Retinoic acid mediates the expression of glutamate transporter-1 in rat astrocytes through genomic RXR action and non-genomic protein kinase C signaling pathway.

abstract：:Alzheimer's disease (AD) is marked by the presence of neurofibrillary tangles and amyloid plaques in the brain of patients. To study plaque formation, we report on further quantitative and qualitative analysis of human and mouse amyloid beta peptides (Abeta) from brain extracts of transgenic mice overexpressing the Lo...

journal_title：Journal of neurochemistry

authors： Pype S,Moechars D,Dillen L,Mercken M

更新日期：2003-02-01 00:00:00

abstract：:The aim of the present study was to explore the possible role of kappa/dynorphin system in the development of tolerance to nicotine antinociception in mice. First, we observed that kappa-opioid receptor (KOP-r) participates in the acute spinal antinociception produced by nicotine (3 and 5 mg/kg, s.c.) since the pre-tr...

journal_title：Journal of neurochemistry

authors： Galeote L,Maldonado R,Berrendero F

更新日期：2008-05-01 00:00:00

abstract：:Brain gangliosides from four vertebrate classes (fish, amphibia, aves, and mammalia) were studied by patterns generated with the use of two-dimensional thin-layer chromatography. In an effort to retain possible alkalilabile gangliosides, samples were not base-hydrolyzed. Resultant chromatograms revealed complex patter...

journal_title：Journal of neurochemistry

authors： Hunter GD,Wiegant VM,Dunn AJ

更新日期：1981-10-01 00:00:00

abstract：:Microglial activation is common in several neurodegenerative disorders. In the present study, we used the murine BV-2 microglial cell line stimulated with gamma-interferon and lipopolysaccharide to gain new insights into the effects of endogenously produced NO on mitochondrial respiratory capacity, iron regulatory pro...

journal_title：Journal of neurochemistry

authors： Chénais B,Morjani H,Drapier JC

更新日期：2002-05-01 00:00:00

abstract：:NMDA (N-methyl-D-aspartate) subtype of glutamate receptors are core components of dendritic spine postsynaptic densities (PSDs), in which they are anchored via their carboxy-terminal tails to cytoskeletal proteins. In this study, we examined the role of the neuronal intermediate filament protein, neurofilament-light (...

journal_title：Journal of neurochemistry

authors： Ratnam J,Teichberg VI

更新日期：2005-02-01 00:00:00

abstract：:In brain, the precursor of imidazoleacetic acid (IAA), a GABAA agonist but a GABAC antagonist, is not known. In the periphery, IAA derives from oxidation of histamine. But in brain, histamine is thought to be metabolized solely by histamine methyltransferase (HMT), forming tele-methylhistamine (t-MH) and tele-methylim...

journal_title：Journal of neurochemistry

authors： Prell GD,Morrishow AM,Duoyon E,Lee WS

更新日期：1997-01-01 00:00:00

abstract：:In adult New Zealand white rabbits, the effects of food deprivation and of massive elevations of plasma uridine or thymidine concentrations on CSF and plasma nucleoside and oxypurine concentrations were studied. Nucleoside and oxypurine levels were determined by high performance liquid chromatography using unequivocal...

journal_title：Journal of neurochemistry

authors： Eells JT,Spector R,Huntoon S

更新日期：1984-06-01 00:00:00

abstract：:Dietary n-6 polyunsaturated fatty acid (PUFA) deprivation in rodents reduces brain arachidonic acid (20:4n-6) concentration and 20:4n-6-preferring cytosolic phospholipase A(2) (cPLA(2) -IVA) and cyclooxygenase (COX)-2 expression, while increasing brain docosahexaenoic acid (DHA, 22:6n-3) concentration and DHA-selectiv...

journal_title：Journal of neurochemistry

authors： Igarashi M,Kim HW,Chang L,Ma K,Rapoport SI

更新日期：2012-03-01 00:00:00

abstract：:Previous studies examining age differences in membrane fluidity and cholesterol content have reported on the average or total change in membrane structure, respectively. However, a membrane consists of an exofacial leaflet and a cytofacial leaflet that differ in fluidity and cholesterol distribution. The purpose of th...

journal_title：Journal of neurochemistry

authors： Igbavboa U,Avdulov NA,Schroeder F,Wood WG

更新日期：1996-04-01 00:00:00

abstract：:Lipocalin-type prostaglandin (PG) D synthase (L-PGDS) is responsible for the production of PGD(2), the main PG in the CNS. PGD(2) is an endogenous sleep inducer, and it is involved in the control of odor and pain responses and body temperature. In addition, PGD synthase transports lipophilic molecules in the subarachn...

