Differential capacities of the RGS1, RGS16 and RGS-GAIP regulators of G protein signaling to enhance alpha2A-adrenoreceptor agonist-stimulated GTPase activity of G(o1)alpha.

abstract：:Tetanus neurotoxin and botulinum neurotoxins are the causative agents of tetanus and botulism. They block the release of neurotransmitters from synaptic vesicles in susceptible animals and man and act in nanogram quantities because of their ability to specifically attack motoneurons. They developed an ingenious strate...

journal_title：Journal of neurochemistry

authors： Binz T,Rummel A

更新日期：2009-06-01 00:00:00

abstract：:Increasing evidence suggests that proteasome inhibition plays a causal role in promoting the neurodegeneration and neuron death observed in multiple disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD). The ability of severe and acute inhibition of proteasome function to induce neuron death and n...

journal_title：Journal of neurochemistry

authors： Ding Q,Dimayuga E,Martin S,Bruce-Keller AJ,Nukala V,Cuervo AM,Keller JN

更新日期：2003-07-01 00:00:00

abstract：:The isolation, characterization, and bioactivity in the feeding circuitry of a novel neuropeptide in the Aplysia californica central nervous system are reported. The 17-residue amidated peptide, NGGTADALYNLPDLEKIamide, has been termed cerebrin due to its primary location in the cerebral ganglion. Liquid chromatographi...

journal_title：Journal of neurochemistry

authors： Li L,Floyd PD,Rubakhin SS,Romanova EV,Jing J,Alexeeva VY,Dembrow NC,Weiss KR,Vilim FS,Sweedler JV

更新日期：2001-06-01 00:00:00

abstract：:Abnormalities in the kynurenine pathway may play a role in Huntington's disease (HD). In this study, tryptophan depletion and loading were used to investigate changes in blood kynurenine pathway metabolites, as well as markers of inflammation and oxidative stress in HD patients and healthy controls. Results showed tha...

journal_title：Journal of neurochemistry

authors： Stoy N,Mackay GM,Forrest CM,Christofides J,Egerton M,Stone TW,Darlington LG

更新日期：2005-05-01 00:00:00

abstract：:A protein has been purified from human brain that appears to be the human equivalent of bovine 14-3-3 protein. On polyacrylamide gel electrophoresis the protein migrates as a faster major component, termed 14-3-3-2 protein, and a slower minor component, termed 14-3-3-1 protein, which consists of approximately 12% of t...

journal_title：Journal of neurochemistry

authors： Boston PF,Jackson P,Kynoch PA,Thompson RJ

更新日期：1982-05-01 00:00:00

abstract：:[3H]Strychnine binding to rat pons + medulla membranes was used as a measure of glycine receptors or glycine receptor-coupled chloride channels in vitro. A series of compounds structurally related to 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP), which previously were shown to antagonize glycine responses in c...

journal_title：Journal of neurochemistry

authors： Braestrup C,Nielsen M,Krogsgaard-Larsen P

更新日期：1986-09-01 00:00:00

abstract：:Sequence variation was found in cDNA coding for the extracellular domain of the rat gamma-aminobutyric acid type A (GABAA) receptor alpha 6 subunit. About 20% of polymerase chain reaction (PCR)-amplified alpha 6 cDNA prepared from rat cerebellar mRNA lacked nucleotides 226-255 as estimated by counting single-stranded ...

journal_title：Journal of neurochemistry

authors： Korpi ER,Kuner T,Kristo P,Köhler M,Herb A,Lüddens H,Seeburg PH

更新日期：1994-09-01 00:00:00

abstract：:The blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) are highly specialized structures that limit molecule entry from the blood and maintain homeostasis within the central nervous system (CNS). BBB and BSCB breakdown are associated with multiple neurodegenerative diseases. Given the key role of neuroprot...

journal_title：Journal of neurochemistry

authors： Kumar V,Lee JD,Coulson EJ,Woodruff TM

更新日期：2020-07-06 00:00:00

abstract：:Thiamine (vitamin B1) deficiency (TD) causes mild and chronic impairment of oxidative metabolism and induces neuronal death in specific brain regions. The mechanisms underlying TD-induced cell death, however, remain unclear. The double-stranded RNA-activated protein kinase (PKR), has been well known for its anti-viral...

journal_title：Journal of neurochemistry

authors： Wang X,Fan Z,Wang B,Luo J,Ke ZJ

更新日期：2007-12-01 00:00:00

abstract：:Glycine residues can introduce flexibility in proteins, give rise to turns and breaks in secondary structure and are key components of some nucleotide binding motifs. In the P2X receptor extracellular ATP binding domain, 11 glycine residues are completely conserved and an additional five are conserved in at least five...

