Loss of metabotropic glutamate receptor-mediated regulation of glutamate transport in chemically activated astrocytes in a rat model of amyotrophic lateral sclerosis.

abstract：:The recycling of synaptic vesicles in nerve terminals involves multiple steps, underlies all aspects of synaptic transmission, and is a key to understanding the basis of synaptic plasticity. The development of styryl dyes as fluorescent molecules that label recycling synaptic vesicles has revolutionized the way in whi...

journal_title：Journal of neurochemistry

authors： Cousin MA,Robinson PJ

更新日期：1999-12-01 00:00:00

abstract：:To examine the effects of glutamatergic neurotransmission on amyloid processing, we stably expressed the metabotropic glutamate receptor subtype 1alpha (mGlu-R1alpha) in HEK 293 cells. Both glutamate and the selective metabotropic agonist 1-amino-1,3-cyclopentanedicarboxylic acid (ACPD) rapidly increased phosphatidyli...

journal_title：Journal of neurochemistry

authors： Nitsch RM,Deng A,Wurtman RJ,Growdon JH

更新日期：1997-08-01 00:00:00

abstract：:Hypothalamic norepinephrine (NE) release regulates arterial pressure by altering sympathetic nervous system activity. Because angiotensin (Ang) (1-7) decreases hypothalamic NE release and this effect may be correlated with a diminished NE synthesis, we hypothesize that Ang-(1-7) down-regulates tyrosine hydroxylase (TH...

journal_title：Journal of neurochemistry

authors： Lopez Verrilli MA,Pirola CJ,Pascual MM,Dominici FP,Turyn D,Gironacci MM

更新日期：2009-04-01 00:00:00

abstract：:Postmortem changes in catecholamines, indoleamines, and their metabolites in rat brain regions following decapitation were determined by LCEC. In the three regions studied neurotransmitter levels declined after decapitation, whereas the metabolite levels increased. Microwave irradiation at 10 kW rapidly inactivated br...

journal_title：Journal of neurochemistry

authors： Ikarashi Y,Sasahara T,Maruyama Y

更新日期：1985-09-01 00:00:00

abstract：:The protein B-50 is dephosphorylated in rat cortical synaptic plasma membranes (SPM) by protein phosphatase type 1 and 2A (PP-1 and PP-2A)-like activities. The present studies further demonstrate that B-50 is dephosphorylated not only by a spontaneously active PP-1-like enzyme, but also by a latent form after pretreat...

journal_title：Journal of neurochemistry

authors： Han YF,Wang W,Schlender KK,Ganjeizadeh M,Dokas LA

更新日期：1992-07-01 00:00:00

abstract：:The mammalian telencephalon, which comprises the cerebral cortex, olfactory bulb, hippocampus, basal ganglia, and amygdala, is the most complex and intricate region of the CNS. It is the seat of all higher brain functions including the storage and retrieval of memories, the integration and processing of sensory and mo...

journal_title：Journal of neurochemistry

authors： Corbin JG,Gaiano N,Juliano SL,Poluch S,Stancik E,Haydar TF

更新日期：2008-09-01 00:00:00

abstract：:The orphan nuclear receptor estrogen-related receptor gamma (ERRγ) is highly expressed in the nervous system during embryogenesis and in adult brains, but its physiological role in neuronal development remains unknown. In this study, we evaluated the relevance of ERRγ in regulating dopaminergic (DAergic) phenotype and...

journal_title：Journal of neurochemistry

authors： Lim J,Choi HS,Choi HJ

更新日期：2015-05-01 00:00:00

abstract：:Although 3,4-dihydroxyphenylethylamine (dopamine, DA) and vasoactive intestinal peptide (VIP) have been reported to stimulate adenylate cyclase activity in the rabbit retina, possible interactions between VIP-sensitive and DA-sensitive adenylate cyclase systems have not been previously investigated. To elucidate the i...

journal_title：Journal of neurochemistry

authors： Pachter JA,Lam DM

更新日期：1986-01-01 00:00:00

abstract：:The AP1 site within the tyrosine hydroxylase gene proximal promoter is essential for the response of the gene to numerous stimuli. Stimulation of this gene is often associated with induction of the AP1 transcription factor, c-Fos. However, many stimuli activate or induce multiple transcription factors that interact wi...

journal_title：Journal of neurochemistry

authors： Sun B,Tank AW

更新日期：2002-01-01 00:00:00

abstract：:Presynaptic modulation of synaptic transmission is the primary function of central nicotinic acetylcholine receptors (nAChRs) in developing and adult brain. nAChR activation regulates release of various neurotransmitters, including norepinephrine (NA). Given evidence that NA may serve a critical functional role in cer...

journal_title：Journal of neurochemistry

authors： O'Leary KT,Leslie FM

更新日期：2003-03-01 00:00:00

abstract：:The ubiquitous second messenger cyclic GMP (cGMP) is synthesized by soluble guanylate cyclases in response to nitric oxide (NO) and degraded by phosphodiesterases (PDE). We studied the homeostasis of cGMP in living thalamic neurons by using the genetically encoded fluorescence resonance energy transfer sensor Cygnet, ...

