Effect of changing potassium ion concentrations on rat cerebral slices in vitro: a study during development.

abstract：:Tau is a microtubule-associated protein whose transcript undergoes complex regulated splicing in the mammalian nervous system. Exon 6 of the gene is an alternatively spliced cassette whose expression pattern and splicing regulation had not been previously analyzed in the human. The expression profile of exon 6 is comp...

journal_title：Journal of neurochemistry

authors： Wei ML,Andreadis A

更新日期：1998-04-01 00:00:00

abstract：:Using antiphosphotyrosine antibodies, we have investigated protein phosphorylation in mouse brain during development in intact animals and in reaggregated cerebral cultures. Under basal conditions, in vivo and in vitro, the levels of two main phosphoproteins, of Mr 120,000 and 180,000 (pp180), increased with developme...

journal_title：Journal of neurochemistry

authors： Girault JA,Chamak B,Bertuzzi G,Tixier H,Wang JK,Pang DT,Greengard P

更新日期：1992-02-01 00:00:00

abstract：:Parkinson's disease (PD) is caused by neuronal cell death. Although a precursor of dopamine and inhibitors of dopamine degradation have been used for PD therapy, cell death progresses during treatment. DJ-1, a causative gene product of a familial form of PD, PARK7, plays roles in transcriptional regulation and anti-ox...

journal_title：Journal of neurochemistry

authors： Miyazaki S,Yanagida T,Nunome K,Ishikawa S,Inden M,Kitamura Y,Nakagawa S,Taira T,Hirota K,Niwa M,Iguchi-Ariga SM,Ariga H

更新日期：2008-06-01 00:00:00

abstract：:Sequences in the transcribed region of the c-fos gene have been suggested to control c-fos induction following exposure of cells to mitogens or stimuli that increase intracellular calcium concentrations. Using a mutational analysis we show that putative regulatory elements present in the first intron of the human c-fo...

journal_title：Journal of neurochemistry

authors： Lange CM,Bading H

更新日期：2001-06-01 00:00:00

abstract：:The characteristics of spiperone inhibition of [3H]5-hydroxytryptamine [(3H]5-HT; [3H]serotonin) binding were examined in dorsal (DH) and ventral (VH) hippocampus, corpus striatum (CS) or caudate nucleus (CN), and frontal cortex (FC) in the rabbit, guinea pig, and cat. Some of the properties of spiperone inhibition of...

journal_title：Journal of neurochemistry

authors： Schnellmann RG,Waters SJ,Nelson DL

更新日期：1984-01-01 00:00:00

abstract：:Receptors for the nerve growth factor protein (NGF) have been isolated from three cell types [embryonic chicken sensory neurons (dorsal root sensory ganglia; DRG), rat pheochromocytoma (PC12) and human neuroblastoma (LAN-1) cells] and have been shown to be similar with respect to equilibrium dissociation constants. Th...

journal_title：Journal of neurochemistry

authors： Stach RW,Lyons CR,Perez-Polo JR

更新日期：1987-10-01 00:00:00

abstract：:Dietary lipids modify brain fatty acid profile, but evidence of their direct effect on neuronal function is sparse. The enthorinal cortex (EC) neurons connecting to the hippocampus play a critical role in learning and memory. Here, we have exposed mice to diets based on canola:soybean oils (40 : 10, g/kg) or safflower...

journal_title：Journal of neurochemistry

authors： Arsenault D,Julien C,Chen CT,Bazinet RP,Calon F

更新日期：2012-07-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor activated by dioxin and polyaromatic hydrocarbons. Recent studies have revealed that AhR activity in central neurons depends on the NMDA receptor. In this study, we investigated how the neuronal activity influence AhR-mediated dioxin-respon...

journal_title：Journal of neurochemistry

authors： Lin CH,Juan SH,Wang CY,Sun YY,Chou CM,Chang SF,Hu SY,Lee WS,Lee YH

更新日期：2008-03-01 00:00:00

abstract：:Ketimine reductase (E.C. 1.5.1.25) was purified to apparent homogeneity from lamb forebrain by means of a rapid multi-step chromatography protocol. The purified enzyme was identified by MS/MS (mass spectrometry) as μ-crystallin. The identity was confirmed by heterologously expressing human μ-crystallin in Escherichia ...

journal_title：Journal of neurochemistry

authors： Hallen A,Cooper AJ,Jamie JF,Haynes PA,Willows RD

更新日期：2011-08-01 00:00:00

abstract：:In a study employing mouse brain synaptosomes and synaptosomal sonicates, the complete metabolic machinery was found to be present for transport of arginine into synaptosomes, its conversion to ornithine, and the formation from the latter of glutamic acid, gamma-aminobutyric acid, and proline. The results show that a ...

