Rat brain mast cells: contribution to brain histamine levels.

abstract：:To identify genes induced by transient forebrain ischemia, we used the mRNA differential display technique in the four-vessel occlusion model in rats. Some genes were identified as candidates that encode ischemia-responsive protein, and one of them was cloned as ischemia-responsive protein 94 kDa (irp94) from the rat ...

journal_title：Journal of neurochemistry

authors： Yagita Y,Kitagawa K,Taguchi A,Ohtsuki T,Kuwabara K,Mabuchi T,Matsumoto M,Yanagihara T,Hori M

更新日期：1999-04-01 00:00:00

abstract：:Somatodendritic voltage-dependent K(+) currents (Kv4.2) channels mediate transient A-type K(+) currents and play critical roles in controlling neuronal excitability. Accumulating evidence has indicated that Kv4.2 channels are key regulatory components of the signaling pathways that lead to synaptic plasticity. In cont...

journal_title：Journal of neurochemistry

authors： Lei Z,Deng P,Xu ZC

更新日期：2008-07-01 00:00:00

abstract：:Presynaptic nicotinic acetylcholine receptors on striatal nerve terminals modulate the release of dopamine. We have compared the effects of a number of nicotinic agonists and antagonists on a perfused synaptosome preparation preloaded with [3H]dopamine. (-)-Nicotine, acetylcholine, and the nicotinic agonists cytisine ...

journal_title：Journal of neurochemistry

authors： Rapier C,Lunt GG,Wonnacott S

更新日期：1990-03-01 00:00:00

abstract：:Calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) was measured in selected regions of the cervical, thoracic, and lumbar spinal cord of untreated rabbits and, following intrathecal injection of the serotonergic neurotoxin 5,7-dihydroxytryptamine (5,7-DHT), in the thoracolumbar cord in rats using a sheep ...

journal_title：Journal of neurochemistry

authors： Fone KC

更新日期：1992-10-01 00:00:00

abstract：:Heme oxygenase (HO) activity in tissue adjacent to an intracerebral hematoma may modulate cellular vulnerability to heme-mediated oxidative injury. Although HO-1 is induced after experimental intracerebral hemorrhage (ICH), the time course of this induction, its effect on tissue HO activity, and its association with o...

journal_title：Journal of neurochemistry

authors： Chen M,Regan RF

更新日期：2007-12-01 00:00:00

abstract：:The anticonvulsant drugs phenobarbital, phenytoin, sodium valproate, and phenytoin-sodium valproate in combination were administered daily to (a) pregnant rats starting on the 5th day after conception, and continued through 17 days postpartum, or (b) to developing rats between 3 and 17 days of age. Each drug was prepa...

journal_title：Journal of neurochemistry

authors： Patsalos PN,Wiggins RC

更新日期：1982-10-01 00:00:00

abstract：:SUMOylation is a post-translational modification that regulates protein signalling and complex formation by adjusting the conformation or protein-protein interactions of the substrate protein. There is a compelling and rapidly expanding body of evidence that, in addition to SUMOylation of nuclear proteins, SUMOylation...

journal_title：Journal of neurochemistry

authors： Henley JM,Seager R,Nakamura Y,Talandyte K,Nair J,Wilkinson KA

更新日期：2020-06-15 00:00:00

abstract：:The N141I missense mutation in presenilin (PS) 2 is tightly linked with a form of autosomal dominant familial Alzheimer's disease (AD) in the Volga German families. We have generated transgenic mouse lines overexpressing human wild-type or mutant PS2 under transcriptional control of the chicken beta-actin promoter. In...

journal_title：Journal of neurochemistry

authors： Oyama F,Sawamura N,Kobayashi K,Morishima-Kawashima M,Kuramochi T,Ito M,Tomita T,Maruyama K,Saido TC,Iwatsubo T,Capell A,Walter J,Grünberg J,Ueyama Y,Haass C,Ihara Y

更新日期：1998-07-01 00:00:00

abstract：:The genetic defect in Friedreich's ataxia (FRDA) is the expansion of a GAA·TCC triplet in the first intron of the FXN gene, which encodes the mitochondrial protein frataxin. Previous studies have established that the repeats reduce transcription of this essential gene, with a concomitant decrease in frataxin protein i...

journal_title：Journal of neurochemistry

authors： Gottesfeld JM,Rusche JR,Pandolfo M

更新日期：2013-08-01 00:00:00

abstract：:A dramatic loss of glutamate transport has been observed in sporadic amyotrophic lateral sclerosis and has been postulated to contribute to the disease. Experimentally, this hypothesis was corroborated by mimicking the chronic loss of glutamate transport in postnatal rat spinal cord organotypic cultures through the us...

