Genomic profiling of the neuronal target genes of the plasticity-related transcription factor -- Zif268.

abstract：:Thymosin beta 4 (Tβ4), a secreted 43 amino acid peptide, promotes oligodendrogenesis, and improves neurological outcome in rat models of neurologic injury. We demonstrated that exogenous Tβ4 treatment up-regulated the expression of the miR-200a in vitro in rat brain progenitor cells and in vivo in the peri-infarct are...

journal_title：Journal of neurochemistry

authors： Santra M,Chopp M,Santra S,Nallani A,Vyas S,Zhang ZG,Morris DC

更新日期：2016-01-01 00:00:00

abstract：:Astrocytes have important roles in control of extracellular environment, de novo synthesis of neurotransmitters, and regulation of neurotransmission and blood flow. All of these functions require energy, suggesting that astrocytic metabolism should rise and fall with changes in neuronal activity and that brain imaging...

journal_title：Journal of neurochemistry

authors： Dienel GA,Schmidt KC,Cruz NF

更新日期：2007-11-01 00:00:00

abstract：:Using tritium-labelled 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol (THPO) its tissue distribution and metabolism were investigated in adult mice and 4-day-old chicks after systemic administration of the drug. It was found not to be significantly metabolized in the brain since metabolites of THPO corresponding to on...

journal_title：Journal of neurochemistry

authors： Schousboe A,Hjeds H,Engler J,Krogsgaard-Larsen P,Wood JD

更新日期：1986-09-01 00:00:00

abstract：:Microinfarcts are small, but strikingly common, ischemic brain lesions in the aging human brain. There is mounting evidence that microinfarcts contribute to vascular cognitive impairment and dementia, but the origins of microinfarcts are unclear. Understanding the vascular pathologies that cause microinfarcts may yiel...

journal_title：Journal of neurochemistry

authors： Hartmann DA,Hyacinth HI,Liao FF,Shih AY

更新日期：2018-03-01 00:00:00

abstract：:Myelin proteolipid protein (PLP) is known to contain long-chain, covalently bound fatty acids. Previous studies, including our own, have suggested the occurrence of an oxyester type of linkage between fatty acids and PLP. However, we found that protein-SH groups are required in the acylation reaction, suggesting the p...

journal_title：Journal of neurochemistry

authors： Bizzozero OA,Good LK

更新日期：1990-12-01 00:00:00

abstract：:Alcohol abuse leads to tolerance, dependence, and memory impairments that involve excitatory glutamatergic NMDA synaptic transmission. The NMDA receptor (NMDAR) is known to undergo activity-dependent adaptive functional changes. Since we observed that acute ethanol inhibition of the NMDAR was regulated by protein tyro...

journal_title：Journal of neurochemistry

authors： Wu PH,Coultrap S,Browning MD,Proctor WR

更新日期：2010-12-01 00:00:00

abstract：:Light stimulates dopamine release in the retina and has been shown to rapidly up-regulate rod opsin mRNA. In the present study, we tested the effect of dopamine on rod opsin mRNA expression and examined the hypothesis that dopamine can mediate a light-evoked increase in opsin gene expression. Northern blots showed tha...

journal_title：Journal of neurochemistry

authors： Alfinito PD,Townes-Anderson E

更新日期：2001-02-01 00:00:00

abstract：:Exogenous phospholipases have been used extensively as tools to study the role of membrane lipids in receptor mechanisms. We used in vitro quantitative autoradiography to evaluate the effect of phospholipase A2 (PLA2) on N-methyl-D-aspartate (NMDA) and non-NMDA glutamate receptors in rat brain. PLA2 pretreatment induc...

journal_title：Journal of neurochemistry

authors： Catania MV,Hollingsworth Z,Penney JB,Young AB

更新日期：1993-01-01 00:00:00

abstract：:Perilymph, which bathes the sensory cells of the cochlea, was collected from guinea pigs exposed to noise and analyzed via two cation-exchange HPLC procedures with fluorescence detection, resolving 51 and 81 primary-amine compounds, respectively, at a sensitivity limit of 0.1 pmol relative to leucine. During a first p...

journal_title：Journal of neurochemistry

authors： Drescher MJ,Drescher DG,Medina JE

更新日期：1983-08-01 00:00:00

abstract：:Selective serotonin reuptake inhibitors (SSRIs) were designed to treat depression by increasing serotonin levels throughout the brain via inhibition of clearance from the extracellular space. Although increases in serotonin levels are observed after acute SSRI exposure, 3-6 weeks of continuous use is required for reli...

journal_title：Journal of neurochemistry

authors： Dankoski EC,Carroll S,Wightman RM

更新日期：2016-03-01 00:00:00

abstract：:Evidence that glucagon-like peptide-1 (GLP-1) (7-36) amide functions as a novel neuropeptide prompted us to study the gene expression of its receptor in rat brain. Northern blot analysis showed transcripts of similar size in RINm5F cells, hypothalamus, and brain-stem. First-strand cDNA was prepared by using RNA from h...

