Sulfatides in prenatal metachromatic leukodystrophy.

abstract：:Neurofibrillary tangles, one of the major pathological hallmarks of Alzheimer-diseased brains, consist primarily of aggregated paired helical filaments (PHFs) of hyperphosphorylated tau protein. Tau from normal brain and especially from foetal brain is also phosphorylated on some of the sites phosphorylated in PHFs, m...

journal_title：Journal of neurochemistry

authors： Reynolds CH,Nebreda AR,Gibb GM,Utton MA,Anderton BH

更新日期：1997-07-01 00:00:00

abstract：:Calmodulin regulated spectrin-associated protein 1 (CAMSAP1) is a vertebrate microtubule-binding protein, and a representative of a family of cytoskeletal proteins that arose with animals. We reported previously that the central region of the protein, which contains no recognized functional domain, inhibited neurite o...

journal_title：Journal of neurochemistry

authors： King MD,Phillips GW,Bignone PA,Hayes NV,Pinder JC,Baines AJ

更新日期：2014-02-01 00:00:00

abstract：:The modulation of 3,4-dihydroxyphenylethylamine (dopamine, DA) synthesis and release in rabbit retina in vitro by high K+; adenylate cyclase activators such as forskolin, 2-chloroadenosine, vasoactive intestinal polypeptide (VIP); and the putative DA autoreceptor agonist N-n-propyl-3-(3-hydroxyphenyl) piperidine (3-PP...

journal_title：Journal of neurochemistry

authors： Ofori S,Magistretti PJ,Schorderet M

更新日期：1986-10-01 00:00:00

abstract：:Cathepsin D (CTSD) deficiencies are fatal neurological diseases that in human infants and in sheep are characterized by extreme loss of neurons and myelin. To date, similar morphological evidence for myelin disruption in CTSD knockout mice has not been reported. Here, we show that CTSD deficiency leads to pronounced m...

journal_title：Journal of neurochemistry

authors： Mutka AL,Haapanen A,Käkelä R,Lindfors M,Wright AK,Inkinen T,Hermansson M,Rokka A,Corthals G,Jauhiainen M,Gillingwater TH,Ikonen E,Tyynelä J

更新日期：2010-01-01 00:00:00

abstract：:There is growing evidence that activation of either protein kinases or protein phosphatases determines the type of plasticity observed after different patterns of hippocampal stimulation. Because activation of the extracellular signal-regulated kinase (ERK) has been shown to be necessary for long-term potentiation, we...

journal_title：Journal of neurochemistry

authors： Norman ED,Thiels E,Barrionuevo G,Klann E

更新日期：2000-01-01 00:00:00

abstract：:gamma-Aminobutyric acid (GABA) concentrations were measured in CSF specimens from two large groups of control subjects, one without neurological or psychiatric disease, and one with a variety of neurological disorders not known to involve altered GABAergic function in brain. CSF GABA was also measured in patients with...

journal_title：Journal of neurochemistry

authors： Perry TL,Hansen S,Wall RA,Gauthier SG

更新日期：1982-03-01 00:00:00

abstract：:Tau pathologically aggregates in Alzheimer's disease, and evidence suggests that reducing tau expression may be safe and beneficial for the prevention or treatment of this disease. We sought to examine the role of the 3'-untranslated region (3'-UTR) of human tau mRNA in regulating tau expression. Tau expresses two 3'-...

journal_title：Journal of neurochemistry

authors： Dickson JR,Kruse C,Montagna DR,Finsen B,Wolfe MS

更新日期：2013-12-01 00:00:00

abstract：:The potential anxiolytic effects of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor subgroup 2 (mGluR₂) were investigated using a self-referencing recording technique with enzyme-based microelectrode arrays (MEAs) that reliably measures tonic and phasic changes in extracellular gluta...

journal_title：Journal of neurochemistry

authors： Hascup ER,Hascup KN,Pomerleau F,Huettl P,Hajos-Korcsok E,Kehr J,Gerhardt GA

更新日期：2012-08-01 00:00:00

abstract：:The hydrolysis of phosphoinositides (PI) elicited in cerebellar granule cell cultures by agonists of metabolotropic glutamate receptors, glutmate and quisqualate, was enhanced when the cells were pretreated with concanavalin A (Con-A). A similar effect was produced by wheat germ agglutinin, but not by several other le...

journal_title：Journal of neurochemistry

authors： Raulli R,Danysz W,Wroblewski JT

更新日期：1991-06-01 00:00:00

abstract：:A procedure is described for the rapid preparation of nerve ending particles (synaptosomes) from 11 regions of one rat brain. The synaptosomal fractions have been characterized by electron microscopy and determination of four marker enzymes, i.e., glutamate decarboxylase (GAD), acetylcholinesterase, succinate dehydrog...

