Nitrotyrosine as a marker for peroxynitrite-induced neurotoxicity: the beginning or the end of the end of dopamine neurons?

abstract：:The uptake of radioactive biotin has been studied in glial cell cultures from dissociated cerebral hemispheres of newborn rats. We describe saturable kinetics for the biotin uptake at biotin concentrations of less than 60 nM and linear at greater than 60 nM. The uptake appeared temperature sensitive, Na+ independent, ...

journal_title：Journal of neurochemistry

authors： Rodriguez-Pombo P,Ugarte M

更新日期：1992-04-01 00:00:00

abstract：:A glutamate binding protein was purified from bovine brain to apparent homogeneity. The procedure used for the purification of this protein involved extraction of a crude synaptic membrane fraction with Na-cholate, followed by solubilization of the binding protein from the membranes by Triton X-100, and, finally, affi...

journal_title：Journal of neurochemistry

authors： Michaelis EK,Chittenden WL,Johnson BE,Galton N,Decedue C

更新日期：1984-02-01 00:00:00

abstract：:Psychostimulants are widely abused drugs that may cause addiction in vulnerable individuals. While the reward circuitry of the brain is involved in addiction establishment, various pathways in the brain may provide protection at the molecular level that limits the acute and chronic effects of drugs. These targets may ...

journal_title：Journal of neurochemistry

authors： Kogias G,Zheng F,Kalinichenko LS,Kornhuber J,Alzheimer C,Mielenz D,Müller CP

更新日期：2020-08-01 00:00:00

abstract：:Circadian clocks are internal timing systems that enable organisms to adjust their behavioral and physiological rhythms to the daily changes of their environment. These clocks generate self-sustained oscillations at the cellular, tissue, and behavioral level. The rhythm-generating mechanism is based on a gene expressi...

journal_title：Journal of neurochemistry

authors： Srikanta SB,Cermakian N

更新日期：2020-07-27 00:00:00

abstract：:The role of asparagine as precursor for the neurotransmitter aspartate was investigated in rat striatum in vitro. 14C-asparagine incubated with striatal slices is converted to a great extent to 14C-aspartate which is released in a calcium-dependent manner by high KCl. Furthermore, a frontoparietal cortex ablation of t...

journal_title：Journal of neurochemistry

authors： Reubi JC,Toggenburger G,Cuénod M

更新日期：1980-10-01 00:00:00

abstract：:We previously identified a nuclear envelope protein repressor element-1 silencing transcription factor (REST)/neuron-restrictive silencer factor (NRSF)-interacting Lin-11, Isl-1 and Mec-3 (LIM) domain protein (RILP) that we proposed functions in the nuclear translocation of the transcriptional repressor REST/NRSF. In ...

journal_title：Journal of neurochemistry

authors： Shimojo M,Hersh LB

更新日期：2006-02-01 00:00:00

abstract：:The neuromodulator adenosine can be released as such, mainly activating inhibitory A1 receptors, or formed from released ATP, preferentially activating facilitatory A2A receptors. We tested if changes in extracellular adenosine metabolism paralleled changes in A1/A2A receptor neuromodulation in the aged rat hippocampu...

journal_title：Journal of neurochemistry

authors： Cunha RA,Almeida T,Ribeiro JA

更新日期：2001-01-01 00:00:00

abstract：:The changes of glutathione S-transferase activity were investigated using rat brain astroglioma C6 cells that were synchronized at different phases of the cell cycle. The enzyme showed two significant activity peaks at G2 and G1 phases. Furthermore, when C6 glioma cells were exposed to a culture medium supplemented wi...

journal_title：Journal of neurochemistry

authors： Senjo M,Ishibashi T

更新日期：1988-01-01 00:00:00

abstract：:This study presents the initial characterization of transgenic mice with mutations in a primary zinc-binding residue (H80), either alone or with a G93A mutation. H80G;G93A superoxide dismutase 1 (SOD1) transgenic mice developed paralysis with motor neuron loss, and ubiquitin inclusion-type rather than mitochondrial va...

journal_title：Journal of neurochemistry

authors： Son M,Srikanth U,Puttaparthi K,Luther C,Elliott JL

更新日期：2011-09-01 00:00:00

abstract：:Beta-amyloid peptides play a major role in the pathogenesis of Alzheimer's disease (AD). Therefore, preventing beta-amyloid formation by inhibition of the beta site amyloid precursor protein-cleaving enzyme (BACE) 1 is considered as a potential strategy to treat AD. Cholinergic mechanisms have been shown to control am...

