Lithium distribution in the brain of normal mice and of "quaking" dysmyelinating mutants.

abstract：:Previous studies have shown that activation of the cyclic AMP (cAMP) pathway down-regulates CREB expression in CATH.a cells, an effect that appears to be mediated via inhibition of CREB gene transcription. In the current study, we compared this effect in CATH.a cells with regulation of CREB expression in another cell ...

journal_title：Journal of neurochemistry

authors： Coven E,Ni Y,Widnell KL,Chen J,Walker WH,Habener JF,Nestler EJ

更新日期：1998-11-01 00:00:00

abstract：:Previously, we demonstrated that systemically injected extracellular domain of neuregulin-1β1 (Nrg1β1), a nerve growth and differentiation factor, passes the blood-brain barrier and rescues dopaminergic neurons of substantia nigra in the 6-hydroxydopamine-mouse model of Parkinson's disease (PD). Here, we studied the e...

journal_title：Journal of neurochemistry

authors： Depboylu C,Rösler TW,de Andrade A,Oertel WH,Höglinger GU

更新日期：2015-05-01 00:00:00

abstract：:The selective metabotropic glutamate receptor agonist trans-1-aminocyclopentane-1,3-dicarboxylic acid (trans-ACPD) stimulates phosphoinositide hydrolysis and elicits several physiological responses in rat hippocampal slices. However, recent studies suggest that the physiological effects of trans-ACPD in the hippocampu...

journal_title：Journal of neurochemistry

authors： Winder DG,Conn PJ

更新日期：1992-07-01 00:00:00

abstract：:The neuromodulator adenosine can be released as such, mainly activating inhibitory A1 receptors, or formed from released ATP, preferentially activating facilitatory A2A receptors. We tested if changes in extracellular adenosine metabolism paralleled changes in A1/A2A receptor neuromodulation in the aged rat hippocampu...

journal_title：Journal of neurochemistry

authors： Cunha RA,Almeida T,Ribeiro JA

更新日期：2001-01-01 00:00:00

abstract：:Experimental evidence suggests that magnesium plays a role in the pathophysiological sequelae of brain injury. The present study examined the variation of blood ionized and total magnesium, as well as potassium, sodium, and ionized calcium, after experimental fluid percussion brain injury in rats. Blood ionized magnes...

journal_title：Journal of neurochemistry

authors： Bareyre FM,Saatman KE,Helfaer MA,Sinson G,Weisser JD,Brown AL,McIntosh TK

更新日期：1999-07-01 00:00:00

abstract：:This paper proposes a tentative amino acid sequence of guinea pig myelin basic protein obtained by comparison of peptide fragments of the guinea pig and bovine proteins. Analyses of the tryptic peptides confirmed the known sequence differences in the NH2-terminal half of the molecule and showed that in the COOH-termin...

journal_title：Journal of neurochemistry

authors： Deibler GE,Martenson RE,Krutzsch HC,Kies MW

更新日期：1984-07-01 00:00:00

abstract：:Obesity is a worldwide health problem that urgently needs to be solved. Leptin is an anti-obesity hormone that activates satiety signals to the brain. Evidence to suggest that leptin resistance is involved in the development of obesity is increasing; however, the molecular mechanisms involved remain unclear. We herein...

journal_title：Journal of neurochemistry

authors： Hosoi T,Matsuzaki S,Miyahara T,Shimizu K,Hasegawa Y,Ozawa K

更新日期：2015-05-01 00:00:00

abstract：:Schwann cells provide a favorable microenvironment for successful regeneration of the injured peripheral nerve. Even though the roles of extracellular matrix proteins in the Schwann cell physiology have long been studied, the precise function of nidogen, a ubiquitous component of the basal lamina, in Schwann cells is ...

journal_title：Journal of neurochemistry

authors： Lee HK,Seo IA,Park HK,Park YM,Ahn KJ,Yoo YH,Park HT

更新日期：2007-08-01 00:00:00

abstract：:By using a 125I-calmodulin overlay assay, three major high-affinity calmodulin-binding proteins, showing apparent molecular masses of 135, 60, and 50 kDa, have been detected in purified nuclear fractions isolated from rat neurons. It has been shown that after extraction of the nuclei with nucleases and high salt, all ...

journal_title：Journal of neurochemistry

authors： Pujol MJ,Bosser R,Vendrell M,Serratosa J,Bachs O

更新日期：1993-04-01 00:00:00

abstract：:An aminopeptidase with specificity directed toward peptides with acidic N-terminal amino acid residues has been isolated from mouse brain cytosol. Purification by ion-exchange chromatography and gel filtration resulted in an enzyme that hydrolyzed aspartyl-phenylalanine methyl ester at a rate of 13.2 mumols/min/mg pro...