journal_title：Journal of neurochemistry

authors： Digby HR,Roberts JA,Sutcliffe MJ,Evans RJ

更新日期：2005-12-01 00:00:00

abstract：:Accumulating evidence indicates that increased intracellular Na(+) concentration ([Na(+) ]i ) in astroglial cells is associated with the development of brain edema under ischemic conditions, but the underlying mechanisms are still elusive. Here, we report that in primary cultured rat cortical astrocytes, elevations of...

journal_title：Journal of neurochemistry

authors： Minieri L,Pivonkova H,Harantova L,Anderova M,Ferroni S

更新日期：2015-02-01 00:00:00

abstract：:Chick pineal glands in organ culture showed a circadian rhythm in the rate of thymidine incorporation. Thymidine incorporation was very markedly inhibited when 3-isobutyl-l-methylxanthine (IBMX) was continuously present. When IBMX was added to cultures in control medium during the photoperiod of the second day in cult...

journal_title：Journal of neurochemistry

authors： Wainwright SD,Wainwright LK

更新日期：1991-05-01 00:00:00

abstract：:Previous work from this laboratory has shown that in PC12 cells the phosphorylation of a specific soluble protein is decreased by nerve growth factor treatment. The protein, designated Nsp100, and its kinase have been separated and partially purified from PC12 cells. In the present work, the tissue distribution of Nsp...

journal_title：Journal of neurochemistry

authors： Hama T,Guroff G

更新日期：1985-10-01 00:00:00

abstract：:Methyl CpG binding protein 2 (MeCP2) binds to methylated DNA and acts as a transcriptional repressor. Mutations of human MECP2 gene lead to Rett syndrome, a severe neural developmental disorder. Here, we report that the MeCP2 protein can be modified by covalent linkage to small ubiquitin-like modifier (SUMO) and SUMOy...

journal_title：Journal of neurochemistry

authors： Cheng J,Huang M,Zhu Y,Xin YJ,Zhao YK,Huang J,Yu JX,Zhou WH,Qiu Z

更新日期：2014-03-01 00:00:00

abstract：:Chronic cocaine use in humans and animal models is known to lead to pronounced alterations in glutamatergic function in brain regions associated with reinforcement. Previous studies have examined ionotropic glutamate receptor (iGluR) subunit protein level changes following acute and chronic experimenter-administered c...

journal_title：Journal of neurochemistry

authors： Tang W,Wesley M,Freeman WM,Liang B,Hemby SE

更新日期：2004-05-01 00:00:00

abstract：:Larval zebrafish offers a good model to approach brain disease mechanisms, as structural abnormalities of their small brains can be correlated to quantifiable behavior. In this study, the structural alterations in one diencephalic dopaminergic nucleus induced by 1-methyl-4-phenylpyridinium (MPP+), a toxin inducing Par...

journal_title：Journal of neurochemistry

authors： Sallinen V,Torkko V,Sundvik M,Reenilä I,Khrustalyov D,Kaslin J,Panula P

更新日期：2009-02-01 00:00:00

abstract：:Metallothionein (MT)-III, a member of the MT family of metal-binding proteins, is mainly expressed in the CNS and is abundant in glutamatergic neurons. Results in genetically altered mice indicate that MT-III may play neuroprotective roles in the brain, but the mechanisms through which this protein functions have not ...

journal_title：Journal of neurochemistry

authors： Montoliu C,Monfort P,Carrasco J,Palacios O,Capdevila M,Hidalgo J,Felipo V

更新日期：2000-07-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) is a potent lipid biomediator that is likely to have diverse roles in the brain. Thus, LPA-induced events in astrocytes were defined. As little as 1 nM LPA induced a rapid increase in the concentration of intracellular free calcium ([Ca2+]i) in astrocytes from neonatal rat brains. This incr...

journal_title：Journal of neurochemistry

authors： Keller JN,Steiner MR,Holtsberg FW,Mattson MP,Steiner SM

更新日期：1997-09-01 00:00:00

abstract：:The time course of changes in extracellular glutamic acid levels and their Ca2+ dependency were studied in the rat striatum during focal cerebral ischaemia, using microdialysis. Ischaemia-induced changes were compared with those produced by high K(+)-evoked local depolarization. To optimize time resolution, glutamate ...

journal_title：Journal of neurochemistry

authors： Wahl F,Obrenovitch TP,Hardy AM,Plotkine M,Boulu R,Symon L

更新日期：1994-09-01 00:00:00

abstract：:Recent evidence supports the emerging hypothesis that the amyloid-β precursor protein C-terminal fragments (APP-CTFs) and dysregulations in both their qualitative and quantitative productions may actively and directly contribute to the neuronal toxicity in early phases of Alzheimer's disease (AD). These new findings r...

