Manipulation of disulfide bonds differentially affects the intracellular transport, sorting, and processing of neuroendocrine secretory proteins.

abstract：:Conditioned medium derived from a rat central nervous system neuronal cell line B104 (B104 CM) was shown previously to contain uncharacterized potent mitogen(s) for oligodendrocyte/type-2 astrocyte (O-2A) progenitor cells. In this study, we demonstrated that B104 cells produce and secrete platelet-derived growth facto...

journal_title：Journal of neurochemistry

authors： Asakura K,Hunter SF,Rodriguez M

更新日期：1997-06-01 00:00:00

abstract：:We investigated the mechanism by which rat retina conserves docosahexaenoic acid during essential fatty acid deficiency. Weanling female albino rats were fed diets containing either 10% by weight hydrogenated coconut oil, safflower oil, or linseed oil for 15 weeks. Plasma and rod outer segment (ROS) membranes were pre...

journal_title：Journal of neurochemistry

authors： Wiegand RD,Koutz CA,Stinson AM,Anderson RE

更新日期：1991-11-01 00:00:00

abstract：:Previously, we demonstrated that systemically injected extracellular domain of neuregulin-1β1 (Nrg1β1), a nerve growth and differentiation factor, passes the blood-brain barrier and rescues dopaminergic neurons of substantia nigra in the 6-hydroxydopamine-mouse model of Parkinson's disease (PD). Here, we studied the e...

journal_title：Journal of neurochemistry

authors： Depboylu C,Rösler TW,de Andrade A,Oertel WH,Höglinger GU

更新日期：2015-05-01 00:00:00

abstract：:Rapid axonal transport of proteins in retinal ganglion cells of the rabbit was studied following intraocular injections of labelled amino acids. Approximately 10% of the transported radioactivity was found in the supernatant following homogenization and high-speed centrifugation of the nerve terminal region. Relativel...

journal_title：Journal of neurochemistry

authors： Karlsson JO

更新日期：1976-11-01 00:00:00

abstract：:Sex differences were investigated in cholinergic neurons of the septal-diagonal band region of adult rats subjected to neonatal treatment with 3,3',5-triiodo-L-thyronine (T3). Neonatal hyperthyroidism resulted in a 44% increase in specific activity of choline acetyltransferase (ChAT; EC 2.3.1.6) in adult male rat sept...

journal_title：Journal of neurochemistry

authors： Westlind-Danielsson A,Gould E,McEwen BS

更新日期：1991-01-01 00:00:00

abstract：:Perlecan is a specific proteoglycan that binds to amyloid precursor protein and beta-amyloid peptide, is present within amyloid deposits, and has been implicated in plaque formation. Because plaque formation is associated with local inflammation, we hypothesized that the mechanisms involved in brain inflammatory respo...

journal_title：Journal of neurochemistry

authors： García de Yébenes E,Ho A,Damani T,Fillit H,Blum M

更新日期：1999-08-01 00:00:00

abstract：:We looked at the possible interactions between astrocytes and neurones during reperfusion using an in vitro model of ischaemia-reperfusion injury, as a controlled environment that lends itself easily to manipulation of the numerous variables involved in such an insult. We constructed a chamber in which O2 can be lower...

journal_title：Journal of neurochemistry

authors： Griffin S,Clark JB,Canevari L

更新日期：2005-11-01 00:00:00

abstract：:Cholinergic signaling plays an important role in regulating the growth and regeneration of axons in the nervous system. The α7 nicotinic receptor (α7) can drive synaptic development and plasticity in the hippocampus. Here, we show that activation of α7 significantly reduces axon growth in hippocampal neurons by coupli...

journal_title：Journal of neurochemistry

authors： Nordman JC,Phillips WS,Kodama N,Clark SG,Del Negro CA,Kabbani N

更新日期：2014-05-01 00:00:00

abstract：:The blood-brain barrier (BBB) is important physiologically. Pathologically, BBB disruption has been implicated in a wide spectrum of neurological disorders including Parkinson's disease (PD). Recent studies indicate that caffeine is protective against PD, but by poorly understood mechanisms. Using a MPTP neurotoxin mo...

journal_title：Journal of neurochemistry

authors： Chen X,Lan X,Roche I,Liu R,Geiger JD

更新日期：2008-11-01 00:00:00

abstract：:Larval zebrafish offers a good model to approach brain disease mechanisms, as structural abnormalities of their small brains can be correlated to quantifiable behavior. In this study, the structural alterations in one diencephalic dopaminergic nucleus induced by 1-methyl-4-phenylpyridinium (MPP+), a toxin inducing Par...