journal_title：Journal of neurochemistry

authors： Rothstein JD,Kuncl RW

更新日期：1995-08-01 00:00:00

abstract：:Evidence based on the ability to accumulate [3H]noradrenaline by a mechanism sensitive to desmethylimipramine suggests that there is a period of hyperinnervation of the cerebellum by noradrenergic fibres around the beginning of the second postnatal week. Different developmental profiles for specific noradrenaline upta...

journal_title：Journal of neurochemistry

authors： Waddington G,Banks P

更新日期：1981-09-01 00:00:00

abstract：:Three unique 5' untranslated regions (UTRs) have been characterized for human microtubule-associated protein-2 (MAP-2) transcripts. All three UTRs shared a common 171-bp sequence adjacent to the MAP-2 coding region and then diverged upstream. The size of the unique upstream sequence was 281, 146, or 104 bp. PCR of gen...

journal_title：Journal of neurochemistry

authors： Kalcheva N,Shafit-Zagardo B

更新日期：1995-10-01 00:00:00

abstract：:Early malnutrition is a risk factor for depression and schizophrenia. Since the offspring of malnourished dams exhibit increased brain levels of serotonin (5-HT), a tryptophan-derived neurotransmitter involved in the pathophysiology of these mental disorders, it is believed that the deleterious effects of early malnut...

journal_title：Journal of neurochemistry

authors： Honório de Melo Martimiano P,de Sa Braga Oliveira A,Ferchaud-Roucher V,Croyal M,Aguesse A,Grit I,Ouguerram K,Lopes de Souza S,Kaeffer B,Bolaños-Jiménez F

更新日期：2017-01-01 00:00:00

abstract：:We recently described a new protein associated exclusively with neuronal clathrin-coated vesicles (CCVs), and characterized two monoclonal antibodies that react with it (S-8G8 and S-6G7). In this report, the association of neuronal protein of 185 kilodaltons (NP185) with CCV kinases and its interaction with tubulin ar...

journal_title：Journal of neurochemistry

authors： Kohtz DS,Puszkin S

更新日期：1989-01-01 00:00:00

abstract：:We applied a differential display PCR technique to isolate molecules that are area-specific in expression in the primate neocortex, and found that growth/differentiation factor 7 (GDF7), a member of the bone morphogenetic protein (BMP)/transforming growth factor (TGF) beta super-family, is preferentially expressed in ...

journal_title：Journal of neurochemistry

authors： Watakabe A,Fujita H,Hayashi M,Yamamori T

更新日期：2001-03-01 00:00:00

abstract：:In vitro, the transport of [14C]nicotine into the isolated choroid plexus, the anatomical locus of the blood--CSF barrier, was studied. The isolated rabbit choroid plexus accumulated [14C]nicotine by two processes: an active saturable transport process and a nonsaturable process. The [14C]nicotine accumulation process...

journal_title：Journal of neurochemistry

authors： Spector R,Goldberg MJ

更新日期：1982-02-01 00:00:00

abstract：:Dietary n-6 polyunsaturated fatty acid (PUFA) deprivation in rodents reduces brain arachidonic acid (20:4n-6) concentration and 20:4n-6-preferring cytosolic phospholipase A(2) (cPLA(2) -IVA) and cyclooxygenase (COX)-2 expression, while increasing brain docosahexaenoic acid (DHA, 22:6n-3) concentration and DHA-selectiv...

journal_title：Journal of neurochemistry

authors： Igarashi M,Kim HW,Chang L,Ma K,Rapoport SI

更新日期：2012-03-01 00:00:00

abstract：:Kindling induces long-term adaptations in neuronal function that lead to a decreased threshold for induction of seizures. In the present study, the influence of amygdala kindling on levels of mRNA for the immediate-early genes (IEGs) c-fos, c-jun, and NGF1-A were examined both before and after an acute electroconvulsi...

journal_title：Journal of neurochemistry

authors： Duman RS,Craig JS,Winston SM,Deutch AY,Hernandez TD

更新日期：1992-11-01 00:00:00

abstract：:Glycogen synthase kinase 3 (GSK3) plays important roles in Wnt and insulin signaling, cell fate determination, and Alzheimer-like tau phosphorylation. We discovered an isoform of tau protein kinase I (TPKI)/GSK3beta with a 13 amino acid insert in the catalytic domain owing to alternative splicing. The alternative tran...

journal_title：Journal of neurochemistry

authors： Mukai F,Ishiguro K,Sano Y,Fujita SC

更新日期：2002-06-01 00:00:00

abstract：:Tumor progression locus 2 (Tpl2)/cancer Osaka thyroid kinase is a newer member of MAP3K family that is now known for its essential role in tumor necrosis factor-aplha (TNFα) expression in macrophages, but its pro-inflammatory signaling, if any, in glia is unknown. When cultures of murine microglia and astrocytes were ...

