Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42.

abstract：:The critical hyaluronan binding motif (HABM) in sialoprotein associated with cones and rods (SPACR) has already been determined. As sialoproteoglycan associated with cones and rods, another interphotoreceptor matrix molecule, binds to chondroitin sulfate and heparin with or without the employment of HABMs, respectivel...

journal_title：Journal of neurochemistry

authors： Zhao J,Yoneda M,Takeyama M,Inoue Y,Kataoka T,Ohno-Jinno A,Isogai Z,Iwaki M,Zako M

更新日期：2008-11-01 00:00:00

abstract：:The pentameric subunit composition of a large population (36%) of the cerebellar granule cell GABAA receptors that show diazepam (or clonazepam)-insensitive [3H]Ro 15-4513 binding has been determined by immunoprecipitation with subunit-specific antibodies. These receptors have alpha 6, alpha 1, gamma 2S, gamma 2L, and...

journal_title：Journal of neurochemistry

authors： Khan ZU,Gutierrez A,De Blas AL

更新日期：1994-07-01 00:00:00

abstract：:Although palmitoylation of the beta(2)-adrenergic receptor (beta(2)AR), as well as its phosphorylation by the cyclic AMP-dependant protein kinase (PKA) and the beta-adrenergic receptor kinase (beta ARK), are known to play important roles in agonist-promoted desensitization, their relative contribution and mutual regul...

journal_title：Journal of neurochemistry

authors： Moffett S,Rousseau G,Lagacé M,Bouvier M

更新日期：2001-01-01 00:00:00

abstract：:A central role of iron in the pathogenesis of Parkinson's disease (PD), due to its increase in substantia nigra pars compacta dopaminergic neurons and reactive microglia and its capacity to enhance production of toxic reactive oxygen radicals, has been discussed for many years. Recent transcranial ultrasound findings ...

journal_title：Journal of neurochemistry

authors： Berg D,Gerlach M,Youdim MB,Double KL,Zecca L,Riederer P,Becker G

更新日期：2001-10-01 00:00:00

abstract：:This paper describes a new, sensitive assay for dopamine-beta-hydroxylase (DBH) activity in human cerebrospinal fluid (CSF), serum and brain tissues by high performance liquid chromatography (HPLC) with electrochemical detection (ED). Dopamine (DA) was used as a substrate and was incubated under optimal conditions. No...

journal_title：Journal of neurochemistry

authors： Matsui H,Kato T,Yamamoto C,Fujita K,Nagatsu T

更新日期：1981-08-01 00:00:00

abstract：:Previously, we demonstrated that systemically injected extracellular domain of neuregulin-1β1 (Nrg1β1), a nerve growth and differentiation factor, passes the blood-brain barrier and rescues dopaminergic neurons of substantia nigra in the 6-hydroxydopamine-mouse model of Parkinson's disease (PD). Here, we studied the e...

journal_title：Journal of neurochemistry

authors： Depboylu C,Rösler TW,de Andrade A,Oertel WH,Höglinger GU

更新日期：2015-05-01 00:00:00

abstract：:Although alterations in serotonin levels and neurotransmission are associated with depressive disorders and effective antidepressant therapy, the exact cause of these disorders and the mode of action of antidepressant drugs are poorly understood. In a genetic rat model of depression [Flinders sensitive line (FSL) rats...

journal_title：Journal of neurochemistry

authors： Zangen A,Overstreet DH,Yadid G

更新日期：1997-12-01 00:00:00

abstract：:Previous work in this laboratory has shown that adrenal medullary transplants into the spinal cord subarachnoid space can reduce pain sensitivity. This analgesia most likely results from the release of neuroactive substances, particularly catecholamines and opioid peptides, from the transplanted cells into the CSF of ...

journal_title：Journal of neurochemistry

authors： Sagen J,Kemmler JE,Wang H

更新日期：1991-02-01 00:00:00

abstract：:Dopamine beta-hydroxylase (DBH; EC 1.14.17.1) exists as membrane-bound and soluble forms in neurosecretory vesicles. The features of DBH required for glycosylation and incorporation into membranes were studied in a cell-free system. Translation of full-length DBH with microsomal membranes generated two glycosylated pr...

journal_title：Journal of neurochemistry

authors： Feng Z,Sabban EL

更新日期：1995-01-01 00:00:00

abstract：:We have shown previously that N-(4-hydroxyphenyl)retinamide (4HPR, fenretinide), a retinoic acid derivative, induces neuronal differentiation in cultured human retinal pigment epithelial (RPE) cells [Chen et al., J. Neurochem., 84 (2003), 972]. We asked the question whether the mitogen-activated protein kinase (MAPK) ...