journal_title：Journal of neurochemistry

authors： Sallinen V,Torkko V,Sundvik M,Reenilä I,Khrustalyov D,Kaslin J,Panula P

更新日期：2009-02-01 00:00:00

abstract：:The time course of the reduction in brain protein synthesis following transient bilateral ischemia in the gerbil was characterized and compared with changes in a number of metabolites related to brain energy metabolism. The recovery of brain protein synthesis was similar following ischemic periods of 5, 10, or 20 min;...

journal_title：Journal of neurochemistry

authors： Nowak TS Jr,Fried RL,Lust WD,Passonneau JV

更新日期：1985-02-01 00:00:00

abstract：:delta 1-Pyrroline, 5-methyl-delta 1-pyrroline, and 5,5-dimethyl-delta 1-pyrroline have been identified as substances metabolized to gamma-aminobutyric acid (GABA), 4-aminopentanoic acid (methylGABA), and 4-amino-4-methylpentanoic acid (dimethylGABA), respectively. An enzyme system residing in the soluble fraction of r...

journal_title：Journal of neurochemistry

authors： Callery PS,Geelhaar LA,Nayar MS,Stogniew M,Rao KG

更新日期：1982-04-01 00:00:00

abstract：:We have examined some of the characteristics of phorbol ester- and agonist-induced down-regulation of astrocyte receptors coupled to phosphoinositide metabolism. Our results show that preincubation of [3H]inositol-labelled astrocyte cultures with phorbol 12-myristate 13-acetate (PMA) resulted in a time- (t 1/2, 1-2 mi...

journal_title：Journal of neurochemistry

authors： Pearce B,Morrow C,Murphy S

更新日期：1988-03-01 00:00:00

abstract：:Endocannabinoids (eCBs) play key roles in short-term and long-term synaptic plasticity in the corticostriatal circuit. By activating cannabinoid receptors expressed in the central nervous system, eCBs regulate several neural functions and behaviors. The major eCB 2-arachidonoyl-glycerol (2-AG) is particularly importan...

journal_title：Journal of neurochemistry

authors： Socodato R

更新日期：2020-05-01 00:00:00

abstract：:A reversed-phase HPLC system was used to concentrate and separate components of substance P-like immunoreactivity (SP-LI) from human CSF. When CSF was injected and fractions collected, no SP-LI could be detected by radioimmunoassay (RIA) at the retention time of SP or SP-sulfoxide. Instead, SP-LI was detected in later...

journal_title：Journal of neurochemistry

authors： Toresson G,Brodin E,Wahlström A,Bertilsson L

更新日期：1988-06-01 00:00:00

abstract：:Proteolytic processing and phosphorylation of amyloid precursor protein (APP), and hyperphosphorylation of tau protein, have been shown to be increased in Alzheimer's disease (AD) brains, leading to increased production of beta-amyloid (Abeta) peptides and neurofibrillary tangles, respectively. These observations sugg...

journal_title：Journal of neurochemistry

authors： Butterfield DA,Abdul HM,Opii W,Newman SF,Joshi G,Ansari MA,Sultana R

更新日期：2006-09-01 00:00:00

abstract：:The effects of gamma-aminobutyric acid (GABA) on the extracellular levels of taurine and on excitability in the dentate gyrus were studied in anesthetized rats by the dialytrode technique. The dentate gyrus was perfused by means of a dialytrode with Krebs-Ringer-bicarbonate or GABA solutions. Amino acid contents in pe...

journal_title：Journal of neurochemistry

authors： Lerma J,Herranz AS,Herreras O,Muñoz D,Solís JM,del Río RM,Delgado JM

更新日期：1985-03-01 00:00:00

abstract：:Isolated rat neurointermediate lobes were incubated in vitro. The release of 3,4-dihydroxyphenylethylamine (dopamine, DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and methoxyphenylethanol (MOPET) was determined by HPLC with electrochemical detection. Under resting conditions, the outflow of metabo...

journal_title：Journal of neurochemistry

authors： Racké K,Muscholl E

更新日期：1986-03-01 00:00:00

abstract：:This study focuses on the potential involvement of carnitine palmitoyltransferase (CPT) on the phospholipid and triglyceride fatty acid turnover in neurons. This category of enzymes, which has been identified in several rat brain tissues, is well known for its role in modulating cellular fatty acid oxidation. Neuronal...

journal_title：Journal of neurochemistry

authors： Arduini A,Denisova N,Virmani A,Avrova N,Federici G,Arrigoni-Martelli E

更新日期：1994-04-01 00:00:00

abstract：:Alzheimer's disease is characterized neuropathologically by the presence of neuritic and amyloid plaques, vascular amyloid, and neurofibrillary tangles in specific brain areas. The main constituent of amyloid deposits is amyloid beta protein, a 40-42 amino acid proteolytic product of the amyloid beta-precursor protein...