journal_title：Journal of neurochemistry

authors： García-Fernández LF,Iñiguez MA,Eguchi N,Fresno M,Urade Y,Muñoz A

更新日期：2000-08-01 00:00:00

abstract：:Recent studies have highlighted the role of mitochondria in dendritic protrusion growth and plasticity. However, the detailed mechanisms that mitochondria regulate dendritic filopodia morphogenesis remain elusive. Cyclophilin D (CypD, gene name: Ppif) controls the opening of mitochondrial permeability transition pore....

journal_title：Journal of neurochemistry

authors： Sui S,Tian J,Gauba E,Wang Q,Guo L,Du H

更新日期：2018-08-01 00:00:00

abstract：:Incubation of beta-endorphin with cytosolic and particulate fractions of rat brain resulted in the formation of several peptides, including gamma-endorphin [beta-endorphin-(1-17)] and beta-endorphin-(18-31), indicating the presence of enzyme activity cleaving the Leu17-Phe18 bond of beta-endorphin. An assay for this L...

journal_title：Journal of neurochemistry

authors： Lebouille JL,Hendriks RW,Soeter NM,Burbach JP

更新日期：1989-06-01 00:00:00

abstract：:Perineuronal nets (PNNs) are presumed to limit plasticity in adult animals. Ischaemic stroke results in the massive breakdown of PNNs resulting in rejuvenating states of neuronal plasticity, but the mechanisms of this phenomenon are largely unknown. As hyaluronic acid (HA) is the structural backbone of PNNs, we hypoth...

journal_title：Journal of neurochemistry

authors： Katarzyna Greda A,Nowicka D

更新日期：2020-12-20 00:00:00

abstract：:Glutamine is a primary precursor for the biosynthesis of the neurotransmitters glutamate and gamma-aminobutyric acid. It is proposed that glutamine, synthesized and released by astrocytes, is transported into the neuron for subsequent conversion to neurotransmitters. To provide a more complete characterization of this...

journal_title：Journal of neurochemistry

authors： Tamarappoo BK,Raizada MK,Kilberg MS

更新日期：1997-03-01 00:00:00

abstract：:Members of the interleukin-1 (IL-1) family of cytokines are key mediators in the regulation of host defence responses and the development of inflammation in response to acute and chronic injury to the brain. Two major agonists, IL-1alpha and IL-1beta, bind to a membrane receptor complex composed of the type-1 IL-1 rec...

journal_title：Journal of neurochemistry

authors： Andre R,Lerouet D,Kimber I,Pinteaux E,Rothwell NJ

更新日期：2005-10-01 00:00:00

abstract：:Nigrostriatal neurodegeneration in Parkinson's disease (PD) has been postulated to be caused by various pathological conditions, such as mitochondrial defects, oxidative stress, and ubiquitin-proteasome system (UPS) dysfunction. Pharmacological strategies designed to interfere with these pathological pathways may effe...

journal_title：Journal of neurochemistry

authors： Zhu W,Xie W,Pan T,Jankovic J,Li J,Youdim MB,Le W

更新日期：2008-06-01 00:00:00

abstract：:The main objective of these studies was to determine whether the acute administration of choline to rats provides supplemental precursor that can be used to support acetylcholine synthesis when the demand for choline is increased by increasing neurotransmitter release. For these experiments, hippocampal and striatal s...

journal_title：Journal of neurochemistry

authors： Wecker L,Cawley G,Rothermel S

更新日期：1989-02-01 00:00:00

abstract：:Microsomal fractions isolated from rat corpus striatum catalyze the oxidation of thiobenzamide to the sulfoxide. The rate of thiobenzamide sulfoxidation is 6.9 +/- 4.8 nmol(min)-1 (mg microsomal protein)-1. The reaction is inhibited by an excess of sulfur- and nitrogen-containing substrates for the microsomal flavin-c...

journal_title：Journal of neurochemistry

authors： Duffel MW,Gillespie SG

更新日期：1984-05-01 00:00:00

abstract：:Math2 (NEX-1/NeuroD6) is a member of the basic helix-loop-helix transcription factor family and is involved in neuronal differentiation and maturation. In this study, we identified the genes targeted by Math2 using DNA microarrays and cultured rat cortical cells transfected with Math2. Of the genes regulated by Math2,...

journal_title：Journal of neurochemistry

authors： Yamada M,Shida Y,Takahashi K,Tanioka T,Nakano Y,Tobe T,Yamada M

更新日期：2008-09-01 00:00:00

abstract：:The activation by endogenous dopamine of the inhibitory 3,4-dihydroxyphenylethylamine (dopamine) receptors modulating the electrically evoked release of [3H]acetylcholine [( 3H]ACh) and [3H]dopamine in rat striatal slices is a function of the concentration of dopamine accumulated in the synaptic cleft during electrica...

