Amyloid precursor protein knockdown by siRNA impairs spontaneous alternation in adult mice.

abstract：:In this study, we have investigated the effect of mivazerol, [3-(1H-imidazol-4-yl)methyl-1]-2-hydroxy-benzamide hydrochloride, a new alpha2-agonist lacking hypotensive properties and a potential anti-ischemic drug, on the evoked release of norepinephrine, aspartate, and glutamate in tissue preparations from hippocampu...

journal_title：Journal of neurochemistry

authors： El Tamer A,Prokopenko I,Wülfert E,Hanin I

更新日期：1996-08-01 00:00:00

abstract：:Traumatic brain injury (TBI) results in significant inflammation which contributes to the evolving pathology. Previously, we have demonstrated that cyclic AMP (cAMP), a molecule involved in inflammation, is down-regulated after TBI. To determine the mechanism by which cAMP is down-regulated after TBI, we determined wh...

journal_title：Journal of neurochemistry

authors： Oliva AA Jr,Kang Y,Furones C,Alonso OF,Bruno O,Dietrich WD,Atkins CM

更新日期：2012-12-01 00:00:00

abstract：:A significant comorbidity exists between alcohol and methamphetamine (Meth) abuse but the neurochemical consequences of this co-abuse are unknown. Alcohol and Meth independently and differentially affect glutamatergic transmission but the unique effects of their serial exposure on glutamate signaling in mediating dama...

journal_title：Journal of neurochemistry

authors： Blaker AL,Moore ER,Yamamoto BK

更新日期：2019-12-01 00:00:00

abstract：:The simple, freshwater polyp Hydra is often used as a model to study development in cnidarians. Recently, a neuropeptide, < Glu-Gln-Pro-Gly-Leu-Trp-NH2, has been isolated from sea anemones that induces metamorphosis in a hydroid planula larva to become a polyp. Here, we have cloned a preprohormone from Hydra magnipapi...

journal_title：Journal of neurochemistry

authors： Leviev I,Williamson M,Grimmelikhuijzen CJ

更新日期：1997-03-01 00:00:00

abstract：:To assess maturation of central serotonin and catecholamine pathways at birth, we measured lumbar CSF homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA), stable acid metabolites of dopamine and serotonin, using HPLC with electrochemical detection. CSFs from 57 neonates (38 premature and 19 at term) and 13...

journal_title：Journal of neurochemistry

authors： Silverstein FS,Donn S,Buchanan K,Johnston MV

更新日期：1984-12-01 00:00:00

abstract：:We examined changes in biosynthetic capacity of sciatic nerve during the early stages of Wallerian degeneration, utilizing a model that permits exclusion of nonresident cells from degenerating nerve. Sciatic nerve segments were placed in either 5-microns pore (allowing infiltration of nonresident cells) or 0.22-micron...

journal_title：Journal of neurochemistry

authors： White FV,Toews AD,Goodrum JF,Novicki DL,Bouldin TW,Morell P

更新日期：1989-04-01 00:00:00

abstract：:Glutamate receptors belonging to the subclass specifically activated by alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) were solubilized from rat forebrain membranes with Triton X-100 and partially purified through a series of three chromatographic steps. Specific [3H]AMPA binding increased 30-60-fold ...

journal_title：Journal of neurochemistry

authors： Bahr BA,Vodyanoy V,Hall RA,Suppiramaniam V,Kessler M,Sumikawa K,Lynch G

更新日期：1992-11-01 00:00:00

abstract：:Choline acetyltransferase (acetyl-CoA: choline O-acetyltransferase, I.U.B. 2.3.1.6) activity and total protein content in visual and extra-visual areas were compared in normal Long-Evans rats and in rats subjected to complete light-deprivation for 21 days from birth. The enzyme activity and the protein content in the ...

journal_title：Journal of neurochemistry

authors： Maletta GJ,Timiras PS

更新日期：1968-08-01 00:00:00

abstract：:Clearance rates for serotonin (5-HT) in heterozygote (+/-) and homozygote (-/-) serotonin transporter (5-HTT) knockout (KO) mice have not been determined in vivo. Moreover, the effect of selective serotonin reuptake inhibitors (SSRIs) on 5-HT clearance in these mice has not been examined. In this study, the rate of cl...

journal_title：Journal of neurochemistry

authors： Montañez S,Owens WA,Gould GG,Murphy DL,Daws LC

更新日期：2003-07-01 00:00:00

abstract：:The elongation of arachidoyl-CoA (20:0-CoA) yielded 22:0 and 24:0 concomitantly, whereas the elongation of behenoyl-CoA (22:0-CoA) yielded only a negligible amount of 24:0 in adult swine cerebral microsomes. The dependence on time, pH, and the substrate concentrations were examined for the synthesis of 22:0 and 24:0 f...

