Cerebral metabolism of 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine in the primate.

abstract：:Transient and time-dependent modulations of neural cell adhesion molecule (NCAM) polysialylation in the dentate gyrus of the rodent hippocampus are a feature of spatial and nonspatial forms of learning. In the hippocampal formation, polysialic acid immunoreactivity was localized to granule-like cells and their mossy f...

journal_title：Journal of neurochemistry

authors： O'Connell AW,Fox GB,Barry T,Murphy KJ,Fichera G,Foley AG,Kelly J,Regan CM

更新日期：1997-06-01 00:00:00

abstract：:We have characterized the structural properties of heparan sulfates from brain and other tissues after depolymerization with a mixture of three heparin and heparan sulfate lyases from Flavobacterium heparinum. The resulting disaccharides were separated by HPLC and identified by comparison with authentic standards. In ...

journal_title：Journal of neurochemistry

authors： Tekotte H,Engel M,Margolis RU,Margolis RK

更新日期：1994-03-01 00:00:00

abstract：:We examined the effects of chronic systemic administration of the mitochondrial toxin 3-nitropropionic acid (3-NP) in doses ranging from 12 to 16 mg/kg/day for 30 days on striatal cytoarchitecture in rats. Administration of 3-NP at a dose of 16 mg/kg/day resulted in large lesions with a central necrotic core that was ...

journal_title：Journal of neurochemistry

authors： Wüllner U,Young AB,Penney JB,Beal MF

更新日期：1994-11-01 00:00:00

abstract：:We have previously shown that in cell extracts from rat striatum, cyclic AMP response element (CRE) binding protein (CREB), rather than AP-1 proteins, preferentially interacts with the CRE-2 element of the proenkephalin second messenger-inducible enhancer, even under conditions in which AP-1 proteins are highly induce...

journal_title：Journal of neurochemistry

authors： Konradi C,Cole RL,Green D,Senatus P,Leveque JC,Pollack AE,Grossbard SJ,Hyman SE

更新日期：1995-09-01 00:00:00

abstract：:Beta-amyloid peptides (A beta) are deposited in an aggregated fibrillar form in both diffuse and senile plaques in the brains of patients with Alzheimer's disease. The neurotoxicity of A beta in cultured neurons is dependent on its aggregation state, but the factors contributing to aggregation and fibril formation are...

journal_title：Journal of neurochemistry

authors： Du Y,Bales KR,Dodel RC,Liu X,Glinn MA,Horn JW,Little SP,Paul SM

更新日期：1998-03-01 00:00:00

abstract：:Histamine stimulated the enzymatic synthesis of phosphatidylcholine from phosphatidylethanolamine in crude synaptic membranes of rat brain containing the methyl donor S-adenosyl-L-methionine (SAM). In the presence of, but not in the absence of SAM, histamine increased cyclic AMP accumulation at the concentrations that...

journal_title：Journal of neurochemistry

authors： Ozawa K,Segawa T

更新日期：1988-05-01 00:00:00

abstract：:Male copulatory behavior in the snail Lymnaea stagnalis is controlled by several types of peptidergic neurons, including a cluster of neurons in the ventral lobe of the right cerebral ganglion that show immunoreactivity to myomodulin-A of Aplysia and innervate the penis complex. We identified structurally myomodulin-A...

journal_title：Journal of neurochemistry

authors： van Golen FA,Li KW,Chen S,Jiménez CR,Geraerts WP

更新日期：1996-01-01 00:00:00

abstract：:Spiroxatrine has been reported to be a 5-HT1A serotonin receptor antagonist. Therefore [3H]spiroxatrine was synthesized and its 5-HT1A receptor binding properties in homogenates of rat hippocampal membranes were characterized with the expectation that it would be the first 5-HT1A antagonist radioligand. [3H]8-Hydroxyd...

journal_title：Journal of neurochemistry

authors： Herrick-Davis K,Titeler M

更新日期：1988-02-01 00:00:00

abstract：:Neuropeptide Y (NPY) and peptide YY (PYY) are related 36-amino acid peptides. NPY is widely distributed in the nervous system and has several physiological roles. PYY serves as an intestinal hormone as well as a neuropeptide. We report here cloning of the npy and pyy genes in zebrafish (Danio rerio). NPY differs at on...

journal_title：Journal of neurochemistry

authors： Söderberg C,Wraith A,Ringvall M,Yan YL,Postlethwait JH,Brodin L,Larhammar D

更新日期：2000-09-01 00:00:00

abstract：:We examined the effect of phenylalanine (50-400 microM) on the electrically stimulated release of endogenous 3,4-dihydroxyphenylethylamine (dopamine or DA) from superfused rat striatal slices. In the absence of tyrosine, phenylalanine (25 microM) partially sustained DA release, but less well than an equimolar concentr...

