Effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin transporter and vesicular monoamine transporter 2 protein and gene expression in rats: implications for MDMA neurotoxicity.

abstract：:Amyotrophic lateral sclerosis is a neurodegenerative fatal disease. The only drug recognized to increase the survival time is riluzole(RLZ). In animal models, minocycline (MNC) delayed the onset of the disease and increased the survival time (in combination with RLZ). The objective of our work was to study the interac...

journal_title：Journal of neurochemistry

authors： Milane A,Fernandez C,Vautier S,Bensimon G,Meininger V,Farinotti R

更新日期：2007-10-01 00:00:00

abstract：:Nerve growth factor (NGF) and insulin-like growth factor-1 (IGF-1) play an important role in promoting axonal growth from dorsal root ganglion (DRG) neurons. Adult DRG neurons exhibit neurotrophin-independent survival, providing an excellent system with which to study trophic factor effects on neurite growth in the ab...

journal_title：Journal of neurochemistry

authors： Jones DM,Tucker BA,Rahimtula M,Mearow KM

更新日期：2003-09-01 00:00:00

abstract：:Dopamine- and cAMP-regulated phosphoprotein (Mr 32 kDa, DARPP-32) is an integrator of multiple neuronal signals and plays a crucial role particularly in mediating the dopaminergic component of the systems involved in the evaluation of stimuli and the ensuing elaboration of complex behavioral responses (e.g., responses...

journal_title：Journal of neurochemistry

authors： Scheggi S,De Montis MG,Gambarana C

更新日期：2018-11-01 00:00:00

abstract：:Pigment epithelium-derived factor (PEDF), purified from human fetal retinal pigment epithelium cell culture medium, was shown to potentiate the differentiation of human Y-79 retinoblastoma cells. To investigate potential neurotrophic effects of PEDF on neurons other than those of retinal derivation, we used cultures o...

journal_title：Journal of neurochemistry

authors： Taniwaki T,Becerra SP,Chader GJ,Schwartz JP

更新日期：1995-06-01 00:00:00

abstract：:Dietary n-6 polyunsaturated fatty acid (PUFA) deprivation in rodents reduces brain arachidonic acid (20:4n-6) concentration and 20:4n-6-preferring cytosolic phospholipase A(2) (cPLA(2) -IVA) and cyclooxygenase (COX)-2 expression, while increasing brain docosahexaenoic acid (DHA, 22:6n-3) concentration and DHA-selectiv...

journal_title：Journal of neurochemistry

authors： Igarashi M,Kim HW,Chang L,Ma K,Rapoport SI

更新日期：2012-03-01 00:00:00

abstract：:The release of gamma-aminobutyric acid (GABA) was studied in slices of the head of the rabbit caudate nucleus. The slices were preincubated with [3H]GABA and then superfused. Aminooxyacetic acid was present throughout. Both the tritium in the slices and that in the superfusate consisted practically entirely of [3H]GAB...

journal_title：Journal of neurochemistry

authors： Limberger N,Späth L,Starke K

更新日期：1986-04-01 00:00:00

abstract：:Previous evidence has suggested that brain catecholamine levels are important in the regulation of central angiotensin II receptors. In the present study, the effects of norepinephrine and 3,4-dihydroxyphenylethylamine (dopamine) on angiotensin II receptor regulation in neuronal cultures from rat hypothalamus and brai...

journal_title：Journal of neurochemistry

authors： Sumners C,Watkins LL,Raizada MK

更新日期：1986-10-01 00:00:00

abstract：:Increasing evidence suggests that proteasome inhibition plays a causal role in promoting the neurodegeneration and neuron death observed in multiple disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD). The ability of severe and acute inhibition of proteasome function to induce neuron death and n...

journal_title：Journal of neurochemistry

authors： Ding Q,Dimayuga E,Martin S,Bruce-Keller AJ,Nukala V,Cuervo AM,Keller JN

更新日期：2003-07-01 00:00:00

abstract：:GM1 ganglioside binding to the crude mitochondrial fraction of rat brain and its effect on (Na+, K+)-ATPase were studied, the following results being obtained: (a) the binding process followed a biphasic kinetics with a break at 50 nM-GM1; GM1 at concentrations below the break was stably associated, while over the bre...

journal_title：Journal of neurochemistry

authors： Leon A,Facci L,Toffano G,Sonnino S,Tettamanti G

更新日期：1981-08-01 00:00:00

abstract：:Proper brain function in the nervous system relies on the accurate establishment of synaptic contacts during development. Countless synapses populate the adult brain in an orderly fashion. In each synapse, a presynaptic terminal loaded with neurotransmitters-containing synaptic vesicles is perfectly aligned to an arra...

