Alterations in ionized and total blood magnesium after experimental traumatic brain injury: relationship to neurobehavioral outcome and neuroprotective efficacy of magnesium chloride.

abstract：:Drosophila melanogaster homogenates incubated with tritiated 5-hydroxytryptophan, 5-hydroxytryptamine, or N-acetylserotonin have the ability of converting them into labelled indolamines, including melatonin. All these compounds were characterized by two-dimensional thin-layer chromatography by comparison with nonradio...

journal_title：Journal of neurochemistry

authors： Finocchiaro L,Callebert J,Launay JM,Jallon JM

更新日期：1988-02-01 00:00:00

abstract：:Calcineurin is a serine/threonine protein phosphatase that regulates neurotransmission, neuronal structure and plasticity, and neuronal excitability in mood disorders, including depression. Increasing evidence has suggested that calcineurin is involved in the regulation of depressive-like behavior. However, little is ...

journal_title：Journal of neurochemistry

authors： Zhu WL,Shi HS,Wang SJ,Wu P,Ding ZB,Lu L

更新日期：2011-06-01 00:00:00

abstract：:Proteolytic fragmentation of [3H]diisopropylfluorophosphate-labelled catalytic subunits of different molecular forms of acetylcholinesterase demonstrates that all forms extracted from the electric organ from Torpedo marmorata are true acetylcholinesterases. This is supported by immunochemical results showing that the ...

journal_title：Journal of neurochemistry

authors： Stieger S,Brodbeck U,Witzemann V

更新日期：1987-08-01 00:00:00

abstract：:It has been proposed that abnormal myo-inositol metabolism may be a factor in the development of diabetic complications. Studies with animal models of diabetes and cultured cells have suggested that hyperglycemia by an unknown mechanism may alter myo-inositol metabolism and content. Recently, we have shown that L-fuco...

journal_title：Journal of neurochemistry

authors： Yorek MA,Dunlap JA,Stefani MR,Davidson EP

更新日期：1992-05-01 00:00:00

abstract：:The uptake of glutamate and other acidic amino acids into barnacle single muscle fibres has been characterized. The uptake of glutamate consists of two components, one Na-independent and one Na-dependent. The Na-dependent uptake is saturable (half-maximal at 250 microM external glutamate) and is inhibited by a variety...

journal_title：Journal of neurochemistry

authors： Revest PA,Baker PF

更新日期：1988-01-01 00:00:00

abstract：:The effects of fatty acids, oleate and palmitate, on gamma-aminobutyric acid (GABA), aspartate, and 3,4- dihydroxyphenylethylamine (dopamine) transport and a variety of other membrane functions were studied in rat brain synaptosomes at a constant lipid-to-protein ratio. Under the conditions utilized oleate, but not pa...

journal_title：Journal of neurochemistry

authors： Troeger MB,Rafalowska U,Erecińska M

更新日期：1984-06-01 00:00:00

abstract：:The protein kinase C γ (PKCγ) undergoes multistep activation and participates in various cellular processes in Purkinje cells. Perturbations in its phosphorylation state, conformation or localization can disrupt kinase signalling, such as in spinocerebellar ataxia type 14 (SCA14) that is caused by missense mutations i...

journal_title：Journal of neurochemistry

authors： Jezierska J,Goedhart J,Kampinga HH,Reits EA,Verbeek DS

更新日期：2014-03-01 00:00:00

abstract：:To examine whether the concentration gradient of glutamine (Gln) drives concentrative Na(+)-independent uptake of neutral amino acids (NAA) in mouse cerebral astrocytes, uptake was compared in "Gln-depleted" and "Gln-replete" cultures. Uptake (30 min in Na(+)-free buffer) of histidine, kynurenine, leucine, tyrosine, a...

journal_title：Journal of neurochemistry

authors： Brookes N

更新日期：1992-07-01 00:00:00

abstract：:Intracerebroventricular (i.c.v.) administration of angiotensin IV (Ang IV) or Leu-Val-Val-haemorphin 7 (LVV-H7) improves memory performance in normal rats and reverses memory deficits in rat models for cognitive impairment. These memory effects were believed to be mediated via the putative 'AT4 receptor'. However, thi...

journal_title：Journal of neurochemistry

authors： De Bundel D,Demaegdt H,Lahoutte T,Caveliers V,Kersemans K,Ceulemans AG,Vauquelin G,Clinckers R,Vanderheyden P,Michotte Y,Smolders I

更新日期：2010-03-01 00:00:00

abstract：:Arachidonic acid (AA) plays an important role as a signaling factor in the CNS. Therefore, exposure to AA may affect cholinergic neurons in the spinal cord. To test this hypothesis, mRNA expression and activity of choline acetyltransferase (ChAT) was measured in cultured spinal cord neurons treated with increasing con...

