Inhibition of the chick pineal rhythm in rate of thymidine incorporation by cyclic AMP.

abstract：:Dual-probe microdialysis was used to study interstitial diffusion in the rat brain. A radiolabelled tracer, (3H]mannitol, was continuously infused at different concentrations via a probe acutely implanted into the striatum of an anaesthetized male rat or into a dilute agar gel. Samples were collected by a second probe...

journal_title：Journal of neurochemistry

authors： Höistad M,Chen KC,Nicholson C,Fuxe K,Kehr J

更新日期：2002-04-01 00:00:00

abstract：:A major hallmark of mutant superoxide dismutase (SOD1)-linked familial amyotrophic lateral sclerosis is SOD1-immunopositive inclusions found within motor neurons. The mechanism by which SOD1 becomes aggregated, however, remains unclear. In this study, we aimed to investigate the role of nitrosative stress and S-nitros...

journal_title：Journal of neurochemistry

authors： Chen X,Zhang X,Li C,Guan T,Shang H,Cui L,Li XM,Kong J

更新日期：2013-01-01 00:00:00

abstract：:In Guadeloupe, epidemiological data have linked atypical parkinsonism with fruit and herbal teas from plants of the Annonaceae family, particularly Annona muricata. These plants contain a class of powerful, lipophilic complex I inhibitors, the annonaceous acetogenins. To determine the neurotoxic potential of these sub...

journal_title：Journal of neurochemistry

authors： Champy P,Höglinger GU,Féger J,Gleye C,Hocquemiller R,Laurens A,Guérineau V,Laprévote O,Medja F,Lombès A,Michel PP,Lannuzel A,Hirsch EC,Ruberg M

更新日期：2004-01-01 00:00:00

abstract：:The relationships between presynaptic acetylcholinesterase (AChE) and high-affinity choline uptake (HACU) were investigated using a monolayer of rat cortex synaptosomes in superfusion conditions. The following sets of experiments were performed: determination of [3H]choline ([3H]Ch) uptake during superfusion with [3H]...

journal_title：Journal of neurochemistry

authors： Raiteri M,Marchi M,Caviglia AM

更新日期：1986-12-01 00:00:00

abstract：:Astrocytic glutamate transporter-1 (GLT-1) is responsible for 90% of forebrain glutamate uptake in the adult CNS. Retinoic acid (RA) is a potent regulator of neural cell differentiation and neuronal maturation in the developing CNS through activation of RA receptors/retinoic X receptors (RXRs) or non-genomic mechanism...

journal_title：Journal of neurochemistry

authors： Chan TJ,Her LS,Liaw HJ,Chen MC,Tzeng SF

更新日期：2012-05-01 00:00:00

abstract：:Alzheimer's disease (AD) is marked by the presence of neurofibrillary tangles and amyloid plaques in the brain of patients. To study plaque formation, we report on further quantitative and qualitative analysis of human and mouse amyloid beta peptides (Abeta) from brain extracts of transgenic mice overexpressing the Lo...

journal_title：Journal of neurochemistry

authors： Pype S,Moechars D,Dillen L,Mercken M

更新日期：2003-02-01 00:00:00

abstract：:Intracranial microdialysis was used to investigate the origin of extracellular gamma-aminobutyric acid (GABA) in the ventral pallidum. Changes in basal GABA levels in response to membrane depolarizers, ion-channel blockers, and receptor agonists were determined. Antagonism of Ca2+ fluxes with high Mg2+ in a Ca(2+)-fre...

journal_title：Journal of neurochemistry

authors： Bourdelais AJ,Kalivas PW

更新日期：1992-06-01 00:00:00

abstract：:To study potential biochemical correlates of dopamine (DA) and serotonin receptor supersensitivity, rats were lesioned at 3 days after birth with 6-hydroxydopamine (6-OHDA; 67 micrograms in each lateral ventricle; desipramine pretreatment, 20 mg/kg i.p., 1 h) and then sensitized with the DA D1 agonist, SKF 38393 HCl (...

journal_title：Journal of neurochemistry

authors： Gong L,Kostrzewa RM,Li C

更新日期：1994-10-01 00:00:00

abstract：:The Na+-dependent synaptosomal uptakes of proline, aspartic acid, glutamic acid, and gamma-aminobutyric acid were strong inhibited by monounsaturated fatty acids. With oleic acid, half-maximal inhibition was observed at about 15 microM. The Na+-independent uptakes of leucine, phenylalanine, histidine, and valine were ...

journal_title：Journal of neurochemistry

authors： Rhoads DE,Kaplan MA,Peterson NA,Raghupathy E

更新日期：1982-05-01 00:00:00

abstract：:Adenosine A2A receptors (A2A R) play a key role in modulating dopamine-dependent locomotor activity, as heralded by the sensitization of locomotor activity upon chronic A2A R blockade, which is associated with elevated dopamine levels and altered corticostriatal synaptic plasticity. Since the orphan receptor GPR37 has...