journal_title：Journal of neurochemistry

authors： Löscher W,Böhme G,Müller F,Pagliusi S

更新日期：1985-09-01 00:00:00

abstract：:The nervous system is frequently the site of symptomatic toxicity of antineoplastic agents. However, there is limited information about the differential vulnerability of neurons, astrocytes and glioma cells. We have analyzed the effects of four chemotherapeutic drugs (lomustine, cisplatin, topotecan and vincristine) o...

journal_title：Journal of neurochemistry

authors： Wick A,Wick W,Hirrlinger J,Gerhardt E,Dringen R,Dichgans J,Weller M,Schulz JB

更新日期：2004-12-01 00:00:00

abstract：:Spinal muscular atrophy (SMA) is a motor neuron disease caused by loss of function mutations in the Survival Motor Neuron 1 (SMN1) gene and reduced expression of the SMN protein, leading to spinal motor neuron death, muscle weakness and atrophy. Although humans harbour the highly homologous SMN2 gene, its defective sp...

journal_title：Journal of neurochemistry

authors： Pagliarini V,Guerra M,Di Rosa V,Compagnucci C,Sette C

更新日期：2020-04-01 00:00:00

abstract：:The major component of the amyloid deposition that characterizes Alzheimer's disease is the 4-kDa beta A4 protein, which is derived from a much larger amyloid protein precursor (APP). A procedure for the complete purification of APP from human brain is described. The same amino terminal sequence of APP was found in tw...

journal_title：Journal of neurochemistry

authors： Moir RD,Martins RN,Bush AI,Small DH,Milward EA,Rumble BA,Multhaup G,Beyreuther K,Masters CL

更新日期：1992-10-01 00:00:00

abstract：:The binding of L-2-[3H]amino-4-phosphonobutyrate ([3H]L-AP4) was examined in brain sections of wild-type mice and mice lacking the mGluR4 subtype of metabotropic glutamate receptors (mGluRs). Very high relative densities of [3H]L-AP4 binding were observed in the molecular layer of the cerebellar cortex, the nucleus ba...

journal_title：Journal of neurochemistry

authors： Thomsen C,Hampson DR

更新日期：1999-02-01 00:00:00

abstract：:Silent information regulator 2, a member of NAD+-dependent histone deacetylase in yeast, and its homologs in mice and humans, participate in numerous important cell functions, including cell protection and cell cycle regulation. The sirtuin family members are highly conserved evolutionarily, and are predicted to have ...

journal_title：Journal of neurochemistry

authors： Anekonda TS,Reddy PH

更新日期：2006-01-01 00:00:00

abstract：:Oxidation of ketone bodies (KBs) generates acetyl coenzyme A (AcCoA), which can be further incorporated into fatty acid. We have determined the rates of lipogenesis from ketone bodies in developing rats and their relation to the activities of enzymes involved in the production of cytoplasmic AcCoA via different pathwa...

journal_title：Journal of neurochemistry

authors： Yeh YY,Ginsburg JR,Tso TB

更新日期：1983-01-01 00:00:00

abstract：:The ontogenesis of alpha 2-adrenoceptors and GTP-binding proteins and their coupling activity were investigated in telencephalon membranes of developing rats. The manganese-induced elevation of [3H]clonidine binding was increased in an age-dependent manner but the guanosine 5'-O-(3-thio)triphosphate-induced decrease i...

journal_title：Journal of neurochemistry

authors： Kitamura Y,Mochii M,Kodama R,Agata K,Watanabe K,Eguchi G,Nomura Y

更新日期：1989-07-01 00:00:00

abstract：:Exposure of neurones in culture to excitotoxic levels of glutamate results in an initial transient spike in [Ca2+]i followed by a delayed, irreversible [Ca2+]i rise governed by rapid kinetics, with Ca2+ originating from the extracellular medium. The molecular mechanism responsible for the secondary Ca2+ rise is unknow...

journal_title：Journal of neurochemistry

authors： Chinopoulos C,Gerencser AA,Doczi J,Fiskum G,Adam-Vizi V

更新日期：2004-10-01 00:00:00

abstract：:Vesicular sequestration is important in the regulation of cytoplasmic concentrations of monoamines such as dopamine. Moreover, recent evidence suggests that increases in cytoplasmic dopamine levels, perhaps attributable to changes in vesicular monoamine transporter function, contribute to methamphetamine-induced dopam...

journal_title：Journal of neurochemistry

authors： Brown JM,Hanson GR,Fleckenstein AE

更新日期：2000-05-01 00:00:00

abstract：:Over 25 years ago it was first reported that intracellular chloride levels (Cl-in ) were higher in developing neurons than in maturity. This finding has had significant implications for understanding the excitability of developing networks and recognizing the underlying causes of hyperexcitability associated with dise...

