Protein kinase FA/GSK-3 phosphorylates tau on Ser235-Pro and Ser404-Pro that are abnormally phosphorylated in Alzheimer's disease brain.

abstract：:Highly purified human serum cholinesterase (EC 3.1.1.8, also known as pseudocholinesterase and butyrylcholinesterase) had peptidase activity toward substance P. Digestion of substance P was monitored by high performance liquid chromatography, which separated three product peptides. The cleavages occurred sequentially....

journal_title：Journal of neurochemistry

authors： Lockridge O

更新日期：1982-07-01 00:00:00

abstract：:A rat kidney epithelial cell line expressing the rat neurokinin-1 receptor (NK-1 R) was used to investigate the relationship between receptor phosphorylation and desensitization. Substance P (SP) maximally stimulated cellular inositol 1,4,5-trisphosphate (IP3) production 14-fold within 3 s, after which cellular IP3 le...

journal_title：Journal of neurochemistry

authors： Vigna SR

更新日期：1999-11-01 00:00:00

abstract：:Kinetic studies on the action of monoamine oxidase (MAO) in the regulation of Na+,K+-ATPase were performed using 3-methoxy-4-hydroxybenzaldehyde (MHB), which is an analogue of 3-methoxy-4-hydroxy-phenylacetylaldehyde (product of MAO-catalysed reaction with dopamine as substrate). It was observed that at 2.6 microM MHB...

journal_title：Journal of neurochemistry

authors： Mayanil CS,Baquer NZ

更新日期：1985-01-01 00:00:00

abstract：:Dermorphin and its Hyp6 analogue are opiate-like heptapeptides originally discovered in frog skin and characterized by the presence of a D-Ala2 residue in their sequence. They were assayed for their capacity to compete with [3H]Leu-enkephalin for binding to opioid receptors in membranes of neuroblastoma x glioma hybri...

journal_title：Journal of neurochemistry

authors： Glaser T,Hübner K,de Castiglione R,Hamprecht B

更新日期：1981-12-01 00:00:00

abstract：:We have examined cyclic GMP concentrations, guanylate cyclase activities, and cyclic GMP phosphodiesterase (PDE) activities in developing retinas of congenic mice with different allelic combinations at the retinal degeneration (rd) and retinal degeneration slow (rds) loci. Although guanylate cyclase activities were fo...

journal_title：Journal of neurochemistry

authors： Fletcher RT,Sanyal S,Krishna G,Aguirre G,Chader GJ

更新日期：1986-04-01 00:00:00

abstract：:The effect of glucose concentration on the in vitro release of histamine (HA) was examined, using two different preparations of the mouse hypothalamus. The HA and tele-methylhistamine released from whole blocks of the hypothalamus into the medium linearly increased during 2-h incubation in normal Krebs-Ringer bicarbon...

journal_title：Journal of neurochemistry

authors： Nishibori M,Oishi R,Itoh Y,Saeki K

更新日期：1986-12-01 00:00:00

abstract：:This study presents the initial characterization of transgenic mice with mutations in a primary zinc-binding residue (H80), either alone or with a G93A mutation. H80G;G93A superoxide dismutase 1 (SOD1) transgenic mice developed paralysis with motor neuron loss, and ubiquitin inclusion-type rather than mitochondrial va...

journal_title：Journal of neurochemistry

authors： Son M,Srikanth U,Puttaparthi K,Luther C,Elliott JL

更新日期：2011-09-01 00:00:00

abstract：:The expression and distribution of mRNA encoding preproatrial natriuretic peptide (ppANP) in rat brain has been investigated by in situ hybridization of two 35S-labeled synthetic DNA oligonucleotides, based on a cDNA clone sequence that encodes rat ppANP. The highest relative concentrations of ppANP mRNA were detected...

journal_title：Journal of neurochemistry

authors： Gundlach AL,Knobe KE

更新日期：1992-08-01 00:00:00

abstract：:U-78518F, a 21-aminosteroid from the novel family of lipid peroxidation inhibitors (lazaroids), increased survival of dopamine (DA) neurons in mesencephalic cell cultures incubated with the neurotoxin 1-methyl-4-phenylpyridinium (MPP+). Protection against DA neuron death occurred with increasing concentrations of U-78...

journal_title：Journal of neurochemistry

authors： Sanchez-Ramos JR,Song S,Mash DC,Weiner WJ

更新日期：1992-01-01 00:00:00

abstract：:Brain homogenate, cerebral microvessels, and endothelial cells (ECs) were prepared from 15-18-week-old human fetuses and analyzed biochemically for the presence of elements of the cholinergic system [acetylcholinesterase (AChE), choline acetyltransferase (ChAT), and butyrylcholinesterase]. The ECs were cultured, and t...