journal_title：Journal of neurochemistry

authors： Samuel W,Kutty RK,Sekhar S,Vijayasarathy C,Wiggert B,Redmond TM

更新日期：2008-07-01 00:00:00

abstract：:The RNA integrity number (RIN) is often considered to be a critical measure of the quality of postmortem human brains. However, it has been suggested that RINs do not necessarily reflect the availability of intact mRNA. Using the Agilent bioanalyzer and qRT-PCR, we explored whether RINs provide a meaningful way of ass...

journal_title：Journal of neurochemistry

authors： Sonntag KC,Tejada G,Subburaju S,Berretta S,Benes FM,Woo TU

更新日期：2016-07-01 00:00:00

abstract：:Adult rat cerebral cortex slices when incubated in media in increasing K+ concentrations, from 3 to 20 mM ("physiological" conditions), exhibited an increase of Ki+ and a decrease of Nai+ and Cli-. This phenomenon appeared at 30 days postnatally, which is fairly late during development. Over 20 mM-K+ ("pathological" c...

journal_title：Journal of neurochemistry

authors： Grisar T,Franck G

更新日期：1981-05-01 00:00:00

abstract：:We report the cloning, genome mapping, functional expression, pharmacology and anatomical distribution of three melanocortin (MC) receptors from zebrafish (z). Phylogenetic analysis showed with high bootstrap support that these genes represent one MC4 receptor and two MC5 receptors. Chromosomal mapping showed conserve...

journal_title：Journal of neurochemistry

authors： Ringholm A,Fredriksson R,Poliakova N,Yan YL,Postlethwait JH,Larhammar D,Schiöth HB

更新日期：2002-07-01 00:00:00

abstract：:Electrical stimulation of an ascending path of the locus ceruleus-norepinephrine system was used to elicit release of norepinephrine at noradrenergic terminal fields of the rat thalamus. Overflow into the extracellular fluid space was measured by fast in vivo chronoamperometry. At pretreated carbon fibers, the electro...

journal_title：Journal of neurochemistry

authors： Ghasemzadeh MB,Capella P,Mitchell K,Adams RN

更新日期：1993-02-01 00:00:00

abstract：:Five subtypes of the muscarinic receptor have been cloned from both the rat and human genomes. Although all five genes have the coding sequences in a single exon, their structures 5' of the initiation codon are largely uncharacterized, except for the M4 receptor. In the brain, muscarinic receptors mediate motor and me...

journal_title：Journal of neurochemistry

authors： Klett CP,Bonner TI

更新日期：1999-03-01 00:00:00

abstract：:The recycling of synaptic vesicle (SV) proteins and transmitter release occur at multiple sites along the axon. These processes are sensitive to inhibition of the small GTP binding protein ARF1, which regulates the adaptor protein 1 and 3 complex (AP-1/AP-3). As the axon matures, SV recycling becomes restricted to the...

journal_title：Journal of neurochemistry

authors： Rampérez A,Sánchez-Prieto J,Torres M

更新日期：2017-06-01 00:00:00

abstract：:Cysteine-string protein (Csp) is a major synaptic vesicle and secretory granule protein first discovered in Drosophila and Torpedo. Csps were subsequently identified from Xenopus, Caenorhabditis elegans, and mammalian species. It is clear from the study of a null mutant in Drosophila that Csp is required for viability...

journal_title：Journal of neurochemistry

authors： Chamberlain LH,Burgoyne RD

更新日期：2000-05-01 00:00:00

abstract：:Parkinson's disease is a debilitating neurodegenerative disease characterized by loss of midbrain dopaminergic neurons. These neurons are particularly sensitive to the neurotoxin 1-methyl-4-phenylpyridinium (MPP+), the active metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), which causes parkinsonian ...

journal_title：Journal of neurochemistry

authors： Chu CT,Zhu JH,Cao G,Signore A,Wang S,Chen J

更新日期：2005-09-01 00:00:00

abstract：:The N-type voltage-gated calcium channel (CaV2.2) is a clinically endorsed target in chronic pain treatments. As directly targeting the channel can lead to multiple adverse side effects, targeting modulators of CaV2.2 may prove better. We previously identified ST1-104, a short peptide from the collapsin response media...

journal_title：Journal of neurochemistry

authors： Ju W,Li Q,Allette YM,Ripsch MS,White FA,Khanna R

更新日期：2013-03-01 00:00:00

abstract：:The uptake of radioactive biotin has been studied in glial cell cultures from dissociated cerebral hemispheres of newborn rats. We describe saturable kinetics for the biotin uptake at biotin concentrations of less than 60 nM and linear at greater than 60 nM. The uptake appeared temperature sensitive, Na+ independent, ...

