Increasing age alters transbilayer fluidity and cholesterol asymmetry in synaptic plasma membranes of mice.

abstract：:At present, treatment for Parkinson's disease (PD) is only symptomatic; therefore, it is important to identify new targets tackling the molecular causes of the disease. We previously found that lymphoblasts from sporadic PD patients display increased activity of the cyclin D3/CDK6/pRb pathway and higher proliferation ...

journal_title：Journal of neurochemistry

authors： Alquézar C,Barrio E,Esteras N,de la Encarnación A,Bartolomé F,Molina JA,Martín-Requero Á

更新日期：2015-06-01 00:00:00

abstract：:Glycine and GABA are likely co-transmitters in the spinal cord. Their possible interactions in presynaptic terminals have, however, not been investigated. We studied the effects of glycine on GABA release using superfused mouse spinal cord synaptosomes. Glycine concentration dependently elicited [(3)H]GABA release whi...

journal_title：Journal of neurochemistry

authors： Raiteri L,Raiteri M,Bonanno G

更新日期：2001-03-01 00:00:00

abstract：:Neuronal nitric oxide synthase (nNOS) is a component of the dystrophin complex in skeletal muscle. The absence of dystrophin protein in Duchenne muscular dystrophy and in mdx mouse causes a redistribution of nNOS from the plasma membrane to the cytosol in muscle cells. Aberrant nNOS activity in the cytosol can induce ...

journal_title：Journal of neurochemistry

authors： Chao DS,Silvagno F,Bredt DS

更新日期：1998-08-01 00:00:00

abstract：:Antisera raised to the 68,000, 145,000 and 200,000 molecular weight subunits of rat neurofilaments were used for immunochemical staining of polypeptides separated by one- and two-dimensional gel electrophoresis. It was found that each antiserum reacts intensely with its corresponding neurofilament subunit and weakly w...

journal_title：Journal of neurochemistry

authors： Autilio-Gambetti L,Velasco ME,Sipple J,Gambetti P

更新日期：1981-11-01 00:00:00

abstract：:Multiple lines of evidence implicate lysosomes in a variety of pathogenic events that produce neurodegeneration. Genetic mutations that cause specific enzyme deficiencies account for more than 40 lysosomal storage disorders. These mostly pre-adult diseases are associated with abnormal brain development and mental reta...

journal_title：Journal of neurochemistry

authors： Bahr BA,Bendiske J

更新日期：2002-11-01 00:00:00

abstract：:Deposits of amyloid beta-peptide (A beta), reduced glucose uptake into brain cells, oxidative damage to cellular proteins and lipids, and excitotoxic mechanisms have all been suggested to play roles in the neurodegenerative process in Alzheimer's disease. Synapse loss is closely correlated with cognitive impairments i...

journal_title：Journal of neurochemistry

authors： Keller JN,Pang Z,Geddes JW,Begley JG,Germeyer A,Waeg G,Mattson MP

更新日期：1997-07-01 00:00:00

abstract：:The importance of the nuclear receptor nurr1 for the appropriate development of mesencephalic dopamine-synthesizing neurons has been clearly demonstrated through the targeted disruption of the nurr1 gene. The persistence of nurr1 expression in adult tissue suggests a possible role for this transcription factor in the ...

journal_title：Journal of neurochemistry

authors： Sacchetti P,Mitchell TR,Granneman JG,Bannon MJ

更新日期：2001-03-01 00:00:00

abstract：:Explants of adrenal medullae were cultured in defined media for up to 48 h, during which time the tissue remained histologically intact. Addition of N6-methyladenosine to the medium led to a diminution in the activity of phenylethanolamine N-methyltransferase (EC 2.1.1.28) in the tissue. The enzyme activity was invers...

journal_title：Journal of neurochemistry

authors： Burke WJ,Joh TH

更新日期：1982-07-01 00:00:00

abstract：:In this study, we show specific intracellular responses evoked by the stimulation of astrocytes with the P1,P5-di(adenosine-5')pentaphosphate, Ap5A. The stimulation of astrocytes with micromolar concentrations of the dinucleotide elicited rapid increases in intracellular calcium concentration ([Ca2+]i), showing an EC5...

journal_title：Journal of neurochemistry

authors： Jiménez AI,Castro E,Delicado EG,Miras-Portugal MT

更新日期：2002-10-01 00:00:00

abstract：:Neuronal differentiation requires exquisitely timed cell cycle arrest for progenitors to acquire an appropriate neuronal cell fate and is achieved by communication between soluble signals, such as growth factors and extracellular matrix molecules. Here we report that the expression of TIMP-2, a matrix metalloproteinas...

