Postmortem changes in catecholamines, indoleamines, and their metabolites in rat brain regions: prevention with 10-kW microwave irradiation.

Abstract:

:Postmortem changes in catecholamines, indoleamines, and their metabolites in rat brain regions following decapitation were determined by LCEC. In the three regions studied neurotransmitter levels declined after decapitation, whereas the metabolite levels increased. Microwave irradiation at 10 kW rapidly inactivated brain enzymes and thus prevented the postmortem changes.

journal_name

J Neurochem

authors

Ikarashi Y,Sasahara T,Maruyama Y

doi

10.1111/j.1471-4159.1985.tb04083.x

subject

Has Abstract

pub_date

1985-09-01 00:00:00

pages

935-9

issue

3

eissn

0022-3042

issn

1471-4159

journal_volume

45

pub_type

杂志文章
  • Investigation of the abundance and subunit composition of GABAA receptor subtypes in the cerebellum of alpha1-subunit-deficient mice.

    abstract::In cerebellum, 75% of all GABAA receptors contain alpha1 subunits. Here, we investigated compensatory changes in GABAA receptor subunit expression and composition in alpha1 subunit-knockout mice. In these mice the total number of cerebellar GABAA receptors was reduced by 46%. Whereas the number of receptors containing...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.2005.03509.x

    authors: Ogris W,Lehner R,Fuchs K,Furtmüller B,Höger H,Homanics GE,Sieghart W

    更新日期:2006-01-01 00:00:00

  • A caspase-3-dependent pathway is predominantly activated by the excitotoxin pregnenolone sulfate and requires early and late cytochrome c release and cell-specific caspase-2 activation in the retinal cell death.

    abstract::This study investigates the implication of mitochondria- and caspase-dependent pathways in the death of retinal neurones exposed to the neurosteroid pregnenolone sulfate (PS) shown to evoke apoptosis and contribute to amplification and propagation of excitotoxicity. After a brief PS challenge of intact retinas, caspas...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1046/j.1471-4159.2002.01229.x

    authors: Cascio C,Guarneri R,Russo D,De Leo G,Guarneri M,Piccoli F,Guarneri P

    更新日期:2002-12-01 00:00:00

  • The peripheral-type benzodiazepine receptor is present in astrocytes but is not a primary site of action for convulsants/anticonvulsants.

    abstract::High-affinity binding sites for [3H]PK 11195 and [3H]Ro 5-4864 with the properties of the peripheral-type benzodiazepine receptor were detected in primary cultures of both mouse neocortical and cerebellar astrocytes. The binding sites were enriched in mitochondrial fractions on differential centrifugation. An 18-kDa p...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1046/j.1471-4159.1994.62020673.x

    authors: Moynagh PN,Schousboe A,Williams DC

    更新日期:1994-02-01 00:00:00

  • Non-proteolytic neurotrophic effects of tissue plasminogen activator on cultured mouse cerebrocortical neurons.

    abstract::Most biological effects of tissue plasminogen activator (tPA), such as fibrinolysis, are mediated by its protease activity. Recent studies, however, have demonstrated that tPA also has several protease-independent effects such as: neuroprotection, microglial activation, and promoting LTP formation. In order to gain a ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.2007.04417.x

    authors: Lee HY,Hwang IY,Im H,Koh JY,Kim YH

    更新日期:2007-06-01 00:00:00

  • Activation of (Na+, K+)-ATPase by nanomolar concentrations of GM1 ganglioside.

    abstract::GM1 ganglioside binding to the crude mitochondrial fraction of rat brain and its effect on (Na+, K+)-ATPase were studied, the following results being obtained: (a) the binding process followed a biphasic kinetics with a break at 50 nM-GM1; GM1 at concentrations below the break was stably associated, while over the bre...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.1981.tb00462.x

    authors: Leon A,Facci L,Toffano G,Sonnino S,Tettamanti G

    更新日期:1981-08-01 00:00:00

  • Distinct promoters regulate tissue-specific and differential expression of kallikrein 6 in CNS demyelinating disease.

    abstract::Kallikrein 6 is a serine protease expressed abundantly in normal adult human and rodent CNS, and therein is regulated by injury. In the case of CNS demyelinating disease, K6 expression in CNS occurs additionally in perivascular and parenchymal inflammatory cells suggesting a role in pathogenesis. Herein we describe tw...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.2004.02826.x

    authors: Christophi GP,Isackson PJ,Blaber S,Blaber M,Rodriguez M,Scarisbrick IA

    更新日期:2004-12-01 00:00:00

  • Phorbol ester-enhanced noradrenaline secretion correlates with the presence and activity of protein kinase C-alpha in human SH-SY5Y neuroblastoma cells.

