A mobile APP for sharing contacts on your cell: An Editorial Highlight for 'The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system' on page 11.

abstract：:Several epidemiological and preclinical studies suggest that non-steroidal anti-inflammatory drugs (NSAIDs), which inhibit cyclooxygenase (COX), reduce the risk of Alzheimer's disease (AD) and can lower β-amyloid (Aβ) production and inhibit neuroinflammation. However, follow-up clinical trials, mostly using selective ...

journal_title：Journal of neurochemistry

authors： Choi SH,Aid S,Caracciolo L,Minami SS,Niikura T,Matsuoka Y,Turner RS,Mattson MP,Bosetti F

更新日期：2013-01-01 00:00:00

abstract：:The kinetics of the reactions of nine opioid peptides with the neutral endopeptidase ("enkephalinase") activities of human kidney, rat kidney, and rat brain have been determined. These opioid peptides can be divided into two classes, those that are good inhibitors of Leu5-enkephalin hydrolysis (Ki less than 75 microM)...

journal_title：Journal of neurochemistry

authors： Hersh LB

更新日期：1984-08-01 00:00:00

abstract：:We have examined the metabolism of phosphate and sulfate groups modifying the P0 protein, the major protein of peripheral nervous system myelin, using an in vitro incubation system. Incorporation of [3H]leucine into the P0 peptide backbone decreased approximately 25-fold between 10 and 90 days of age, a finding reflec...

journal_title：Journal of neurochemistry

authors： Toews AD,Fischer HR,Goodrum JF,Windes S,Morell P

更新日期：1987-03-01 00:00:00

abstract：:The physiological mechanisms regulating activity of the sodium-dependent, high-affinity choline transporter and the molecular events in the translocation process remain unclear; the protein has not been purified or characterized biochemically. In the present study, [3H]choline mustard aziridinium ion [( 3H]ChM Az), a ...

journal_title：Journal of neurochemistry

authors： Rylett RJ

更新日期：1988-12-01 00:00:00

abstract：:Published evidence has linked glutamate with the pathogenesis of Alzheimer's disease (AD) and the up-regulation of a variety of chemokines, including monocyte chemotactic protein-1 (MCP-1)/chemokine ligand 2, with AD-associated pathological changes. In this study, we assessed the potential molecular basis for the role...

journal_title：Journal of neurochemistry

authors： Lee EO,Park HJ,Kang JL,Kim HS,Chong YH

更新日期：2010-03-01 00:00:00

abstract：:The effect of Gi/o protein-coupled receptors on adenylyl cyclase type 2 (AC2) has been studied in Sf9 insect cells. Stimulation of cells expressing AC2 with the phorbol ester 12-O-tetradecanoyl phorbol-13-acetate (TPA) led to a twofold stimulation of cAMP synthesis that could be blocked with the protein kinase C inhib...

journal_title：Journal of neurochemistry

authors： Näsman J,Kukkonen JP,Holmqvist T,Akerman KE

更新日期：2002-12-01 00:00:00

abstract：:Depletion of glutathione in the substantia nigra is one of the earliest changes observed in Parkinson's disease (PD) and could initiate dopaminergic neuronal degeneration. Nevertheless, experimental glutathione depletion does not result in preferential toxicity to dopaminergic neurons either in vivo or in vitro. Moreo...

journal_title：Journal of neurochemistry

authors： Nakamura K,Wright DA,Wiatr T,Kowlessur D,Milstien S,Lei XG,Kang UJ

更新日期：2000-06-01 00:00:00

abstract：:The levels and conformers of alpha-synuclein are critical in the pathogenesis of Parkinson's Disease and related synucleinopathies. Homeostatic mechanisms in protein degradation and secretion have been identified as regulators of alpha-synuclein at different stages of its intracellular trafficking and transcellular pr...

journal_title：Journal of neurochemistry

authors： Stefanis L,Emmanouilidou E,Pantazopoulou M,Kirik D,Vekrellis K,Tofaris GK

更新日期：2019-09-01 00:00:00

abstract：:This paper describes the interaction of neurotensin with mouse neuroblastoma N1E115 cells. Neurotensin binding sites are undetectable in nondifferentiated neuroblastoma cells. They appear during cell differentiation in the presence of a low serum concentration and dimethyl sulfoxide, and reach a maximal level after 50...

journal_title：Journal of neurochemistry

authors： Poustis C,Mazella J,Kitabgi P,Vincent JP

更新日期：1984-04-01 00:00:00

abstract：:Niemann-Pick type C disease (NPCD) was first described in 1914 and affects approximately 1 in 150 000 live births. It is characterized clinically by diverse symptoms affecting liver, spleen, motor control, and brain; premature death invariably results. Its molecular origins were traced, as late as 1997, to a protein o...

