Abstract:
:Expression of the carboxyl-terminal fragment (CT) of the beta-amyloid precursor protein (APP) in transgenic animals has been linked with neurotoxicity. However, it remains to be clarified whether the neurotoxicity is caused by beta-amyloid proteins (A betas) derived from CT or by CT itself. To study the in vivo neurotoxicity of CT, mice were given a single intracerebroventricular injection of a recombinant 105-amino acid CT (CT105; 68.5-685 pmol, intracerebroventricularly), and changes in behavior and in brain histology were examined. Animals given CT105 (410 or 685 pmol, intracerebroventricularly) showed a dose-dependent impairment in the passive avoidance performance, whereas boiled CT105 had no effect. CT105 (685 pmol, intracerebroventricularly) induced reactive gliosis in neocortex and hippocampus and neurodegeneration in neocortex. These results indicate that centrally administered CT105 induces behavioral impairment and neuropathologic changes, suggesting a direct toxic effect of CT105 per se.
journal_name
J Neurochemjournal_title
Journal of neurochemistryauthors
Song DK,Won MH,Jung JS,Lee JC,Kang TC,Suh HW,Huh SO,Paek SH,Kim YH,Kim SH,Suh YHdoi
10.1046/j.1471-4159.1998.71020875.xsubject
Has Abstractpub_date
1998-08-01 00:00:00pages
875-8issue
2eissn
0022-3042issn
1471-4159journal_volume
71pub_type
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