High serotonin and 5-hydroxyindoleacetic acid levels in limbic brain regions in a rat model of depression: normalization by chronic antidepressant treatment.

abstract：:Plasma osmolality and the levels of water, taurine, and total amino nitrogen (detected as ninhydrin-positive substances) have been measured in the cerebral cortices of nonpregnant and 19-day pregnant Wistar rats. Plasma osmolality fell by 11 mosmol/kg during pregnancy. Brain water content remained unaltered, but level...

journal_title：Journal of neurochemistry

authors： Law RO

更新日期：1989-07-01 00:00:00

abstract：:Neuromodulation is a fundamental process in the brain that regulates synaptic transmission, neuronal network activity and behavior. Emerging evidence demonstrates that astrocytes, a major population of glial cells in the brain, play previously unrecognized functions in neuronal modulation. Astrocytes can detect the le...

journal_title：Journal of neurochemistry

authors： Fellin T

更新日期：2009-02-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disease resulting in progressive cognitive decline. Amyloid plaque deposits consisting specifically of beta-amyloid peptides that have formed fibrils displaying beta-pleated sheet conformation are associated with activated microglia and astrocytes, are colocalized with C...

journal_title：Journal of neurochemistry

authors： Zhou J,Fonseca MI,Pisalyaput K,Tenner AJ

更新日期：2008-09-01 00:00:00

abstract：:Sprague-Dawley rats were fed one of three purified diets--10% corn oil, 10% hydrogenated coconut oil, or 10% linseed oil--through two generations. At 60-80 days of age the animals were sacrificed. The fatty acyl composition of phosphatidylcholine, phosphatidylethanolamine, plasmalogen phosphatidylethanolamine, and com...

journal_title：Journal of neurochemistry

authors： Brown ML,Marshall LA,Johnston PV

更新日期：1984-11-01 00:00:00

abstract：:Myelination of peripheral nerves by Schwann cells depends upon a gene regulatory network controlled by early growth response Egr2/Krox20, which is specifically required for Schwann cells to initiate and maintain myelination. To elucidate the mechanism by which Egr2 regulates gene expression during myelination, we have...

journal_title：Journal of neurochemistry

authors： Jang SW,Srinivasan R,Jones EA,Sun G,Keles S,Krueger C,Chang LW,Nagarajan R,Svaren J

更新日期：2010-12-01 00:00:00

abstract：:p-glycoprotein (p-gp) is an ATP-binding cassette transporter and its overexpression is responsible for the acquisition of the multidrug resistance phenotype in human tumors. p-gp is localized at the blood-brain barrier and is involved in brain cytoprotection. Our previous work used immunoprecipitation to show that cav...

journal_title：Journal of neurochemistry

authors： Barakat S,Demeule M,Pilorget A,Régina A,Gingras D,Baggetto LG,Béliveau R

更新日期：2007-04-01 00:00:00

abstract：:Mutations in the presenilin-1 (PS-1) and presenilin-2 (PS-2) genes account for the majority of cases of early-onset familial Alzheimer's disease (AD). Alternative splicing forms of the PS-1 and PS-2 gene products have previously been reported in fibroblast and brain tissue from both familial and sporadic AD patients, ...

journal_title：Journal of neurochemistry

authors： Sato N,Hori O,Yamaguchi A,Lambert JC,Chartier-Harlin MC,Robinson PA,Delacourte A,Schmidt AM,Furuyama T,Imaizumi K,Tohyama M,Takagi T

更新日期：1999-06-01 00:00:00

abstract：:The effect of clinical, spontaneous-onset seizures on extracellular fluid lactate was investigated by the method of lactography, the in vivo on-line measurement of lactate levels using microdialysis. Studies of experimental animals have suggested that generation of extracellular lactate as measured by microdialysis is...

journal_title：Journal of neurochemistry

authors： During MJ,Fried I,Leone P,Katz A,Spencer DD

更新日期：1994-06-01 00:00:00

abstract：:The brain adapts to dynamic environmental conditions by altering its epigenetic state, thereby influencing neuronal transcriptional programs. An example of an epigenetic modification is protein methylation, catalyzed by protein arginine methyltransferases (PRMT). One member, Prmt8, is selectively expressed in the cent...

journal_title：Journal of neurochemistry

authors： Lee PK,Goh WW,Sng JC

更新日期：2017-02-01 00:00:00

abstract：:Recombinant baculoviral vectors efficiently transduce several types of cells in the brain. To characterize host responses to virus challenge, thus verifying the suitability of using baculovirus for the development of gene therapy strategies in the central nervous system, we used cDNA microarray technology to examine i...

