The subunit composition of a GABAA/benzodiazepine receptor from rat cerebellum.

abstract：:Experimental allergic encephalomyelitis (EAE) is an autoimmune, animal model of multiple sclerosis (MS) in which demyelination and paralysis are evident. Quinolinic acid (QUIN) is a neurotoxin and endogenous N-methyl-D-aspartate receptor agonist formed from tryptophan. The role of neurotoxins in general and QUIN in pa...

journal_title：Journal of neurochemistry

authors： Flanagan EM,Erickson JB,Viveros OH,Chang SY,Reinhard JF Jr

更新日期：1995-03-01 00:00:00

abstract：:Molecular mechanisms underlying tauopathy remain undetermined. In the current study, single cell gene expression profiling was coupled with custom-designed cDNA array analysis to evaluate tau expression and other cytoskeletal elements within individual neuronal populations in patients with no cognitive impairment (NCI...

journal_title：Journal of neurochemistry

authors： Ginsberg SD,Che S,Counts SE,Mufson EJ

更新日期：2006-03-01 00:00:00

abstract：:A recent study has linked the butyrylcholinesterase (BChE) K-variant and the apolipoprotein epsilon4 isoform to late-onset Alzheimer's disease. These findings have been controversial and have led us to examine the differences between wild-type and K-variant BChE in enzyme activity, protein stability, and quaternary st...

journal_title：Journal of neurochemistry

authors： Altamirano CV,Bartels CF,Lockridge O

更新日期：2000-02-01 00:00:00

abstract：:Acetyl-L-carnitine (ALCAR) is an endogenous metabolic intermediate that facilitates the influx and efflux of acetyl groups across the mitochondrial inner membrane. Exogenously administered ALCAR has been used as a nutritional supplement and also as an experimental drug with reported neuroprotective properties and effe...

journal_title：Journal of neurochemistry

authors： Scafidi S,Fiskum G,Lindauer SL,Bamford P,Shi D,Hopkins I,McKenna MC

更新日期：2010-08-01 00:00:00

abstract：:Calmodulin (CaM)-dependent enzymes, such as CaM-dependent phosphodiesterase (CaM-PDE), CaM-dependent protein phosphatase (CN), and CaM-dependent protein kinase II (CaM kinase II), are found in high concentrations in differentiated mammalian neurons. In order to determine whether neuroblastoma cells express these CaM-d...

journal_title：Journal of neurochemistry

authors： Pennypacker KR,Kincaid RL,Polli JW,Billingsley ML

更新日期：1989-05-01 00:00:00

abstract：:The present study demonstrates that [3H]imipramine binds to both high- and low-affinity imipramine binding components on membranes prepared from rat cerebral cortex. Scatchard and computer analyses of saturation experiments using a wide range of [3H]imipramine concentrations (0.5 nM-50 nM) revealed the presence of two...

journal_title：Journal of neurochemistry

authors： Conway PG,Brunswick DJ

更新日期：1985-07-01 00:00:00

abstract：:We recently reported an abnormal production of interleukin-1 (IL-1) in peripheral macrophages of several neurological mutant mice that exhibit patterns of neuronal degeneration, especially in the cerebellum. After in vitro activation by lipopolysaccharide acid (LPS), these macrophages hyperexpress IL-1 beta mRNA and h...

journal_title：Journal of neurochemistry

authors： Kopmels B,Mariani J,Delhaye-Bouchaud N,Audibert F,Fradelizi D,Wollman EE

更新日期：1992-01-01 00:00:00

abstract：:Neuronal death due to excessive activation of N-methyl-d-aspartate (NMDA) receptors is a hallmark of neurodegenerative diseases. The polyamines: putrescine, spermine, and spermidine, bind to specific sites on the NMDA receptor and promote its activation, but their role in NMDA-induced neuronal death is ill defined. In...

journal_title：Journal of neurochemistry

authors： Pernet V,Bourgeois P,Di Polo A

更新日期：2007-11-01 00:00:00

abstract：:Microglial activation is common in several neurodegenerative disorders. In the present study, we used the murine BV-2 microglial cell line stimulated with gamma-interferon and lipopolysaccharide to gain new insights into the effects of endogenously produced NO on mitochondrial respiratory capacity, iron regulatory pro...

journal_title：Journal of neurochemistry

authors： Chénais B,Morjani H,Drapier JC

更新日期：2002-05-01 00:00:00

abstract：:We have shown recently that the presence of albumin in astrocytes triggers the synthesis and release of oleic acid, which behaves as a neurotrophic factor for neurons. Thus, oleic acid promotes axonal growth together with the expression of the axonal growth-associated protein, GAP-43. Here we attempted to elucidate wh...