journal_title：Journal of neurochemistry

authors： Pinto MJ,Almeida RD

更新日期：2016-12-01 00:00:00

abstract：:Cell culture studies have shown that the Alzheimer amyloid precursor protein (APP) is secreted after full-length APP is cleaved by a putative secretase at the Lys16-Leu17 bond (secretase cleavage I) of the amyloid peptide sequence. Because this cleavage event is incompatible with amyloid production, it has been assume...

journal_title：Journal of neurochemistry

authors： Anderson JP,Chen Y,Kim KS,Robakis NK

更新日期：1992-12-01 00:00:00

abstract：:Microglia are the main players of the brain immune response. They act as active sensors that rapidly respond to injurious insults by shifting into different activated states. Elevated levels of unconjugated bilirubin (UCB) induce cell death, immunostimulation and oxidative stress in both neurons and astrocytes. We rec...

journal_title：Journal of neurochemistry

authors： Silva SL,Osório C,Vaz AR,Barateiro A,Falcão AS,Silva RF,Brites D

更新日期：2011-05-01 00:00:00

abstract：:Galanin is a recently isolated neuropeptide that is of particular interest in dementing disorders because of its known colocalization with choline acetyltransferase in magnocellular neurons of the basal nucleus of Meynert. These neurons degenerate in Alzheimer's disease, and there is a corresponding deficiency of cort...

journal_title：Journal of neurochemistry

authors： Beal MF,Clevens RA,Chattha GK,MacGarvey UM,Mazurek MF,Gabriel SM

更新日期：1988-12-01 00:00:00

abstract：:The (R) and (S) forms of 5-amino-2-hydroxyvaleric acid (2-OH-DAVA) and 5-amino-4-hydroxyvaleric acid (4-OH-DAVA) were designed as structural hybrids of the 4-aminobutyric acidB (GABAB) agonist (R)-(-)-4-amino-3-hydroxybutyric acid [(R)-(-)-3-OH-GABA] and the GABAB antagonist 5-aminovaleric acid (DAVA). (S)-(-)-2-OH-DA...

journal_title：Journal of neurochemistry

authors： Kristiansen U,Hedegaard A,Herdeis C,Lund TM,Nielsen B,Hansen JJ,Falch E,Hjeds H,Krogsgaard-Larsen P

更新日期：1992-03-01 00:00:00

abstract：:The serotonin 5-HT3 receptor, a ligand-gated ion channel, has previously been shown to be present on a subpopulation of brain nerve terminals, where, on activation, the 5-HT3 receptors induce Ca2+ influx. Whereas postsynaptic 5-HT3 receptors induce depolarization, being permeant to Na+ and K+, the basis of presynaptic...

journal_title：Journal of neurochemistry

authors： Rondé P,Nichols RA

更新日期：1998-03-01 00:00:00

abstract：:Sphingosine-1-phosphate (S1P) is a potent biomediator that can act as either an intracellular or an intercellular messenger. In the nervous system it exerts a wide range of actions, and specific membrane receptors for it have been identified in various regions. However, the physiological origin of extracellular S1P in...

journal_title：Journal of neurochemistry

authors： Anelli V,Bassi R,Tettamanti G,Viani P,Riboni L

更新日期：2005-03-01 00:00:00

abstract：:To evaluate the role of various growth factors in naturally occurring cell death during development of the neural retina, we examined the effects of such factors on the nuclear morphology and the size of DNA in cultured chick embryonic neural retina cells. Basic fibroblast growth factor (bFGF) increased internucleosom...

journal_title：Journal of neurochemistry

authors： Yokoyama Y,Ozawa S,Seyama Y,Namiki H,Hayashi Y,Kaji K,Shirama K,Shioda M,Kano K

更新日期：1997-05-01 00:00:00

abstract：:Both increased gamma-aminobutyric acid (GABA)-ergic and decreased glutamatergic neurotransmission have been suggested relative to the pathophysiology of hepatic encephalopathy. This proposed disturbance in neurotransmitter balance, however, is based mainly on brain tissue analysis. Because the approach of whole tissue...

journal_title：Journal of neurochemistry

authors： Bosman DK,Deutz NE,Maas MA,van Eijk HM,Smit JJ,de Haan JG,Chamuleau RA

更新日期：1992-08-01 00:00:00

abstract：:Synapses are often located at great distances from the cell body and so must be capable of transducing signals into both local and distant responses. Although progress has been made in understanding biochemical cascades involved in neuronal death during development of the nervous system and in various neurodegenerativ...

journal_title：Journal of neurochemistry

authors： Duan W,Rangnekar VM,Mattson MP

更新日期：1999-06-01 00:00:00

abstract：:Membrane vesicles, showing a 21 +/- 2-fold enrichment in the activity of 5'-nucleotidase and a 11 +/- 4-fold enrichment in the activity of angiotensin-converting enzyme relative to homogenate, were prepared from the myenteric plexus-containing longitudinal muscle layer of guinea pig ileum. Incubation of the vesicles w...