journal_title：Journal of neurochemistry

authors： Milner JD,Irie K,Wurtman RJ

更新日期：1986-11-01 00:00:00

abstract：:We have examined the binding of the adenosine agonist radioligands [3N]N6-cyclohexyladenosine ([3H]CHA) and [3H]5'-N-ethylcarboxamidoadenosine ([3H]NECA) to membranes prepared from postmortem human pineal glands. The results showed that the A-1-specific ligand CHA did not bind to membranes. By contrast, [3H]NECA, a no...

journal_title：Journal of neurochemistry

authors： Reynaud D,Gharib A,Lagarde M,Sarda N

更新日期：1990-10-01 00:00:00

abstract：:Human immunodeficiency virus (HIV)-1-associated neurocognitive disorders (HAND) associated with infection and activation of mononuclear phagocytes (MP) in the brain, occur late in disease. Infected/activated MP initiate neuroinflammation activating glial cells and ultimately disrupting neuronal function. Astrocytes se...

journal_title：Journal of neurochemistry

authors： Fields J,Gardner-Mercer J,Borgmann K,Clark I,Ghorpade A

更新日期：2011-07-01 00:00:00

abstract：:The glycine receptor is a member of the Cys-loop, ligand-gated ion channel family and is responsible for inhibition in the CNS. We examined the orientation of amino acids I229 in transmembrane 1 (TM1) and A288 in TM3, which are both critical for alcohol and volatile anesthetic action. We mutated these two amino acids ...

journal_title：Journal of neurochemistry

authors： Lobo IA,Harris RA,Trudell JR

更新日期：2008-03-01 00:00:00

abstract：:Although isoelectric focusing has been used to demonstrate the presence of oligoclonal IgG in the CSF, the technique has not allowed detection of oligoclonal IgG in unconcentrated CSF. A new technique is reported, by which unconcentrated CSF is separated by isoelectric focusing, and the IgG bands are then detected by ...

journal_title：Journal of neurochemistry

authors： Lasne Y,Benzerara O,Chazot G,Creyssel R

更新日期：1981-05-01 00:00:00

abstract：:Nerve growth factor (NGF) serves a critical survival-promoting function for developing sympathetic neurons. Following removal of NGF, sympathetic neurons undergo apoptosis characterized by the activation of c-Jun N-terminal kinases (JNKs), up-regulation of BH3-only proteins including BcL-2-interacting mediator of cell...

journal_title：Journal of neurochemistry

authors： Lomb DJ,Straub JA,Freeman RS

更新日期：2007-12-01 00:00:00

abstract：:Ion channels are classically understood to regulate the flux of ions across the plasma membrane in response to a variety of environmental and intracellular cues. Ion channels serve a number of functions in intracellular membranes as well. These channels may be temporarily localized to intracellular membranes as a func...

journal_title：Journal of neurochemistry

authors： Dong XP,Wang X,Xu H

更新日期：2010-04-01 00:00:00

abstract：:Previous studies have purified from brain a Ca2+/calmodulin-dependent protein kinase II (designated CaM-kinase II) that phosphorylates synapsin I, a synaptic vesicle-associated phosphoprotein. CaM-kinase II is composed of a major Mr 50K polypeptide and a minor Mr 60K polypeptide; both bind calmodulin and are phosphory...

journal_title：Journal of neurochemistry

authors： Shields SM,Vernon PJ,Kelly PT

更新日期：1984-12-01 00:00:00

abstract：:In one 21-week-old fetus with prenatally diagnosed metachromatic leukodystrophy, galactolipid contents were determined in the forebrain cortex, cerebellum, brainstem, spinal cord, and kidney and compared to an appropriate control. Spinal cord and kidney showed the highest sulfatide accumulation as a consequence of def...

journal_title：Journal of neurochemistry

authors： Baier W,Harzer K

更新日期：1983-12-01 00:00:00

abstract：:Real-time alterations in intracellular Ca2+ ([Ca2+]i) were monitored in fluo-3-loaded cerebellar granule neurons (CGNs) exposed to the brevetoxin PbTx-1. [Ca2+]i was measured using a fluorescent plate reader (FLIPR), which measures simultaneously the mean intracellular Ca2+ change in a population of cultured cells in ...

journal_title：Journal of neurochemistry

authors： Berman FW,Murray TF

更新日期：2000-04-01 00:00:00

abstract：:This study investigates the functioning of synaptosomal ouabain-sensitive Na+ -K+ -ATPase in cold-induced edema. During vasogenic brain edema development, the enzyme affinities for Na+ and K+ are progressively decreased paralleling the increase in the tissue water content, whereas maximal velocity of the reaction is n...

journal_title：Journal of neurochemistry

authors： Averet N,Rigoulet M,Cohadon F

更新日期：1984-01-01 00:00:00

abstract：:Synaptic scaffolding molecule (S-SCAM) is a synaptic protein that consists of PDZ domains, a guanylate kinase domain, and WW domains. It interacts with N-methyl-d-aspartate receptor subunits, neuroligin, and beta-catenin. Here, we identified Axin as a novel binding partner of S-SCAM. Axin was co-immunoprecipitated wit...