journal_title：Journal of neurochemistry

authors： Wheeler S,Sillence DJ

更新日期：2020-06-01 00:00:00

abstract：:Saturable and specific binding sites for 5-[3H]hydroxytryptamine (5-HT, serotonin) characterized by a KD of 3.5-4.5 nM were detected in the chick embryo brain and were shown to develop linearly as a function of age, weight, and protein content. Saturation and displacement studies using unlabeled 5-HT as the displacing...

journal_title：Journal of neurochemistry

authors： Soblosky JS,Jeng I

更新日期：1985-02-01 00:00:00

abstract：:Traumatic spinal cord injury has recently been shown to cause a rapid increase in free fatty acids (FFAs) and lipid degradation in cats. The present studies report a more delayed, time-dependent increase in FFAs and a concomitant decrease in phospholipids following traumatic spinal injury in rats. The largest percenta...

journal_title：Journal of neurochemistry

authors： Faden AI,Chan PH,Longar S

更新日期：1987-06-01 00:00:00

abstract：:Staufen is an RNA-binding protein, first identified for its role in oogenesis and CNS development in Drosophila. Two mammalian homologs of Staufen have been identified and shown to bind double-stranded RNA and tubulin, and to function in the somatodendritic transport of mRNA in neurons. Here, we examined whether Stauf...

journal_title：Journal of neurochemistry

authors： Bélanger G,Stocksley MA,Vandromme M,Schaeffer L,Furic L,DesGroseillers L,Jasmin BJ

更新日期：2003-08-01 00:00:00

abstract：:The characteristics of the cerebral GABA(B) receptor/cyclic AMP (cAMP)-generating system were investigated using the in vivo microdialysis technique in freely moving rats. Addition of forskolin, an activator of adenylate cyclase, to perfusate for 20 min resulted in a dose-dependent increase of cAMP efflux from the str...

journal_title：Journal of neurochemistry

authors： Hashimoto T,Kuriyama K

更新日期：1997-07-01 00:00:00

abstract：:The effects of temperature on the interaction of various ligands with the benzodiazepine receptor were studied in rat brain membrane preparations. The affinities of all ligands studied were reduced on raising the temperature from 4 to 37 degrees C. The variation of affinity constant with temperature deviated from the ...

journal_title：Journal of neurochemistry

authors： Doble A

更新日期：1983-06-01 00:00:00

abstract：:Increased arachidonic acid release occurred during activation of catecholamine secretion from cultured bovine adrenal medullary chromaffin cells. The nicotinic agonist 1,1-dimethyl-4- phenylpiperazinium (DMPP) caused an increased release of preincubated [3H]arachidonic acid over a time course which corresponded to the...

journal_title：Journal of neurochemistry

authors： Frye RA,Holz RW

更新日期：1984-07-01 00:00:00

abstract：:Decreased cerebral blood flow, hence decreased oxygen and glucose, leads to ischemic brain injury via complex pathophysiological events, including excitotoxicity, mitochondrial dysfunction, increased intracellular Ca2+, and reactive oxygen species (ROS) generation. Each of these could also contribute to cerebral edema...

journal_title：Journal of neurochemistry

authors： MacGregor DG,Avshalumov MV,Rice ME

更新日期：2003-06-01 00:00:00

abstract：:Aging in rats is associated with a loss of hippocampal neurons, which may contribute to age-related cognitive deficits. Several lines of evidence suggest that stress and glucocorticoids may contribute to age-related declines in hippocampal neuronal number. Excitatory amino acids (EAAs) have been implicated in the gluc...

journal_title：Journal of neurochemistry

authors： Lowy MT,Wittenberg L,Yamamoto BK

更新日期：1995-07-01 00:00:00

abstract：:Cyclic AMP phosphodiesterase activity in bovine brain coated vesicles displayed a Km of approximately 22 microM for cyclic AMP, a Vmax of 3.2 nmol/min/mg protein, and a Hill coefficient of 1.5, suggesting positive cooperativity. The enzyme activity was stimulated by cyclic GMP with maximal indexes of stimulation rangi...

journal_title：Journal of neurochemistry

authors： Silva WI,Schook W,Mittag TW,Puszkin S

更新日期：1986-04-01 00:00:00

abstract：:The microtubule-based motor protein kinesin is thought to drive anterograde organelle transport in axons, but nothing is known about how its force-generating activity or organelle-binding properties are regulated. Studies in other motility systems suggest that protein phosphorylation is a reasonable candidate for this...