journal_title：Journal of neurochemistry

authors： Alvarez E,Roncero I,Chowen JA,Thorens B,Blázquez E

更新日期：1996-03-01 00:00:00

abstract：:MDL 72145, (E)-2-(3',4'-dimethoxyphenyl)-3-fluoroallylamine hydrochloride, was designed and synthesised as a potential enzyme-activated irreversible inhibitor of monoamine oxidase (MAO). In vitro, the compound displayed time-dependent pseudo-first-order irreversible inhibitory characteristics with high selectivity for...

journal_title：Journal of neurochemistry

authors： Zreika M,McDonald IA,Bey P,Palfreyman MG

更新日期：1984-08-01 00:00:00

abstract：:This study was undertaken to explore the metabolic fate of acetyl-L-carnitine in rat brain. To measure the flux of carbon atoms into anabolic processes occurring at regional levels, we have injected [1-(14)C]acetyl-L-carnitine into the lateral brain ventricle of conscious rats. After injection of [1-(14)C]acetyl-L-car...

journal_title：Journal of neurochemistry

authors： Ricciolini R,Scalibastri M,Kelleher JK,Carminati P,Calvani M,Arduini A

更新日期：1998-12-01 00:00:00

abstract：:Most G protein-coupled receptors contain a conserved pair of extracellular cysteine residues that are predicted to form a disulfide bond linking the first and second extracellular loops. Previous studies have shown that this disulfide bond may be critical for ligand binding, receptor activation, and/or proper receptor...

journal_title：Journal of neurochemistry

authors： Zeng FY,Soldner A,Schöneberg T,Wess J

更新日期：1999-06-01 00:00:00

abstract：:(R)-[3H]Tomoxetine is a radioligand that binds to the norepinephrine (NE) uptake site with high affinity but also binds to a second, lower-affinity site. The goal of the present study was to identify the nature of this low-affinity site by comparing the binding properties of (R)-[3H]tomoxetine with those of (R/S)-[3H]...

journal_title：Journal of neurochemistry

authors： Gehlert DR,Schober DA,Gackenheimer SL

更新日期：1995-06-01 00:00:00

abstract：:Converging lines of evidence implicate the beta-amyloid peptide (Ass) as causative in Alzheimer's disease. We describe a novel class of compounds that reduce A beta production by functionally inhibiting gamma-secretase, the activity responsible for the carboxy-terminal cleavage required for A beta production. These mo...

journal_title：Journal of neurochemistry

authors： Dovey HF,John V,Anderson JP,Chen LZ,de Saint Andrieu P,Fang LY,Freedman SB,Folmer B,Goldbach E,Holsztynska EJ,Hu KL,Johnson-Wood KL,Kennedy SL,Kholodenko D,Knops JE,Latimer LH,Lee M,Liao Z,Lieberburg IM,Motter RN,

更新日期：2001-01-01 00:00:00

abstract：:We applied a differential display PCR technique to isolate molecules that are area-specific in expression in the primate neocortex, and found that growth/differentiation factor 7 (GDF7), a member of the bone morphogenetic protein (BMP)/transforming growth factor (TGF) beta super-family, is preferentially expressed in ...

journal_title：Journal of neurochemistry

authors： Watakabe A,Fujita H,Hayashi M,Yamamori T

更新日期：2001-03-01 00:00:00

abstract：:Recently, we described estrogen and agonists of the G-protein coupled estrogen receptor GPR30 to induce protein kinase C (PKC)ε-dependent pain sensitization. PKCε phosphorylates the ion channel transient receptor potential, vanilloid subclass I (TRPV1) close to a novel microtubule-TRPV1 binding site. We now modeled th...

journal_title：Journal of neurochemistry

authors： Goswami C,Kuhn J,Dina OA,Fernández-Ballester G,Levine JD,Ferrer-Montiel A,Hucho T

更新日期：2011-06-01 00:00:00

abstract：:Tumor progression locus 2 (Tpl2)/cancer Osaka thyroid kinase is a newer member of MAP3K family that is now known for its essential role in tumor necrosis factor-aplha (TNFα) expression in macrophages, but its pro-inflammatory signaling, if any, in glia is unknown. When cultures of murine microglia and astrocytes were ...

journal_title：Journal of neurochemistry

authors： Hirschhorn J,Mohanty S,Bhat NR

更新日期：2014-03-01 00:00:00

abstract：:Previous studies have shown that activation of the cyclic AMP (cAMP) pathway down-regulates CREB expression in CATH.a cells, an effect that appears to be mediated via inhibition of CREB gene transcription. In the current study, we compared this effect in CATH.a cells with regulation of CREB expression in another cell ...