journal_title：Journal of neurochemistry

authors： Hepp R,Tricoire L,Hu E,Gervasi N,Paupardin-Tritsch D,Lambolez B,Vincent P

更新日期：2007-09-01 00:00:00

abstract：:We attempted to obtain evidence for the occurrence of oxidant injury following seizure activity by measuring hippocampal F2-isoprostanes (F2-IsoPs), a reliable marker of free radical-induced lipid peroxidation. Formation of F2-IsoPs esterified in hippocampal phospholipids was correlated with hippocampal neuronal loss ...

journal_title：Journal of neurochemistry

authors： Patel M,Liang LP,Roberts LJ 2nd

更新日期：2001-12-01 00:00:00

abstract：:The exact molecular mechanism of ischemic neuronal death still remains unclear from rodents to primates. A number of studies using lower species animals have suggested implication of apoptosis cascade, while using monkeys the authors recently claimed necrosis cascade by calpain-induced leakage of lysosomal cathepsins ...

journal_title：Journal of neurochemistry

authors： Tsukada T,Watanabe M,Yamashima T

更新日期：2001-12-01 00:00:00

abstract：:G protein-coupled receptors are important regulators of cellular signaling processes. Within the large family of rhodopsin-like receptors, those binding to biogenic amines form a discrete subgroup. Activation of biogenic amine receptors leads to transient changes of intracellular Ca²⁺-([Ca²⁺](i)) or 3',5'-cyclic adeno...

journal_title：Journal of neurochemistry

authors： Balfanz S,Jordan N,Langenstück T,Breuer J,Bergmeier V,Baumann A

更新日期：2014-04-01 00:00:00

abstract：:Gap junctions serve as intercellular conduits that allow the exchange of small molecular weight molecules (up to 1 kDa) including ions, metabolic precursors and second messengers. Microglia are capable of recognizing peptidoglycan (PGN) derived from the outer cell wall of Staphylococcus aureus, a prevalent CNS pathoge...

journal_title：Journal of neurochemistry

authors： Garg S,Md Syed M,Kielian T

更新日期：2005-10-01 00:00:00

abstract：:Attempts were made to label tachykinin NK2 binding sites in the adult rat brain using [125I]neurokinin A (NKA) as ligand in the presence of NK1 and NK3 agonist or antagonist to avoid labelling of NK1 and NK3 binding sites, respectively. A high-affinity, specifically NK2-sensitive, [125I]NKA-binding, temperature-depend...

journal_title：Journal of neurochemistry

authors： Saffroy M,Torrens Y,Glowinski J,Beaujouan JC

更新日期：2001-12-01 00:00:00

abstract：:A neurochemical evaluation of beagle dogs with naturally occurring spontaneous generalized convulsive seizures was performed. Amino acid profiles of serum, cerebrospinal fluid (CSF), and biopsied cerebral cortex from epileptic dogs were compared with those from seizure-free siblings. No differences in absolute levels ...

journal_title：Journal of neurochemistry

authors： van Gelder NM,Edmonds HL Jr,Hegreberg GA,Chatburn CC,Clemmons RM,Sylvester DM

更新日期：1980-11-01 00:00:00

abstract：:Tachykinins play an important role in peripheral inflammatory diseases and disorders of the CNS. Most members of the tachykinin family are generated by alternative post-transcriptional splicing of the prepro-tachykinin (PPT) A gene. Here, we examined the simultaneous expression of PPT-A splice variants in individual n...

journal_title：Journal of neurochemistry

authors： Springer J,McGregor GP,Fink L,Fischer A

更新日期：2003-05-01 00:00:00

abstract：:Expression of the carboxyl-terminal fragment (CT) of the beta-amyloid precursor protein (APP) in transgenic animals has been linked with neurotoxicity. However, it remains to be clarified whether the neurotoxicity is caused by beta-amyloid proteins (A betas) derived from CT or by CT itself. To study the in vivo neurot...

journal_title：Journal of neurochemistry

authors： Song DK,Won MH,Jung JS,Lee JC,Kang TC,Suh HW,Huh SO,Paek SH,Kim YH,Kim SH,Suh YH

更新日期：1998-08-01 00:00:00

abstract：:The effect of hypoglycaemic, hypoxic, and ischaemic conditions on high-affinity neurotransmitter transport was studied in the human astrocytoma clone D384 and the human neuroblastoma clone SH-SY5Y. Both cell lines expressed a sodium-dependent glutamate/aspartate transporter. Km values for D-[3H]aspartate uptake were 6...