journal_title：Journal of neurochemistry

authors： Hollenbeck PJ

更新日期：1993-06-01 00:00:00

abstract：:Calcium-activated neutral proteases (calpains) are regulated by specific endogenous protein inhibitors, the calpastatins, which are widely distributed in mammalian tissues. Calpastatins from different species or in various tissues from the same species exhibit considerable size heterogeneity on sodium dodecyl sulfate ...

journal_title：Journal of neurochemistry

authors： Mohan PS,Nixon RA

更新日期：1995-02-01 00:00:00

abstract：:This study investigated the temporal expression and cell subtype distribution of activated caspase-3 following cortical impact-induced traumatic brain injury in rats. The animals were killed and examined for protein expression of the proteolytically active subunit of caspase-3, p18, at intervals from 6 h to 14 days af...

journal_title：Journal of neurochemistry

authors： Beer R,Franz G,Srinivasan A,Hayes RL,Pike BR,Newcomb JK,Zhao X,Schmutzhard E,Poewe W,Kampfl A

更新日期：2000-09-01 00:00:00

abstract：:Increased awareness for a role of oxidative stress in the pathogenesis of Alzheimer's disease has highlighted the issue of whether oxidative damage is a fundamental step in the pathogenesis or instead results from disease-associated pathology. In vitro experiments support both possibilities: Oxidative stress increases...

journal_title：Journal of neurochemistry

authors： Smith MA,Hirai K,Hsiao K,Pappolla MA,Harris PL,Siedlak SL,Tabaton M,Perry G

更新日期：1998-05-01 00:00:00

abstract：:Glutathione-S-transferase activity in the brain of male mammals (rat and mouse) was found to be relatively lower than in that of females. In contrast, the male aves (pigeon, kite, vulture, and crow) exhibited comparatively higher activity in brain glutathione-S-transferase than the corresponding females. Postnatal dev...

journal_title：Journal of neurochemistry

authors： Das M,Dixit R,Seth PK,Mukhtar H

更新日期：1981-04-01 00:00:00

abstract：:The technique of intracerebral dialysis in combination with a sensitive and specific radioenzymatic method was used for recovery and quantification of endogenous extracellular acetylcholine from the striata of freely moving rats. A thin dialysis tube was inserted transversally through the caudate nuclei, and the tube ...

journal_title：Journal of neurochemistry

authors： Consolo S,Wu CF,Fiorentini F,Ladinsky H,Vezzani A

更新日期：1987-05-01 00:00:00

abstract：:Diadenosine tetraphosphate (Ap4A) and diadenosine pentaphosphate (Ap5A) have been identified in bovine adrenal medullary tissue using an HPLC method. The values obtained were 0.1 +/- 0.05 mumol/g of tissue for both compounds. The subcellular fraction where Ap4A and Ap5A were present in the highest concentration was ch...

journal_title：Journal of neurochemistry

authors： Rodriguez del Castillo A,Torres M,Delicado EG,Miras-Portugal MT

更新日期：1988-12-01 00:00:00

abstract：:Neurosecretory terminals (neurosecretosomes, NSS) were isolated from rat neurohypophyses. High [K+]o or veratridine stimulated secretion of vasopressin and oxytocin by up to approximately 100-fold. Stimulated secretion was dependent on calcium and temperature, and could be elicited from NSS maintained in culture for 4...

journal_title：Journal of neurochemistry

authors： Payza K,Russell JT

更新日期：1991-08-01 00:00:00

abstract：:The myocyte enhancer factor 2A-D (MEF2) proteins are members of the MCM1-agamous-deficiens-serum response factor family of transcription factors. Various MEF2 isoform proteins are enriched in neurons and exhibit distinct patterns of expression in different regions of the brain. In neurons, MEF2 functions as a convergi...

journal_title：Journal of neurochemistry

authors： She H,Yang Q,Mao Z

更新日期：2012-09-01 00:00:00

abstract：:Three serine residues (Ser193, Ser194, Ser197) in the fifth transmembrane-spanning region of the D2 dopamine receptor have been mutated separately to alanine and the effects of the mutations determined in ligand-binding experiments with [3H] spiperone. For many antagonists the mutations had little effect, showing that...

journal_title：Journal of neurochemistry

authors： Woodward R,Coley C,Daniell S,Naylor LH,Strange PG

更新日期：1996-01-01 00:00:00

abstract：:We recently demonstrated that the presenilin-dependent gamma-secretase complex regulates the expression and activity of neprilysin, one of the main enzymes that degrade the amyloid beta-peptide (Abeta) which accumulates in Alzheimer's disease. Here, we examined the influence of endogenous nicastrin (NCT), a member of ...

journal_title：Journal of neurochemistry

authors： Pardossi-Piquard R,Dunys J,Yu G,St George-Hyslop P,Alves da Costa C,Checler F

更新日期：2006-05-01 00:00:00