Muscarinic and nicotinic cholinergic binding sites in the terminal abdominal ganglion of the cricket (Acheta domesticus).

abstract：:Cathepsin D (CTSD) deficiencies are fatal neurological diseases that in human infants and in sheep are characterized by extreme loss of neurons and myelin. To date, similar morphological evidence for myelin disruption in CTSD knockout mice has not been reported. Here, we show that CTSD deficiency leads to pronounced m...

journal_title：Journal of neurochemistry

authors： Mutka AL,Haapanen A,Käkelä R,Lindfors M,Wright AK,Inkinen T,Hermansson M,Rokka A,Corthals G,Jauhiainen M,Gillingwater TH,Ikonen E,Tyynelä J

更新日期：2010-01-01 00:00:00

abstract：:Ion channels are classically understood to regulate the flux of ions across the plasma membrane in response to a variety of environmental and intracellular cues. Ion channels serve a number of functions in intracellular membranes as well. These channels may be temporarily localized to intracellular membranes as a func...

journal_title：Journal of neurochemistry

authors： Dong XP,Wang X,Xu H

更新日期：2010-04-01 00:00:00

abstract：:The long-term regulation of tyrosine hydroxylase (TH) by serotonin has been studied with cultures of newborn rat locus ceruleus explants. The presence of serotonin in the culture medium for a 24-h period was followed by an inhibition of TH activity in the explants. This effect lasted several days, with a maximal effec...

journal_title：Journal of neurochemistry

authors： Devau G,Multon MF,Pujol JF,Buda M

更新日期：1987-09-01 00:00:00

abstract：:Glial cells secrete proinflammatory mediators in the brain in response to exogenous stimuli such as infection and injury. Previously, we documented that systemic maternal lipopolysaccharide (LPS)-exposure at embryonic gestation day 18 causes oligodendrocyte (OL)-injury/hypomyelination in the developing brain which can...

journal_title：Journal of neurochemistry

authors： Paintlia MK,Paintlia AS,Khan M,Singh I,Singh AK

更新日期：2008-05-01 00:00:00

abstract：:Galanin is a recently isolated neuropeptide that is of particular interest in dementing disorders because of its known colocalization with choline acetyltransferase in magnocellular neurons of the basal nucleus of Meynert. These neurons degenerate in Alzheimer's disease, and there is a corresponding deficiency of cort...

journal_title：Journal of neurochemistry

authors： Beal MF,Clevens RA,Chattha GK,MacGarvey UM,Mazurek MF,Gabriel SM

更新日期：1988-12-01 00:00:00

abstract：:Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD-1 gene product, ataxin-3. Ataxin-3 is degraded by the proteasome. However, the precise mechanism of ataxin-3 degradation remains to be elucidated. In this st...

journal_title：Journal of neurochemistry

authors： Wang H,Jia N,Fei E,Wang Z,Liu C,Zhang T,Fan J,Wu M,Chen L,Nukina N,Zhou J,Wang G

更新日期：2007-06-01 00:00:00

abstract：:Microglia are the main players of the brain immune response. They act as active sensors that rapidly respond to injurious insults by shifting into different activated states. Elevated levels of unconjugated bilirubin (UCB) induce cell death, immunostimulation and oxidative stress in both neurons and astrocytes. We rec...

journal_title：Journal of neurochemistry

authors： Silva SL,Osório C,Vaz AR,Barateiro A,Falcão AS,Silva RF,Brites D

更新日期：2011-05-01 00:00:00

abstract：:Pretreatment of rats with the excitatory amino acid antagonist 2-amino-7-phosphonoheptanoic acid (2-APH; 0.5 mmol/kg, i.p.) protected against insulin-induced clonic seizures. Complete protection was observed in 38% of the rats and partial protection in an additional 50%. Lesioning of the corticostriatal pathway by fro...

journal_title：Journal of neurochemistry

authors： Chapman AG,Engelsen B,Meldrum BS

更新日期：1987-07-01 00:00:00

abstract：:The hippocampal formation has been extensively research in terms of its putative neurotransmitters, anatomical connections, and behavioral relevance. An aspect of importance is the assessment of apparent neurotransmitter receptors by using receptor binding assays. In the present study, such assays were done in vitro t...

journal_title：Journal of neurochemistry

authors： Dooley DJ,Bittiger H

更新日期：1982-06-01 00:00:00

abstract：:Several epidemiological and preclinical studies suggest that non-steroidal anti-inflammatory drugs (NSAIDs), which inhibit cyclooxygenase (COX), reduce the risk of Alzheimer's disease (AD) and can lower β-amyloid (Aβ) production and inhibit neuroinflammation. However, follow-up clinical trials, mostly using selective ...