journal_title：Journal of neurochemistry

authors： Boulaire J,Zhao Y,Wang S

更新日期：2009-06-01 00:00:00

abstract：:Despite considerable efforts to unravel the role of cellular prion protein (PrP(C)) in neuronal functions, the mechanisms by which PrP(C) takes part in the homeostasis of a defined neuronal phenotype remain poorly characterized. By taking advantage of a neuroectodermal cell line (1C11) endowed with the capacity to dif...

journal_title：Journal of neurochemistry

authors： Pradines E,Loubet D,Mouillet-Richard S,Manivet P,Launay JM,Kellermann O,Schneider B

更新日期：2009-08-01 00:00:00

abstract：:Epidermal growth factor (EGF) is a member of a structurally related family containing heparin-binding EGF-like growth factor (HB-EGF) and transforming growth factor alpha (TGFalpha) that exerts neurotrophic activity on midbrain dopaminergic neurons. To examine neurotrophic abnormality in Parkinson's disease (PD), we m...

journal_title：Journal of neurochemistry

authors： Iwakura Y,Piao YS,Mizuno M,Takei N,Kakita A,Takahashi H,Nawa H

更新日期：2005-05-01 00:00:00

abstract：:Circulating antibody to the bovine white matter proteolipid apoprotein was detected in rabbits 1 month ater a single injection of the water-soluble form of the apoprotein. By double immunodiffusion, the antiserum reacted specifically with the delipidated proteolipid apoprotein and the crude proteolipid fraction contai...

journal_title：Journal of neurochemistry

authors： Macklin WB,Schwarting GA,Lees MB,Cohen SR

更新日期：1981-01-01 00:00:00

abstract：:It has been proposed that abnormal myo-inositol metabolism may be a factor in the development of diabetic complications. Studies with animal models of diabetes and cultured cells have suggested that hyperglycemia by an unknown mechanism may alter myo-inositol metabolism and content. Recently, we have shown that L-fuco...

journal_title：Journal of neurochemistry

authors： Yorek MA,Dunlap JA,Stefani MR,Davidson EP

更新日期：1992-05-01 00:00:00

abstract：:Brain trauma was induced in mice using a closed head injury (CHI) model. At 1, 6 or 24 h after trauma, brains were dissected into the cortex, striatum and hippocampus. Changes in levels of processed X-box protein 1 (xbp1), glucose-regulated protein 78 (grp78), growth arrest and DNA damage-inducible gene 153 (gadd153) ...

journal_title：Journal of neurochemistry

authors： Paschen W,Yatsiv I,Shoham S,Shohami E

更新日期：2004-02-01 00:00:00

abstract：:Release-regulating heterocarriers exist on brain nerve endings. We have investigated in this study the mechanisms involved in the neurotransmitter release evoked by GABA heterocarrier activation. GABA increased the basal release of [3H]acetylcholine and [3H]noradrenaline from rat hippocampal synaptosomes and of [3H]do...

journal_title：Journal of neurochemistry

authors： Fassio A,Bonanno G,Fontana G,Usai C,Marchi M,Raiteri M

更新日期：1996-04-01 00:00:00

abstract：:The anticonvulsant drugs phenobarbital, phenytoin, sodium valproate, and phenytoin-sodium valproate in combination were administered daily to (a) pregnant rats starting on the 5th day after conception, and continued through 17 days postpartum, or (b) to developing rats between 3 and 17 days of age. Each drug was prepa...

journal_title：Journal of neurochemistry

authors： Patsalos PN,Wiggins RC

更新日期：1982-10-01 00:00:00

abstract：:The beta-amyloid peptide (Abeta) is considered responsible for the pathogenesis of Alzheimer's disease. Despite the magnitude of reports describing a neurotoxic role of extracellular Abeta, the role for intracellular Abeta (iAbeta) has not been elucidated. We previously demonstrated that in rat pheochromocytoma cells ...

journal_title：Journal of neurochemistry

authors： Arvanitis DN,Ducatenzeiler A,Ou JN,Grodstein E,Andrews SD,Tendulkar SR,Ribeiro-da-Silva A,Szyf M,Cuello AC

更新日期：2007-10-01 00:00:00

abstract：:Two semisynthetic acetyl derivatives of the alkaloid sauroine from Huperzia saururus, monoacetyl sauroine, and diacetyl sauroine (DAS) were obtained and their chemical structures were analyzed by NMR. While monoacetyl sauroine is the typical product of acetylation, DAS is an unexpected derivative related to the keto-e...

journal_title：Journal of neurochemistry

authors： Vallejo M,Loyola S,Contreras D,Ugarte G,Cifuente D,Ortega G,Cabrera JL,Zeise M,Tonn C,Carreño M,Delgado R,Morales B,Agnese M

更新日期：2014-06-01 00:00:00

abstract：:Cultures of neonatal rat superior cervical ganglia (SCG) were used to test the hypothesis that the cytokines leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) control GTP cyclohydrolase I (GTPCH) gene expression and 5,6,7,8-tetrahydrobiopterin (BH4) content as traits of the noradrenergic phenotyp...

