Brain iron pathways and their relevance to Parkinson's disease.

abstract：:The present paper describes the isolation and characterization of a clone of hybrid myelomas (3-E7) secreting a mouse monoclonal antibody to beta-endorphin. An examination of its specificity against a series of human beta-lipotropin fragments and other opioid peptides revealed that the N-terminus portion of beta-endor...

journal_title：Journal of neurochemistry

authors： Gramsch C,Meo T,Riethmüller G,Herz A

更新日期：1983-05-01 00:00:00

abstract：:Rotating disk electrode voltammetry at glassy carbon electrodes and ultraviolet/visible spectroscopy were used to demonstrate that dopamine binds to neurotensin with a dissociation constant of 7.5 x 10(-8). By measuring the binding constants of various neurotensin analogs, it was found that the -Arg8-Arg9-portion of t...

journal_title：Journal of neurochemistry

authors： Adachi DK,Kalivas PW,Schenk JO

更新日期：1990-04-01 00:00:00

abstract：:Animals treated with high doses of amphetamines have been used as a model of schizophrenia due to the similarities between the psychosis associated with this mental disorder and that induced by chronic amphetamine abuse. When administered to naive rats in high doses, the amphetamine-like CNS stimulant methamphetamine ...

journal_title：Journal of neurochemistry

authors： Schmidt CJ,Sonsalla PK,Hanson GR,Peat MA,Gibb JW

更新日期：1985-03-01 00:00:00

abstract：:alpha-Conotoxins interact with nicotinic acetylcholine receptors (nAChRs) and acetylcholine-binding proteins (AChBPs) at the sites for agonists/competitive antagonists. alpha-Conotoxins blocking muscle-type or alpha7 nAChRs compete with alpha-bungarotoxin. However, alpha-conotoxin ImII, a close homolog of the alpha7 n...

journal_title：Journal of neurochemistry

authors： Kasheverov IE,Zhmak MN,Fish A,Rucktooa P,Khruschov AY,Osipov AV,Ziganshin RH,D'hoedt D,Bertrand D,Sixma TK,Smit AB,Tsetlin VI

更新日期：2009-11-01 00:00:00

abstract：:The transmission of pain signalling involves the cytoskeleton, but mechanistically this is poorly understood. We recently demonstrated that the capsaicin receptor TRPV1, a non-selective cation channel expressed by nociceptors that is capable of detecting multiple pain-producing stimuli, directly interacts with the tub...

journal_title：Journal of neurochemistry

authors： Goswami C,Dreger M,Otto H,Schwappach B,Hucho F

更新日期：2006-01-01 00:00:00

abstract：:After traumatic brain injury, progesterone has important neuroprotective effects in the nervous system. There is better functional outcome and less oedema formation in pseudopregnant rat females (high levels of endogenous progesterone) than in males. In addition to intracellular progesterone receptors, membrane bindin...

journal_title：Journal of neurochemistry

authors： Meffre D,Delespierre B,Gouézou M,Leclerc P,Vinson GP,Schumacher M,Stein DG,Guennoun R

更新日期：2005-06-01 00:00:00

abstract：:The potential anxiolytic effects of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor subgroup 2 (mGluR₂) were investigated using a self-referencing recording technique with enzyme-based microelectrode arrays (MEAs) that reliably measures tonic and phasic changes in extracellular gluta...

journal_title：Journal of neurochemistry

authors： Hascup ER,Hascup KN,Pomerleau F,Huettl P,Hajos-Korcsok E,Kehr J,Gerhardt GA

更新日期：2012-08-01 00:00:00

abstract：:Dp71 has an important role in the central nervous system. To better understand the function of Dp71 domains in neuronal differentiation, PC12 cells were stably transfected with a dystrophin mutant, Dp71Δ(78-79) , which lacks exons 78 and 79. Based on the percentage of cells bearing neurites and neurite length analyses...

journal_title：Journal of neurochemistry

authors： Aragón J,Romo-Yáñez J,Martínez-Herrera A,Ceja V,Rendon A,Montañez C

更新日期：2011-11-01 00:00:00

abstract：:Amyloid-β peptide (Aβ) concentration in CSF is potentially a diagnostic and therapeutic target for Alzheimer's disease (AD). The purpose of this study was to clarify the elimination mechanism of human Aβ(1-40) [hAβ (1-40)] from CSF. After intracerebroventricular (ICV) administration, [(125) I]hAβ(1-40) was eliminated ...

journal_title：Journal of neurochemistry

authors： Fujiyoshi M,Tachikawa M,Ohtsuki S,Ito S,Uchida Y,Akanuma S,Kamiie J,Hashimoto T,Hosoya K,Iwatsubo T,Terasaki T

更新日期：2011-08-01 00:00:00

abstract：:An aminopeptidase with specificity directed toward peptides with acidic N-terminal amino acid residues has been isolated from mouse brain cytosol. Purification by ion-exchange chromatography and gel filtration resulted in an enzyme that hydrolyzed aspartyl-phenylalanine methyl ester at a rate of 13.2 mumols/min/mg pro...