journal_title：Journal of neurochemistry

authors： Baud P,Arbilla S,Langer SZ

更新日期：1985-02-01 00:00:00

abstract：:The tracers 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine (6-[18F]fluoro-L-DOPA) and L-[14C]DOPA were injected simultaneously into rhesus monkeys, and the time course of their metabolites was measured in the striatum and in the occipital and frontal cortices. In the striatum, 6-[18F]fluoro-L-DOPA was metabolized to 6-[18...

journal_title：Journal of neurochemistry

authors： Firnau G,Sood S,Chirakal R,Nahmias C,Garnett ES

更新日期：1987-04-01 00:00:00

abstract：:In the present study we have applied a brain microdialysis technique to investigate the effects of ouabain infusion on the release of dopamine, acetylcholine, and amino acids from striatal neurons in freely moving rats. Ouabain caused an increase in the dialysate levels of dopamine; its metabolite 3,4-dihydroxyphenyla...

journal_title：Journal of neurochemistry

authors： Westerink BH,Damsma G,de Vries JB

更新日期：1989-03-01 00:00:00

abstract：:Protein L-isoaspartyl methyltransferase (PIMT) repairs the damaged proteins which have accumulated abnormal aspartyl residues during cell aging. Gene targeting has elucidated a physiological role for PIMT by showing that mice lacking PIMT died prematurely from fatal epileptic seizures. Here we investigated the role of...

journal_title：Journal of neurochemistry

authors： Lanthier J,Bouthillier A,Lapointe M,Demeule M,Béliveau R,Desrosiers RR

更新日期：2002-11-01 00:00:00

abstract：:In the present study we have used perfused hippocampal slices to examine the hypothesis that nitric oxide (NO) can evoke the release of adenosine from nervous tissue. ATP stores were labeled by incubation with [3H]adenine. Electrical field stimulation at 5 Hz for 5 min evoked the release of 3H-purines, and this was en...

journal_title：Journal of neurochemistry

authors： Fallahi N,Broad RM,Jin S,Fredholm BB

更新日期：1996-07-01 00:00:00

abstract：:JNK/SAPK has been implicated in the pathogenesis of Alzheimer's disease, but the upstream cascade leading to JNK/SAPK activation has not been elucidated in the disease. In this study, we focused on one of the physiological activators of JNK/SAPK, JNK kinase 1 (JKK1). Although there was no significant difference in the...

journal_title：Journal of neurochemistry

authors： Zhu X,Ogawa O,Wang Y,Perry G,Smith MA

更新日期：2003-04-01 00:00:00

abstract：:The effect of tumor necrosis factor-alpha (TNF-alpha) on neuronal viability has been investigated in the SK-N-BE neuroblastoma cell line. These cells undergo differentiation upon chronic treatment with retinoic acid. Exposure of SK-N-BE cells to TNF-alpha produced a proliferative response in undifferentiated cells, wh...

journal_title：Journal of neurochemistry

authors： Condorelli F,Sortino MA,Stella AM,Canonico PL

更新日期：2000-09-01 00:00:00

abstract：:Expression of the Ca(2+)-dependent phospholipids binding protein annexin A2 (ANX2) in the brain is thought to be largely associated with brain pathological conditions such as tumor, inflammation, and neurodegeneration. The recent findings that ANX2 heterotetramer is involved in learning and neuronal activities necessi...

journal_title：Journal of neurochemistry

authors： Zhao WQ,Lu B

更新日期：2007-03-01 00:00:00

abstract：:p-glycoprotein (p-gp) is an ATP-binding cassette transporter and its overexpression is responsible for the acquisition of the multidrug resistance phenotype in human tumors. p-gp is localized at the blood-brain barrier and is involved in brain cytoprotection. Our previous work used immunoprecipitation to show that cav...

journal_title：Journal of neurochemistry

authors： Barakat S,Demeule M,Pilorget A,Régina A,Gingras D,Baggetto LG,Béliveau R

更新日期：2007-04-01 00:00:00

abstract：:ATP-gated P2X3 receptors of sensory ganglion neurons are important transducers of painful stimuli and are modulated by extracellular algogenic substances, via changes in the receptor phosphorylation state. The present study investigated the role of calcium/calmodulin-dependent serine protein kinase (CASK) in interacti...

journal_title：Journal of neurochemistry

authors： Gnanasekaran A,Sundukova M,Hullugundi S,Birsa N,Bianchini G,Hsueh YP,Nistri A,Fabbretti E

更新日期：2013-07-01 00:00:00

abstract：:Neuromodulation is a fundamental process in the brain that regulates synaptic transmission, neuronal network activity and behavior. Emerging evidence demonstrates that astrocytes, a major population of glial cells in the brain, play previously unrecognized functions in neuronal modulation. Astrocytes can detect the le...

journal_title：Journal of neurochemistry

authors： Fellin T

更新日期：2009-02-01 00:00:00