journal_title：Journal of neurochemistry

authors： Kelly JA,Neidle EL,Neidle A

更新日期：1983-06-01 00:00:00

abstract：:Both vasoactive intestinal peptide (VIP) and glucagon rapidly elevated cyclic AMP levels in embryonic chick retinal pigment epithelium (RPE), in culture as well as in freshly dissected tissue. In cultured cells, the half-maximal activities of VIP and glucagon were 5 X 10(-8) M and 3 X 10(-8) M, respectively. After 3 m...

journal_title：Journal of neurochemistry

authors： Koh SW,Chader GJ

更新日期：1984-12-01 00:00:00

abstract：:Binding of DL-alpha-[3H]amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid ([3H]AMPA) to lysed rat brain membranes in the presence of potassium thiocyanate resulted in curvilinear Scatchard plots that could be resolved by regression analysis into a large low-affinity component and a small high-affinity component. Sol...

journal_title：Journal of neurochemistry

authors： Hall RA,Kessler M,Lynch G

更新日期：1992-12-01 00:00:00

abstract：:The autoradiographic method with L-[35S]methionine was used to determine the effects of an n-3 fatty acid deficiency on brain protein synthesis. Brain protein synthesis was significantly increased (from 50 to 150%) in 45 of the 52 brain structures studied in n-3 fatty acid-deficient rats as compared with control anima...

journal_title：Journal of neurochemistry

authors： Giaume M,Gay N,Baubet V,Gharib A,Durand G,Bobillier P,Sarda N

更新日期：1994-11-01 00:00:00

abstract：:Developmental profiles were determined for the activities of eight enzymes involved in fatty acid beta-oxidation in rat brain. The enzymes studied were the palmitoyl-CoA, octanoyl-CoA, butyryl-CoA, glutaryl-CoA, and 3-hydroxyacyl-CoA dehydrogenases, the enoyl-CoA hydratase (crotonase), and the C4- and C10-thiolases. W...

journal_title：Journal of neurochemistry

authors： Reichmann H,Maltese WA,DeVivo DC

更新日期：1988-08-01 00:00:00

abstract：:Mutations in the tau gene cause frontotemporal dementia and parkinsonism linked to chromosome-17 (FTDP-17). Functionally, about half of the known mutations increase the alternative mRNA splicing of exon 10 of the tau gene, resulting in the overproduction of tau isoforms with four microtubule-binding repeats. The other...

journal_title：Journal of neurochemistry

authors： Yoshida H,Crowther RA,Goedert M

更新日期：2002-02-01 00:00:00

abstract：:Published evidence has linked glutamate with the pathogenesis of Alzheimer's disease (AD) and the up-regulation of a variety of chemokines, including monocyte chemotactic protein-1 (MCP-1)/chemokine ligand 2, with AD-associated pathological changes. In this study, we assessed the potential molecular basis for the role...

journal_title：Journal of neurochemistry

authors： Lee EO,Park HJ,Kang JL,Kim HS,Chong YH

更新日期：2010-03-01 00:00:00

abstract：:(R)-[3H]Tomoxetine is a radioligand that binds to the norepinephrine (NE) uptake site with high affinity but also binds to a second, lower-affinity site. The goal of the present study was to identify the nature of this low-affinity site by comparing the binding properties of (R)-[3H]tomoxetine with those of (R/S)-[3H]...

journal_title：Journal of neurochemistry

authors： Gehlert DR,Schober DA,Gackenheimer SL

更新日期：1995-06-01 00:00:00

abstract：:Cyclic-AMP-binding proteins in membrane and soluble fractions from rat forebrain were compared; membrane fractions included smooth and rough microsomes and a plasma membrane fraction enriched in synaptic membranes. Protein fractions were treated with 8-azido-[32P]cyclic AMP and ultraviolet irradiation to covalently ta...

journal_title：Journal of neurochemistry

authors： Strocchi P,Sapirstein VS,Rubin CS,Gilbert JM

更新日期：1984-08-01 00:00:00

abstract：:We compared the characteristics of secretion stimulated by EGTA-buffered Ba(2+)- and Ca(2+)-containing solutions in digitonin-permeabilized bovine adrenal chromaffin cells. Half-maximal secretion occurred at approximately 100 microM Ba2+ or 1 microM Ca2+. Ba(2+)-stimulated release was not due to release of sequestered...

journal_title：Journal of neurochemistry

authors： TerBush DR,Holz RW

更新日期：1992-02-01 00:00:00

abstract：:Protracted opiate withdrawal can extend for months of disrupted hormonal circadian rhythms. We examined rodent behaviors and these circadian disturbances in hormone and peptide levels as well as brain clock gene expression during 60 days of protracted withdrawal. Our behavioral tests included open field, elevated plus...

journal_title：Journal of neurochemistry

authors： Li SX,Liu LJ,Jiang WG,Sun LL,Zhou SJ,Le Foll B,Zhang XY,Kosten TR,Lu L

更新日期：2010-10-01 00:00:00

abstract：:A great body of evidence points toward a functional interaction between metabotropic glutamate 5 receptors (mGluR5) and NMDA receptors (NMDAR) that enhances synaptic plasticity and cognition. However, the molecular mechanism underlying this interaction remains unclear. Here, we show that co-activation of mGluR5 and NM...