journal_title：Journal of neurochemistry

authors： Conn KJ,Pietropaolo M,Ju ST,Abraham CR

更新日期：1996-05-01 00:00:00

abstract：:Calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) was measured in selected regions of the cervical, thoracic, and lumbar spinal cord of untreated rabbits and, following intrathecal injection of the serotonergic neurotoxin 5,7-dihydroxytryptamine (5,7-DHT), in the thoracolumbar cord in rats using a sheep ...

journal_title：Journal of neurochemistry

authors： Fone KC

更新日期：1992-10-01 00:00:00

abstract：:The presynaptic terminals of skate (Raja montagui) electric organ were tested for their sensitivity to calcium channel antagonists. Acetylcholine (ACh) release and the elevation of intraterminal Ca2+ concentrations triggered by K+ depolarisation were studied. ACh release was measured as 3H efflux from slices of organ ...

journal_title：Journal of neurochemistry

authors： Richardson CM,Dowdall MJ,Green AC,Bowman D

更新日期：1995-02-01 00:00:00

abstract：:We previously identified a nuclear envelope protein repressor element-1 silencing transcription factor (REST)/neuron-restrictive silencer factor (NRSF)-interacting Lin-11, Isl-1 and Mec-3 (LIM) domain protein (RILP) that we proposed functions in the nuclear translocation of the transcriptional repressor REST/NRSF. In ...

journal_title：Journal of neurochemistry

authors： Shimojo M,Hersh LB

更新日期：2006-02-01 00:00:00

abstract：:The glial glutamate transporter EAAT2 (excitatory amino acid transporter 2) is the major mediator of glutamate clearance that terminates glutamate-mediated neurotransmission. Loss of EAAT2 and associated glutamate uptake function has been reported in the brains of patients with Alzheimer's disease (AD). We previously ...

journal_title：Journal of neurochemistry

authors： Tian G,Kong Q,Lai L,Ray-Chaudhury A,Lin CL

更新日期：2010-05-01 00:00:00

abstract：:Cerebral cortex tissue was obtained at autopsy from neonatal Poll Hereford calves with clinically confirmed maple syrup urine disease (MSUD), neonatal Holstein-Friesian calves with clinically confirmed citrullinemia, and matched controls. From this, synaptosomes were prepared for studies of neurotransmitter amino acid...

journal_title：Journal of neurochemistry

authors： Dodd PR,Williams SH,Gundlach AL,Harper PA,Healy PJ,Dennis JA,Johnston GA

更新日期：1992-08-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common neurodegenerative disorder and is, on a histopathological level, characterized by the presence of extracellular amyloid plaques composed of the protein fragment Aβ, and intracellular neurofibrillary tangles, which contain the microtubule-associated protein tau in a hyperphos...

journal_title：Journal of neurochemistry

authors： Brandt R,Bakota L

更新日期：2017-11-01 00:00:00

abstract：:Superfusion of striatal slices with a medium deficient in Ca2+ and Mg2+ caused a large and sustained increase in release of lactate dehydrogenase, a finding indicative of the disruption of plasma membranes. This was associated with an efflux of dopamine (DA) and the depletion of DA from the tissue. In addition, wherea...

journal_title：Journal of neurochemistry

authors： Lonart G,Zigmond MJ

更新日期：1991-04-01 00:00:00

abstract：:Phospholipase C gamma 1 (PLC-gamma 1) is involved at an early step in signal transduction of many hormones and growth factors and catalyzes the hydrolysis of phosphatidylinositol (PI) 4,5-bisphosphate to diacylglycerol and inositol trisphosphate, two potent intracellular second messenger molecules. The transformation ...

journal_title：Journal of neurochemistry

authors： Widmer HR,Kaplan DR,Rabin SJ,Beck KD,Hefti F,Knüsel B

更新日期：1993-06-01 00:00:00

abstract：:Neurodegenerative diseases are a worldwide health problem and are a major cause of death and disability. A progressive loss of defined neuronal populations is triggered by a diverse array of stimuli that converge in deficient neurotrophic signaling. Therefore, much effort has been placed in recent years in the charact...

journal_title：Journal of neurochemistry

authors： Hernández-Kelly LC,Ortega A

更新日期：2020-10-19 00:00:00

abstract：:JNK/SAPK has been implicated in the pathogenesis of Alzheimer's disease, but the upstream cascade leading to JNK/SAPK activation has not been elucidated in the disease. In this study, we focused on one of the physiological activators of JNK/SAPK, JNK kinase 1 (JKK1). Although there was no significant difference in the...

journal_title：Journal of neurochemistry

authors： Zhu X,Ogawa O,Wang Y,Perry G,Smith MA

更新日期：2003-04-01 00:00:00