    abstract::The effect of inhibition and down-regulation of protein kinase C (PKC) subtypes alpha, epsilon, and zeta on noradrenaline (NA) secretion from human SH-SY5Y neuroblastoma cells was investigated. The PKC inhibitor Ro 31-7549 inhibited carbachol-evoked NA release (IC(50) 0.6 microM) but not 100 mM (K+)-evoked release. In...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1046/j.1471-4159.1996.66062381.x

    authors: Turner NA,Walker JH,Ball SG,Vaughan PF

    更新日期:1996-06-01 00:00:00

  • Glycosylation of proteins in developing human brain.

    abstract::The carbohydrate content of human brain glycoproteins was studied during development from the age of 12 fetal weeks to 8 postnatal months. The concentration of all the glycoprotein monosaccharides increased with age. The total amount of glycoprotein monosaccharides per lipid-free dry tissue increased by about 150% fro...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.1982.tb08011.x

    authors: Korpeinen T,Mononen I,Krusius T,Järnefelt J

    更新日期:1982-12-01 00:00:00

  • Effects of methylphenidate analogues on phenethylamine substrates for the striatal dopamine transporter: potential as amphetamine antagonists?

    abstract::Methylphenidate (MPD) was found to inhibit competitively the striatal dopamine transporter (DAT) and bind at sites on the DAT in common with both cocaine (a non-substrate site ligand) and amphetamine (a substrate site ligand). Some methylphenidate analogues modified on the aromatic ring and/or at the nitrogen were tes...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1046/j.1471-4159.1999.0721266.x

    authors: Wayment HK,Deutsch H,Schweri MM,Schenk JO

    更新日期:1999-03-01 00:00:00

  • Integrins stimulate phosphorylation of neurofilament NF-M subunit KSP repeats through activation of extracellular regulated-kinases (Erk1/Erk2) in cultured motoneurons and transfected NIH 3T3 cells.

    abstract::Integrin-mediated interactions of cells with components of the extracellular matrix (ECM) regulate cell survival, cell proliferation, cell differentiation and cell migration through activation of multiple intracellular signal transduction pathways. In this study, we have demonstrated that integrin-matrix interactions ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1046/j.1471-4159.2001.00064.x

    authors: Li BS,Daniels MP,Pant HC

    更新日期:2001-02-01 00:00:00

  • Synthesis and degradation of retinal proteins in darkness and during photic stimulation.

    abstract::Rabbit retinas were maintained in a physiological state in vitro and exposed to 0.5-h pulses of labeled leucine. Protein synthesis was determined from incorporation of the label, and degradation from its subsequent release. The retinas were treated as test-control pairs. The control retina remained in darkness while t...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.1980.tb12499.x

    authors: Ames A 3rd,Parks JM,Nesbett FB

    更新日期:1980-07-01 00:00:00

  • Ischemia-induced changes in cerebral mitochondrial free fatty acids, phospholipids, and respiration in the rat.

    abstract::Changes in the free fatty acid pool size and fatty acyl chain composition of mitochondrial membrane phospholipids and their relation to disruption of mitochondrial function were examined in rat brains after 30 min of cerebral ischemia (Pulsinelli-Brierley model) and 60 min of normoxic reoxygenation. During ischemia, s...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1046/j.1471-4159.1994.62051921.x

    authors: Sun D,Gilboe DD

    更新日期:1994-05-01 00:00:00

  • Shift in the ratio of three-repeat tau and four-repeat tau mRNAs in individual cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease.

    abstract::Molecular mechanisms underlying tauopathy remain undetermined. In the current study, single cell gene expression profiling was coupled with custom-designed cDNA array analysis to evaluate tau expression and other cytoskeletal elements within individual neuronal populations in patients with no cognitive impairment (NCI...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.2005.03641.x

    authors: Ginsberg SD,Che S,Counts SE,Mufson EJ

    更新日期:2006-03-01 00:00:00

  • Transfer of glutamine between astrocytes and neurons.

    abstract::The export of glutamine from astrocytes, and the uptake of glutamine by neurons, are integral steps in the glutamate-glutamine cycle, a major pathway for the replenishment of neuronal glutamate. We review here the functional and molecular identification of the transporters that mediate this transfer. The emerging pict...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章,评审

    doi:10.1046/j.1471-4159.2001.00322.x

    authors: Bröer S,Brookes N

    更新日期:2001-05-01 00:00:00

  • Inhibition of glucosylceramide synthase stimulates autophagy flux in neurons.

