Stimulation of the serotonin autoreceptor prevents the calcium-calmodulin-dependent increase of serotonin biosynthesis in rat raphe slices.

abstract：:The P2Y11 nucleotide receptor detects high extracellular ATP concentrations. Mutations of the human P2RY11 gene can play a role in brain autoimmune responses, and the P2Y11 receptor alanine-87-threonine (A87T) polymorphism has been suggested to affect immune-system functions. We investigated receptor functionality of ...

journal_title：Journal of neurochemistry

authors： Haas M,Shaaban A,Reiser G

更新日期：2014-05-01 00:00:00

abstract：:Major depressive disorder is a severe and chronic illness with high lifetime prevalence and a high incidence of suicide as the cause of death for patients with this diagnosis. Major depressive disorder is often treated with anti-depressants. Although these drugs have been used for many years, their exact mode of actio...

journal_title：Journal of neurochemistry

authors： Gulbins E,Walter S,Becker KA,Halmer R,Liu Y,Reichel M,Edwards MJ,Müller CP,Fassbender K,Kornhuber J

更新日期：2015-07-01 00:00:00

abstract：:The metabolic pathway of inositol phospholipids represents a series of synthetic and hydrolytic reactions with inositol as a by-product. Hence, the rate of [3H]inositol release from prelabeled phospholipids can be used as a reflection of activity of this pathway. In the frog sympathetic ganglion prelabeled with [3H]in...

journal_title：Journal of neurochemistry

authors： Rubio R,Bencherif M,Berne RM

更新日期：1989-03-01 00:00:00

abstract：:Adenosine A(1) receptors (A(1)Rs) have been characterized in primary cultures of neurons from cerebral cortex. The specific adenosine A(1) antagonist 8-cyclopentyl-1,3-[(3)H]dipropylxanthine bound to both membranes and intact cells. When saturation experiments were performed in membranes, a K(D) value of 0.76 nM and a...

journal_title：Journal of neurochemistry

authors： Ruiz MA,Escriche M,Lluis C,Franco R,Martín M,Andrés A,Ros M

更新日期：2000-08-01 00:00:00

abstract：:Optimal neuronal activity requires that supporting cells provide both efficient nutrient delivery and waste disposal. The incomplete processing of engulfed waste by their lysosomes can lead to accumulation of residual material and compromise their support of neurons. As most degradative lysosomal enzymes function best...

journal_title：Journal of neurochemistry

authors： Guha S,Baltazar GC,Tu LA,Liu J,Lim JC,Lu W,Argall A,Boesze-Battaglia K,Laties AM,Mitchell CH

更新日期：2012-08-01 00:00:00

abstract：:Mutations in Parkin, an E3 ligase, which participates in the ubiquitin-proteasome system (UPS), cause juvenile onset Parkinson's disease (PD). Some mutants aggregate upon over-expression, but the effects of such aggregation on the UPS and neuronal survival have not been characterized. We show in this study that transi...

journal_title：Journal of neurochemistry

authors： Kyratzi E,Pavlaki M,Kontostavlaki D,Rideout HJ,Stefanis L

更新日期：2007-08-01 00:00:00

abstract：:The role of the glutamate dehydrogenase reaction as a pathway of glutamate synthesis was studied by incubating synaptosomes with 5 mM 15NH4Cl and then utilizing gas chromatography-mass spectrometry to measure isotopic enrichment in glutamate and aspartate. The rate of formation of [15N]glutamate and [15N]aspartate fro...

journal_title：Journal of neurochemistry

authors： Yudkoff M,Nissim I,Nelson D,Lin ZP,Erecińska M

更新日期：1991-07-01 00:00:00

abstract：:Chronic exposure to manganese (Mn) can cause manganism, a neurodegenerative disorder similar to Parkinson's disease. The toxicity of Mn includes impairment of astrocytic glutamate transporters. 17beta-Estradiol (E2) has been shown to be neuroprotective in various neurodegenerative diseases including Parkinson's diseas...

journal_title：Journal of neurochemistry

authors： Lee ES,Sidoryk M,Jiang H,Yin Z,Aschner M

更新日期：2009-07-01 00:00:00

abstract：:Changes in cellular energetic and metabolic parameters were analyzed at several time points during apoptosis of differentiated PC12 cells following removal of nerve growth factor (NGF). As approximately 60% of the population died during the period of study (24 h), most of the measured metabolic indicators declined ove...

journal_title：Journal of neurochemistry

authors： Mills JC,Nelson D,Erecińska M,Pittman RN

更新日期：1995-10-01 00:00:00

abstract：:The expression and distribution of mRNA encoding preproatrial natriuretic peptide (ppANP) in rat brain has been investigated by in situ hybridization of two 35S-labeled synthetic DNA oligonucleotides, based on a cDNA clone sequence that encodes rat ppANP. The highest relative concentrations of ppANP mRNA were detected...