journal_title：Journal of neurochemistry

authors： Johnson JL,Roberts E

更新日期：1984-04-01 00:00:00

abstract：:We demonstrated that glutamate increased the cyclic AMP level in cultured neurons from rat spinal cord. A bath application of glutamate (300 microM) elicited a rapid increase of the cyclic AMP concentration reaching a level three times as high as the basal level in approximately 3 min, and its content then decreased t...

journal_title：Journal of neurochemistry

authors： Tsuji K,Nakamura Y,Ogata T,Shibata T,Kataoka K

更新日期：1995-10-01 00:00:00

abstract：:Previous studies have purified from brain a Ca2+/calmodulin-dependent protein kinase II (designated CaM-kinase II) that phosphorylates synapsin I, a synaptic vesicle-associated phosphoprotein. CaM-kinase II is composed of a major Mr 50K polypeptide and a minor Mr 60K polypeptide; both bind calmodulin and are phosphory...

journal_title：Journal of neurochemistry

authors： Shields SM,Vernon PJ,Kelly PT

更新日期：1984-12-01 00:00:00

abstract：:The biggest risk factor for Alzheimer's disease is the process of ageing, but the mechanisms that lead to the manifestation of the disease remain to be elucidated. Why age triggers the disease is unclear but an emerging theme is the inability for a cell to efficiently maintain many key processes such as energy product...

journal_title：Journal of neurochemistry

authors： Roberts BR,Ryan TM,Bush AI,Masters CL,Duce JA

更新日期：2012-01-01 00:00:00

abstract：:Rho kinase (ROCK) may play an important role in regulating biological events of cells, including proliferation, differentiation and survival/death. Blockade of ROCK promotes axonal regeneration and neuron survival in vivo and in vitro, thereby exhibiting potential clinical applications in spinal cord damage and stroke...

journal_title：Journal of neurochemistry

authors： Ding J,Li QY,Wang X,Sun CH,Lu CZ,Xiao BG

更新日期：2010-09-01 00:00:00

abstract：:We have shown previously that N-(4-hydroxyphenyl)retinamide (4HPR, fenretinide), a retinoic acid derivative, induces neuronal differentiation in cultured human retinal pigment epithelial (RPE) cells [Chen et al., J. Neurochem., 84 (2003), 972]. We asked the question whether the mitogen-activated protein kinase (MAPK) ...

journal_title：Journal of neurochemistry

authors： Samuel W,Kutty RK,Sekhar S,Vijayasarathy C,Wiggert B,Redmond TM

更新日期：2008-07-01 00:00:00

abstract：:Abstract The dualistic activities of the amyloid beta (Abeta) peptide as a pro-oxidant and ubiquitous constituent of amyloid deposits in Alzheimer's disease plaques and as an antioxidant of purported physiological function has been suggested but the mechanisms are far from being understood. In this report we measure s...

journal_title：Journal of neurochemistry

authors： Kuperstein F,Brand A,Yavin E

更新日期：2004-11-01 00:00:00

abstract：:Neuropeptide Y (NPY) and peptide YY (PYY) are related 36-amino acid peptides. NPY is widely distributed in the nervous system and has several physiological roles. PYY serves as an intestinal hormone as well as a neuropeptide. We report here cloning of the npy and pyy genes in zebrafish (Danio rerio). NPY differs at on...

journal_title：Journal of neurochemistry

authors： Söderberg C,Wraith A,Ringvall M,Yan YL,Postlethwait JH,Brodin L,Larhammar D

更新日期：2000-09-01 00:00:00

abstract：:Dopamine- and cAMP-regulated phosphoprotein (Mr 32 kDa, DARPP-32) is an integrator of multiple neuronal signals and plays a crucial role particularly in mediating the dopaminergic component of the systems involved in the evaluation of stimuli and the ensuing elaboration of complex behavioral responses (e.g., responses...

journal_title：Journal of neurochemistry

authors： Scheggi S,De Montis MG,Gambarana C

更新日期：2018-11-01 00:00:00

abstract：:Chick imprinting behavior is a good model for the study of learning and memory. Imprinting object is recognized and processed in the visual wulst, and the memory is stored in the intermediate medial mesopallium in the dorsal pallium of the telencephalon. We identified chicken cholecystokinin (CCK)-expressing cells loc...

journal_title：Journal of neurochemistry

authors： Maekawa F,Nakamori T,Uchimura M,Fujiwara K,Yada T,Tsukahara S,Kanamatsu T,Tanaka K,Ohki-Hamazaki H

更新日期：2007-09-01 00:00:00

abstract：:Five subtypes of the muscarinic receptor have been cloned from both the rat and human genomes. Although all five genes have the coding sequences in a single exon, their structures 5' of the initiation codon are largely uncharacterized, except for the M4 receptor. In the brain, muscarinic receptors mediate motor and me...