    abstract::Aggregate-prone mutant proteins, such as α-synuclein and huntingtin, play a prominent role in the pathogenesis of various neurodegenerative disorders; thus, it has been hypothesized that reducing the aggregate-prone proteins may be a beneficial therapeutic strategy for these neurodegenerative disorders. Here, we ident...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/jnc.12672

    authors: Shen W,Henry AG,Paumier KL,Li L,Mou K,Dunlop J,Berger Z,Hirst WD

    更新日期:2014-06-01 00:00:00

  • Aminobutyric acid greatly increases the in vivo extracellular taurine in the rat hippocampus.

    abstract::The effects of gamma-aminobutyric acid (GABA) on the extracellular levels of taurine and on excitability in the dentate gyrus were studied in anesthetized rats by the dialytrode technique. The dentate gyrus was perfused by means of a dialytrode with Krebs-Ringer-bicarbonate or GABA solutions. Amino acid contents in pe...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.1985.tb12913.x

    authors: Lerma J,Herranz AS,Herreras O,Muñoz D,Solís JM,del Río RM,Delgado JM

    更新日期:1985-03-01 00:00:00

  • Two monoclonal antibodies recognize Alzheimer's neurofibrillary tangles, neurofilament, and microtubule-associated proteins.

    abstract::Two monoclonal antibodies that recognize Alzheimer's neurofibrillary tangles (ANTs), AD10 and AB18, have been characterized by immunoblotting against human and calf spinal cord neurofilament (NF) and calf brain microtubule preparations. Both antibodies bind to the 200-kilodalton (kd) (NF-H) and 160-kd (NF-M) but not t...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.1987.tb04114.x

    authors: Ksiezak-Reding H,Yen SH

    更新日期:1987-02-01 00:00:00

  • Ammonium influx pathways into astrocytes and neurones of hippocampal slices.

    abstract::Ammonium (NH(4) (+) ) is required to maintain pathways involved in shuttling metabolic precursors between astrocytes and neurones. Under hyperammonaemic conditions, increases in the cellular influx of NH(4) (+) , and accompanying changes in ion concentrations, may contribute to disruptions in metabolism and neurotrans...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.2010.07009.x

    authors: Kelly T,Rose CR

    更新日期:2010-12-01 00:00:00

  • Cell-free synthesis of the myelin basic proteins in a wheat germ system programmed with brain messenger RNA.

    abstract::Poly A(+) messenger RNA (mRNA) was isolated from the brains of 3-week-old mice and translated in a cell-free system derived from wheat germ. Maximal stimulation of the system by brain mRNA was observed at a relatively low K+ concentration (45 mM) and low mRNA concentration (1-10 microgram/ml). The translational system...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.1980.tb07084.x

    authors: Matthees J,Campagnoni AT

    更新日期:1980-10-01 00:00:00

  • Direct cytotoxicity of ethylcholine mustard aziridinium in cerebral microvascular endothelial cells.

    abstract::The choline analogue ethylcholine mustard aziridinium (AF64A) is a potent and irreversible inhibitor of choline uptake in brain synaptosomes and is used as a neurotoxin to produce animal models of cholinergic hypofunction. However, previous studies have shown that intraocular administration of AF64A in rats not only r...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.1993.tb03318.x

    authors: Gómez C,Martín C,Galea E,Estrada C

    更新日期:1993-04-01 00:00:00

  • Arachidonic acid increases choline acetyltransferase activity in spinal cord neurons through a protein kinase C-mediated mechanism.

    abstract::Arachidonic acid (AA) plays an important role as a signaling factor in the CNS. Therefore, exposure to AA may affect cholinergic neurons in the spinal cord. To test this hypothesis, mRNA expression and activity of choline acetyltransferase (ChAT) was measured in cultured spinal cord neurons treated with increasing con...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.2004.02535.x

    authors: Chalimoniuk M,King-Pospisil K,Pedersen WA,Malecki A,Wylegala E,Mattson MP,Hennig B,Toborek M

    更新日期:2004-08-01 00:00:00

  • The effect of chronic treatment with the GABA transaminase inhibitors gamma-vinyl-GABA and ethanolamine-O-sulphate on the in vivo release of GABA from rat hippocampus.

    abstract::The effects of chronic treatment with the specific, mechanism-based, irreversible inhibitors of 4-aminobutyrate aminotransferase (EC 2.6.1.19; GABA transaminase), ethanolamine O-sulphate (EOS), and 4-aminohexenoate [vigabatrin; gamma-vinyl-GABA (GVG)] on the extracellular concentrations of GABA in the hippocampus have...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1046/j.1471-4159.1995.64052256.x

    authors: Qume M,Whitton PS,Fowler LJ

    更新日期:1995-05-01 00:00:00

  • Induction of functional interleukin-2 receptor in mouse microglia.