journal_title：Journal of neurochemistry

authors： Yoshida S,Takeshita M

更新日期：1986-05-01 00:00:00

abstract：:Monoclonal antibody BM88 recognizes a neurospecific surface antigen in the CNS and the PNS. In the present study, the antigen recognized by BM88 was immunopurified from pig brain and shown to be a 22-kDa polypeptide by reducing sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Under nonreducing conditions a p...

journal_title：Journal of neurochemistry

authors： Patsavoudi E,Hurel C,Matsas R

更新日期：1991-03-01 00:00:00

abstract：:The membrane-bound or solubilized melatonin receptors were treated with protein-modifying agents under specific conditions and then assayed for 125I-melatonin binding in order to obtain information on amino acids present in the ligand binding domain. The reagents specific for sulfhydryl (N-ethylmaleimide and p-chlorom...

journal_title：Journal of neurochemistry

authors： Kosar E,Teisinger J,Vyskocil F,Vanĕcek J

更新日期：1994-08-01 00:00:00

abstract：:The effects of acute and chronic administration of a subconvulsive dose of picrotoxin on t-[35S]butylbicyclophosphorothionate ([3S]TBPS), [3H]muscimol, and [3H]flunitrazepam binding characteristics in various regions and on the convulsant potency of picrotoxin in Sprague-Dawley rats were examined. Acute administration...

journal_title：Journal of neurochemistry

authors： Ito Y,Lim DK,Nabeshima T,Ho IK

更新日期：1989-04-01 00:00:00

abstract：:Using antiphosphotyrosine antibodies, we have investigated protein phosphorylation in mouse brain during development in intact animals and in reaggregated cerebral cultures. Under basal conditions, in vivo and in vitro, the levels of two main phosphoproteins, of Mr 120,000 and 180,000 (pp180), increased with developme...

journal_title：Journal of neurochemistry

authors： Girault JA,Chamak B,Bertuzzi G,Tixier H,Wang JK,Pang DT,Greengard P

更新日期：1992-02-01 00:00:00

abstract：:In the presence of somatostatin-14 or some of its receptorial agonists, the uptake of large neutral amino acids by isolated brain microvessels was found to be inhibited up to 50%, no other transport system being affected. Although the luminal and abluminal sides of brain endothelial cells are both capable of taking up...

journal_title：Journal of neurochemistry

authors： Cardelli P,Fiori A,Corleto VD,Savi MR,Granata F,Ceci F,Ferraguti G,Potenza RL,Delle Fave G,Jensen RT,Strom R

更新日期：2001-07-01 00:00:00

abstract：:Administration of kainate or pentylenetetrazole increased c-fos, c-jun, junB, and junD mRNA levels in rat brain in a dose-dependent manner. Kainate increased these mRNA levels predominantly in the hippocampus, and pentylenetetrazole was more effective in the cortex. Adrenalectomy (3 days) was used to eliminate endogen...

journal_title：Journal of neurochemistry

authors： Li X,Song L,Kolasa K,Jope RS

更新日期：1992-06-01 00:00:00

abstract：:Early onset familial Alzheimer's disease (FAD) is linked to autosomal dominant mutations in the amyloid precursor protein (APP) and presenilin 1 and 2 (PS1 and PS2) genes. These are critical mediators of total amyloid beta-peptide (Abeta) production, inducing cell death through uncertain mechanisms. Tauroursodeoxychol...

journal_title：Journal of neurochemistry

authors： Ramalho RM,Borralho PM,Castro RE,Solá S,Steer CJ,Rodrigues CM

更新日期：2006-09-01 00:00:00

abstract：:Adult rat cerebral cortex slices when incubated in media in increasing K+ concentrations, from 3 to 20 mM ("physiological" conditions), exhibited an increase of Ki+ and a decrease of Nai+ and Cli-. This phenomenon appeared at 30 days postnatally, which is fairly late during development. Over 20 mM-K+ ("pathological" c...

journal_title：Journal of neurochemistry

authors： Grisar T,Franck G

更新日期：1981-05-01 00:00:00

abstract：:Using a chemical-induced model of dentate granule (DG) cell death, cDNA microarray analysis was used to identify gene profiles from the laser-captured microdissected (LCM) hippocampal DG cell region versus the CA pyramidal cell layer (CA) from 21-day-old male CD1 mice injected with trimethyltin hydroxide (TMT; 3.0 mg/...

journal_title：Journal of neurochemistry

authors： Lefebvre d'Hellencourt C,Harry GJ

更新日期：2005-04-01 00:00:00

abstract：:(-)-[3H]Nicotine was found to bind specifically to membranes of human brains obtained at autopsy. The binding was stereospecific, (-)-nicotine being 40 times more potent than (+)-nicotine in displacing labeled (-)-nicotine. Saturation binding studies revealed the presence of two binding sites with dissociation constan...