journal_title：Journal of neurochemistry

authors： Jaworski DM,Pérez-Martínez L

更新日期：2006-07-01 00:00:00

abstract：:Converging lines of evidence suggest that progressive accumulation of the amyloid beta-protein (A beta) plays a central role in the genesis of Alzheimer's disease, but it was long assumed that A beta had to be assembled into extracellular amyloid fibrils to exert its cytotoxic effects. Over the past decade, data have ...

journal_title：Journal of neurochemistry

authors： Walsh DM,Selkoe DJ

更新日期：2007-06-01 00:00:00

abstract：:Mitochondria and releasable endoplasmic reticulum (ER) calcium modulate neuronal calcium signaling, and both change in Alzheimer's disease (AD). The releasable calcium stores in the ER are exaggerated in fibroblasts from AD patients and in multiple models of AD. The activity of the alpha-ketoglutarate dehydrogenase co...

journal_title：Journal of neurochemistry

authors： Chen H,Cross AC,Thakkar A,Xu H,Li A,Paull D,Noggle SA,Kruger L,Denton TT,Gibson GE

更新日期：2020-08-31 00:00:00

abstract：:The glutamate (Glu) terminals in rat neostriatum were removed by a unilateral frontal decortication. One to two weeks later the effects of insulin-induced hypoglycemia on the steady-state levels of amino acids [Glu, glutamine (Gln), aspartate (Asp), gamma-aminobutyric acid (GABA), taurine] and energy metabolites (gluc...

journal_title：Journal of neurochemistry

authors： Engelsen B,Westerberg E,Fonnum F,Wieloch T

更新日期：1986-11-01 00:00:00

abstract：:Since emotional stress elicits brain activation, mitochondria should be a key component of stressed brain response. However, few studies have focused on mitochondria functioning in these conditions. In this work, we aimed to determine the effects of an acute restraint stress on rat brain mitochondrial functions, with ...

journal_title：Journal of neurochemistry

authors： Batandier C,Poulet L,Hininger I,Couturier K,Fontaine E,Roussel AM,Canini F

更新日期：2014-11-01 00:00:00

abstract：:The expression of facilitative glucose transporter (GLUT) isoforms in human astrocytic tumors was examined. Reverse transcriptase-polymerase chain reaction of a surgically biopsied glioblastoma was carried out using the degenerative oligonucleotide primers corresponding to the sequences of the human facilitative gluco...

journal_title：Journal of neurochemistry

authors： Nagamatsu S,Sawa H,Wakizaka A,Hoshino T

更新日期：1993-12-01 00:00:00

abstract：:The characteristics of glycosylation of a brain-specific glycoprotein, 1D4 antigen, and the epitope recognized by its monoclonal antibody were studied. Removal of high-mannose and hybrid types of N-linked oligosaccharides by treatment with endoglycosidase H converted the molecular mass of the 1D4 antigen from 89 kDa t...

journal_title：Journal of neurochemistry

authors： Sano S,Ito S,Nakamura M,Nakagawa H

更新日期：1990-10-01 00:00:00

abstract：:In all the species examined thus far, the behavior of microglia during development appears to be highly stereotyped. This reproducibility supports the notion that these cells have a physiological role in development. Microglia are macrophages that migrate from the yolk sac and colonize the central nervous system early...

journal_title：Journal of neurochemistry

authors： Pont-Lezica L,Béchade C,Belarif-Cantaut Y,Pascual O,Bessis A

更新日期：2011-12-01 00:00:00

abstract：:The effects of hypoxia and hypoglycaemia on the redox state in vitro have been studied. NADH and NAD+ were extracted simultaneously from superfused cerebral cortex slices and assayed by bioluminescence. The results show a nonsignificant increase in NADH and the redox ratio in "mild hypoxia," whereas "severe hypoxia" p...

journal_title：Journal of neurochemistry

authors： Garofalo O,Cox DW,Bachelard HS

更新日期：1988-07-01 00:00:00

abstract：:Carboxypeptidase E (CPE) functions in the posttranslational processing of bioactive peptides. Like other peptide processing enzymes, CPE is initially produced as a precursor ("proCPE") that undergoes posttranslational processing at a site containing five adjacent Arg residues near the N-terminus and at other sites nea...

journal_title：Journal of neurochemistry

authors： Song L,Fricker L

更新日期：1995-07-01 00:00:00

abstract：:We report the cloning, genome mapping, functional expression, pharmacology and anatomical distribution of three melanocortin (MC) receptors from zebrafish (z). Phylogenetic analysis showed with high bootstrap support that these genes represent one MC4 receptor and two MC5 receptors. Chromosomal mapping showed conserve...

journal_title：Journal of neurochemistry

authors： Ringholm A,Fredriksson R,Poliakova N,Yan YL,Postlethwait JH,Larhammar D,Schiöth HB

