Abstract:
:The time course of Ca2+-dependent [3H]acetylcholine [( 3H]ACh) release and inactivation of 45Ca2+ entry were examined in rat brain synaptosomes depolarized by 45 mM [K+]0. Under conditions where the intrasynaptosomal stores of releasable [3H]ACh were neither exhausted nor replenished in the course of stimulation, the K+-evoked release consisted of a major (40% of the releasable [3H]ACh pool), rapidly terminating phase (t1/2 = 17.8 s), and a subsequent, slow efflux that could be detected only during a prolonged, maintained depolarization. The time course of inactivation of K+-stimulated Ca2+ entry suggests the presence of fast-inactivating, slow-inactivating, and noninactivating, or very slowly inactivating, components. The fast-inactivating component of the K+-stimulated Ca2+ entry into synaptosomes appears to be responsible for the rapidly terminating phase of transmitter release during the first 60 s of K+ stimulus. The noninactivating Ca2+ entry may account for the slow phase of transmitter release. These results indicate that under conditions of maintained depolarization of synaptosomes by high [K+]0 the time course and the amount of transmitter released may be a function of the kinetics of inactivation of the voltage-dependent Ca channels.
journal_name
J Neurochemjournal_title
Journal of neurochemistryauthors
Suszkiw JB,O'Leary MEdoi
10.1111/j.1471-4159.1983.tb04820.xsubject
Has Abstractpub_date
1983-09-01 00:00:00pages
868-73issue
3eissn
0022-3042issn
1471-4159journal_volume
41pub_type
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journal_title:Journal of neurochemistry
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abstract::beta-Amyloid peptide accumulates in the brain of patients affected by sporadic or familial forms of Alzheimer's disease. It derives from the proteolytic attacks of the beta-amyloid precursor protein (betaAPP) by beta- and gamma-secretase activities. An additional epsilon cleavage taking place a few residues C-terminal...
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更新日期:1991-05-01 00:00:00
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更新日期:2015-04-01 00:00:00
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journal_title:Journal of neurochemistry
pub_type: 杂志文章
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journal_title:Journal of neurochemistry
pub_type: 杂志文章
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更新日期:2003-04-01 00:00:00
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journal_title:Journal of neurochemistry
pub_type: 杂志文章
doi:10.1111/j.1471-4159.1990.tb01914.x
更新日期:1990-02-01 00:00:00
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journal_title:Journal of neurochemistry
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更新日期:2008-02-01 00:00:00
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更新日期:2005-11-01 00:00:00
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journal_title:Journal of neurochemistry
pub_type: 杂志文章,评审
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更新日期:2001-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:1996-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-04-01 00:00:00
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journal_title:Journal of neurochemistry
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更新日期:2010-09-01 00:00:00
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更新日期:1992-02-01 00:00:00
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更新日期:2008-12-01 00:00:00
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journal_title:Journal of neurochemistry
pub_type: 杂志文章
doi:10.1111/j.1471-4159.1988.tb13235.x
更新日期:1988-01-01 00:00:00
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journal_title:Journal of neurochemistry
pub_type: 杂志文章
doi:10.1111/j.1471-4159.1991.tb08287.x
更新日期:1991-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:1984-12-01 00:00:00