journal_title：Journal of neurochemistry

authors： Nau R,Schäfer G,Deacon CF,Cole T,Agoston DV,Conlon JM

更新日期：1986-09-01 00:00:00

abstract：:The contribution of neuromelanin (NM) to the pathogenesis of Parkinson's disease (PD) has long been suspected. In particular, a correlation has been reported between the estimated cell loss in the mesencephalic dopaminergic cell groups and the percentage of NM-pigmented neurons in these cell groups. To test whether th...

journal_title：Journal of neurochemistry

authors： Kastner A,Hirsch EC,Lejeune O,Javoy-Agid F,Rascol O,Agid Y

更新日期：1992-09-01 00:00:00

abstract：:The epitope for HNK-1 and patient's monoclonal autoantibodies in demyelinating polyneuropathy associated with immunoglobulin M gammopathy is borne by different types of N-linked oligosaccharide structures in human P0 and myelin-associated glycoprotein (MAG). Fourteen glycopeptide fractions bearing different oligosacch...

journal_title：Journal of neurochemistry

authors： Burger D,Perruisseau G,Simon M,Steck AJ

更新日期：1992-03-01 00:00:00

abstract：:We attempted to obtain evidence for the occurrence of oxidant injury following seizure activity by measuring hippocampal F2-isoprostanes (F2-IsoPs), a reliable marker of free radical-induced lipid peroxidation. Formation of F2-IsoPs esterified in hippocampal phospholipids was correlated with hippocampal neuronal loss ...

journal_title：Journal of neurochemistry

authors： Patel M,Liang LP,Roberts LJ 2nd

更新日期：2001-12-01 00:00:00

abstract：:Amyloid beta (Aβ) peptide is the major constituent of the extracellular amyloid plaques deposited in the brains of Alzheimer's disease patients and is central to the pathogenic pathway causing this disease. The identity of the neurotoxic Aβ species remains elusive. We previously reported that Aβ toxicity correlates st...

journal_title：Journal of neurochemistry

authors： Jana MK,Cappai R,Pham CL,Ciccotosto GD

更新日期：2016-02-01 00:00:00

abstract：:The N-type voltage-dependent calcium channels play a significant role in neurotransmitter release. The alpha1B subunit of the N-type calcium channel functions as the primary subunit that forms the pore and contains the structural motifs that mediate the pharmacological and gating properties of the channel. We report o...

journal_title：Journal of neurochemistry

authors： Ghasemzadeh MB,Pierce RC,Kalivas PW

更新日期：1999-10-01 00:00:00

abstract：:5-Hydroxytryptamine (5-HT) receptors contain seven putative transmembrane domains and couple via different guanine nucleotide binding proteins to specific effector enzymes. Studies with other receptors identify the second and third intracellular loops or the C-terminus of the receptor as important for selective effect...

journal_title：Journal of neurochemistry

authors： Oksenberg D,Havlik S,Peroutka SJ,Ashkenazi A

更新日期：1995-04-01 00:00:00

abstract：:Recent etiological study in twins (Tanner et al. 1999) strongly suggests that environmental factors play an important role in typical, non-familial Parkinson's disease (PD), beginning after age 50. Epidemiological risk factor analyses of typical PD cases have identified several neurotoxicants, including MPP(+) (the ac...

journal_title：Journal of neurochemistry

authors： Chun HS,Gibson GE,DeGiorgio LA,Zhang H,Kidd VJ,Son JH

更新日期：2001-02-01 00:00:00

abstract：:Glycogen synthase kinase-3beta (GSK-3beta) is a multifunctional enzyme involved in a variety of biological events including development, glucose metabolism and cell death. Its activity is inhibited by phosphorylation of the Ser9 residue and up-regulated by Tyr216 phosphorylation. Activated GSK-3beta increases phosphor...

journal_title：Journal of neurochemistry

authors： Hawkes C,Jhamandas JH,Kar S

更新日期：2005-10-01 00:00:00

abstract：:Mitochondria are important in the pathophysiology of several neurodegenerative diseases, and mitochondrial production of reactive oxygen species (ROS), membrane depolarization, permeability changes and release of apoptogenic proteins are involved in these processes. Following brain insults, cell death often occurs in ...

journal_title：Journal of neurochemistry

authors： Mattiasson G,Friberg H,Hansson M,Elmér E,Wieloch T

更新日期：2003-10-01 00:00:00

abstract：:Axonal growth cone motility requires precise regulation of adhesion to navigate the complex environment of the nervous system and reach its target. Myristoylated alanine-rich C kinase substrate (MARCKS) protein is enriched in the developing brain and plays an important, phosphorylation-dependent role in the modulation...

journal_title：Journal of neurochemistry

authors： Sosa LJ,Malter JS,Hu J,Bustos Plonka F,Oksdath M,Nieto Guil AF,Quiroga S,Pfenninger KH

更新日期：2016-06-01 00:00:00