journal_title：Journal of neurochemistry

authors： Rodríguez-Rodríguez RA,Tabernero A,Velasco A,Lavado EM,Medina JM

更新日期：2004-03-01 00:00:00

abstract：:Caveolin-1 is the predominant structural protein of caveolae, a subset of (lipid) membrane rafts that compartmentalize cell signaling. Caveolin-1 binds most to G protein-coupled receptors and their signaling partners, thereby enhancing interactions among signaling cascade components and the relative activation of spec...

journal_title：Journal of neurochemistry

authors： Chakrabarti S,Chang A,Liu NJ,Gintzler AR

更新日期：2016-12-01 00:00:00

abstract：:The presynaptic regulation of amino acid release from nerve terminals was investigated using synaptosomes prepared from the rat spinal cord. The basal releases of endogenous glutamate (Glu), aspartate (Asp), and gamma-amino-butyric acid (GABA) were 34.6, 21.5, and 10.0 pmol/min/mg of protein, respectively. Exposure to...

journal_title：Journal of neurochemistry

authors： Kamisaki Y,Hamada T,Maeda K,Ishimura M,Itoh T

更新日期：1993-02-01 00:00:00

abstract：:Glycogen synthase kinase-3beta (GSK-3beta) is a multifunctional enzyme involved in a variety of biological events including development, glucose metabolism and cell death. Its activity is inhibited by phosphorylation of the Ser9 residue and up-regulated by Tyr216 phosphorylation. Activated GSK-3beta increases phosphor...

journal_title：Journal of neurochemistry

authors： Hawkes C,Jhamandas JH,Kar S

更新日期：2005-10-01 00:00:00

abstract：:A mitochondrial fraction, purified from pig brain, was found to contain associated polypeptides with the same electrophoretic migration and isoelectric points as the alpha- and beta-tubulin subunits present in brain microtubules. When analyzed by Western blotting these polypeptides reacted specifically with purified t...

journal_title：Journal of neurochemistry

authors： Hargreaves AJ,Avila J

更新日期：1985-08-01 00:00:00

abstract：:Dopamine and norepinephrine are involved in regulation of melatonin synthesis in the pineal gland. In bovine pineal gland, D1- and D2-dopaminergic and alpha 1-adrenergic receptors have been characterized pharmacologically in several laboratories, while beta 1-adrenergic receptors have been studied using physiological ...

journal_title：Journal of neurochemistry

authors： Simonneaux V,Happe HK,Ebadi M,Murrin LC

更新日期：1991-11-01 00:00:00

abstract：:We found in cultured glioma (C6BU-1) cells that excitatory amino acids (EAAs) such as glutamate, N-methyl-D-aspartate (NMDA), aspartate, and metabotropic glutamate receptor agonist trans-(+/-)-1-amino-1,3-cyclopentanedicarboxylate caused an increase in the inositol 1,4,5-trisphosphate formation and the intracellular C...

journal_title：Journal of neurochemistry

authors： Shinno H,Mikuni M,Saitoh K,Tomita U,Yamawaki S,Takahashi K

更新日期：1994-10-01 00:00:00

abstract：:In this study we examined the functional expression of the extraneuronal monoamine transporter (EMT) in normal human astrocytes (NHA). RT-PCR with EMT-specific primers demonstrated the presence of EMT mRNA in NHA. The RT-PCR products were subjected to restriction-site analysis using three different enzymes (HinfI, Sac...

journal_title：Journal of neurochemistry

authors： Inazu M,Takeda H,Matsumiya T

更新日期：2003-01-01 00:00:00

abstract：:Cyclosporin A (CsA) is a clinically important immunosuppressive drug widely used to prevent graft rejection following organ or bone marrow transplantation. Although there are reports of serious neurologic alterations associated with the use of the drug, the precise mechanism of its action on the CNS still remains unkn...

journal_title：Journal of neurochemistry

authors： Mosieniak G,Figiel I,Kaminska B

更新日期：1997-03-01 00:00:00

abstract：:Nerve growth factor (NGF) and insulin-like growth factor-1 (IGF-1) play an important role in promoting axonal growth from dorsal root ganglion (DRG) neurons. Adult DRG neurons exhibit neurotrophin-independent survival, providing an excellent system with which to study trophic factor effects on neurite growth in the ab...

journal_title：Journal of neurochemistry

authors： Jones DM,Tucker BA,Rahimtula M,Mearow KM

更新日期：2003-09-01 00:00:00

abstract：:Over the last two decades, a number of studies have underlined the importance of lysosomal-based degradative pathways in maintaining the homeostasis of post-mitotic cells, and revealed the remarkable contribution of a functional autophagic machinery in the promotion of longevity. In contrast, defects in the clearance ...

