Identification of truncated C-terminal fragments of the Alzheimer's disease amyloid protein precursor derived from sequential proteolytic pathways.

abstract：:Currently, the underlying mechanisms and the specific cell types associated with Japanese encephalitis-associated leukocyte trafficking are not understood. Brain microvascular endothelial cells represent a functional barrier and could play key roles in leukocyte central nervous system trafficking. We found that cultur...

journal_title：Journal of neurochemistry

authors： Lai CY,Ou YC,Chang CY,Pan HC,Chang CJ,Liao SL,Su HL,Chen CJ

更新日期：2012-10-01 00:00:00

abstract：:Several cholinesterase inhibitors used in the treatment of Alzheimer's disease (AD) have been shown to interact with an allosteric site on the nicotinic acetylcholine receptor (nAChR). A possible linkage between the phosphorylation state of tau, the major component of paired helical filaments found in AD brain, and st...

journal_title：Journal of neurochemistry

authors： Hellström-Lindahl E,Moore H,Nordberg A

更新日期：2000-02-01 00:00:00

abstract：:Addiction is thought to be a memory process between perception and environmental cues and addicted patients often relapse when they come into contact with the drug-related context once again. Here, we used a conditioned place preference protocol to seek a more effective extinction methodology of methamphetamine (METH)...

journal_title：Journal of neurochemistry

authors： Huang CH,Yu YJ,Chang CH,Gean PW

更新日期：2016-04-01 00:00:00

abstract：:IMP-GMP 5'-nucleotidase has been purified to homogeneity from total rat brain extracts. This preparation showed a unique band (Mr 54,000 +/- 1,509) in sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The enzyme presented the following properties: optimal pH value, 6.5-6.8; relative velocity measured in the p...

journal_title：Journal of neurochemistry

authors： Marques AF,Teixeira NA,Gambaretto C,Sillero A,Sillero MA

更新日期：1998-09-01 00:00:00

abstract：:Expression of the Ca(2+)-dependent phospholipids binding protein annexin A2 (ANX2) in the brain is thought to be largely associated with brain pathological conditions such as tumor, inflammation, and neurodegeneration. The recent findings that ANX2 heterotetramer is involved in learning and neuronal activities necessi...

journal_title：Journal of neurochemistry

authors： Zhao WQ,Lu B

更新日期：2007-03-01 00:00:00

abstract：:Epilepsy is a serious neurological condition exhibiting complex pathology and deserving of more serious attention. More than 30% of people with epilepsy are not responsive to more than 20 anti-epileptic drugs currently available, reflecting an unmet clinical need for novel therapeutic strategies. Not much is known abo...

journal_title：Journal of neurochemistry

authors： Paudel YN,Semple BD,Jones NC,Othman I,Shaikh MF

更新日期：2019-12-01 00:00:00

abstract：:Previous studies have shown that activation of the cyclic AMP (cAMP) pathway down-regulates CREB expression in CATH.a cells, an effect that appears to be mediated via inhibition of CREB gene transcription. In the current study, we compared this effect in CATH.a cells with regulation of CREB expression in another cell ...

journal_title：Journal of neurochemistry

authors： Coven E,Ni Y,Widnell KL,Chen J,Walker WH,Habener JF,Nestler EJ

更新日期：1998-11-01 00:00:00

abstract：:Two GABAA receptor subunit-specific antibodies anti-alpha 6 and anti-alpha 1 have been used for elucidating the relationship between the presence of alpha 1 and/or alpha 6 subunits in the cerebellar GABAA receptors and the benzodiazepine-binding specificity. Receptor immunoprecipitation with the subunit-specific antib...

journal_title：Journal of neurochemistry

authors： Khan ZU,Gutiérrez A,De Blas AL

更新日期：1996-02-01 00:00:00

abstract：:The effectiveness of intranasal drug administration to stimulate central neuronal systems is well known from drug addiction and has also been considered as an alternative pharmacokinetic approach to treat brain disorders such as Parkinson's disease. In the present study, the possible neurochemical effects of intranasa...

journal_title：Journal of neurochemistry

authors： De Souza Silva MA,Mattern C,Häcker R,Nogueira PJ,Huston JP,Schwarting RK

更新日期：1997-01-01 00:00:00

abstract：:Antibodies raised against the synthetic peptide NH2-QKSDDDYEDYASNKTC-COOH (gamma 2 1-15 Cys), which corresponds to the N-terminal amino acid sequence with a C-terminal cysteine of the human gamma 2 subunit of the gamma-aminobutyric acidA (GABAA) receptor, were used to study the quantitative immunoprecipitation of agon...