journal_title：Journal of neurochemistry

authors： Sarantis K,Tsiamaki E,Kouvaros S,Papatheodoropoulos C,Angelatou F

更新日期：2015-11-01 00:00:00

abstract：:Based on our initial finding that the nitric oxide (NO) sensitive fluorochrome diaminofluorescein (DAF) was localized to mitochondria in cultured primary neurons, we investigated whether brain mitochondria produce NO through a mitochondrial NO synthase (mtNOS) enzyme. Isolated brain mitochondria were loaded with DAF a...

journal_title：Journal of neurochemistry

authors： Lacza Z,Horn TF,Snipes JA,Zhang J,Roychowdhury S,Horváth EM,Figueroa JP,Kollai M,Szabó C,Busija DW

更新日期：2004-08-01 00:00:00

abstract：:beta-Adrenergic receptor subtypes, beta 1 and beta 2, were studied during pre- and postnatal development in the rat brain. [125I]Iodocyanopindolol (6-300 pmol/L) binding assays in the presence of 5-hydroxytryptamine (0.6-6 mumol/L) were used to measure exclusively beta-adrenergic receptors. In forebrain tissue, satura...

journal_title：Journal of neurochemistry

authors： Erdtsieck-Ernste BH,Feenstra MG,Boer GJ

更新日期：1991-09-01 00:00:00

abstract：:We have examined some of the characteristics of phorbol ester- and agonist-induced down-regulation of astrocyte receptors coupled to phosphoinositide metabolism. Our results show that preincubation of [3H]inositol-labelled astrocyte cultures with phorbol 12-myristate 13-acetate (PMA) resulted in a time- (t 1/2, 1-2 mi...

journal_title：Journal of neurochemistry

authors： Pearce B,Morrow C,Murphy S

更新日期：1988-03-01 00:00:00

abstract：:A vesicular glutamate transporter (VGLUT) is responsible for the accumulation of l-glutamate in synaptic vesicles in glutamatergic neurons. Two isoforms, VGLUT1 and VGLUT2, have been identified, which are complementarily expressed in these neurons. Mammalian pinealocytes, endocrine cells for melatonin, are also glutam...

journal_title：Journal of neurochemistry

authors： Morimoto R,Hayashi M,Yatsushiro S,Otsuka M,Yamamoto A,Moriyama Y

更新日期：2003-01-01 00:00:00

abstract：:We have shown recently that the presence of albumin in astrocytes triggers the synthesis and release of oleic acid, which behaves as a neurotrophic factor for neurons. Thus, oleic acid promotes axonal growth together with the expression of the axonal growth-associated protein, GAP-43. Here we attempted to elucidate wh...

journal_title：Journal of neurochemistry

authors： Rodríguez-Rodríguez RA,Tabernero A,Velasco A,Lavado EM,Medina JM

更新日期：2004-03-01 00:00:00

abstract：:Oxidative stress has been implicated in mechanisms leading to neuronal cell injury in various pathological states of the brain. Here, we investigated the effect of peroxide exposure on the expression of genes coding for cytoplasmic and endoplasmic reticulum (ER) stress proteins. Primary neuronal cell cultures were exp...

journal_title：Journal of neurochemistry

authors： Paschen W,Mengesdorf T,Althausen S,Hotop S

更新日期：2001-03-01 00:00:00

abstract：:Synaptic vesicles are key organelles in neurotransmission. Vesicle integral or membrane-associated proteins mediate the various functions the organelle fulfills during its life cycle. These include organelle transport, interaction with the nerve terminal cytoskeleton, uptake and storage of low molecular weight constit...

journal_title：Journal of neurochemistry

authors： Burré J,Volknandt W

更新日期：2007-06-01 00:00:00

abstract：:Microglia are brain macrophages, which can undergo multinucleation to give rise to multinucleated giant cells that accumulate with ageing and some brain pathologies. However, the origin, regulation and function of multinucleate microglia remain unclear. We found that inflammatory stimuli, including lipopolysaccharide,...

journal_title：Journal of neurochemistry

authors： Hornik TC,Neniskyte U,Brown GC

更新日期：2014-03-01 00:00:00

abstract：:Brain homogenate, cerebral microvessels, and endothelial cells (ECs) were prepared from 15-18-week-old human fetuses and analyzed biochemically for the presence of elements of the cholinergic system [acetylcholinesterase (AChE), choline acetyltransferase (ChAT), and butyrylcholinesterase]. The ECs were cultured, and t...

journal_title：Journal of neurochemistry

authors： Kasa P,Pakaski M,Joó F,Lajtha A

更新日期：1991-06-01 00:00:00