Abstract:
:In Alzheimer's disease, the neuritic or senile amyloid plaques in hippocampus and association cortex, the diffuse plaques in brain areas such as the cerebellum and sensorimotor cortex, and the amyloid deposits in the walls of pial and parenchymal blood vessels are mainly composed of amyloid beta-peptides. In the present study, either soluble 40-residue amyloid beta-peptide radiolabeled with 125I (I-sAbeta) or [14C]polyethylene glycol ([14C]PEG, a reference material) was briefly infused into one lateral ventricle of normal rats. By 3.5 min, 30% of the I-sAbeta was cleared from ventricular CSF into blood; another 30% was removed over the next 6.5 min. No [14C]PEG was lost from the CSF-brain system during the first 5 min, and only 20% was cleared by 10 min. Much of the I-sAbeta that reached the subarachnoid space was retained by pial arteries and arterioles. Virtually no I-sAbeta was found in brain. The clearance of amyloid beta-peptides from the CSF-brain system, reported herein for normal rats, may be reduced in Alzheimer's disease, thus contributing to amyloid deposition in cerebral tissue and blood vessels.
journal_name
J Neurochemjournal_title
Journal of neurochemistryauthors
Ghersi-Egea JF,Gorevic PD,Ghiso J,Frangione B,Patlak CS,Fenstermacher JDdoi
10.1046/j.1471-4159.1996.67020880.xsubject
Has Abstractpub_date
1996-08-01 00:00:00pages
880-3issue
2eissn
0022-3042issn
1471-4159journal_volume
67pub_type
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pub_type: 杂志文章
doi:10.1111/j.1471-4159.2005.03166.x
更新日期:2005-07-01 00:00:00
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pub_type: 杂志文章
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abstract::This Editorial highlights an ingenious study by Li and Freeman published in this issue of J. Neurochem. Accurately knowing the brain extracellular levels of the two main substrates, that is, glucose and lactate, while a well-controlled and graded-stimulus is applied, might be extremely useful to finely understand how ...
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pub_type: 评论,社论
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更新日期:2015-11-01 00:00:00
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