journal_title：Journal of neurochemistry

authors： Duggan MJ,Pollard S,Stephenson FA

更新日期：1992-01-01 00:00:00

abstract：:Microglia are the main players of the brain immune response. They act as active sensors that rapidly respond to injurious insults by shifting into different activated states. Elevated levels of unconjugated bilirubin (UCB) induce cell death, immunostimulation and oxidative stress in both neurons and astrocytes. We rec...

journal_title：Journal of neurochemistry

authors： Silva SL,Osório C,Vaz AR,Barateiro A,Falcão AS,Silva RF,Brites D

更新日期：2011-05-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by a selective loss of motor neurones accompanied by intense gliosis in lesioned areas of the brain and spinal cord. Glutamate-mediated excitotoxicity resulting from impaired astroglial uptake constitutes one of the current pathophysiolog...

journal_title：Journal of neurochemistry

authors： Vermeiren C,Hemptinne I,Vanhoutte N,Tilleux S,Maloteaux JM,Hermans E

更新日期：2006-02-01 00:00:00

abstract：:A glycoprotein ATPase in cholinergic synaptic vesicles of Torpedo electric organ was solubilized with octa-ethylene glycol dodecyl ether detergent. Study of potential stabilizing factors identified crude brain phosphatidylserine, glycerol, dithiothreitol, and protease inhibitors as of value in maintaining activity. Th...

journal_title：Journal of neurochemistry

authors： Yamagata SK,Noremberg K,Parsons SM

更新日期：1989-11-01 00:00:00

abstract：:Several analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were synthesized and screened for their capacity to be oxidized by monoamine oxidase (MAO-A or MAO-B) and their capacity to produce nigrostriatal dopaminergic neurotoxicity in mice. All of the compounds were relatively weak substrates for MAO-A but...

journal_title：Journal of neurochemistry

authors： Youngster SK,Sonsalla PK,Heikkila RE

更新日期：1987-03-01 00:00:00

abstract：:Benzodiazepine receptor binding was measured in cerebellar cortex of 15 patients with dominantly inherited olivopontocerebellar atrophy (OPCA). The majority of these patients had a moderate to marked Purkinje cell loss, as judged by the lowered levels of dentate nucleus gamma-aminobutyric acid (GABA), a marker of Purk...

journal_title：Journal of neurochemistry

authors： Kish SJ,Perry TL,Hornykiewicz O

更新日期：1984-02-01 00:00:00

abstract：:Cannabinoid receptors and the endocannabinoids anandamide and 2-arachidonoylglycerol have been suggested to regulate food intake in several animal phyla. Orthologs of the mammalian cannabinoid CB(1) and CB(2) receptors have been identified in fish. We investigated the presence of this endocannabinoid system in the bra...

journal_title：Journal of neurochemistry

authors： Valenti M,Cottone E,Martinez R,De Pedro N,Rubio M,Viveros MP,Franzoni MF,Delgado MJ,Di Marzo V

更新日期：2005-11-01 00:00:00

abstract：:Oligodendroglial cell death in the myelin proteolipid protein (PLP) mutants can be partially rescued by the environment factor(s) supplied by the wild-type cells in vivo and in vitro. It is possible that the presence of PLP or DM-20 results in secretion of a factor or factors in the CNS influencing oligodendrocyte dev...

journal_title：Journal of neurochemistry

authors： Nakao J,Yamada M,Kagawa T,Kim SU,Miyao Y,Shimizu K,Mikoshiba K,Ikenaka K

更新日期：1995-06-01 00:00:00

abstract：:Recent evidence indicates that tyrosine phosphorylation may play important roles in retinal photoreceptor rod outer segments (ROS). We investigated the tyrosine phosphorylation of endogenous proteins in isolated bovine ROS. Several proteins with apparent molecular masses of 31, 39, 60, 83, 90, 97, 120, 140, and 180 kD...

journal_title：Journal of neurochemistry

authors： Bell MW,Desai N,Guo XX,Ghalayini AJ

更新日期：2000-11-01 00:00:00

abstract：:We examined the potential importance of dexamethasone-mediated alterations in energy metabolism in providing protection against hypoxic-ischemic brain damage in immature rats. Seven-day-old rats (n = 165) that had been treated with dexamethasone (0.1 mg/kg, i.p.) or vehicle were assigned to control or hypoxic-ischemic...

journal_title：Journal of neurochemistry

authors： Tuor UI,Yager JY,Bascaramurty S,Del Bigio MR

更新日期：1997-11-01 00:00:00

abstract：:Gap junctions serve as intercellular conduits that allow the exchange of small molecular weight molecules (up to 1 kDa) including ions, metabolic precursors and second messengers. Microglia are capable of recognizing peptidoglycan (PGN) derived from the outer cell wall of Staphylococcus aureus, a prevalent CNS pathoge...

