Regional profile of developmental changes in the sensitivity of the N-methyl-D-aspartate receptor to polyamines.

abstract：:We sought to investigate whether dexamethasone produces a coordinated, time-dependent effect on all enzymes in the catecholamine biosynthetic pathway in PC12 cells. The levels of mRNAs of tyrosine hydroxylase (TH), aromatic L-amino acid decarboxylase (AADC), and dopamine beta-hydroxylase (DBH) were examined at 0, 6, 1...

journal_title：Journal of neurochemistry

authors： Kim KT,Park DH,Joh TH

更新日期：1993-03-01 00:00:00

abstract：:Cultures of bovine adrenomedullary chromaffin cells accumulated 1-[methyl-3H]methyl-4-phenylpyridinium ([3H]MPP+) in a time- and concentration-dependent manner with an apparent Km of 0.7 microM and a Vmax of 3 pmol/min/10(6) cells. The uptake was sodium dependent and sensitive to inhibitors of the cell-surface catecho...

journal_title：Journal of neurochemistry

authors： Reinhard JF Jr,Diliberto EJ Jr,Daniels AJ

更新日期：1989-04-01 00:00:00

abstract：:One of the fundamental goals of lipidomics research is to identify the linkage of an individual gene with a given lipidome, thereby revealing the role of that gene in lipid metabolism, transport, and homeostasis. In this study, we have identified four apolipoprotein E (apoE)-induced alterations in the lipidome of mous...

journal_title：Journal of neurochemistry

authors： Cheng H,Jiang X,Han X

更新日期：2007-04-01 00:00:00

abstract：:We report on the expression of ionotropic glutamate receptor subunits in primary neuronal cultures from rat cortex, hippocampus and cerebellum and of metabotropic glutamate (mGlu) receptor subtypes in these neuronal cultures as well as in cortical astroglial cultures. We found that the NMDA receptor (NR) subunits NR1,...

journal_title：Journal of neurochemistry

authors： Janssens N,Lesage AS

更新日期：2001-06-01 00:00:00

abstract：:According to the amyloid hypothesis, accumulation of amyloid beta-peptide (A beta) in the brain is the primary pathogenic event in Alzheimer's disease (AD). Recent evidence indicates that A beta within the intravascular space is linked to A beta deposited in the brain suggesting that transport of A beta between the br...

journal_title：Journal of neurochemistry

authors： Zlokovic BV

更新日期：2004-05-01 00:00:00

abstract：:Abstract Huntingtin is a large, multi-domain protein of unknown function in the brain. An abnormally elongated polyglutamine stretch in its N-terminus causes Huntington's disease (HD), a progressive neurodegenerative disorder. Huntingtin has been proposed to play a functional role in membrane trafficking via proteins ...

journal_title：Journal of neurochemistry

authors： Suopanki J,Götz C,Lutsch G,Schiller J,Harjes P,Herrmann A,Wanker EE

更新日期：2006-02-01 00:00:00

abstract：:gamma-Aminobutyric acid (GABA) concentrations were measured in CSF specimens from two large groups of control subjects, one without neurological or psychiatric disease, and one with a variety of neurological disorders not known to involve altered GABAergic function in brain. CSF GABA was also measured in patients with...

journal_title：Journal of neurochemistry

authors： Perry TL,Hansen S,Wall RA,Gauthier SG

更新日期：1982-03-01 00:00:00

abstract：:Hypothalamic norepinephrine (NE) release regulates arterial pressure by altering sympathetic nervous system activity. Because angiotensin (Ang) (1-7) decreases hypothalamic NE release and this effect may be correlated with a diminished NE synthesis, we hypothesize that Ang-(1-7) down-regulates tyrosine hydroxylase (TH...

journal_title：Journal of neurochemistry

authors： Lopez Verrilli MA,Pirola CJ,Pascual MM,Dominici FP,Turyn D,Gironacci MM

更新日期：2009-04-01 00:00:00

abstract：:The subunit compositions of the NR1 C2 exon-containing N-methyl-D-aspartate (NMDA) receptors of adult mammalian forebrain were determined by using a combination of immunoaffinity chromatography and immunoprecipitation studies with NMDA receptor subunit-specific antibodies. NMDA receptors were solubilised by sodium deo...

journal_title：Journal of neurochemistry

authors： Chazot PL,Stephenson FA

更新日期：1997-11-01 00:00:00

abstract：:Five muscarinic receptor genes (m1-m5) that encode distinct muscarinic receptor subtypes have been cloned. Because of their structural homology and pharmacological similarity, ligand binding probes currently available do not clearly distinguish among the subtypes. To obtain a clear distribution within the CNS of molec...

journal_title：Journal of neurochemistry

authors： Wei J,Walton EA,Milici A,Buccafusco JJ

更新日期：1994-09-01 00:00:00

abstract：:A previous report has described the presence of t-[35S]-butylbicyclophosphorothionate binding sites and GABA-gated Cl- flux in the human neuroblastoma IMR-32 cell line. We now report the further characterisation of this binding site and, even more important, the identification of the GABAA receptor alpha 3 sub-unit ex...