journal_title：Journal of neurochemistry

authors： Kasa P,Pakaski M,Joó F,Lajtha A

更新日期：1991-06-01 00:00:00

abstract：:In multiple sclerosis (MS), oligodendrocytes in lesions are lost, leaving damaged tissue virtually devoid of these myelin-producing cells. Our group has recently demonstrated enhanced expression of insulin-like growth factor (IGF) binding protein-1 (IGFBP-1) in oligodendrocytes (CNPase(+)) localized adjacent to MS les...

journal_title：Journal of neurochemistry

authors： Chesik D,De Keyser J,Bron R,Fuhler GM

更新日期：2010-06-01 00:00:00

abstract：:We assessed the effects of cold and isolation stress on arginine vasopressin (AVP) mRNA in the paraventricular (PVN) and supraoptic (SON) nuclei of the hypothalamus. Vasopressin mRNA levels were determined by in situ hybridization histochemistry at the cellular level. In posterior magnocellular neurons of the PVN isol...

journal_title：Journal of neurochemistry

authors： Angulo JA,Ledoux M,McEwen BS

更新日期：1991-06-01 00:00:00

abstract：:The characteristics of spiperone inhibition of [3H]5-hydroxytryptamine [(3H]5-HT; [3H]serotonin) binding were examined in dorsal (DH) and ventral (VH) hippocampus, corpus striatum (CS) or caudate nucleus (CN), and frontal cortex (FC) in the rabbit, guinea pig, and cat. Some of the properties of spiperone inhibition of...

journal_title：Journal of neurochemistry

authors： Schnellmann RG,Waters SJ,Nelson DL

更新日期：1984-01-01 00:00:00

abstract：:The P2Y11 nucleotide receptor detects high extracellular ATP concentrations. Mutations of the human P2RY11 gene can play a role in brain autoimmune responses, and the P2Y11 receptor alanine-87-threonine (A87T) polymorphism has been suggested to affect immune-system functions. We investigated receptor functionality of ...

journal_title：Journal of neurochemistry

authors： Haas M,Shaaban A,Reiser G

更新日期：2014-05-01 00:00:00

abstract：:Cyclosporin A (CsA) is a clinically important immunosuppressive drug widely used to prevent graft rejection following organ or bone marrow transplantation. Although there are reports of serious neurologic alterations associated with the use of the drug, the precise mechanism of its action on the CNS still remains unkn...

journal_title：Journal of neurochemistry

authors： Mosieniak G,Figiel I,Kaminska B

更新日期：1997-03-01 00:00:00

abstract：:Myelinogenesis in developing rats was studied following chronic dosing with triethyl tin (TET), at a level of 1.0 mg TET/kg body wt/day. Experiments included starved controls with body weights depressed by 17 to 40% to equal those of the TET-treated groups. Rats at ages of 16, 21, and 30 days showed decreases relative...

journal_title：Journal of neurochemistry

authors： Blaker WD,Krigman MR,Thomas DJ,Mushak P,Morell P

更新日期：1981-01-01 00:00:00

abstract：:Neuroactive steroid family includes molecules synthesized in peripheral glands (i.e., hormonal steroids) and directly in the nervous system (i.e., neurosteroids) which are key regulators of the nervous function. As already reported in clinical and experimental studies, neurodegenerative diseases affect the levels of n...

journal_title：Journal of neurochemistry

authors： Caruso D,Melis M,Fenu G,Giatti S,Romano S,Grimoldi M,Crippa D,Marrosu MG,Cavaletti G,Melcangi RC

更新日期：2014-08-01 00:00:00

abstract：:Astrocytic glutamate transporter-1 (GLT-1) is responsible for 90% of forebrain glutamate uptake in the adult CNS. Retinoic acid (RA) is a potent regulator of neural cell differentiation and neuronal maturation in the developing CNS through activation of RA receptors/retinoic X receptors (RXRs) or non-genomic mechanism...

journal_title：Journal of neurochemistry

authors： Chan TJ,Her LS,Liaw HJ,Chen MC,Tzeng SF

更新日期：2012-05-01 00:00:00

abstract：:The ability of activated glia to affect cerebral vascular tone has been evaluated using an in vitro experimental system in which basilar arteries were incubated with glial cultures activated by treatment with lipopolysaccharide (LPS). Vascular tone was measured with an isometric myograph. Contraction in response to hi...

journal_title：Journal of neurochemistry

authors： Chisari M,Salomone S,Laureanti F,Copani A,Sortino MA

更新日期：2004-12-01 00:00:00

abstract：:Our previous work demonstrated that immunoproteasome is up-regulated in the retina and brain in response to injury that does not involve an inflammatory response (J. Neurochem. 2008; 106:158). These results suggest additional non-immune functions for the immunoproteasome in the cellular stress response pathway. The pr...