journal_title：Journal of neurochemistry

authors： Shimohama S,Taniguchi T,Fujiwara M,Kameyama M

更新日期：1985-08-01 00:00:00

abstract：:Cultures of bovine adrenomedullary chromaffin cells accumulated 1-[methyl-3H]methyl-4-phenylpyridinium ([3H]MPP+) in a time- and concentration-dependent manner with an apparent Km of 0.7 microM and a Vmax of 3 pmol/min/10(6) cells. The uptake was sodium dependent and sensitive to inhibitors of the cell-surface catecho...

journal_title：Journal of neurochemistry

authors： Reinhard JF Jr,Diliberto EJ Jr,Daniels AJ

更新日期：1989-04-01 00:00:00

abstract：:Ischemia-induced changes in 31P NMR relaxation were examined in 16 piglets. NMR spectra were acquired under control conditions and during complete cerebral ischemia induced via cardiac arrest. Changes in T1 were assessed directly in six animals during control conditions and after 30-45 min of complete ischemia when ch...

journal_title：Journal of neurochemistry

authors： Corbett RJ,Laptook AR

更新日期：1993-07-01 00:00:00

abstract：:The recycling of synaptic vesicle (SV) proteins and transmitter release occur at multiple sites along the axon. These processes are sensitive to inhibition of the small GTP binding protein ARF1, which regulates the adaptor protein 1 and 3 complex (AP-1/AP-3). As the axon matures, SV recycling becomes restricted to the...

journal_title：Journal of neurochemistry

authors： Rampérez A,Sánchez-Prieto J,Torres M

更新日期：2017-06-01 00:00:00

abstract：:Both trafficking and secretion critically depend on accurate and specific membrane recognition and fusion. A key step in these processes is the assembly of a complex consisting of a small number of proteins, i.e., the exocytic core complex. In nerve terminals, this set consists of VAMP and synaptotagmin, which reside ...

journal_title：Journal of neurochemistry

authors： Linial M

更新日期：1997-11-01 00:00:00

abstract：:This study presents the initial characterization of transgenic mice with mutations in a primary zinc-binding residue (H80), either alone or with a G93A mutation. H80G;G93A superoxide dismutase 1 (SOD1) transgenic mice developed paralysis with motor neuron loss, and ubiquitin inclusion-type rather than mitochondrial va...

journal_title：Journal of neurochemistry

authors： Son M,Srikanth U,Puttaparthi K,Luther C,Elliott JL

更新日期：2011-09-01 00:00:00

abstract：:cDNAs have been cloned that encode the chicken (Gallus domesticus) gamma-aminobutyric acidA receptor gamma 1 subunit, the mature sequence of which shares 90, 79, and 69% identity with those of the rat gamma 1, gamma 2, and gamma 3 subunits, respectively. In situ hybridization reveals that there are pronounced differen...

journal_title：Journal of neurochemistry

authors： Glencorse TA,Darlison MG,Barnard EA,Bateson AN

更新日期：1993-12-01 00:00:00

abstract：:The effects of acute and chronic administration of buspirone, a serotonin 5-HT1A agonist, on the 5-HT synthesis rates in various rat brain structures were investigated using alpha-[14C]methyl-L-tryptophan (alpha-[14C]MTrp) and an autoradiographic method. In the acute treatment study, buspirone (10 mg/kg) was injected ...

journal_title：Journal of neurochemistry

authors： Okazawa H,Yamane F,Blier P,Diksic M

更新日期：1999-05-01 00:00:00

abstract：:The oxidation of differentially labelled glucose, pyruvate and glutamate in brain slices from rats aged 20 days to 26 months has been studied and the partition of the glucose used into the glycolytic-tricarboxylic acid cycle pathway, the pentose phosphate pathway and the glutamate-GABA shunt has been calculated. Over ...

journal_title：Journal of neurochemistry

authors： Zubairu S,Hothersall JS,El-Hassan A,McLean P,Greenbaum AL

更新日期：1983-07-01 00:00:00

abstract：:Unilateral frontal cortex ablations were performed in rats so that the glutamate terminals in the ipsilateral rostral neostriatum were removed. At 1 or 7 days later, intraperitoneal injections of ammonium acetate induced different changes in amino acid concentrations in the intact and deafferentated neostriatum. After...

journal_title：Journal of neurochemistry

authors： Engelsen BA,Fosse VM,Fonnum F

更新日期：1987-03-01 00:00:00

abstract：:Antibodies raised against the synthetic peptide NH2-QKSDDDYEDYASNKTC-COOH (gamma 2 1-15 Cys), which corresponds to the N-terminal amino acid sequence with a C-terminal cysteine of the human gamma 2 subunit of the gamma-aminobutyric acidA (GABAA) receptor, were used to study the quantitative immunoprecipitation of agon...

journal_title：Journal of neurochemistry

authors： Duggan MJ,Pollard S,Stephenson FA

更新日期：1992-01-01 00:00:00