journal_title：Journal of neurochemistry

authors： Hirabayashi S,Nishimura W,Iida J,Kansaku A,Kishida S,Kikuchi A,Tanaka N,Hata Y

更新日期：2004-07-01 00:00:00

abstract：:α-Synuclein causes Parkinson's disease if mutated or aberrantly produced in neurons. α-Synuclein-lipid interactions are important for the normal function of the protein, but can also contribute to pathogenesis. We previously reported that deletion of the first 10 N-terminal amino acids dramatically reduced lipid bindi...

journal_title：Journal of neurochemistry

authors： Vamvaca K,Lansbury PT Jr,Stefanis L

更新日期：2011-10-01 00:00:00

abstract：:delta 1-Pyrroline, 5-methyl-delta 1-pyrroline, and 5,5-dimethyl-delta 1-pyrroline have been identified as substances metabolized to gamma-aminobutyric acid (GABA), 4-aminopentanoic acid (methylGABA), and 4-amino-4-methylpentanoic acid (dimethylGABA), respectively. An enzyme system residing in the soluble fraction of r...

journal_title：Journal of neurochemistry

authors： Callery PS,Geelhaar LA,Nayar MS,Stogniew M,Rao KG

更新日期：1982-04-01 00:00:00

abstract：:The NMDA receptor has recently been found to be phosphorylated on tyrosine. To assess the possible connection between tyrosine phosphorylation of the NMDA receptor and signaling pathways in the postsynaptic cell, we have investigated the relationship between tyrosine phosphorylation and the binding of NMDA receptor su...

journal_title：Journal of neurochemistry

authors： Gurd JW,Bissoon N

更新日期：1997-08-01 00:00:00

abstract：:Primary rat fibroblasts genetically modified to express Drosophila choline acetyltransferase (dChAT) synthesize and release acetylcholine (ACh) in vitro. The ACh produced from the transduced fibroblasts was found to be enhanced by increasing amounts of choline chloride in the culture media. These dChAT-expressing cell...

journal_title：Journal of neurochemistry

authors： Fisher LJ,Schinstine M,Salvaterra P,Dekker AJ,Thal L,Gage FH

更新日期：1993-10-01 00:00:00

abstract：:The binding of the potent adenosine uptake inhibitor [3H]nitrobenzylthioinosine ([3H]NBI) to brain membrane fractions was investigated. Reversible, saturable, specific, high-affinity binding was demonstrated in both rat and human brain. The KD in both was 0.15 nM with Bmax values of 140-200 fmol/mg protein. Linear Sca...

journal_title：Journal of neurochemistry

authors： Marangos PJ,Patel J,Clark-Rosenberg R,Martino AM

更新日期：1982-07-01 00:00:00

abstract：:Many models of Parkinson's disease (PD) have succeeded in replicating dopaminergic neuron loss or alpha-synuclein aggregation but not the formation of classical Lewy bodies, the pathological hallmark of PD. Our cybrid model of sporadic PD was created by introducing the mitochondrial genes from PD patients into neurobl...

journal_title：Journal of neurochemistry

authors： Trimmer PA,Borland MK,Keeney PM,Bennett JP Jr,Parker WD Jr

更新日期：2004-02-01 00:00:00

abstract：:The transport kinetics of gamma-aminobutyric acid (GABA), taurine, and beta-alanine in addition to the mutual inhibition patterns of these compounds were investigated in cultures of neurons and astrocytes derived from mouse cerebral cortex. A high-affinity uptake system for each amino acid was demonstrated both in neu...

journal_title：Journal of neurochemistry

authors： Larsson OM,Griffiths R,Allen IC,Schousboe A

更新日期：1986-08-01 00:00:00

abstract：:Recently, in the course of our search for the prostacyclin receptor in the brain, we found a novel subtype, designated as IP2, which was finely discriminated by use of the specific ligand (15R)-16-m-tolyl-17,18,19,20-tetranorisocarbacyclin (15R-TIC) and specifically localized in the rostral part of the brain. In the p...

journal_title：Journal of neurochemistry

authors： Watanabe Y,Matsumura K,Takechi H,Kato K,Morii H,Björkman M,Långström B,Noyori R,Suzuki M,Watanabe Y

更新日期：1999-06-01 00:00:00

abstract：:P25alpha is a protein normally expressed in oligodendrocytes and subcellular relocalization of p25alpha occurs in multiple system atrophy, Parkinson's disease and Lewy body dementia along with ectopic expression in neurons. Moreover, it accumulates in Lewy body inclusions with aggregated alpha-synuclein and is a poten...

journal_title：Journal of neurochemistry

authors： Kleinnijenhuis AJ,Hedegaard C,Lundvig D,Sundbye S,Issinger OG,Jensen ON,Jensen PH

更新日期：2008-07-01 00:00:00