journal_title：Journal of neurochemistry

authors： Coven E,Ni Y,Widnell KL,Chen J,Walker WH,Habener JF,Nestler EJ

更新日期：1998-11-01 00:00:00

abstract：:Cytokines have been suggested to be involved in the cross talk between the immune and the nervous systems, under normal and pathological conditions. For example, the cytokine interleukin-2 was suggested to be involved in response to CNS trauma and spontaneous regeneration. Here, we examined whether mammalian CNS has a...

journal_title：Journal of neurochemistry

authors： Eizenberg O,Faber-Elman A,Lotan M,Schwartz M

更新日期：1995-05-01 00:00:00

abstract：:Prolonged stress affects homeostasis in various organs and induces stress-associated disorders. We examined the cellular changes of pituitary gland under the continuous stress condition using a rat model in which rats were kept in a cage filled with water to a height of 1.5 cm for up to 5 days. Among the pituitary hor...

journal_title：Journal of neurochemistry

authors： Ogawa T,Shishioh-Ikejima N,Konishi H,Makino T,Sei H,Kiryu-Seo S,Tanaka M,Watanabe Y,Kiyama H

更新日期：2009-06-01 00:00:00

abstract：:Myelination, during both normal development and with respect to disorders of myelination, is commonly studied by morphological and/or biochemical techniques that assay as their end-points the extent of myelination. The rate of myelination is potentially a more useful parameter, but it is difficult and time-consuming t...

journal_title：Journal of neurochemistry

authors： Muse ED,Jurevics H,Toews AD,Matsushima GK,Morell P

更新日期：2001-01-01 00:00:00

abstract：:The adenylate cyclase activity of rat hippocampal plasma membranes can be stimulated by vasoactive intestinal polypeptide (VIP). Low concentrations (10(-9) to 19(-7) M) of 5'-guanylyl-imido diphosphate (GppNHp) evoke a transient inhibition of the enzyme, which is followed by stimulation with increasing GppNHp concentr...

journal_title：Journal of neurochemistry

authors： Girardot JM,Kempf J,Cooper DM

更新日期：1983-09-01 00:00:00

abstract：:Action mechanism of lipopolysaccharide (LPS), interleukin-1β (IL-1β), and lysophosphatidic acid (LPA) to regulate motility, an important process of astrogliosis, was investigated in rat astrocytes. While LPA exerted no significant effect on the cell migration, the prior treatment of the cells with LPS or IL-1β resulte...

journal_title：Journal of neurochemistry

authors： Sato K,Horiuchi Y,Jin Y,Malchinkhuu E,Komachi M,Kondo T,Okajima F

更新日期：2011-04-01 00:00:00

abstract：:The human NMDAR2D subunit was cloned, and the pharmacological properties of receptors resulting from injection of transcripts encoding human NMDAR1A and NMDAR2D subunits in Xenopus oocytes were characterized by profiling NMDA receptor agonists and antagonists. We found that glutamate, NMDA, glycine, and D-serine were ...

journal_title：Journal of neurochemistry

authors： Hess SD,Daggett LP,Deal C,Lu CC,Johnson EC,Veliçelebi G

更新日期：1998-03-01 00:00:00

abstract：:Transcriptional dysregulation is a hallmark of Huntington's disease (HD) and one cause of this dysregulation is enhanced activity of the REST-mSIN3a-mSIN3b-CoREST-HDAC repressor complex, which silences transcription through REST binding to the RE1/NRSE silencer. Normally, huntingtin (HTT) prevents this binding, allowi...

journal_title：Journal of neurochemistry

authors： Conforti P,Zuccato C,Gaudenzi G,Ieraci A,Camnasio S,Buckley NJ,Mutti C,Cotelli F,Contini A,Cattaneo E

更新日期：2013-10-01 00:00:00

abstract：:Conversion of the cellular prion protein (PrP(C)) into the abnormal scrapie isoform (PrP(Sc)) is the hallmark of prion diseases, which are fatal and transmissible neurodegenerative disorders. ER-retained anti-prion recombinant single-chain Fv fragments have been proved to be an effective tool for inhibition of PrP(C) ...

journal_title：Journal of neurochemistry

authors： Filesi I,Cardinale A,Mattei S,Biocca S

更新日期：2007-06-01 00:00:00

abstract：:Abnormal tau accumulations were observed and documented in post-mortem brains of patients affected by Alzheimer's disease (AD) long before the identification of mutations in the Microtubule-associated protein tau (MAPT) gene, encoding the tau protein, in a different neurodegenerative disease called Frontotemporal deme...

journal_title：Journal of neurochemistry

authors： Hannan SB,Dräger NM,Rasse TM,Voigt A,Jahn TR

更新日期：2016-04-01 00:00:00

abstract：:Microglial activation can lead to microglial apoptosis, which may serve to remove highly reactive and possibly neurotoxic microglia. However the loss of microglia may have consequences for future recovery, protection and repair. P53, a nuclear phosphoprotein transcription factor, is critical for activating the express...

journal_title：Journal of neurochemistry

authors： Davenport CM,Sevastou IG,Hooper C,Pocock JM

更新日期：2010-01-01 00:00:00