journal_title：Journal of neurochemistry

authors： Morató X,Gonçalves FQ,Lopes JP,Jauregui O,Soler C,Fernández-Dueñas V,Cunha RA,Ciruela F

更新日期：2019-03-01 00:00:00

abstract：:Brain gangliosides from four vertebrate classes (fish, amphibia, aves, and mammalia) were studied by patterns generated with the use of two-dimensional thin-layer chromatography. In an effort to retain possible alkalilabile gangliosides, samples were not base-hydrolyzed. Resultant chromatograms revealed complex patter...

journal_title：Journal of neurochemistry

authors： Hunter GD,Wiegant VM,Dunn AJ

更新日期：1981-10-01 00:00:00

abstract：:Exposure of bovine chromaffin cells in primary culture to 0.01-1 microM reserpine caused a dose- and time-dependent increase in intracellular levels of the amidated enkephalin peptide metorphamide. Maximal levels (approximately 800% of control) were obtained at 0.1 microM reserpine and increased levels were apparent b...

journal_title：Journal of neurochemistry

authors： Eiden LE,Zamir N

更新日期：1986-05-01 00:00:00

abstract：:Myelination, during both normal development and with respect to disorders of myelination, is commonly studied by morphological and/or biochemical techniques that assay as their end-points the extent of myelination. The rate of myelination is potentially a more useful parameter, but it is difficult and time-consuming t...

journal_title：Journal of neurochemistry

authors： Muse ED,Jurevics H,Toews AD,Matsushima GK,Morell P

更新日期：2001-01-01 00:00:00

abstract：:The human neuroblastoma SH-SY5Y was found to express annexins I, II, IV, V, and VI by western blot analysis. Calcium-dependent membrane-binding proteins were isolated from SH-SY5Y and analysed by 2-dimensional gel electrophoresis. Proteins with Mr and Pi values similar to those of annexins I, II, III, IV, V, and VI we...

journal_title：Journal of neurochemistry

authors： Blanchard S,Barwise JL,Gerke V,Goodall A,Vaughan PF,Walker JH

更新日期：1996-08-01 00:00:00

abstract：:We have previously shown that Regulator of Calcineurin 1 (RCAN1) regulates multiple stages of vesicle exocytosis. However, the mechanisms by which RCAN1 affects secretory vesicle exocytosis and quantal release kinetics remain unknown. Here, we use carbon fibre amperometry to detect exocytosis from chromaffin cells and...

journal_title：Journal of neurochemistry

authors： Zanin MP,Mackenzie KD,Peiris H,Pritchard MA,Keating DJ

更新日期：2013-02-01 00:00:00

abstract：:The molecular basis of neuroendocrine-specific expression of chromogranin B gene (Chgb) has remained elusive. Utilizing wild-type and mutant Chgb promoter/luciferase reporter constructs, this study established a crucial role for the cAMP response element (CRE) box at -102/-95 bp in endocrine [rat pheochromocytoma (chr...

journal_title：Journal of neurochemistry

authors： Mahapatra NR,Mahata M,Ghosh S,Gayen JR,O'Connor DT,Mahata SK

更新日期：2006-10-01 00:00:00

abstract：:Parkinson's disease (PD) is caused by neuronal cell death. Although a precursor of dopamine and inhibitors of dopamine degradation have been used for PD therapy, cell death progresses during treatment. DJ-1, a causative gene product of a familial form of PD, PARK7, plays roles in transcriptional regulation and anti-ox...

journal_title：Journal of neurochemistry

authors： Miyazaki S,Yanagida T,Nunome K,Ishikawa S,Inden M,Kitamura Y,Nakagawa S,Taira T,Hirota K,Niwa M,Iguchi-Ariga SM,Ariga H

更新日期：2008-06-01 00:00:00

abstract：:The binding of the potent adenosine uptake inhibitor [3H]nitrobenzylthioinosine ([3H]NBI) to brain membrane fractions was investigated. Reversible, saturable, specific, high-affinity binding was demonstrated in both rat and human brain. The KD in both was 0.15 nM with Bmax values of 140-200 fmol/mg protein. Linear Sca...

journal_title：Journal of neurochemistry

authors： Marangos PJ,Patel J,Clark-Rosenberg R,Martino AM

更新日期：1982-07-01 00:00:00

abstract：:Myelinogenesis in developing rats was studied following chronic dosing with triethyl tin (TET), at a level of 1.0 mg TET/kg body wt/day. Experiments included starved controls with body weights depressed by 17 to 40% to equal those of the TET-treated groups. Rats at ages of 16, 21, and 30 days showed decreases relative...

journal_title：Journal of neurochemistry

authors： Blaker WD,Krigman MR,Thomas DJ,Mushak P,Morell P

更新日期：1981-01-01 00:00:00

abstract：:The concentration of dopamine (DA) in the synaptic cleft in the mouse striatum in vivo was estimated from the competition between the synaptic DA and the 3H-labelled DA D2 receptor agonists N-n-propylnorapomorphine (NPA) or N,N-diethyl-N'-[(3 alpha, 4a alpha, 10 beta)-1,2,3,4,4a,5,10,10a-octahydro- 7-hydroxyl-1-propyl...

