Abstract:
:Vesicular sequestration is important in the regulation of cytoplasmic concentrations of monoamines such as dopamine. Moreover, recent evidence suggests that increases in cytoplasmic dopamine levels, perhaps attributable to changes in vesicular monoamine transporter function, contribute to methamphetamine-induced dopaminergic deficits. Hence, we examined whether striatal vesicular uptake is altered following methamphetamine treatment. Multiple administrations of methamphetamine rapidly (within 1 h) decreased vesicular dopamine uptake and dihydrotetrabenazine binding, an effect that (a) persisted at least 24 h, (b) was associated with dopamine and not serotonin neurons, and (c) was unrelated to residual drug introduced by the original methamphetamine treatment. These data suggest that methamphetamine rapidly decreases vesicular monoamine transporter function in dopaminergic neurons, a phenomenon that may be associated with the long-term damage caused by this stimulant.
journal_name
J Neurochemjournal_title
Journal of neurochemistryauthors
Brown JM,Hanson GR,Fleckenstein AEdoi
10.1046/j.1471-4159.2000.0742221.xkeywords:
subject
Has Abstractpub_date
2000-05-01 00:00:00pages
2221-3issue
5eissn
0022-3042issn
1471-4159journal_volume
74pub_type
杂志文章abstract::Glutamate is the major excitatory transmitter in the vertebrate brain and its extracellular levels are tightly regulated to prevent excitotoxic effects. The Na(+)-dependent glutamate/aspartate transporter GLAST/EAAT1 is regulated in the short and in the long term by glutamate. A receptors-independent change in its mem...
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journal_title:Journal of neurochemistry
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journal_title:Journal of neurochemistry
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