journal_title：Journal of neurochemistry

authors： Kelly JA,Neidle EL,Neidle A

更新日期：1983-06-01 00:00:00

abstract：:In the presence of lithium, carbamylcholine chloride (carbachol) and epinephrine increase the accumulation of inositol monophosphate severalfold in hippocampal slices from the rat. The stimulation by carbachol (EC50, 31 microM) is mediated by muscarinic receptors, whereas the effects of epinephrine (EC50, 2 microM) ar...

journal_title：Journal of neurochemistry

authors： Lenox RH,Hendley D,Ellis J

更新日期：1988-02-01 00:00:00

abstract：:We studied the effects of 12-O-tetradecanoylphorbol 13-acetate (TPA), a protein kinase C (PKC) activator, and calyculin A (CLA), an inhibitor of type 1 and 2A serine/threonine phosphatases, on serotonin uptake by a human placenta choriocarcinoma cell line (BeWo) and COS-7 cells expressing recombinant serotonin transpo...

journal_title：Journal of neurochemistry

authors： Sakai N,Sasaki K,Nakashita M,Honda S,Ikegaki N,Saito N

更新日期：1997-06-01 00:00:00

abstract：:We have investigated the effects of fetal hypophysectomy (HX) with or without thyroxine (T4)replacement on the plasma concentrations of free methionine-enkephalin (free Met-Enk), noradrenaline, and adrenaline in late gestation sheep fetus. Plasma adrenaline concentrations were significantly higher in intact fetal shee...

journal_title：Journal of neurochemistry

authors： Simonetta G,Young IR,McMillen IC

更新日期：1994-10-01 00:00:00

abstract：:Drebrin is a well-known side-binding protein of F-actin in the brain. Immunohistochemical data suggest that the peripheral parts of growing axons are enriched in the drebrin E isoform and mature axons are not. It has also been observed that drebrin E is concentrated in the growth cones of PC12 cells. These data strong...

journal_title：Journal of neurochemistry

authors： Mizui T,Kojima N,Yamazaki H,Katayama M,Hanamura K,Shirao T

更新日期：2009-04-01 00:00:00

abstract：:We have examined the metabolism of phosphate and sulfate groups modifying the P0 protein, the major protein of peripheral nervous system myelin, using an in vitro incubation system. Incorporation of [3H]leucine into the P0 peptide backbone decreased approximately 25-fold between 10 and 90 days of age, a finding reflec...

journal_title：Journal of neurochemistry

authors： Toews AD,Fischer HR,Goodrum JF,Windes S,Morell P

更新日期：1987-03-01 00:00:00

abstract：:Cortical areas including the anterior cingulate cortex (ACC) play critical roles in different types of chronic pain. Most of previous studies focus on the sensory inputs from somatic areas, and less information about plastic changes in the cortex for visceral pain. In this study, chronic visceral pain animal model was...

journal_title：Journal of neurochemistry

authors： Liu SB,Wang XS,Yue J,Yang L,Li XH,Hu LN,Lu JS,Song Q,Zhang K,Yang Q,Zhang MM,Bernabucci M,Zhao MG,Zhuo M

更新日期：2020-04-01 00:00:00

abstract：:Deacetylation of melatonin to 5-methoxytryptamine (5-MT) in vitro and in vivo was investigated in rat liver and brain tissue, using a gas chromatographic--mass spectrometric 5-MT assay method. In vitro incubation of liver but not brain (hypothalamic, Mesencephalic) slices with melatonin led to a concentration-dependen...

journal_title：Journal of neurochemistry

authors： Beck O,Jonsson G

更新日期：1981-06-01 00:00:00

abstract：:Fresh myelin, isolated from brainstems of adult rats, was incubated in the presence of Cu2+ and H2O2. Electrophoretic analysis of the reisolated myelin membrane revealed a gradual loss of the protein moiety from the characteristic pattern and an increase in aggregated material appearing at the origin of the gel. The a...

journal_title：Journal of neurochemistry

authors： Konat GW,Wiggins RC

更新日期：1985-10-01 00:00:00

abstract：:Mutations in the tau gene cause frontotemporal dementia and parkinsonism linked to chromosome-17 (FTDP-17). Functionally, about half of the known mutations increase the alternative mRNA splicing of exon 10 of the tau gene, resulting in the overproduction of tau isoforms with four microtubule-binding repeats. The other...

journal_title：Journal of neurochemistry

authors： Yoshida H,Crowther RA,Goedert M

更新日期：2002-02-01 00:00:00

abstract：:Exosomes are small extracellular vesicles released by almost all cell types in physiological and pathological conditions. The exosomal potential to unravel disease mechanisms, or to be used as a source of biomarkers, is being explored, in particularly in the field of neurodegenerative diseases. Alzheimer's disease (AD...