journal_title：Journal of neurochemistry

authors： Ross SB

更新日期：1991-01-01 00:00:00

abstract：:The adenylate cyclase activity of rat hippocampal plasma membranes can be stimulated by vasoactive intestinal polypeptide (VIP). Low concentrations (10(-9) to 19(-7) M) of 5'-guanylyl-imido diphosphate (GppNHp) evoke a transient inhibition of the enzyme, which is followed by stimulation with increasing GppNHp concentr...

journal_title：Journal of neurochemistry

authors： Girardot JM,Kempf J,Cooper DM

更新日期：1983-09-01 00:00:00

abstract：:Adenosine transport by rat and guinea pig synaptosomes was studied to establish the basis for the marked differences in the potency of some transport inhibitors in these species. An analysis of transport kinetics in the presence and absence of nitrobenzylthioinosine (NBTI) using synaptosomes derived from several areas...

journal_title：Journal of neurochemistry

authors： Shank RP,Baldy WJ

更新日期：1990-08-01 00:00:00

abstract：:Compound AF64A, ethylcholine mustard aziridinium ion (0.4-8 nmol) was stereotaxically administered into rat dorsal hippocampus, and neurochemical changes were determined 5 days later. AF64A treatment, over an almost 10-fold dose range, resulted in a significant (up to 70%) decline in choline acetyltransferase activity...

journal_title：Journal of neurochemistry

authors： Mantione CR,Zigmond MJ,Fisher A,Hanin I

更新日期：1983-07-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a neurotrophic factor essential for maintenance of motor neurons. Loss of this factor produces a phenotype similar to amyotrophic lateral sclerosis (ALS). We recently showed that ALS-producing mutations of Cu/Zn-superoxide dismutase (SOD1) disrupt post-transcriptional regul...

journal_title：Journal of neurochemistry

authors： Li X,Lu L,Bush DJ,Zhang X,Zheng L,Suswam EA,King PH

更新日期：2009-02-01 00:00:00

abstract：:The putative neuroprotective properties of various flavonoids have long been reported. Among this class of chemicals, quercetin, a major flavone/flavonol naturally occurring in plants, deserves focused attention because of the myriad of beneficial effects observed in various in vitro and in vivo models of central nerv...

journal_title：Journal of neurochemistry

authors： Lee YJ,Bernstock JD,Nagaraja N,Ko B,Hallenbeck JM

更新日期：2016-07-01 00:00:00

abstract：:45Ca2+ uptake measurements were performed on intact and osmotically lysed synaptosomes from rat brain to study the possible influence of prostaglandins (PGs) on Ca2+ movements into and within the nerve endings. The K+-induced 45Ca2+ uptake of intact synaptosomes was not influenced by several inhibitors of PG synthesis...

journal_title：Journal of neurochemistry

authors： Denzlinger C,Hertting G,Jackisch R

更新日期：1982-08-01 00:00:00

abstract：:Previous histological, electrophysiological, and biochemical reports have addressed the hypothesis that serotonin functions as a neurotransmitter in mammalian retinas. We have tested the effect on the levels of cyclic AMP of the application of exogenous serotonin, 5-methoxytryptamine, melatonin, and 5-methoxydimethyl-...

journal_title：Journal of neurochemistry

authors： Blazynski C,Ferrendelli JA,Cohen AI

更新日期：1985-08-01 00:00:00

abstract：:The neurotoxin 1-methyl-4-phenylpyridinium ion (MPP+) in the brain striatum has recently been shown to bind at a putatively vesicular site labeled by [3H]tyramine ([3H]TY). Whereas in the rat and mouse striatum MPP+ antagonized TY binding competitively, in the cerebellum there was a mixed-type antagonism, which sugges...

journal_title：Journal of neurochemistry

authors： Vaccari A,Saba PL,Gessa GL,Del Zompo M

更新日期：1993-02-01 00:00:00

abstract：:The characteristics of glycosylation of a brain-specific glycoprotein, 1D4 antigen, and the epitope recognized by its monoclonal antibody were studied. Removal of high-mannose and hybrid types of N-linked oligosaccharides by treatment with endoglycosidase H converted the molecular mass of the 1D4 antigen from 89 kDa t...

journal_title：Journal of neurochemistry

authors： Sano S,Ito S,Nakamura M,Nakagawa H

更新日期：1990-10-01 00:00:00

abstract：:Chronic exposure to manganese (Mn) can cause manganism, a neurodegenerative disorder similar to Parkinson's disease. The toxicity of Mn includes impairment of astrocytic glutamate transporters. 17beta-Estradiol (E2) has been shown to be neuroprotective in various neurodegenerative diseases including Parkinson's diseas...

journal_title：Journal of neurochemistry

authors： Lee ES,Sidoryk M,Jiang H,Yin Z,Aschner M

更新日期：2009-07-01 00:00:00