    abstract::Interleukin (IL)-2, initially discovered for its mitogenic activity on T cells, also acts on monocytes, resulting in the activation of cytokine production, superoxide production, and tumoricidal activity. Because severe brain damage was observed in IL-2-transgenic mice, this cytokine may have some influence(s) on the ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1046/j.1471-4159.1995.64051973.x

    authors: Sawada M,Suzumura A,Marunouchi T

    更新日期:1995-05-01 00:00:00

  • Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology.

    abstract::Studies suggest that activation of phosphoinositide 3-kinase-Akt may protect against neuronal cell death in Alzheimer's disease (AD). Here, however, we provide evidence of increased Akt activation, and hyperphosphorylation of critical Akt substrates in AD brain, which link to AD pathogenesis, suggesting that treatment...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.2004.02949.x

    authors: Griffin RJ,Moloney A,Kelliher M,Johnston JA,Ravid R,Dockery P,O'Connor R,O'Neill C

    更新日期:2005-04-01 00:00:00

  • The role of tumor progression locus 2 protein kinase in glial inflammatory response.

    abstract::Tumor progression locus 2 (Tpl2)/cancer Osaka thyroid kinase is a newer member of MAP3K family that is now known for its essential role in tumor necrosis factor-aplha (TNFα) expression in macrophages, but its pro-inflammatory signaling, if any, in glia is unknown. When cultures of murine microglia and astrocytes were ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/jnc.12522

    authors: Hirschhorn J,Mohanty S,Bhat NR

    更新日期:2014-03-01 00:00:00

  • Clonidine inhibition of norepinephrine release from normal and morphine-tolerant guinea pig cortical slices.

    abstract::Endogenous norepinephrine (NE) release in cerebral cortex slices taken from normal and morphine-tolerant guinea pigs was measured by HPLC. In normal slices, a linear relationship was found between electrically evoked NE release and the log of the frequency of stimulation in the range of 1-20 Hz. The efficiency of the ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.1992.tb11361.x

    authors: Tomasini C,Guidorzi R,Bianchi C,Beani L

    更新日期:1992-04-01 00:00:00

  • Tmem30a deficiency leads to retinal rod bipolar cell degeneration.

    abstract::Phospholipids are asymmetrically distributed across the mammalian plasma membrane, with phosphatidylserine (PS) and phosphatidylethanolamine concentrated in the cytoplasmic leaflet of the membrane bilayer and phosphatidylcholine in the exoplasmic leaflet. This asymmetric distribution is dependent on a group of P4 ATPa...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/jnc.14643

    authors: Yang Y,Liu W,Sun K,Jiang L,Zhu X

    更新日期:2019-02-01 00:00:00

  • Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha(1)-adrenergic receptor subtypes.

    abstract::Transcriptional responses to growth factor and G protein-coupled receptors were compared in PC12 cells using retroviral luciferase reporters. In cells stably expressing alpha(1A)-adrenergic receptors, norepinephrine activated all five reporters [AP1 (activator protein-1), SRE (serum response element), CRE (cyclic AMP ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1046/j.1471-4159.2000.0742392.x

    authors: Minneman KP,Lee D,Zhong H,Berts A,Abbott KL,Murphy TJ

    更新日期:2000-06-01 00:00:00

  • Changes in extracellular amino acids during soman- and kainic acid-induced seizures.

    abstract::Extracellular amino acid levels in the rat piriform cortex, an area highly susceptible to seizure-induced neuropathology, were determined by means of intracranial microdialysis. Seizures were induced by systemic administration of either soman (O-1,2,2-trimethylpropyl methylphosphonofluoridate), a potent inhibitor of a...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.1987.tb02912.x

    authors: Wade JV,Samson FE,Nelson SR,Pazdernik TL

    更新日期:1987-08-01 00:00:00

  • Dopamine neuronal transport kinetics and effects of amphetamine.

    abstract::The dopamine (DA) transporter (DAT) regulates DA neurotransmission by recycling DA back into neurons. Drugs that interfere with DAT function, e.g., cocaine and amphetamine, can have profound behavioral effects. The kinetics of DA transport by DAT in isolated synaptosomal or single cell preparations have been previousl...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1046/j.1471-4159.1999.0732406.x

    authors: Jones SR,Joseph JD,Barak LS,Caron MG,Wightman RM

    更新日期:1999-12-01 00:00:00