journal_title：Journal of neurochemistry

authors： Lindsly C,Gonzalez-Islas C,Wenner P

更新日期：2017-03-01 00:00:00

abstract：:Somatostatin (SS) and neuropeptide Y (NPY) are coproduced in a subpopulation of neurons that are selectively resistant to NMDA neurotoxicity. We have previously reported that quinolinic acid (QUIN), an NMDA receptor agonist, augments SS mRNA in cultured fetal rat cortical neurons. This study examines coregulation of S...

journal_title：Journal of neurochemistry

authors： Patel YC,Liu JL,Warszynska A,Kent G,Papachristou DN,Patel SC

更新日期：1995-09-01 00:00:00

abstract：:Microglia, the resident macrophage of the brain, can release substances that aid neuronal development, differentiation and survival. We have investigated the effects of non-activated microglia on the survival of cultured rat cerebellar granule neurones. Microglial-conditioned medium, collected from primary rat microgl...

journal_title：Journal of neurochemistry

authors： Morgan SC,Taylor DL,Pocock JM

更新日期：2004-07-01 00:00:00

abstract：:The effect of ascorbic acid on Ca2+ uptake in cultured rat astrocytes was examined in the presence of ouabain and monensin, which are considered to drive the Na(+)-Ca2+ exchanger in the reverse mode. Ascorbic acid at 0.1-1 mM inhibited Na(+)-dependent Ca2+ uptake significantly but not Na(+)-dependent glutamate uptake ...

journal_title：Journal of neurochemistry

authors： Takuma K,Matsuda T,Asano S,Baba A

更新日期：1995-04-01 00:00:00

abstract：:Glutaminyl cyclases (QC) catalyze the formation of neurotoxic pGlu-modified amyloid-β peptides found in the brains of people with Alzheimer's disease (AD). Reports of several-fold increases in soluble QC (sQC) expression in the brain and peripheral circulation of AD individuals has prompted the development of QC inhib...

journal_title：Journal of neurochemistry

authors： Gunn AP,Wong BX,McLean C,Fowler C,Barnard PJ,Duce JA,Roberts BR,AIBL Research Group.

更新日期：2020-07-02 00:00:00

abstract：:Both vasoactive intestinal peptide (VIP) and glucagon rapidly elevated cyclic AMP levels in embryonic chick retinal pigment epithelium (RPE), in culture as well as in freshly dissected tissue. In cultured cells, the half-maximal activities of VIP and glucagon were 5 X 10(-8) M and 3 X 10(-8) M, respectively. After 3 m...

journal_title：Journal of neurochemistry

authors： Koh SW,Chader GJ

更新日期：1984-12-01 00:00:00

abstract：:Microglial activation by blood-borne factors following blood-brain barrier damage may play a significant role in subsequent neuropathogenesis of several neurodegenerative diseases. Exposure of primary cultured rat brain microglia to pure, fatty acid- and lipid-deficient rat serum albumin or fraction V, (fatty acid and...

journal_title：Journal of neurochemistry

authors： Hooper C,Pinteaux-Jones F,Fry VA,Sevastou IG,Baker D,Heales SJ,Pocock JM

更新日期：2009-05-01 00:00:00

abstract：:Activation of extracellular signal-regulated protein kinase 1/2 (ERK1/2) are implicated in the pathophysiology of spinal cord injury (SCI). However, the specific functions of individual ERK isoforms in neurodegeneration are largely unknown. We investigated the hypothesis that ERK2 activation may contribute to patholog...

journal_title：Journal of neurochemistry

authors： Yu CG,Yezierski RP,Joshi A,Raza K,Li Y,Geddes JW

更新日期：2010-04-01 00:00:00

abstract：:The sodium-coupled, hemicholinium-3-sensitive, high-affinity choline transporter (CHT) is responsible for transport of choline into cholinergic nerve terminals from the synaptic cleft following acetylcholine release and hydrolysis. In this study, we address regulation of CHT function by plasma membrane cholesterol. We...

journal_title：Journal of neurochemistry

authors： Cuddy LK,Winick-Ng W,Rylett RJ

更新日期：2014-03-01 00:00:00

abstract：:Increasing evidence suggests that glucagon-like peptide-1 (GLP-1), an incretin hormone of current interest in type 2 diabetes, is neuroprotective in both cell culture and animal models. To characterize the neuroprotective properties of GLP-1 and associated underlying mechanisms, we over-expressed the GLP-1 receptor (G...

journal_title：Journal of neurochemistry

authors： Li Y,Tweedie D,Mattson MP,Holloway HW,Greig NH

更新日期：2010-06-01 00:00:00

abstract：:Agonist-induced down-regulation of opioid receptors appears to require the phosphorylation of the receptor protein. However, the identities of the specific protein kinases that perform this task remain uncertain. Protein kinase C (PKC) has been shown to catalyze the phosphorylation of several G protein-coupled recepto...

journal_title：Journal of neurochemistry

authors： Kramer HK,Simon EJ

更新日期：1999-02-01 00:00:00