journal_title：Journal of neurochemistry

authors： Klett CP,Bonner TI

更新日期：1999-03-01 00:00:00

abstract：:beta-Arrestin 1-GFP or beta-arrestin 2-GFP were coexpressed transiently with G protein-coupled receptor kinase 2 within cells stably expressing the orexin-1, apelin or melanin-concentrating hormone (MCH), receptors. In response to agonist ligands both the orexin-1 and apelin receptors were able to rapidly translocate ...

journal_title：Journal of neurochemistry

authors： Evans NA,Groarke DA,Warrack J,Greenwood CJ,Dodgson K,Milligan G,Wilson S

更新日期：2001-04-01 00:00:00

abstract：:The translocation of intravenously administered tritiated 3-O-methyl-D-glucopyranose (3-OMG) into brain has been studied in an intact nephrectomized rat preparation by infusing a series of hexoses into one internal carotid artery. 3-OMG rapidly penetrated into brain with peak concentrations, attained 5-8 min after inj...

journal_title：Journal of neurochemistry

authors： Bidder TG

更新日期：1968-08-01 00:00:00

abstract：:A naturally occurring point mutation (R231H) within one of the major 3gamma-binding surface (switch II region) on the a subunit of Gs (alpha(s)) has previously been found to disrupt receptor-mediated activation of Gs. The disruption caused by mutating this conserved residue may be a general phenomenon for all a subuni...

journal_title：Journal of neurochemistry

authors： Ho MK,Yung LY,Wong YH

更新日期：1999-11-01 00:00:00

abstract：:Previous studies have suggested that protein kinase C is important in the regulation of angiotensin II receptors in neuronal cultures, because the C-kinase agonists, phorbol esters, are able to increase the number of these receptors. In the present study, we have further investigated the role of protein kinase C in an...

journal_title：Journal of neurochemistry

authors： Sumners C,Rueth SM,Myers LM,Kalberg CJ,Crews FT,Raizada MK

更新日期：1988-07-01 00:00:00

abstract：:Induction of the prodynorphin gene occurs in a tissue-specific manner following different physiological stimuli. Using electrophoretic mobility shift assays, we studied the relative activity of the five major regulatory sites in the rat prodynorphin promoter. Prodynorphin cyclic AMP-responsive element 2 (DynCRE2), Dyn...

journal_title：Journal of neurochemistry

authors： Carrión AM,Mellström B,Luckman SM,Naranjo JR

更新日期：1998-03-01 00:00:00

abstract：:Intracellular calcium ions regulate the structure and functions of cytoskeletal proteins. On the other hand, recent studies have shown that the cytoskeleton, and actin filaments in particular, can modulate calcium influx through plasma membrane ligand- and voltage-gated channels. We now report that calcium release fro...

journal_title：Journal of neurochemistry

authors： Wang Y,Mattson MP,Furukawa K

更新日期：2002-08-01 00:00:00

abstract：:Stimulation of glutamate binding by the dipeptide L-phenylalanyl-L-glutamate (Phe-Glu) was inhibited by the peptidase inhibitor bestatin, suggesting that the stimulation was caused by glutamate liberated from the dipeptide and not by the dipeptide itself. It further suggests that this form of glutamate binding should ...

journal_title：Journal of neurochemistry

authors： Kessler M,Petersen G,Vu HM,Baudry M,Lynch G

更新日期：1987-04-01 00:00:00

abstract：:During CNS injury and diseases, nitric oxide (NO) is released at a high flux rate leading to formation of peroxynitrite (ONOO(*)) and other reactive nitrogenous species, which nitrate tyrosines of proteins to form 3-nitrotyrosine (3NY), leading to cell death. Previously, we have found that motor neurons exposed to low...

journal_title：Journal of neurochemistry

authors： Bishop A,Gooch R,Eguchi A,Jeffrey S,Smallwood L,Anderson J,Estevez AG

更新日期：2009-04-01 00:00:00

abstract：:The effect of ascorbic acid on Ca2+ uptake in cultured rat astrocytes was examined in the presence of ouabain and monensin, which are considered to drive the Na(+)-Ca2+ exchanger in the reverse mode. Ascorbic acid at 0.1-1 mM inhibited Na(+)-dependent Ca2+ uptake significantly but not Na(+)-dependent glutamate uptake ...

journal_title：Journal of neurochemistry

authors： Takuma K,Matsuda T,Asano S,Baba A

更新日期：1995-04-01 00:00:00

abstract：:Larval zebrafish offers a good model to approach brain disease mechanisms, as structural abnormalities of their small brains can be correlated to quantifiable behavior. In this study, the structural alterations in one diencephalic dopaminergic nucleus induced by 1-methyl-4-phenylpyridinium (MPP+), a toxin inducing Par...

journal_title：Journal of neurochemistry

authors： Sallinen V,Torkko V,Sundvik M,Reenilä I,Khrustalyov D,Kaslin J,Panula P

更新日期：2009-02-01 00:00:00