Abstract:
:Neuroprotection is one of the prominent functions of the interleukin (IL)-6-type cytokine family, for which the underlying mechanism(s) are not fully understood. We have previously shown that neuroprotection and neuromodulation mediated by IL-6 require neuronal adenosine A(1) receptor (A(1) R) function. We now have investigated whether two other IL-6-type cytokines [oncostatin M (OSM) and leukemia inhibitory factor (LIF)] use a similar mechanism. It is presented here that OSM but not LIF, enhanced the expression of A(1) Rs (both mRNA and protein levels) in cultured neurons. Whereas the neuroprotective effect of LIF was unchanged in A(1) R deficient neurons, OSM failed to protect neurons in the absence of A(1) R. In addition, OSM pre-treatment for 4 h potentiated the A(1) R-mediated inhibition of electrically evoked excitatory post-synaptic currents recorded from hippocampal slices either under normal or hypoxic conditions. No such effect was observed after LIF pre-treatment. Our findings thus strongly suggest that, despite known structural and functional similarities, OSM and LIF use different mechanisms to achieve neuroprotection and neuromodulation.
journal_name
J Neurochemjournal_title
Journal of neurochemistryauthors
Moidunny S,Dias RB,Wesseling E,Sekino Y,Boddeke HW,Sebastião AM,Biber Kdoi
10.1111/j.1471-4159.2010.06881.xsubject
Has Abstractpub_date
2010-09-01 00:00:00pages
1667-77issue
6eissn
0022-3042issn
1471-4159pii
JNC6881journal_volume
114pub_type
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