journal_title：Journal of neurochemistry

authors： Hirschhorn J,Mohanty S,Bhat NR

更新日期：2014-03-01 00:00:00

abstract：:Calf brain 3'-phosphoadenosine 5'-phosphosulfate (PAPS):proteoheparan sulfate (PHS) N-sulfotransferase activity is solubilized by extracting salt-washed microsomes with 1% Cutscum. A protocol is described for the partial purification of the sulfotransferase activity utilizing: (1) diethylaminoethyl (DEAE)-Sephacel, (2...

journal_title：Journal of neurochemistry

authors： Miller RR,Waechter CJ

更新日期：1988-07-01 00:00:00

abstract：:At 1, 2, and 4 weeks after unilateral premotor and motor cortex ablation in rats, a significant and lasting decrease in glutamate levels in the ipsilateral versus contralateral striatum was observed. A significant corresponding fall in aspartate was seen only after 1 week. In contrast, there was a large increase in th...

journal_title：Journal of neurochemistry

authors： Hassler R,Haug P,Nitsch C,Kim JS,Paik K

更新日期：1982-04-01 00:00:00

abstract：:The endogenous cannabinoid anandamide has been reported to produce well-defined behavioral tolerance, but studies on the possible mechanisms underlying this process are few and often contradictory. The present study was designed to survey the cellular events involved in anandamide tolerance, in terms of the effects on...

journal_title：Journal of neurochemistry

authors： Rubino T,Viganò D,Costa B,Colleoni M,Parolaro D

更新日期：2000-12-01 00:00:00

abstract：:Iron deficiency (ID) anemia during infancy results in long-term neurological consequences, yet the mediating mechanisms remain unclear. Infant monkeys often become naturally anemic during the first 6 months of life, presenting an opportunity to determine the effect of developmental iron deficiency. After weaning, anim...

journal_title：Journal of neurochemistry

authors： Geguchadze RN,Coe CL,Lubach GR,Clardy TW,Beard JL,Connor JR

更新日期：2008-04-01 00:00:00

abstract：:We have recently shown that disrupting the expression and post-synaptic clustering of gephyrin in cultured hippocampal pyramidal cells, by either gephyrin RNAi (RNA interference) or over-expression of a dominant negative gephyrin-enhanced green fluorescent protein (EGFP) fusion protein, leads to decreased number of po...

journal_title：Journal of neurochemistry

authors： Yu W,De Blas AL

更新日期：2008-02-01 00:00:00

abstract：:The cochleo-vestibular ganglion contains neural crest-derived glial cells and sensory neurons that are derived from the neurogenic otic placode. Little is known about the molecular mechanisms that regulate the tightly orchestrated development of this structure. Here, we report that Sox10, a high-mobility group DNA-bin...

journal_title：Journal of neurochemistry

authors： Breuskin I,Bodson M,Thelen N,Thiry M,Borgs L,Nguyen L,Stolt C,Wegner M,Lefebvre PP,Malgrange B

更新日期：2010-09-01 00:00:00

abstract：:After intraperitoneal injection of rats with 6-fluorotryptophan (6-FT), brain 5-hydroxytryptamine (5-HT) levels decreased exponentially over 1 h. Depletion was dose-dependent and maximum depletion was observed at 200 mg/kg. 6-FT (200 mg/kg) did not significantly alter the content of 5-hydroxyindoleacetic acid. Turnove...

journal_title：Journal of neurochemistry

authors： Miwa S,Fujiwara M,Lee K,Fujiwara M

更新日期：1987-05-01 00:00:00

abstract：:We report the isolation of cDNA clones encoding the somatic form of the E1 alpha subunit of the pyruvate dehydrogenase complex of rat. The deduced amino acid sequence has 99.5, 98, and 97% identity, respectively, with the orthologous proteins of mouse, human, and pig and 98.5% identity with a rat E1 alpha sequence rep...

journal_title：Journal of neurochemistry

authors： Cullingford TE,Clark JB,Phillips IR

更新日期：1994-05-01 00:00:00

abstract：:Transcriptional responses to growth factor and G protein-coupled receptors were compared in PC12 cells using retroviral luciferase reporters. In cells stably expressing alpha(1A)-adrenergic receptors, norepinephrine activated all five reporters [AP1 (activator protein-1), SRE (serum response element), CRE (cyclic AMP ...

journal_title：Journal of neurochemistry

authors： Minneman KP,Lee D,Zhong H,Berts A,Abbott KL,Murphy TJ

更新日期：2000-06-01 00:00:00

abstract：:Temporal carbohydrate expression patterns at cell surfaces are thought to be of crucial regulatory significance during developmental processes. Hitherto, however, data on individual membrane proteins undergoing development-associated changes in glycosylation are sparsely. Here, we show that the two natriuretic peptide...

journal_title：Journal of neurochemistry

authors： Müller D,Hildebrand M,Lübberstedt J,Kuhn M,Middendorff R

更新日期：2010-11-01 00:00:00