journal_title：Journal of neurochemistry

authors： Hussong SA,Kapphahn RJ,Phillips SL,Maldonado M,Ferrington DA

更新日期：2010-06-01 00:00:00

abstract：:The ontogeny of chick brain and heart ventricle calcium antagonist binding sites was determined, using [3H]nitrendipine ([3H]NDP), as the ligand. The binding of [3H]NDP to adult heart and brain was kinetically very similar, with the former displaying a KD of 0.28 +/- 0.02 nM and a Bmax of 138 +/- 17 fmol/mg protein, a...

journal_title：Journal of neurochemistry

authors： Marangos PJ,Sperelakis N,Patel J

更新日期：1984-05-01 00:00:00

abstract：:Recovery of AChE activity in the motor end plate region and end plate free region of the rat diaphragm was studied after irreversible inhibition by soman. Recovery was slow during the first 2 days and only 4 S and 10 S molecular forms of AChE were present in the end plate region. However, cytochemical evidence indicat...

journal_title：Journal of neurochemistry

authors： Grubić Z,Sketelj J,Klinar B,Brzin M

更新日期：1981-10-01 00:00:00

abstract：:[3H]Strychnine binding to rat pons + medulla membranes was used as a measure of glycine receptors or glycine receptor-coupled chloride channels in vitro. A series of compounds structurally related to 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP), which previously were shown to antagonize glycine responses in c...

journal_title：Journal of neurochemistry

authors： Braestrup C,Nielsen M,Krogsgaard-Larsen P

更新日期：1986-09-01 00:00:00

abstract：:The distribution of cerebellar gangliosides was studied in staggerer (sg/sg) mutant mice, where the majority of granule cells die after completing their migration across the molecular layer. In addition, the external granule cell layer in sg/sg mice persists longer than in normal mice. Moreover, in the sg/sg cerebellu...

journal_title：Journal of neurochemistry

authors： Seyfried TN,Bernard DJ,Yu RK

更新日期：1984-10-01 00:00:00

abstract：:Mitochondrial dysfunction and oxidative stress are known to occur following acute seizure activity but their contribution during epileptogenesis is largely unknown. The goal of this study was to determine the extent of mitochondrial oxidative stress, changes to redox status, and mitochondrial DNA (mtDNA) damage during...

journal_title：Journal of neurochemistry

authors： Waldbaum S,Liang LP,Patel M

更新日期：2010-12-01 00:00:00

abstract：:The decrease in receptor-stimulated cyclic AMP production after chronic ethanol exposure was suggested previously to be secondary to an ethanol-induced increase in extracellular adenosine. The present study was undertaken to ascertain whether a similar mechanism was responsible for the ethanol-induced desensitization ...

journal_title：Journal of neurochemistry

authors： Rabin RA,Fiorella D,Van Wylen DG

更新日期：1993-03-01 00:00:00

abstract：:It has been established that neurosteroids can either inhibit or enhance GABA(A) receptor activity. Although GABA is the main inhibitory neurotransmitter in the mammalian retina, the effects of neurosteroids on retinal GABAergic activity have not been investigated. The aim of this work was to study the neurochemical a...

journal_title：Journal of neurochemistry

authors： Jaliffa CO,Howard S,Hoijman E,Salido E,Sarmiento MI,Arias P,Rosenstein RE

更新日期：2005-09-01 00:00:00

abstract：:: The amyloid cascade hypothesis of Alzheimer's disease envisages that the initial elevation of amyloid β-peptide (Aβ) levels, especially of Aβ(1-42) , is the primary trigger for the neuronal cell death specific to onset of Alzheimer's disease. There is now substantial evidence that brain amyloid levels are manipulabl...

journal_title：Journal of neurochemistry

authors： Nalivaeva NN,Beckett C,Belyaev ND,Turner AJ

更新日期：2012-01-01 00:00:00

abstract：:Neuron-astrocyte interactions are critical for signalling, energy metabolism, extracellular ion and glutamate homeostasis, volume regulation and neuroprotection in the CNS. Glutamate uptake by astrocytes may prevent excitotoxic glutamate elevation and determine neuronal survival. However, an excess of glutamate can ca...

journal_title：Journal of neurochemistry

authors： Szydlowska K,Zawadzka M,Kaminska B

更新日期：2006-11-01 00:00:00

abstract：:In vivo microdialysis was used to determine the extent to which ionotropic glutamate receptors in the ventral tegmental area (VTA) regulate dopamine release in the nucleus accumbens. Coapplication of 2-amino-5-phosphonopentanoic acid (AP5; 200 microM) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX; 50 microM) to the V...

journal_title：Journal of neurochemistry

authors： Taber MT,Das S,Fibiger HC

更新日期：1995-09-01 00:00:00