journal_title：Journal of neurochemistry

authors： Zuchner T,Schliebs R,Perez-Polo JR

更新日期：2005-10-01 00:00:00

abstract：:Endogenous norepinephrine (NE) release in cerebral cortex slices taken from normal and morphine-tolerant guinea pigs was measured by HPLC. In normal slices, a linear relationship was found between electrically evoked NE release and the log of the frequency of stimulation in the range of 1-20 Hz. The efficiency of the ...

journal_title：Journal of neurochemistry

authors： Tomasini C,Guidorzi R,Bianchi C,Beani L

更新日期：1992-04-01 00:00:00

abstract：:The structure and function of mitochondrial respiratory-chain enzyme proteins were studied postmortem in the substantia nigra of nine patients with Parkinson's disease and nine matched controls. Total protein and mitochondrial mass were similar in the two groups. NADH-ubiquinone reductase (Complex I) and NADH cytochro...

journal_title：Journal of neurochemistry

authors： Schapira AH,Cooper JM,Dexter D,Clark JB,Jenner P,Marsden CD

更新日期：1990-03-01 00:00:00

abstract：:We investigated the role of Ca(2+)-dependent protein kinases in the regulation of astrocytic cell volume. Calmodulin (CaM) antagonists were used to inhibit CaM and thus Ca2+/CaM-dependent protein kinase. The effect of these inhibitors as well as activators and inhibitors of protein kinase C (PKC) on astrocytic volume ...

journal_title：Journal of neurochemistry

authors： Bender AS,Neary JT,Blicharska J,Norenberg LO,Norenberg MD

更新日期：1992-05-01 00:00:00

abstract：:In the last 40 years, especially with the application of new neurochemical and molecular biological techniques, there has been explosive progress in understanding how certain ligands and drugs are transported across the blood-brain barrier and choroid plexus out of brain and CSF. In the CNS, there are several separate...

journal_title：Journal of neurochemistry

authors： Spector R

更新日期：2010-01-01 00:00:00

abstract：:Adenosine A2A receptors (A2A R) play a key role in modulating dopamine-dependent locomotor activity, as heralded by the sensitization of locomotor activity upon chronic A2A R blockade, which is associated with elevated dopamine levels and altered corticostriatal synaptic plasticity. Since the orphan receptor GPR37 has...

journal_title：Journal of neurochemistry

authors： Morató X,Gonçalves FQ,Lopes JP,Jauregui O,Soler C,Fernández-Dueñas V,Cunha RA,Ciruela F

更新日期：2019-03-01 00:00:00

abstract：:Choline acetyltransferase (ChAT), the enzyme synthesizing acetylcholine, is known to be activated by brain derived neurotrophic factor (BDNF). We found that the specific removal of the carbohydrate polysialic acid (PSA) significantly increased BDNF-induced ChAT-activity in embryonic septal neurons. Using a p75 neurotr...

journal_title：Journal of neurochemistry

authors： Burgess A,Aubert I

更新日期：2006-11-01 00:00:00

abstract：:This paper describes a new, sensitive assay for dopamine-beta-hydroxylase (DBH) activity in human cerebrospinal fluid (CSF), serum and brain tissues by high performance liquid chromatography (HPLC) with electrochemical detection (ED). Dopamine (DA) was used as a substrate and was incubated under optimal conditions. No...

journal_title：Journal of neurochemistry

authors： Matsui H,Kato T,Yamamoto C,Fujita K,Nagatsu T

更新日期：1981-08-01 00:00:00

abstract：:The effects of a potent adenosine deaminase inhibitor, deoxycoformycin, on purine and amino acid neuro-transmitter release from the ischemic rat cerebral cortex were studied with the cortical cup technique. Cerebral ischemia (20 min) was elicited by four-vessel occlusion. Purine and amino acid releases were compared f...

journal_title：Journal of neurochemistry

authors： Phillis JW,Walter GA,Simpson RE

更新日期：1991-02-01 00:00:00

abstract：:Repeated cocaine administration results in persistent changes in synaptic function in the mesolimbic dopamine system that are thought to be critical for the transition to addiction. Cytoskeletal rearrangement and actin dynamics are essential for this drug-dependent plasticity. Cocaine administration increases levels o...

journal_title：Journal of neurochemistry

authors： Lavaur J,Mineur YS,Picciotto MR

更新日期：2009-12-01 00:00:00

abstract：:Fused in sarcoma (FUS) is a ubiquitously expressed RNA/DNA-binding protein that plays different roles in the cell. FUS pathology has been reported in neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Mutations in FUS have also been linked to a subset of familial ALS. FUS...