journal_title：Journal of neurochemistry

authors： Soares Martins T,Trindade D,Vaz M,Campelo I,Almeida M,Trigo G,da Cruz E Silva OAB,Henriques AG

更新日期：2020-07-03 00:00:00

abstract：:Neuromelanin (NM) is a compound which highly accumulates mainly in catecholamine neurons of the substantia nigra (SN), and is contained in organelles (NM-containing organelles) with lipid bodies and proteins. These neurons selectively degenerate in Parkinson's disease and NM can play either a protective or toxic role....

journal_title：Journal of neurochemistry

authors： Biesemeier A,Eibl O,Eswara S,Audinot JN,Wirtz T,Pezzoli G,Zucca FA,Zecca L,Schraermeyer U

更新日期：2016-07-01 00:00:00

abstract：:Complex biological systems are best modeled as highly modular, fluid systems exhibiting a plasticity that allows them to adapt to a vast array of changing conditions. Here we highlight several novel network-based approaches to elucidate genetic networks underlying complex traits. These integrative genomic approaches c...

journal_title：Journal of neurochemistry

authors： Lum PY,Chen Y,Zhu J,Lamb J,Melmed S,Wang S,Drake TA,Lusis AJ,Schadt EE

更新日期：2006-04-01 00:00:00

abstract：:Neuroimage analysis in alcoholic corpus callosum (CC) suggests that microstructural abnormalities are higher in the genu followed by the body and the splenium. Molecular mechanisms underlying these dysmorphologys are still unclear. Protein expression was performed using the CC body samples [(nine controls, seven uncom...

journal_title：Journal of neurochemistry

authors： Kashem MA,Etages HD,Kopitar-Jerala N,McGregor IS,Matsumoto I

更新日期：2009-07-01 00:00:00

abstract：:In the epididymal portion of rat vas deferens, facilitation of noradrenaline release mediated by adenosine A2A receptors, but not that mediated by beta2-adrenoceptors or by direct activation of adenylyl cyclase, was attenuated by blockade of alpha2-adrenoceptors and abolished by simultaneous blockade of alpha2-adrenoc...

journal_title：Journal of neurochemistry

authors： Queiroz G,Talaia C,Gonçalves J

更新日期：2003-05-01 00:00:00

abstract：:[3H]Cocaine dissociates from its binding sites in the mouse cerebral cortex with a half-time of 25 s. The dissociation kinetics in the striatum is consonant with the presence of two populations of sites with dissociation half times of 2 s and 27 s, comprising 88% and 12%, respectively, of the total binding sites. On t...

journal_title：Journal of neurochemistry

authors： Reith ME,Sershen H,Lajtha A

更新日期：1986-01-01 00:00:00

abstract：:3,4-Methylenedioxymethamphetamine (MDMA; 'Ecstasy') is a popular recreational drug used worldwide. This study aimed to determine the effects of this compound on the expression of nerve terminal serotonergic markers in rats. Experiment 1 investigated MDMA-induced changes in levels of the serotonin transporter (SERT) an...

journal_title：Journal of neurochemistry

authors： Biezonski DK,Meyer JS

更新日期：2010-02-01 00:00:00

abstract：:Kainate receptors (KARs) modulate synaptic transmission at both pre-synaptic and post-synaptic sites. The overlap in the distribution of KA-2 and GluR6/7 subunits in several brain regions suggests the co-assembly of these subunits in native KARs. The molecular mechanisms that control the assembly and surface expressio...

journal_title：Journal of neurochemistry

authors： Gallyas F Jr,Ball SM,Molnar E

更新日期：2003-09-01 00:00:00

abstract：:The olfactory bulb (OB) contains the highest concentration of the insulin receptor (IR) kinase in the central nervous system; however, its functional role and modulation in this region remains poorly understood. IR kinase contains a number of proline-rich motifs, making it an excellent candidate for modulation by SH(3...

journal_title：Journal of neurochemistry

authors： Marks DR,Fadool DA

更新日期：2007-11-01 00:00:00

abstract：:An acid-hydrolyzable conjugate of 3,4-dihydroxyphenylethylamine (dopamine, DA) was detected in superfusates from slices from rat striatum. The concentrations of endogenous free and conjugated DA, and of the acid metabolites (3,4-dihydroxyphenylacetic acid [DOPAC] and homovanillic acid [HVA]) in superfusates were measu...

journal_title：Journal of neurochemistry

authors： Tyce GM,Rorie DK

更新日期：1982-11-01 00:00:00

abstract：:Microglia are known to be a primary inflammatory cell type in the brain. However, microglial inflammatory responses are attenuated in the injured brain compared to those in cultured pure microglia. In the present study, we found that astrocytes challenged by oxygen-glucose deprivation (OGD) or H(2) O(2) released solub...

journal_title：Journal of neurochemistry

authors： Kim JH,Min KJ,Seol W,Jou I,Joe EH

更新日期：2010-12-01 00:00:00