journal_title：Journal of neurochemistry

authors： Mosser S,Gerber H,Fraering PC

更新日期：2020-08-05 00:00:00

abstract：:Leptin, the obese gene product, was reported to stimulate prolactin (PRL) secretion, but the neuroendocrine mechanism underlying this hormonal response is largely unknown. Thus, in this study we examined the involvement of several important PRL regulators in the leptin-induced PRL secretion in male rats. Compared with...

journal_title：Journal of neurochemistry

authors： Watanobe H,Schiöth HB,Izumi J

更新日期：2003-04-01 00:00:00

abstract：:The beta-amyloid peptide (Abeta) is considered responsible for the pathogenesis of Alzheimer's disease. Despite the magnitude of reports describing a neurotoxic role of extracellular Abeta, the role for intracellular Abeta (iAbeta) has not been elucidated. We previously demonstrated that in rat pheochromocytoma cells ...

journal_title：Journal of neurochemistry

authors： Arvanitis DN,Ducatenzeiler A,Ou JN,Grodstein E,Andrews SD,Tendulkar SR,Ribeiro-da-Silva A,Szyf M,Cuello AC

更新日期：2007-10-01 00:00:00

abstract：:The effect of phorbol esters was investigated on the down-regulation of protein kinase C (PKC) and on the release of [3H]norepinephrine (NE) in synaptosomes from the rat cerebrum. Treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) promoted the translocation of PKC activity in a P2 fraction from the cytosol to t...

journal_title：Journal of neurochemistry

authors： Oda T,Shearman MS,Nishizuka Y

更新日期：1991-04-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disease resulting in progressive cognitive decline. Amyloid plaque deposits consisting specifically of beta-amyloid peptides that have formed fibrils displaying beta-pleated sheet conformation are associated with activated microglia and astrocytes, are colocalized with C...

journal_title：Journal of neurochemistry

authors： Zhou J,Fonseca MI,Pisalyaput K,Tenner AJ

更新日期：2008-09-01 00:00:00

abstract：:Rat-1 fibroblasts were transduced to express Drosophila choline acetyltransferase. The presence of an active enzyme in these cells (Rat-1/dChAT) was confirmed using various methods. Rat-1/dChAT fibroblasts released acetylcholine (ACh) into the culture medium. Moreover, intra- and extracellular levels of ACh could be i...

journal_title：Journal of neurochemistry

authors： Schinstine M,Rosenberg MB,Routledge-Ward C,Friedmann T,Gage FH

更新日期：1992-06-01 00:00:00

abstract：:To gain insight into the mechanism through which the neurotransmitter glutamate causally participates in several neurological diseases, in vitro cultured cerebellar granule cells were exposed to glutamate and oxygen radical production was investigated. To this aim, a novel procedure was developed to detect oxygen radi...

journal_title：Journal of neurochemistry

authors： Atlante A,Gagliardi S,Minervini GM,Ciotti MT,Marra E,Calissano P

更新日期：1997-05-01 00:00:00

abstract：:Exposure of bovine chromaffin cells in primary culture to 0.01-1 microM reserpine caused a dose- and time-dependent increase in intracellular levels of the amidated enkephalin peptide metorphamide. Maximal levels (approximately 800% of control) were obtained at 0.1 microM reserpine and increased levels were apparent b...

journal_title：Journal of neurochemistry

authors： Eiden LE,Zamir N

更新日期：1986-05-01 00:00:00

abstract：:Fresh myelin, isolated from brainstems of adult rats, was incubated in the presence of Cu2+ and H2O2. Electrophoretic analysis of the reisolated myelin membrane revealed a gradual loss of the protein moiety from the characteristic pattern and an increase in aggregated material appearing at the origin of the gel. The a...

journal_title：Journal of neurochemistry

authors： Konat GW,Wiggins RC

更新日期：1985-10-01 00:00:00

abstract：:RGS (regulators of G-protein signaling) proteins comprise a large family that modulates heterotrimeric G-protein signaling. This protein family has a common RGS domain and functions as GTPase-activating proteins for the alpha-subunits of heterotrimeric G-proteins located at the plasma membrane. RGS8 was identified as ...

journal_title：Journal of neurochemistry

authors： Masuho I,Itoh M,Itoh H,Saitoh O

更新日期：2004-01-01 00:00:00

abstract：:Microdialysis probes were inserted bilaterally into the striatum of 7-day-old rat pups (n = 30) to examine extracellular fluid levels of dopamine, its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), and the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA). The dialysis samples w...

journal_title：Journal of neurochemistry

authors： Gordon K,Statman D,Johnston MV,Robinson TE,Becker JB,Silverstein FS

更新日期：1990-02-01 00:00:00