journal_title：Journal of neurochemistry

authors： Stegenga SL,Hirayama K,Kapatos G

更新日期：1996-06-01 00:00:00

abstract：:The effects of a potent adenosine deaminase inhibitor, deoxycoformycin, on purine and amino acid neuro-transmitter release from the ischemic rat cerebral cortex were studied with the cortical cup technique. Cerebral ischemia (20 min) was elicited by four-vessel occlusion. Purine and amino acid releases were compared f...

journal_title：Journal of neurochemistry

authors： Phillis JW,Walter GA,Simpson RE

更新日期：1991-02-01 00:00:00

abstract：:We have tested the hypothesis that exocytosis is a possible export route for calcium from bovine adrenal medullary cells. After prelabelling cells in primary tissue culture with 45Ca, evoked 45Ca export and catecholamine secretion show the same time course, a similar fraction of the total pool of 45Ca and catecholamin...

journal_title：Journal of neurochemistry

authors： von Grafenstein HR,Powis DA

更新日期：1989-08-01 00:00:00

abstract：:The purpose of this study was to determine whether vasoactive intestinal peptide (VIP) might have a presynaptic modulatory effect at cholinergic terminals in the rat hippocampal formation. The exposure of rat hippocampal slices to VIP increased [3H]acetylcholine ([3H]ACh) synthesis from the precursor [3H]choline when ...

journal_title：Journal of neurochemistry

authors： Lapchak PA,Collier B

更新日期：1988-01-01 00:00:00

abstract：:When synaptosomes from rat brain were incubated with S-adenosylmethionine (10(-3) M), noradrenaline uptake and KCl-stimulated release were decreased. These effects were dependent on MgCl2, temperature, and incubation time. We have investigated the enzymatic methylation of phosphatidylethanolamine to give phosphatidylc...

journal_title：Journal of neurochemistry

authors： Fonlupt P,Rey C,Pacheco H

更新日期：1982-06-01 00:00:00

abstract：:The effect of phorbol esters was investigated on the down-regulation of protein kinase C (PKC) and on the release of [3H]norepinephrine (NE) in synaptosomes from the rat cerebrum. Treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) promoted the translocation of PKC activity in a P2 fraction from the cytosol to t...

journal_title：Journal of neurochemistry

authors： Oda T,Shearman MS,Nishizuka Y

更新日期：1991-04-01 00:00:00

abstract：:In all the species examined thus far, the behavior of microglia during development appears to be highly stereotyped. This reproducibility supports the notion that these cells have a physiological role in development. Microglia are macrophages that migrate from the yolk sac and colonize the central nervous system early...

journal_title：Journal of neurochemistry

authors： Pont-Lezica L,Béchade C,Belarif-Cantaut Y,Pascual O,Bessis A

更新日期：2011-12-01 00:00:00

abstract：:The presence of gamma-hydroxybutyric acid (GHB) in synaptosome-enriched fractions of rat brain was ascertained using a GLC technique. The stability of GHB in synaptosomes was evaluated by addition of various gamma-aminobutyric acid (GABA) transaminase (GABA-T) inhibitors, GHB, or ethosuximide to the homogenizing mediu...

journal_title：Journal of neurochemistry

authors： Snead OC 3rd

更新日期：1987-01-01 00:00:00

abstract：:Aging was associated with an increase in the density of specific binding sites for [3H]imipramine in postmortem specimens of human hypothalamus, frontal cortex, and parietal cortex. In general, [3H]imipramine binding was not affected by factors considered difficult to control in postmortem studies, i.e., time from dea...

journal_title：Journal of neurochemistry

authors： Severson JA,Marcusson JO,Osterburg HH,Finch CE,Winblad B

更新日期：1985-11-01 00:00:00

abstract：:The recycling of synaptic vesicles in nerve terminals involves multiple steps, underlies all aspects of synaptic transmission, and is a key to understanding the basis of synaptic plasticity. The development of styryl dyes as fluorescent molecules that label recycling synaptic vesicles has revolutionized the way in whi...

journal_title：Journal of neurochemistry

authors： Cousin MA,Robinson PJ

更新日期：1999-12-01 00:00:00

abstract：:The levels of hexokinase, as well as those of the cytoplasmic glycolytic enzyme lactate dehydrogenase and the mitochondrial tricarboxylic acid cycle enzymes fumarase and citrate synthase, have been determined in whole rat brain and in neuronal, astrocytic, and oligodendroglial fractions isolated from rat brain. Compar...

journal_title：Journal of neurochemistry

authors： Snyder CD,Wilson JE

更新日期：1983-04-01 00:00:00