journal_title：Journal of neurochemistry

authors： Gundlach AL,Knobe KE

更新日期：1992-08-01 00:00:00

abstract：:For more than three decades, the venom of the black widow spider and its principal active components, latrotoxins, have been used to induce release of neurotransmitters and hormones and to study the mechanisms of exocytosis. Given the complex nature of alpha--latrotoxin (alpha-LTX) actions, this research has been cont...

journal_title：Journal of neurochemistry

authors： Silva JP,Suckling J,Ushkaryov Y

更新日期：2009-10-01 00:00:00

abstract：:The effects of phorbol esters were investigated on the survival of chick sympathetic neurons in a serum-free culture medium. The protein kinase C activator phorbol 12,13-dibutyrate (PDB) supported about 40% of the plated sympathetic neurons. This number was comparable to that supported by nerve growth factor (NGF). A ...

journal_title：Journal of neurochemistry

authors： Wakade AR,Wakade TD,Malhotra RK,Bhave SV

更新日期：1988-09-01 00:00:00

abstract：:The natural vitamin E tocotrienols possess properties not shared by tocopherols. Nanomolar alpha-tocotrienol, not alpha-tocopherol, is potently neuroprotective. On a concentration basis, this finding represents the most potent of all biological functions exhibited by any natural vitamin E molecule. We sought to dissec...

journal_title：Journal of neurochemistry

authors： Khanna S,Roy S,Parinandi NL,Maurer M,Sen CK

更新日期：2006-09-01 00:00:00

abstract：:Neurofilament (NF) proteins are distributed in a diminishing proximodistal gradient along rat sciatic nerve when compared with total noncollagen or other proteins in nerve. About a twofold decline of NF proteins can be detected by quantitating nerve proteins that have been separated by gel electrophoresis. A similar d...

journal_title：Journal of neurochemistry

authors： Schlaepfer WW,Bruce J

更新日期：1990-08-01 00:00:00

abstract：:Intrastriatal microdialysis was used to administer muscarinic drugs in freely moving rats for 40 min at a flow rate of 2 microl/min. Administration of the nonselective agonist pilocarpine at 10 mM increased striatal dopamine release and decreased extracellular GABA and glutamate overflow. Perfusion with the muscarinic...

journal_title：Journal of neurochemistry

authors： Smolders I,Bogaert L,Ebinger G,Michotte Y

更新日期：1997-05-01 00:00:00

abstract：:After intraperitoneal injection of rats with 6-fluorotryptophan (6-FT), brain 5-hydroxytryptamine (5-HT) levels decreased exponentially over 1 h. Depletion was dose-dependent and maximum depletion was observed at 200 mg/kg. 6-FT (200 mg/kg) did not significantly alter the content of 5-hydroxyindoleacetic acid. Turnove...

journal_title：Journal of neurochemistry

authors： Miwa S,Fujiwara M,Lee K,Fujiwara M

更新日期：1987-05-01 00:00:00

abstract：:The neuronal protein B-50 may be involved in diverse functions including neural development, axonal regeneration, neural plasticity, and synaptic transmission. The rat B-50 sequence contains 226 amino acids which include 14 Ser and 14 Thr residues, all putative sites for phosphorylation by calcium/phospholipid-depende...

journal_title：Journal of neurochemistry

authors： Coggins PJ,Zwiers H

更新日期：1989-12-01 00:00:00

abstract：:Astrocytes can either exacerbate or ameliorate secondary degeneration at sites of injury in the CNS but the contextual basis for eliciting these opposing phenotypes is poorly understood. In this study, we demonstrate that the two major cytokines produced by Th1 and Th2 cells, interferon-gamma (IFN-gamma), and interleu...

journal_title：Journal of neurochemistry

authors： Garg SK,Kipnis J,Banerjee R

更新日期：2009-03-01 00:00:00

abstract：:The consequences of H(2)O(2)/Fe(2+)-induced oxidative stress on translocation of ethanolamine phosphoglyceride (EPG) and serine phosphoglyceride (SPG) were studied in an oligodendroglia-like cell line (OLN 93) following 3 days of supplementation with 0.1 mM docosahexaenoic acid (DHA) and a series of polar head group p...

journal_title：Journal of neurochemistry

authors： Brand A,Yavin E

更新日期：2001-09-01 00:00:00

abstract：:CNS synapses are produced rapidly upon pre- and post-synaptic recruitment. However, their composition is known to change during development and we reasoned that this may be reflected in the gross biochemical properties of synapses. We found synaptic structure in adult cortical synaptosomes to be resistant to digestion...