journal_title：Journal of neurochemistry

authors： Arenas A,Kuang L,Zhang J,Kingren MS,Zhu H

更新日期：2020-12-22 00:00:00

abstract：:Schwann cells provide a favorable microenvironment for successful regeneration of the injured peripheral nerve. Even though the roles of extracellular matrix proteins in the Schwann cell physiology have long been studied, the precise function of nidogen, a ubiquitous component of the basal lamina, in Schwann cells is ...

journal_title：Journal of neurochemistry

authors： Lee HK,Seo IA,Park HK,Park YM,Ahn KJ,Yoo YH,Park HT

更新日期：2007-08-01 00:00:00

abstract：:In the preceding report we demonstrated a dose-dependent increase in 32P-phosphoprotein labeling after 24-h exposure of cultured cerebellar granule neurons to methyl mercury (MeHg), a response that was not observed in glial cultures. In the present study we have examined 32P-labeled phosphoproteins by two-dimensional ...

journal_title：Journal of neurochemistry

authors： Sarafian T,Verity MA

更新日期：1990-09-01 00:00:00

abstract：:Neuroprotection is one of the prominent functions of the interleukin (IL)-6-type cytokine family, for which the underlying mechanism(s) are not fully understood. We have previously shown that neuroprotection and neuromodulation mediated by IL-6 require neuronal adenosine A(1) receptor (A(1) R) function. We now have in...

journal_title：Journal of neurochemistry

authors： Moidunny S,Dias RB,Wesseling E,Sekino Y,Boddeke HW,Sebastião AM,Biber K

更新日期：2010-09-01 00:00:00

abstract：:To investigate if the prevention of disulfide bond formation affects the intracellular transport, sorting, and processing of a distinct set of neuroendocrine proteins in the regulated secretory pathway, we have treated Xenopus intermediate pituitaries with the thiol-reducing agent dithiothreitol. Pulse-chase incubatio...

journal_title：Journal of neurochemistry

authors： Van Horssen AM,Van Kuppeveld FJ,Martens GJ

更新日期：1998-07-01 00:00:00

abstract：:Intracerebral administration of [3H]arachidonic acid ([3H]ArA) into 19-20-day-old rat embryos, resulted in a rapid incorporation of label into brain lipids. One hour after injection, 55.6 +/- 8.2, 18.0 +/- 3.4, and 13.7 +/- 1.3% of the total radioactivity was associated with phosphatidylcholine, phosphatidylinositol, ...

journal_title：Journal of neurochemistry

authors： Kunievsky B,Bazan NG,Yavin E

更新日期：1992-11-01 00:00:00

abstract：:Neural stem/progenitor cells (NSPCs) are multipotent cells within the embryonic and adult brain that give rise to both neuronal and glial cell lineages. Maintenance of NSPC multipotency is promoted by low oxygen tension, although the metabolic underpinnings of this trait have not been described. In this study, we inve...

journal_title：Journal of neurochemistry

authors： Candelario KM,Shuttleworth CW,Cunningham LA

更新日期：2013-05-01 00:00:00

abstract：:The glycogen content of primary cultured astrocytes was approximately doubled by incubation with 1 mM L-glutamate or L-aspartate. Other amino acids and excitatory neurotransmitters were without effect. The increase in glycogen level was not blocked by the glutamate receptor antagonist kynurenic acid but was completely...

journal_title：Journal of neurochemistry

authors： Swanson RA,Yu AC,Chan PH,Sharp FR

更新日期：1990-02-01 00:00:00

abstract：:Oxidative stress has been shown to play a role in aging and in neurodegenerative disorders. Some of the consequences of oxidative stress are DNA base modifications, lipid peroxidation, and protein modifications such as formation of carbonyls and nitrotyrosine. These events may play a role in apoptosis, another factor ...

journal_title：Journal of neurochemistry

authors： Kaufmann JA,Bickford PC,Taglialatela G

更新日期：2001-02-01 00:00:00

abstract：:Painful neuropathy is one of the most serious complications of diabetes and remains difficult to treat. The muscarinic acetylcholine receptor (mAChR) agonists have a profound analgesic effect on painful diabetic neuropathy. Here we determined changes in T-type and high voltage-activated Ca(2+) channels (HVACCs) and th...

journal_title：Journal of neurochemistry

authors： Cao XH,Byun HS,Chen SR,Pan HL

更新日期：2011-11-01 00:00:00

abstract：:In the early postnatal period, energy metabolism in the suckling rodent brain relies to a large extent on metabolic pathways alternate to glucose such as the utilization of ketone bodies (KBs). However, how KBs affect neuronal excitability is not known. Using recordings of single NMDA and GABA-activated channels in ne...

journal_title：Journal of neurochemistry

authors： Rheims S,Holmgren CD,Chazal G,Mulder J,Harkany T,Zilberter T,Zilberter Y

更新日期：2009-08-01 00:00:00