journal_title：Journal of neurochemistry

authors： Noble PJ,Anderson SM,De Souza RJ,Cross AJ,Stephenson FA

更新日期：1993-08-01 00:00:00

abstract：:Conversion of the cellular prion protein (PrP(C)) into the abnormal scrapie isoform (PrP(Sc)) is the hallmark of prion diseases, which are fatal and transmissible neurodegenerative disorders. ER-retained anti-prion recombinant single-chain Fv fragments have been proved to be an effective tool for inhibition of PrP(C) ...

journal_title：Journal of neurochemistry

authors： Filesi I,Cardinale A,Mattei S,Biocca S

更新日期：2007-06-01 00:00:00

abstract：:Since emotional stress elicits brain activation, mitochondria should be a key component of stressed brain response. However, few studies have focused on mitochondria functioning in these conditions. In this work, we aimed to determine the effects of an acute restraint stress on rat brain mitochondrial functions, with ...

journal_title：Journal of neurochemistry

authors： Batandier C,Poulet L,Hininger I,Couturier K,Fontaine E,Roussel AM,Canini F

更新日期：2014-11-01 00:00:00

abstract：:Iron, a transition metal and essential nutrient, is a typical pro-oxidant forming free radicals, lipid peroxides and causing cell damage when added at high (> or = 50 microM) concentrations to oligodendroglia-like OLN-93 cells that have been enriched for 3 days with 10 microM docosahexaenoic acid (DHA, 22 : 6 n-3). At...

journal_title：Journal of neurochemistry

authors： Brand A,Schonfeld E,Isharel I,Yavin E

更新日期：2008-05-01 00:00:00

abstract：:The monoamines dopamine, norepinephrine, epinephrine, and serotonin and their major metabolites 3,4-dihydroxyphenylacetic acid, homovanillic acid, 3-methoxy-4-hydroxyphenylethylene glycol, and 5-hydroxyindoleacetic acid were measured in the CNS of the rat during development from fetal day 18 to young adult. The catech...

journal_title：Journal of neurochemistry

authors： Herregodts P,Velkeniers B,Ebinger G,Michotte Y,Vanhaelst L,Hooghe-Peters E

更新日期：1990-09-01 00:00:00

abstract：:Neolactoglycolipids are derived from neolactotetraosylceramide (nLcOse4Cer). They are found during the embryonic and neonatal developmental periods in the rat cerebral cortex and disappear shortly after birth. These glycolipids are, however, abundant in the adult cerebellum. Lactotriosylceramide (LcOse3Cer):galactosyl...

journal_title：Journal of neurochemistry

authors： Chou DK,Jungalwala FB

更新日期：1994-01-01 00:00:00

abstract：:Histamine stimulates cyclic AMP accumulation in astrocyte-enriched and neuronal primary cultures from rat brain in the presence of the phosphodiesterase inhibitor isobutylmethylxanthine. The response in the astrocyte cultures (Emax = 304 +/- 44% over basal, EC50 = 43 +/- 5 microM) was much higher than in neuronal cult...

journal_title：Journal of neurochemistry

authors： Agulló L,Picatoste F,García A

更新日期：1990-11-01 00:00:00

abstract：:rho(1) GABA(C) receptor antagonists inhibit myopia in chick but the site of this effect is not known. The sclera ultimately determines the shape and size of the globe and thus an untested possibility is that GABA agents have a scleral mechanism. Whether rho(1) GABA(C) receptors are expressed and located in chick scler...

journal_title：Journal of neurochemistry

authors： Cheng ZY,Chebib M,Schmid KL

更新日期：2011-07-01 00:00:00

abstract：:Hyperexcitability of the hippocampus is a commonly observed phenomenon in the years preceding a diagnosis of Alzheimer's disease (AD). Our previous work suggests a dysregulation in glutamate neurotransmission may mediate this hyperexcitability, and glutamate dysregulation correlates with cognitive deficits in the rTg(...

journal_title：Journal of neurochemistry

authors： Hunsberger HC,Weitzner DS,Rudy CC,Hickman JE,Libell EM,Speer RR,Gerhardt GA,Reed MN

更新日期：2015-10-01 00:00:00

abstract：:Several cholinesterase inhibitors used in the treatment of Alzheimer's disease (AD) have been shown to interact with an allosteric site on the nicotinic acetylcholine receptor (nAChR). A possible linkage between the phosphorylation state of tau, the major component of paired helical filaments found in AD brain, and st...

journal_title：Journal of neurochemistry

authors： Hellström-Lindahl E,Moore H,Nordberg A

更新日期：2000-02-01 00:00:00

abstract：:The Review "The malleable brain: plasticity of neural circuits and behavior - A review from students to students" has been written by a group of students following the International Society for Neurochemistry and Journal of Neurochemistry Flagship School. Comprehensively written by students for students, it provides b...