journal_title：Journal of neurochemistry

authors： Chalimoniuk M,King-Pospisil K,Pedersen WA,Malecki A,Wylegala E,Mattson MP,Hennig B,Toborek M

更新日期：2004-08-01 00:00:00

abstract：:Sequence data from key fragments of the P2 protein established the order of cyanogen bromide (CNBr) peptides in the structure of the protein and the primary structure for approximately one-half of the molecule. Data were obtained from the three tryptic peptides of blocked NH2-terminal CNBr peptide (CN3), the large CNB...

journal_title：Journal of neurochemistry

authors： Weise MJ,Hsieh DL,Levit S,Brostoff SW

更新日期：1980-08-01 00:00:00

abstract：:Activation of extracellular signal-regulated protein kinase 1/2 (ERK1/2) are implicated in the pathophysiology of spinal cord injury (SCI). However, the specific functions of individual ERK isoforms in neurodegeneration are largely unknown. We investigated the hypothesis that ERK2 activation may contribute to patholog...

journal_title：Journal of neurochemistry

authors： Yu CG,Yezierski RP,Joshi A,Raza K,Li Y,Geddes JW

更新日期：2010-04-01 00:00:00

abstract：:PC12D cells, a new subline of conventional PC12 cells, respond not only to nerve growth factor but also to cyclic AMP by extending their neurites. These cells are flat in shape and are similar in appearance to PC12 cells that have been treated with nerve growth factor for a few days. In both cell lines, we have charac...

journal_title：Journal of neurochemistry

authors： Katoh-Semba R,Oohira A,Sano M,Watanabe K,Kitajima S,Kashiwamata S

更新日期：1989-03-01 00:00:00

abstract：:Traumatic spinal cord injury has recently been shown to cause a rapid increase in free fatty acids (FFAs) and lipid degradation in cats. The present studies report a more delayed, time-dependent increase in FFAs and a concomitant decrease in phospholipids following traumatic spinal injury in rats. The largest percenta...

journal_title：Journal of neurochemistry

authors： Faden AI,Chan PH,Longar S

更新日期：1987-06-01 00:00:00

abstract：:RIC-3 enhances the functional expression of certain nicotinic acetylcholine receptors (nAChRs) in vertebrates and invertebrates and increases the availability of functional receptors in cultured cells and Xenopus laevis oocytes. Maximal activity of RIC-3 may be cell-type dependent, so neither mammalian nor invertebrat...

journal_title：Journal of neurochemistry

authors： Bennett HM,Lees K,Harper KM,Jones AK,Sattelle DB,Wonnacott S,Wolstenholme AJ

更新日期：2012-12-01 00:00:00

abstract：:We investigated the effects of 17beta-estradiol, an estrogen, on [(3)H]norepinephrine ([(3)H]NE) secretion in PC12 cells. Pretreatment with 17beta-estradiol reduced 70 mM K(+)-induced [(3)H]NE secretion in a concentration-dependent manner with a half-maximal inhibitory concentration (IC(50)) of 2 +/- 1 microM. The 70 ...

journal_title：Journal of neurochemistry

authors： Kim YJ,Hur EM,Park TJ,Kim KT

更新日期：2000-06-01 00:00:00

abstract：:Voltage-dependent calcium channels from ileal smooth muscle can be affinity-labeled with a [3H]dihydropyridine isothiocyanate radioligand. We examined the binding of this agent to brain membranes, to compare the properties of calcium channel drug binding sites in brain with those previously described in ileum. In brai...

journal_title：Journal of neurochemistry

authors： Greenberg DA,Cooper EC,Carpenter CL

更新日期：1985-01-01 00:00:00

abstract：:We examined the effects of chronic (2 weeks) treatment with a typical neuroleptic, haloperidol (1 mg/kg, s.c.), and an atypical neuroleptic, clozapine (20 mg/kg, s.c.), on neurotensin receptor (NTR) mRNA levels by in situ hybridization histochemistry. Quantitative OD analysis showed haloperidol-induced NTR mRNA levels...

journal_title：Journal of neurochemistry

authors： Bolden-Watson C,Watson MA,Murray KD,Isackson PJ,Richelson E

更新日期：1993-09-01 00:00:00

abstract：:Tissue plasminogen activator (tPA) administration beyond 4.5 h of stroke symptoms is beneficial for patients but has an increased risk of cerebral hemorrhage. Thus, increasing the therapeutic window of tPA is important for stroke recovery. We previously showed that prothymosin alpha (ProTα) or its mimetic hexapeptide ...

journal_title：Journal of neurochemistry

authors： Halder SK,Matsunaga H,Ueda H

更新日期：2020-06-01 00:00:00

abstract：:In this study, we have investigated the effect of mivazerol, [3-(1H-imidazol-4-yl)methyl-1]-2-hydroxy-benzamide hydrochloride, a new alpha2-agonist lacking hypotensive properties and a potential anti-ischemic drug, on the evoked release of norepinephrine, aspartate, and glutamate in tissue preparations from hippocampu...