journal_title：Journal of neurochemistry

authors： O'Neill CM,Ball SG,Vaughan PF

更新日期：1994-08-01 00:00:00

abstract：:Microglia are activated in humans following infection with human immunodeficiency virus (HIV), and brain inflammation is thought to be involved in neuronal injury and dysfunction during HIV infection. Numerous studies indicate a role for the HIV regulatory protein Tat in HIV-related inflammatory and neurodegenerative ...

journal_title：Journal of neurochemistry

authors： Bruce-Keller AJ,Barger SW,Moss NI,Pham JT,Keller JN,Nath A

更新日期：2001-09-01 00:00:00

abstract：:Both acidosis and oxidative stress contribute to ischemic brain injury. The present study examines interactions between acidosis and oxidative stress in murine cortical cultures. Acidosis (pH 6.2) was found to potentiate markedly neuronal death induced by H2O2 exposure. To determine if this effect was mediated by decr...

journal_title：Journal of neurochemistry

authors： Ying W,Han SK,Miller JW,Swanson RA

更新日期：1999-10-01 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) receptor complex as defined by the binding of [3H]MK-801 has been solubilized from membranes prepared from both rat and porcine brain using the anionic detergent deoxycholate (DOC). Of the detergents tested DOC extracted the most receptors (21% for rat, 34% for pig), and the soluble com...

journal_title：Journal of neurochemistry

authors： McKernan RM,Castro S,Poat JA,Wong EH

更新日期：1989-03-01 00:00:00

abstract：:Microfluorimetric measurements of intracellular calcium ion concentration [Ca(2+)](i) were employed to examine the effects of chronic hypoxia (2.5% O(2), 24 h) on Ca(2+) stores and capacitative Ca(2+) entry in human neuroblastoma (SH-SY5Y) cells. Activation of muscarinic receptors evoked rises in [Ca(2+)](i) which wer...

journal_title：Journal of neurochemistry

authors： Smith IF,Boyle JP,Vaughan PF,Pearson HA,Peers C

更新日期：2001-11-01 00:00:00

abstract：:GABAA receptors are activated via low-affinity binding sites for the agonists GABA or muscimol. Evidence has been provided that the amino acid residue alpha 1F64 located at the beta2(+)/alpha1(-) subunit interface forms part of this binding site. In radioactive ligand binding studies the agonist [3H]muscimol has been ...

journal_title：Journal of neurochemistry

authors： Baur R,Sigel E

更新日期：2003-10-01 00:00:00

abstract：:Apolipoprotein (apo) A-I is the major protein component of high-density lipoproteins (HDLs), which are responsible for reverse cholesterol transport from peripheral tissues to the liver. A low level of plasma HDL is correlated with susceptibility to atherosclerosis and coronary heart disease. Mammalian apo A-I synthes...

journal_title：Journal of neurochemistry

authors： Möckel B,Zinke H,Flach R,Weiss B,Weiler-Güttler H,Gassen HG

更新日期：1994-02-01 00:00:00

abstract：:Circulating antibody to the bovine white matter proteolipid apoprotein was detected in rabbits 1 month ater a single injection of the water-soluble form of the apoprotein. By double immunodiffusion, the antiserum reacted specifically with the delipidated proteolipid apoprotein and the crude proteolipid fraction contai...

journal_title：Journal of neurochemistry

authors： Macklin WB,Schwarting GA,Lees MB,Cohen SR

更新日期：1981-01-01 00:00:00

abstract：:We investigated, using adult (2-month-old) and senescent (12- and 24-month-old) rats, the effects of aging on the relationship between the alpha 1-adrenergic coupling system and the membrane viscosity of the cerebral cortex. There was no age-related difference in the KD values of [3H]prazosin binding on the membranes....

journal_title：Journal of neurochemistry

authors： Miyamoto A,Araiso T,Koyama T,Ohshika H

更新日期：1990-07-01 00:00:00

abstract：:Frontotemporal lobar degeneration (FTLD) is the second leading cause of dementia in individuals under age 65. In many patients, the predominant pathology includes neuronal cytoplasmic or intranuclear inclusions of ubiquitinated TAR DNA binding protein 43 (FTLD-TDP). Recently, a genome-wide association study identified...

journal_title：Journal of neurochemistry

authors： Nicholson AM,Finch NA,Wojtas A,Baker MC,Perkerson RB 3rd,Castanedes-Casey M,Rousseau L,Benussi L,Binetti G,Ghidoni R,Hsiung GY,Mackenzie IR,Finger E,Boeve BF,Ertekin-Taner N,Graff-Radford NR,Dickson DW,Rademakers R

更新日期：2013-09-01 00:00:00

abstract：:Recent studies have shown that mast cells (MCs) are present in rat brain, that they have a predominantly thalamic localization, and that they contain histamine (HA). However, the degree to which these cells contribute to brain HA levels has remained unclear. Our recent studies of the precise distribution of rat brain ...

journal_title：Journal of neurochemistry

authors： Goldschmidt RC,Hough LB,Glick SD

更新日期：1985-06-01 00:00:00