更新日期：2002-07-01 00:00:00

abstract：:Although myelin oligodendrocyte glycoprotein is a candidate autoantigen in multiple sclerosis, its function remains unknown. In humans, mRNA expressed by the myelin oligodendrocyte glycoprotein gene is alternatively spliced resulting in at least nine unique protein isoforms. In this study, we investigated the sub-cell...

journal_title：Journal of neurochemistry

authors： Boyle LH,Traherne JA,Plotnek G,Ward R,Trowsdale J

更新日期：2007-09-01 00:00:00

abstract：:Abnormal expansion of a polyglutamine tract in huntingtin (Htt) protein results in Huntington's disease (HD), an autosomal dominant neurodegenerative disorder involving progressive loss of motor and cognitive function. Contrasting with the ubiquitous tissue expression of polyglutamine-expanded Htt, HD pathology is cha...

journal_title：Journal of neurochemistry

authors： Han I,You Y,Kordower JH,Brady ST,Morfini GA

更新日期：2010-06-01 00:00:00

abstract：:F2-isoprostanes (F2-IsoPs) are well-established sensitive and specific markers of oxidative stress in vivo. Isofurans (IsoFs) are also products of lipid peroxidation, but in contrast to F2-IsoPs, their formation is favored when oxygen tension is increased in vitro or in vivo. Mitochondrial dysfunction in Parkinson's d...

journal_title：Journal of neurochemistry

authors： Fessel JP,Hulette C,Powell S,Roberts LJ 2nd,Zhang J

更新日期：2003-05-01 00:00:00

abstract：:Research on stem cells has developed as one of the most promising areas of neurobiology. In the beginning of the 1990s, neurogenesis in the adult brain was indisputably accepted, eliciting great research efforts. Neural stem cells in the adult mammalian brain are located in the 'neurogenic' areas of the subventricular...

journal_title：Journal of neurochemistry

authors： Bellenchi GC,Volpicelli F,Piscopo V,Perrone-Capano C,di Porzio U

更新日期：2013-01-01 00:00:00

abstract：:Neurodegenerative diseases such as Alzheimer's disease (AD) are characterized by an abnormal aggregation of misfolded beta-sheet rich proteins such as β-amyloid (Aβ). Various ubiquitously expressed molecular chaperones control the correct folding of cellular proteins and prevent the accumulation of harmful species. We...

journal_title：Journal of neurochemistry

authors： Hoshino A,Helwig M,Rezaei S,Berridge C,Eriksen JL,Lindberg I

更新日期：2014-02-01 00:00:00

abstract：:Tissue plasminogen activator (tPA) administration beyond 4.5 h of stroke symptoms is beneficial for patients but has an increased risk of cerebral hemorrhage. Thus, increasing the therapeutic window of tPA is important for stroke recovery. We previously showed that prothymosin alpha (ProTα) or its mimetic hexapeptide ...

journal_title：Journal of neurochemistry

authors： Halder SK,Matsunaga H,Ueda H

更新日期：2020-06-01 00:00:00

abstract：:Transmitter release at high probability phasic synapses of crayfish neuromuscular junctions depresses by over 50% in 60 min when stimulated at 0.2 Hz. Inhibition of the protein phosphatase calcineurin by intracellular pre-synaptic injection of autoinhibitory peptide inhibited low-frequency depression (LFD) and resulte...

journal_title：Journal of neurochemistry

authors： Silverman-Gavrila LB,Charlton MP

更新日期：2009-05-01 00:00:00

abstract：:Cell and tissue concentrations of NO2- and NO3- are important indicators of nitric oxide synthase activity and crucial in the regulation of many metabolic functions, as well as in nonenzymatic nitric oxide release. We adapted the capillary electrophoresis technique to quantify NO2- and NO3- levels in single identified...

journal_title：Journal of neurochemistry

authors： Cruz L,Moroz LL,Gillette R,Sweedler JV

更新日期：1997-07-01 00:00:00

abstract：:Cholinergic signaling plays an important role in regulating the growth and regeneration of axons in the nervous system. The α7 nicotinic receptor (α7) can drive synaptic development and plasticity in the hippocampus. Here, we show that activation of α7 significantly reduces axon growth in hippocampal neurons by coupli...

journal_title：Journal of neurochemistry

authors： Nordman JC,Phillips WS,Kodama N,Clark SG,Del Negro CA,Kabbani N

更新日期：2014-05-01 00:00:00

abstract：:Phospholipids are asymmetrically distributed across the mammalian plasma membrane, with phosphatidylserine (PS) and phosphatidylethanolamine concentrated in the cytoplasmic leaflet of the membrane bilayer and phosphatidylcholine in the exoplasmic leaflet. This asymmetric distribution is dependent on a group of P4 ATPa...

journal_title：Journal of neurochemistry

authors： Yang Y,Liu W,Sun K,Jiang L,Zhu X

更新日期：2019-02-01 00:00:00