Abstract：
:In the early postnatal period, energy metabolism in the suckling rodent brain relies to a large extent on metabolic pathways alternate to glucose such as the utilization of ketone bodies (KBs). However, how KBs affect neuronal excitability is not known. Using recordings of single NMDA and GABA-activated channels in neocortical pyramidal cells we studied the effects of KBs on the resting membrane potential (E(m)) and reversal potential of GABA-induced anionic currents (E(GABA)), respectively. We show that during postnatal development (P3-P19) if neocortical brain slices are adequately supplied with KBs, E(m) and E(GABA) are both maintained at negative levels of about -83 and -80 mV, respectively. Conversely, a KB deficiency causes a significant depolarization of both E(m) (>5 mV) and E(GABA) (>15 mV). The KB-mediated shift in E(GABA) is largely determined by the interaction of the NKCC1 cotransporter and Cl(-)/HCO3 transporter(s). Therefore, by inducing a hyperpolarizing shift in E(m) and modulating GABA signaling mode, KBs can efficiently control the excitability of neonatal cortical neurons.
journal_name
J Neurochemjournal_title
Journal of neurochemistryauthors
Rheims S,Holmgren CD,Chazal G,Mulder J,Harkany T,Zilberter T,Zilberter Ydoi
10.1111/j.1471-4159.2009.06230.xsubject
Has Abstractpub_date
2009-08-01 00:00:00pages
1330-8issue
4eissn
0022-3042issn
1471-4159pii
JNC6230journal_volume
110pub_type
杂志文章abstract：:The regional and developmental expression of NMDA receptors containing the NR2D subunit was analyzed on the level of the subunit mRNA and protein in rat brain. RNase protection experiments indicated that among two proposed splice variants of the NR2D subunit, only the NR2D-2 subunit is expressed. The regional distribu...
journal_title：Journal of neurochemistry
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doi：10.1111/j.1471-4159.1982.tb08637.x
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pub_type： 杂志文章
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更新日期：1988-08-01 00:00:00
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journal_title：Journal of neurochemistry
pub_type： 杂志文章
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journal_title：Journal of neurochemistry
pub_type： 杂志文章
doi：10.1046/j.1471-4159.1995.64052256.x
更新日期：1995-05-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2007-02-01 00:00:00
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更新日期：2014-07-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Journal of neurochemistry
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journal_title：Journal of neurochemistry
pub_type： 杂志文章
doi：10.1046/j.1471-4159.1995.64041819.x
更新日期：1995-04-01 00:00:00
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更新日期：1989-10-01 00:00:00
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journal_title：Journal of neurochemistry
pub_type： 杂志文章
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更新日期：1996-10-01 00:00:00
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journal_title：Journal of neurochemistry
pub_type： 杂志文章
doi：10.1111/jnc.12666
更新日期：2014-05-01 00:00:00