journal_title：Journal of neurochemistry

authors： Choi SH,Aid S,Caracciolo L,Minami SS,Niikura T,Matsuoka Y,Turner RS,Mattson MP,Bosetti F

更新日期：2013-01-01 00:00:00

abstract：:Calcium-activated neutral proteases (calpains) are regulated by specific endogenous protein inhibitors, the calpastatins, which are widely distributed in mammalian tissues. Calpastatins from different species or in various tissues from the same species exhibit considerable size heterogeneity on sodium dodecyl sulfate ...

journal_title：Journal of neurochemistry

authors： Mohan PS,Nixon RA

更新日期：1995-02-01 00:00:00

abstract：:The metabolism of 2-fluoro-2-deoxy-D-glucose (FDG) in vivo was observed noninvasively in rat brain using 19F nuclear magnetic resonance (NMR) spectroscopy following an intravenous injection of FDG (400 mg/kg). At 3 h after infusion, four resonances with discrete chemical shifts were resolved. Chemical shift analysis o...

journal_title：Journal of neurochemistry

authors： Nakada T,Kwee IL,Conboy CB

更新日期：1986-01-01 00:00:00

abstract：:The regional and developmental expression of NMDA receptors containing the NR2D subunit was analyzed on the level of the subunit mRNA and protein in rat brain. RNase protection experiments indicated that among two proposed splice variants of the NR2D subunit, only the NR2D-2 subunit is expressed. The regional distribu...

journal_title：Journal of neurochemistry

authors： Wenzel A,Villa M,Mohler H,Benke D

更新日期：1996-03-01 00:00:00

abstract：:The formation of long-term memory has been shown to require protein kinase-mediated gene expression. One such kinase, mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK), can lead to the phosphorylation of serum response factor (SRF) and Elk-1, enhancing the expression of target genes. Ho...

journal_title：Journal of neurochemistry

authors： Dash PK,Orsi SA,Moore AN

更新日期：2005-04-01 00:00:00

abstract：:Local cerebral glucose utilization (LCGU) was measured, using the quantitative autoradiographic [14C]2-deoxy-D-glucose method, in 56 brain regions of 3-month-old, awake Fischer-344 rats, after intraperitoneal administration of sulpiride (SULP) 100 mg/kg. SULP, an "atypical" neuroleptic, is a selective antagonist of D2...

journal_title：Journal of neurochemistry

authors： Pizzolato G,Soncrant TT,Larson DM,Rapoport SI

更新日期：1987-08-01 00:00:00

abstract：:As a basis for attempts to define the structures of the proteins within myelin, methods have been developed for their extraction and isolation in solutions of non-denaturing detergents. With use of solutions of deoxycholate or Triton X-100, up to 90% of the protein has been extracted from bovine CNS myelin, along with...

journal_title：Journal of neurochemistry

authors： Smith R,Cook J,Dickens PA

更新日期：1984-02-01 00:00:00

abstract：:The cellular prion protein (PrP(c)) is a glycosylphosphatidylinositol (GPI)-anchored plasma membrane protein whose conformational altered forms (PrP(sc)) are known to cause neurodegenerative diseases in mammals. In order to investigate the intracellular traffic of mammalian PrP(c) in living cells, we have generated a ...

journal_title：Journal of neurochemistry

authors： Lee KS,Magalhães AC,Zanata SM,Brentani RR,Martins VR,Prado MA

更新日期：2001-10-01 00:00:00

abstract：:The ontogenesis of rat forebrain adenosine uptake sites labelled by [3H]nitrobenzylthioinosine ([3H]NBI) was determined and compared to that of rat forebrain adenosine receptors labelled by N6-cyclohexyl[3H]adenosine ([3H]-CHA). [3H]NBI binding is highly invariant with similar levels of [3H]NBI binding sites from embr...

journal_title：Journal of neurochemistry

authors： Morgan PF,Montgomery P,Marangos PJ

更新日期：1987-09-01 00:00:00

abstract：:Carboxypeptidase E (CPE) functions in the posttranslational processing of bioactive peptides. Like other peptide processing enzymes, CPE is initially produced as a precursor ("proCPE") that undergoes posttranslational processing at a site containing five adjacent Arg residues near the N-terminus and at other sites nea...

journal_title：Journal of neurochemistry

authors： Song L,Fricker L

更新日期：1995-07-01 00:00:00

abstract：:Rat cerebral cortex synaptosomes were exposed in superfusion to various depolarizing stimuli and the release of somatostatin-like immunoreactivity (SRIF-LI) was measured by means of a radioimmunoassay procedure. High KCl (9-50 mM) concentration dependently evoked SRIF-LI release; the evoked overflow reached a plateau ...