journal_title：Journal of neurochemistry

authors： Khaing ZZ,Fidler L,Nandy N,Phillips GR

更新日期：2006-07-01 00:00:00

abstract：:The effect of hydrocephalus on cerebral energy metabolites and on intermediates of membrane phospholipid metabolism has been studied in H-Tx rats with inherited infantile hydrocephalus. Hydrocephalic rats and rats with shunts placed at 4-5 days or at 10 days after birth were subjected to magnetic resonance imaging in ...

journal_title：Journal of neurochemistry

authors： Harris NG,Plant HD,Briggs RW,Jones HC

更新日期：1996-11-01 00:00:00

abstract：:The cleavage-product of amyloid precursor protein (APP) constitutes the core component of plaques found in the brains of Alzheimer's disease (AD) patients. APP is ubiquitously expressed and its precise physiological functions remain unclear. This protein has been proposed to regulate synaptic function and processes un...

journal_title：Journal of neurochemistry

authors： Senechal Y,Kelly PH,Cryan JF,Natt F,Dev KK

更新日期：2007-09-01 00:00:00

abstract：:The dopamine (DA) transporter (DAT) regulates DA neurotransmission by recycling DA back into neurons. Drugs that interfere with DAT function, e.g., cocaine and amphetamine, can have profound behavioral effects. The kinetics of DA transport by DAT in isolated synaptosomal or single cell preparations have been previousl...

journal_title：Journal of neurochemistry

authors： Jones SR,Joseph JD,Barak LS,Caron MG,Wightman RM

更新日期：1999-12-01 00:00:00

abstract：:The activities of the three major catecholamine-synthesizing enzymes were determined in brain tissue pellets dissected from 500-micrometers thick horizontal sections of rat lower brainstem. The rostrocaudal distributions of the three enzymatic activities were generally not parallel, suggesting differences in the respe...

journal_title：Journal of neurochemistry

authors： Chamba G,Denoroy L,Renaud B

更新日期：1982-08-01 00:00:00

abstract：:Primary cortical neurones exposed to an oxidative insult in the form of hydrogen peroxide (H(2)O(2)) for 30 min showed a concentration-dependent increase in oxidative stress followed by a delayed NMDA receptor-dependent cell death measured 24 h later. Extracellular signal-regulated protein kinase (ERK1/2), c-jun N-ter...

journal_title：Journal of neurochemistry

authors： Crossthwaite AJ,Hasan S,Williams RJ

更新日期：2002-01-01 00:00:00

abstract：:We have examined the metabolism of phosphate and sulfate groups modifying the P0 protein, the major protein of peripheral nervous system myelin, using an in vitro incubation system. Incorporation of [3H]leucine into the P0 peptide backbone decreased approximately 25-fold between 10 and 90 days of age, a finding reflec...

journal_title：Journal of neurochemistry

authors： Toews AD,Fischer HR,Goodrum JF,Windes S,Morell P

更新日期：1987-03-01 00:00:00

abstract：:The protein tyrosine kinase Src is known to regulate NMDA receptors in native neurons. While NR2A, NR2B and NR2D are known to be phosphorylated on tyrosine residues, the exact sites have remained unidentified. Immunoprecipitation of NMDA receptor subunits followed by western blotting was used to analyze the state of t...

journal_title：Journal of neurochemistry

authors： Yang M,Leonard JP

更新日期：2001-04-01 00:00:00

abstract：:Stimulation of glutamate binding by the dipeptide L-phenylalanyl-L-glutamate (Phe-Glu) was inhibited by the peptidase inhibitor bestatin, suggesting that the stimulation was caused by glutamate liberated from the dipeptide and not by the dipeptide itself. It further suggests that this form of glutamate binding should ...

journal_title：Journal of neurochemistry

authors： Kessler M,Petersen G,Vu HM,Baudry M,Lynch G

更新日期：1987-04-01 00:00:00

abstract：:We investigated the role of Ca(2+)-dependent protein kinases in the regulation of astrocytic cell volume. Calmodulin (CaM) antagonists were used to inhibit CaM and thus Ca2+/CaM-dependent protein kinase. The effect of these inhibitors as well as activators and inhibitors of protein kinase C (PKC) on astrocytic volume ...

journal_title：Journal of neurochemistry

authors： Bender AS,Neary JT,Blicharska J,Norenberg LO,Norenberg MD

更新日期：1992-05-01 00:00:00

abstract：:A glutamate binding protein was purified from bovine brain to apparent homogeneity. The procedure used for the purification of this protein involved extraction of a crude synaptic membrane fraction with Na-cholate, followed by solubilization of the binding protein from the membranes by Triton X-100, and, finally, affi...

journal_title：Journal of neurochemistry

authors： Michaelis EK,Chittenden WL,Johnson BE,Galton N,Decedue C

更新日期：1984-02-01 00:00:00