journal_title：Journal of neurochemistry

authors： El Tamer A,Prokopenko I,Wülfert E,Hanin I

更新日期：1996-08-01 00:00:00

abstract：:Stimulated dopamine overflow has been measured with in vivo voltammetry in the caudate-putamen and nucleus accumbens. Overflow was induced by electrical stimulation of the medial forebrain bundle with 120 1-ms, 300-microA, biphasic pulses at frequencies between 10 and 60 Hz. Overflow was measured with a Nafion-coated,...

journal_title：Journal of neurochemistry

authors： May LJ,Wightman RM

更新日期：1989-09-01 00:00:00

abstract：:Monoclonal antibodies were raised against the synaptosomal plasma membranes (SPMs) purified from the electric organ of the Torpedo. One antibody that reacts preferentially with SPMs rather than with other membrane fractions isolated from this tissue was previously found to inhibit hydrophilic and amphiphilic choline-O...

journal_title：Journal of neurochemistry

authors： Eder-Colli L,Briand PA,Pellegrinelli N,Dunant Y

更新日期：1989-11-01 00:00:00

abstract：:Fragile X syndrome (FXS) is caused by the loss of functional fragile X mental retardation protein (FMRP). Loss of FMRP results in an elevated basal protein expression profile of FMRP targeted mRNAs, a loss of local metabotropic glutamate receptor (mGluR)-regulated protein synthesis, exaggerated long-term depression an...

journal_title：Journal of neurochemistry

authors： Schmit TL,Dowell JA,Maes ME,Wilhelm M

更新日期：2013-12-01 00:00:00

abstract：:The monoclonal L5 antibody reacts with an N-glycosidically linked carbohydrate structure which is present on the neural cell adhesion molecule L1, neural chondroitin sulfate proteoglycans, and other not yet identified glycosylated proteins. Using this antibody, we isolated and characterized proteoglycans from adult mo...

journal_title：Journal of neurochemistry

authors： Streit A,Faissner A,Gehrig B,Schachner M

更新日期：1990-11-01 00:00:00

abstract：:The glial-derived neurotrophic protein S100beta has been implicated in the development and maintenance of the nervous system. S100beta has also been postulated to play a role in mechanisms of neuropathology because of its specific localization and selective overexpression in Alzheimer's disease. However, the exact rel...

journal_title：Journal of neurochemistry

authors： Hu J,Ferreira A,Van Eldik LJ

更新日期：1997-12-01 00:00:00

abstract：:Aggregate-prone mutant proteins, such as α-synuclein and huntingtin, play a prominent role in the pathogenesis of various neurodegenerative disorders; thus, it has been hypothesized that reducing the aggregate-prone proteins may be a beneficial therapeutic strategy for these neurodegenerative disorders. Here, we ident...

journal_title：Journal of neurochemistry

authors： Shen W,Henry AG,Paumier KL,Li L,Mou K,Dunlop J,Berger Z,Hirst WD

更新日期：2014-06-01 00:00:00

abstract：:5-Hydroxytryptamine (5-HT) receptors contain seven putative transmembrane domains and couple via different guanine nucleotide binding proteins to specific effector enzymes. Studies with other receptors identify the second and third intracellular loops or the C-terminus of the receptor as important for selective effect...

journal_title：Journal of neurochemistry

authors： Oksenberg D,Havlik S,Peroutka SJ,Ashkenazi A

更新日期：1995-04-01 00:00:00

abstract：:Changes in cellular energetic and metabolic parameters were analyzed at several time points during apoptosis of differentiated PC12 cells following removal of nerve growth factor (NGF). As approximately 60% of the population died during the period of study (24 h), most of the measured metabolic indicators declined ove...

journal_title：Journal of neurochemistry

authors： Mills JC,Nelson D,Erecińska M,Pittman RN

更新日期：1995-10-01 00:00:00

abstract：:Extracellular amino acid levels in the rat piriform cortex, an area highly susceptible to seizure-induced neuropathology, were determined by means of intracranial microdialysis. Seizures were induced by systemic administration of either soman (O-1,2,2-trimethylpropyl methylphosphonofluoridate), a potent inhibitor of a...

journal_title：Journal of neurochemistry

authors： Wade JV,Samson FE,Nelson SR,Pazdernik TL

更新日期：1987-08-01 00:00:00

abstract：:The time course of Ca2+-dependent [3H]acetylcholine [( 3H]ACh) release and inactivation of 45Ca2+ entry were examined in rat brain synaptosomes depolarized by 45 mM [K+]0. Under conditions where the intrasynaptosomal stores of releasable [3H]ACh were neither exhausted nor replenished in the course of stimulation, the ...

journal_title：Journal of neurochemistry

authors： Suszkiw JB,O'Leary ME

更新日期：1983-09-01 00:00:00