journal_title：Journal of neurochemistry

authors： Cogo S,Manzoni C,Lewis PA,Greggio E

更新日期：2020-02-01 00:00:00

abstract：:Retinoid-related orphan receptor alpha1 (RORalpha1) is a member of the nuclear receptor superfamily. It is highly expressed in CNS particularly in the cerebellum. Absence of this transcription factor in mice leads to several abnormalities, such as cerebellar atrophy linked to Purkinje cell death and impaired different...

journal_title：Journal of neurochemistry

authors： Duplus E,Gras C,Soubeyre V,Vodjdani G,Lemaigre-Dubreuil Y,Brugg B

更新日期：2008-03-01 00:00:00

abstract：:The neuronal protein B-50 may be involved in diverse functions including neural development, axonal regeneration, neural plasticity, and synaptic transmission. The rat B-50 sequence contains 226 amino acids which include 14 Ser and 14 Thr residues, all putative sites for phosphorylation by calcium/phospholipid-depende...

journal_title：Journal of neurochemistry

authors： Coggins PJ,Zwiers H

更新日期：1989-12-01 00:00:00

abstract：:We sought to investigate whether dexamethasone produces a coordinated, time-dependent effect on all enzymes in the catecholamine biosynthetic pathway in PC12 cells. The levels of mRNAs of tyrosine hydroxylase (TH), aromatic L-amino acid decarboxylase (AADC), and dopamine beta-hydroxylase (DBH) were examined at 0, 6, 1...

journal_title：Journal of neurochemistry

authors： Kim KT,Park DH,Joh TH

更新日期：1993-03-01 00:00:00

abstract：:Neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease, and Huntington's disease, are considered incurable and significantly reduce the quality of life of the patients. A variety of drugs that modulate neurotransmitter levels have been used for the treatment of the neurodegenerative diseases but ...

journal_title：Journal of neurochemistry

authors： Huang M,Rathore SS,Lindau M

更新日期：2019-10-01 00:00:00

abstract：:Intracerebroventricular (i.c.v.) administration of angiotensin IV (Ang IV) or Leu-Val-Val-haemorphin 7 (LVV-H7) improves memory performance in normal rats and reverses memory deficits in rat models for cognitive impairment. These memory effects were believed to be mediated via the putative 'AT4 receptor'. However, thi...

journal_title：Journal of neurochemistry

authors： De Bundel D,Demaegdt H,Lahoutte T,Caveliers V,Kersemans K,Ceulemans AG,Vauquelin G,Clinckers R,Vanderheyden P,Michotte Y,Smolders I

更新日期：2010-03-01 00:00:00

abstract：:The Cys-loop receptor family consists of nicotinic acetylcholine receptors (nAChR), glycine receptor, GABA-A and some other receptors. They fulfill a plethora of functions, whereas their malfunctioning is associated with many diseases. All three domains - extracellular ligand-binding, membrane and cytoplasmic - of the...

journal_title：Journal of neurochemistry

authors： Tsetlin V,Kuzmin D,Kasheverov I

更新日期：2011-03-01 00:00:00

abstract：:Incubation of rat pheochromocytoma PC12 cells with 4 beta-phorbol-12 beta-myristate-13 alpha-acetate (PMA), an activator of Ca2+/phospholipid-dependent protein kinase (protein kinase C), or forskolin, an activator of adenylate cyclase, is associated with increased activity and enhanced phosphorylation of tyrosine hydr...

journal_title：Journal of neurochemistry

authors： Tachikawa E,Tank AW,Weiner DH,Mosimann WF,Yanagihara N,Weiner N

更新日期：1987-05-01 00:00:00

abstract：:Previous pharmacological studies have indicated that impairment of GABAergic transmission may be involved in the pathophysiology of dystonia in the mutant dtsz hamster, i.e., a genetic animal model for idiopathic dystonia. In the present experiments, the kinetic constants of [3H]flumazenil binding to the benzodiazepin...

journal_title：Journal of neurochemistry

authors： Pratt GD,Richter A,Möhler H,Löscher W

更新日期：1995-05-01 00:00:00

abstract：:In situ phosphorylation of the presynaptic protein kinase C substrate B-50 was investigated in rat hippocampal slices incubated with the convulsant drug 4-aminopyridine (4-AP). Phosphorylation of B-50 was significantly enhanced 1 min after the addition of 4-AP (100 microM). This increase by 4-AP was concentration depe...

journal_title：Journal of neurochemistry

authors： Heemskerk FM,Schrama LH,Gianotti C,Spierenburg H,Versteeg DH,De Graan PN,Gispen WH

更新日期：1990-03-01 00:00:00

abstract：:We report the distribution of choline acetyltransferase (ChAT) activity in the laminae of the rat olfactory tubercle. Within its posterior medical portion, the tubercle contains three parallel histological laminae that can be separated by cutting tangential sections from frozen tissue. ChAT was measured in homogenates...

journal_title：Journal of neurochemistry

authors： Gordon CR,Krieger NR

更新日期：1983-01-01 00:00:00