journal_title：Journal of neurochemistry

authors： Bonanno G,Parodi B,Cafaggi S,Raiteri M

更新日期：1991-10-01 00:00:00

abstract：:We assessed the effects of cold and isolation stress on arginine vasopressin (AVP) mRNA in the paraventricular (PVN) and supraoptic (SON) nuclei of the hypothalamus. Vasopressin mRNA levels were determined by in situ hybridization histochemistry at the cellular level. In posterior magnocellular neurons of the PVN isol...

journal_title：Journal of neurochemistry

authors： Angulo JA,Ledoux M,McEwen BS

更新日期：1991-06-01 00:00:00

abstract：:Presynaptic nicotinic acetylcholine receptors on striatal nerve terminals modulate the release of dopamine. We have compared the effects of a number of nicotinic agonists and antagonists on a perfused synaptosome preparation preloaded with [3H]dopamine. (-)-Nicotine, acetylcholine, and the nicotinic agonists cytisine ...

journal_title：Journal of neurochemistry

authors： Rapier C,Lunt GG,Wonnacott S

更新日期：1990-03-01 00:00:00

abstract：:To determine whether prolonged nicotine exposure persistently inactivates rat alpha4beta2 nicotinic receptors expressed in Xenopus oocytes, we measured the voltage-clamped alpha4beta2 response to acetylcholine (ACh) before and 24 h after, 1-h or 12-h incubations in 10 microm nicotine. A 12-h incubation in 10 microm ni...

journal_title：Journal of neurochemistry

authors： Jia L,Flotildes K,Li M,Cohen BN

更新日期：2003-02-01 00:00:00

abstract：:The content of the tryptophan metabolites quinolinic acid (QUIN), 5-hydroxytryptamine (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) was measured in various brain areas of rats bearing a portocaval anastomosis (PCA) for 4 weeks, using mass fragmentography or HPLC. In these animals, the content of the excitotoxic comp...

journal_title：Journal of neurochemistry

authors： Moroni F,Lombardi G,Carlà V,Pellegrini D,Carassale GL,Cortesini C

更新日期：1986-03-01 00:00:00

abstract：:Mitochondrial respiratory function, assessed from the rate of oxygen uptake by homogenates of rat brain subregions, was examined after 30 min of forebrain ischemia and at recirculation periods of up to 48 h. Ischemia-sensitive regions which develop extensive neuronal loss during the recirculation period (dorsal-latera...

journal_title：Journal of neurochemistry

authors： Sims NR,Pulsinelli WA

更新日期：1987-11-01 00:00:00

abstract：:Five-day-old rats subjected to prolonged asphyxia at 37 degrees C show a slower rate of synthesis of 5-HT as measured by the accumulation of the amine after inhibition of monoamine oxidase. During recovery from asphyxia 5-HT synthesis is markedly stimulated when measured over a 50 or 90 min period. No change in 5-HT s...

journal_title：Journal of neurochemistry

authors： Tricklebank MD,Pickard FJ,Dobbing J

更新日期：1976-11-01 00:00:00

abstract：:The transcription factor cAMP response element binding protein (CREB), a member of the basic region leucine zipper (bZIP) family of proteins, is the major cAMP response element (CRE) binding. Other bZIP proteins, including CREB2, activating transcription factor 2 (ATF2), or CAAT/enhancer binding protein (C/EBP) have b...

journal_title：Journal of neurochemistry

authors： Thiel G,Al Sarraj J,Vinson C,Stefano L,Bach K

更新日期：2005-01-01 00:00:00

abstract：:Reactive oxygen species (ROS) and oxidative stress have long been linked to cell death of neurons in many neurodegenerative conditions. However, the exact molecular mechanisms triggered by oxidative stress in neurodegeneration are at present unclear. In the current work we have used the human neuroblastoma SH-SY5Y cel...

journal_title：Journal of neurochemistry

authors： Sanvicens N,Gómez-Vicente V,Messeguer A,Cotter TG

更新日期：2006-08-01 00:00:00

abstract：:Cytidine, as cytidine 5'-diphosphate choline, is a major precursor in the synthesis of phosphatidylcholine in cell membranes. In the present study, we examined the relationships between extracellular levels of cytidine, the conversion of [14C]choline to [14C]phosphatidylcholine, and the net syntheses of phosphatidylch...

journal_title：Journal of neurochemistry

authors： G-Coviella IL,Wurtman RJ

更新日期：1992-07-01 00:00:00

abstract：:The 5-hydroxytryptamine (serotonin, 5-HT) type 3 (5-HT3) receptor belongs to the superfamily of Cys-loop ligand-gated ion channels, and can be either homopentameric (5-HT3A) or heteropentameric (5-HT3AB) receptor. Several modulators are known, which either inhibit or potentiate this channel, but few have any appreciab...

journal_title：Journal of neurochemistry

authors： Nakamura Y,Ishida Y,Yamada T,Kondo M,Shimada S

更新日期：2013-04-01 00:00:00