journal_title：Journal of neurochemistry

authors： Garg S,Md Syed M,Kielian T

更新日期：2005-10-01 00:00:00

abstract：:We have studied neurotoxicity induced by pharmacological concentrations of 3-hydroxykynurenine (3-HK), an endogenous toxin implicated in certain neurodegenerative diseases, in cerebellar granule cells, PC12 pheochromocytoma cells, and GT1-7 hypothalamic neurosecretory cells. In all three cell types, the toxicity was i...

journal_title：Journal of neurochemistry

authors： Wei H,Leeds P,Chen RW,Wei W,Leng Y,Bredesen DE,Chuang DM

更新日期：2000-07-01 00:00:00

abstract：:The N-type voltage-gated calcium channel (CaV2.2) is a clinically endorsed target in chronic pain treatments. As directly targeting the channel can lead to multiple adverse side effects, targeting modulators of CaV2.2 may prove better. We previously identified ST1-104, a short peptide from the collapsin response media...

journal_title：Journal of neurochemistry

authors： Ju W,Li Q,Allette YM,Ripsch MS,White FA,Khanna R

更新日期：2013-03-01 00:00:00

abstract：:The metabolism of [2-13C]glycine in astroglia-rich primary cultures obtained from brains of neonatal Wistar rats was investigated using 13C NMR spectroscopy. After a 24-h incubation of the cells in a medium containing glucose, glutamate, cysteine, and [2-13C]glycine, cell extracts and incubation media were analyzed fo...

journal_title：Journal of neurochemistry

authors： Dringen R,Verleysdonk S,Hamprecht B,Willker W,Leibfritz D,Brand A

更新日期：1998-02-01 00:00:00

abstract：:The binding of a series of glycosylated beta-galactosidases to a fraction rich in synaptic membrane of bovine brain was examined. beta-galactosidase modified with p-aminophenyl beta-D-galactopyranoside (beta-D-Gal beta-gal) was found the most effective in binding to synaptic membrane, followed by that modified with be...

journal_title：Journal of neurochemistry

authors： Naoi M,Nagatsu T

更新日期：1986-02-01 00:00:00

abstract：:Inflammatory cell signaling leading to transcriptional activation is primarily mediated by signal transduction via mitogen-activated protein kinase (MAPK) and NFkappaB pathways. A common upstream kinase that signals the activation of these pathways is TGFbeta-activated kinase 1 (TAK1), which itself becomes activated i...

journal_title：Journal of neurochemistry

authors： Bhat NR,Shen Q,Fan F

更新日期：2003-10-01 00:00:00

abstract：:The pathophysiology of major depressive disorders is not completely understood. In this issue of Journal of Neurochemistry, Ni and colleagues investigate the role of cyclic adenosine monophosphate response element-binding protein (CREB)-dependent signaling in the hippocampus on depressive-like behaviors. This editoria...

journal_title：Journal of neurochemistry

authors： Davis RL

更新日期：2019-04-01 00:00:00

abstract：:This study investigated mRNA expression and protein localization of equilibrative and concentrative nucleoside transporters (ENTs, CNTs) in primary cultures of rat brain endothelial cells (RBEC) and rat choroid plexus epithelial cells (RCPEC). Reverse transcriptase PCR analysis revealed that RBEC and RCPEC contained m...

journal_title：Journal of neurochemistry

authors： Redzic ZB,Biringer J,Barnes K,Baldwin SA,Al-Sarraf H,Nicola PA,Young JD,Cass CE,Barrand MA,Hladky SB

更新日期：2005-09-01 00:00:00

abstract：:We have previously shown that Regulator of Calcineurin 1 (RCAN1) regulates multiple stages of vesicle exocytosis. However, the mechanisms by which RCAN1 affects secretory vesicle exocytosis and quantal release kinetics remain unknown. Here, we use carbon fibre amperometry to detect exocytosis from chromaffin cells and...

journal_title：Journal of neurochemistry

authors： Zanin MP,Mackenzie KD,Peiris H,Pritchard MA,Keating DJ

更新日期：2013-02-01 00:00:00

abstract：:This Editorial highlights an ingenious study by Li and Freeman published in this issue of J. Neurochem. Accurately knowing the brain extracellular levels of the two main substrates, that is, glucose and lactate, while a well-controlled and graded-stimulus is applied, might be extremely useful to finely understand how ...

journal_title：Journal of neurochemistry

authors： Leloup C

更新日期：2015-11-01 00:00:00

abstract：:The blood-brain barrier (BBB) is important physiologically. Pathologically, BBB disruption has been implicated in a wide spectrum of neurological disorders including Parkinson's disease (PD). Recent studies indicate that caffeine is protective against PD, but by poorly understood mechanisms. Using a MPTP neurotoxin mo...

journal_title：Journal of neurochemistry

authors： Chen X,Lan X,Roche I,Liu R,Geiger JD

更新日期：2008-11-01 00:00:00