DB,Williams SK,Müller A,Diem R,Fairless R

更新日期：2020-06-01 00:00:00