journal_title：Journal of neurochemistry

authors： Rodriguez-Pombo P,Ugarte M

更新日期：1992-04-01 00:00:00

abstract：:Antibodies raised against the synthetic peptide NH2-QKSDDDYEDYASNKTC-COOH (gamma 2 1-15 Cys), which corresponds to the N-terminal amino acid sequence with a C-terminal cysteine of the human gamma 2 subunit of the gamma-aminobutyric acidA (GABAA) receptor, were used to study the quantitative immunoprecipitation of agon...

journal_title：Journal of neurochemistry

authors： Duggan MJ,Pollard S,Stephenson FA

更新日期：1992-01-01 00:00:00

abstract：:Sex differences were investigated in cholinergic neurons of the septal-diagonal band region of adult rats subjected to neonatal treatment with 3,3',5-triiodo-L-thyronine (T3). Neonatal hyperthyroidism resulted in a 44% increase in specific activity of choline acetyltransferase (ChAT; EC 2.3.1.6) in adult male rat sept...

journal_title：Journal of neurochemistry

authors： Westlind-Danielsson A,Gould E,McEwen BS

更新日期：1991-01-01 00:00:00

abstract：:The effect of thyroid hormones (THs) on the expression of actin gene during fetal human brain development and the period of sensitivity to the hormones have been investigated. Developmental profile of actin in the cytoskeletal (CSK) and noncytoskeletal (non-CSK) fractions in the fetal cerebra showed a pronounced rise ...

journal_title：Journal of neurochemistry

authors： Pal U,Biswas SC,Sarkar PK

更新日期：1997-09-01 00:00:00

abstract：:Cannabinoid receptors and the endocannabinoids anandamide and 2-arachidonoylglycerol have been suggested to regulate food intake in several animal phyla. Orthologs of the mammalian cannabinoid CB(1) and CB(2) receptors have been identified in fish. We investigated the presence of this endocannabinoid system in the bra...

journal_title：Journal of neurochemistry

authors： Valenti M,Cottone E,Martinez R,De Pedro N,Rubio M,Viveros MP,Franzoni MF,Delgado MJ,Di Marzo V

更新日期：2005-11-01 00:00:00

abstract：:Tumor necrosis factor-alpha is a pluripotent cytokine that is reportedly mitogenic to astrocytes. We examined expression of the astrocyte intermediate filament component glial fibrillary acidic protein in astrocyte cultures and the U373 glioblastoma cell line after treatment with tumor necrosis factor-alpha. Treatment...

journal_title：Journal of neurochemistry

authors： Murphy GM Jr,Lee YL,Jia XC,Yu AC,Majewska A,Song Y,Schmidt K,Eng LF

更新日期：1995-12-01 00:00:00

abstract：:Mitochondrial dysfunction and oxidative stress are known to occur following acute seizure activity but their contribution during epileptogenesis is largely unknown. The goal of this study was to determine the extent of mitochondrial oxidative stress, changes to redox status, and mitochondrial DNA (mtDNA) damage during...

journal_title：Journal of neurochemistry

authors： Waldbaum S,Liang LP,Patel M

更新日期：2010-12-01 00:00:00

abstract：:Stressful stimuli induce two distinct cellular reactions, the heat-shock (stress) response and programmed cell death. This study utilizes a dual procedure involving immunocytochemistry for heat-shock protein localization and the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling...

journal_title：Journal of neurochemistry

authors： Belay HT,Brown IR

更新日期：2006-04-01 00:00:00

abstract：:Although alterations in mitochondrial dynamics are associated with cellular responses to injury, the functional role of these dynamic changes in ischemic neurons is underexplored. One of these dynamic responses to injury includes mitochondrial biogenesis. Various sublethal pre-conditioning stimuli that induce an ische...

journal_title：Journal of neurochemistry

authors： Stetler RA,Leak RK,Yin W,Zhang L,Wang S,Gao Y,Chen J

更新日期：2012-11-01 00:00:00

abstract：:A photolabile trifluoromethyldiazoketone derivative of kainate (KA), (2'S,3'S,4'R)-2'-carboxy-4'-(2-diazo-1-oxo-3, 3,3-trifluoropropyl)-3'-pyrrolidinyl acetate (DZKA), was synthesized and evaluated as an irreversible inhibitor of the high-affinity KA site on rat forebrain synaptic plasma membranes (SPMs). In the absen...

journal_title：Journal of neurochemistry

authors： Willis CL,Wacker DA,Bartlett RD,Bleakman D,Lodge D,Chamberlin AR,Bridges RJ

更新日期：1997-04-01 00:00:00

abstract：:The kinetic properties of soluble tyrosine hydroxylase from rat striatum and the activation of the enzyme by the polyanion heparin were assessed as a function of the monovalent cations K+, Na+, tetramethylammonium (TMA+), and Tris. Substitution of K+ or Na+ for TMA+ or Tris can alter the kinetic properties of tyrosine...

journal_title：Journal of neurochemistry

authors： Kuczenski R

更新日期：1981-09-01 00:00:00