journal_title：Journal of neurochemistry

authors： Schulz JB,Hausmann L

更新日期：2017-09-01 00:00:00

abstract：:Gliosis is commonly observed in the CNS following tissue damage, and it also occurs in aging and in many neurodegenerative diseases. Glial fibrillary acidic protein (GFAP) accumulation is a prominent feature of astrocytic gliosis. An inhibition or delay in GFAP synthesis could mitigate scar formation and thus reduce t...

journal_title：Journal of neurochemistry

authors： Li XM,Qi J,Juorio AV,Boulton AA

更新日期：1993-10-01 00:00:00

abstract：:We recently reported that prostaglandin E2 (PGE2) stimulated phosphoinositide metabolism in cultured bovine adrenal chromaffin cells and that PGE2 and ouabain, an inhibitor of Na+,K+-ATPase, synergistically induced a gradual secretion of catecholamines from the cells. The effect on catecholamine release was specific f...

journal_title：Journal of neurochemistry

authors： Tanaka T,Yokohama H,Negishi M,Hayashi H,Ito S,Hayaishi O

更新日期：1990-01-01 00:00:00

abstract：:Acetylcholine is a key neurotransmitter of the inner ear efferent system. In this study, we identify two novel nAChR subunits in the inner ear: α1 and γ, encoded by Chrna1 and Chrng, respectively. In situ hybridization shows that the messages of these two subunits are present in vestibular and cochlear hair cells duri...

journal_title：Journal of neurochemistry

authors： Scheffer D,Sage C,Plazas PV,Huang M,Wedemeyer C,Zhang DS,Chen ZY,Elgoyhen AB,Corey DP,Pingault V

更新日期：2007-12-01 00:00:00

abstract：:Local application of K+ via micropressure-ejection, coupled with in vivo electrochemical detection, was used to study stimulated release from monoaminergic nerve terminals in the striatum of anesthetized rats and mice. K+-evoked releases were reversible, reproducible, and dose-dependent. In contrast, releases of elect...

journal_title：Journal of neurochemistry

authors： Gerhardt GA,Rose GM,Hoffer BJ

更新日期：1986-03-01 00:00:00

abstract：:Quinolinic acid (QUIN), an excitotoxic compound present in the mammalian CNS and periphery, has been hypothetically linked to human neurodegenerative disorders such as Huntington's disease and epilepsy. Quinolinic acid phosphoribosyltransferase (QPRT), the catabolic enzyme of QUIN, is found in the CNS and peripheral o...

journal_title：Journal of neurochemistry

authors： Foster AC,Schwarcz R

更新日期：1985-07-01 00:00:00

abstract：:Multiple sclerosis (MS) pathology is marked by the massive infiltration of myelin-specific T cells into the CNS. Hallmarks of T helper (Th) cells during active disease are pro-inflammatory Th1/Th17 cells that predominate over immunoregulatory Th2/Treg cells. Neurodegeneration, a major factor in progressive MS, is ofte...

journal_title：Journal of neurochemistry

authors： Trager N,Smith A,Wallace Iv G,Azuma M,Inoue J,Beeson C,Haque A,Banik NL

更新日期：2014-07-01 00:00:00

abstract：:Heterozygous CB1 receptor knockout mice were used to examine the effect of reduced CB1 receptor density on G-protein activation in membranes prepared from four brain regions: cerebellum, hippocampus, striatum/globus pallidus (striatum/GP) and cingulate cortex. Results showed that CB1 receptor levels were approximately...

journal_title：Journal of neurochemistry

authors： Selley DE,Rorrer WK,Breivogel CS,Zimmer AM,Zimmer A,Martin BR,Sim-Selley LJ

更新日期：2001-05-01 00:00:00

abstract：:Extracellular adenosine is transported into chromaffin cells by a high-affinity transport system. The action of adenosine receptor ligands was studied in this cellular model. 5'-(N-Ethylcarboxamido)adenosine (NECA), an agonist of A2 receptors, activated adenosine transport. Km values for adenosine were 4.6 +/- 1.0 (n ...

journal_title：Journal of neurochemistry

authors： Delicado EG,Rodrigues A,Sen RP,Sebastiao AM,Ribeiro JA,Miras-Portugal MT

更新日期：1990-06-01 00:00:00

abstract：:Tau is a microtubule-associated protein that loses microtubule binding activity and aggregates into paired helical filaments (PHFs) in Alzheimer's disease. Nonenzymic glycation is one of the posttranslational modifications detected in PHF-tau, but not in normal tau. PHF-tau has reduced ability to bind to microtubules....

journal_title：Journal of neurochemistry

authors： Nacharaju P,Ko L,Yen SH

更新日期：1997-10-01 00:00:00