Characterization and biosynthesis of cyclic-AMP-binding proteins in the rat central nervous system.

abstract：:Increasing reports support that air pollution causes neuroinflammation and is linked to central nervous system (CNS) disease/damage. Diesel exhaust particles (DEP) are a major component of urban air pollution, which has been linked to microglial activation and Parkinson's disease-like pathology. To begin to address ho...

journal_title：Journal of neurochemistry

authors： Levesque S,Taetzsch T,Lull ME,Johnson JA,McGraw C,Block ML

更新日期：2013-06-01 00:00:00

abstract：:Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD-1 gene product, ataxin-3. Ataxin-3 is degraded by the proteasome. However, the precise mechanism of ataxin-3 degradation remains to be elucidated. In this st...

journal_title：Journal of neurochemistry

authors： Wang H,Jia N,Fei E,Wang Z,Liu C,Zhang T,Fan J,Wu M,Chen L,Nukina N,Zhou J,Wang G

更新日期：2007-06-01 00:00:00

abstract：:The nuclear factor 1 (NF-1) motifs, NF-1 II/III, In the two 98-bp repeats of the transcription-regulatory region of JC virus (JCV), have a critical role in brain-specific transcription from the JCV early promoter-enhancer. In this study, the role of these motifs in transactivation of the JCV late promoter-enhancer (JC...

journal_title：Journal of neurochemistry

authors： Kumar KU,Devireddy LR,Tang SC,Pater A,Pater MM

更新日期：1996-08-01 00:00:00

abstract：:The glutamine cycle has been proposed as a pathway in which glutamine synthesized in glia provides substrate for synthesis of the neurotransmitters glutamate and GABA as they are lost from neurons. To test whether GABA may regulate this pathway, the effect of elevated GABA on the glial enzyme glutamine synthetase was ...

journal_title：Journal of neurochemistry

authors： Waniewski RA,Martin DL

更新日期：1995-07-01 00:00:00

abstract：:Synaptic scaffolding molecule (S-SCAM) is a synaptic protein that consists of PDZ domains, a guanylate kinase domain, and WW domains. It interacts with N-methyl-d-aspartate receptor subunits, neuroligin, and beta-catenin. Here, we identified Axin as a novel binding partner of S-SCAM. Axin was co-immunoprecipitated wit...

journal_title：Journal of neurochemistry

authors： Hirabayashi S,Nishimura W,Iida J,Kansaku A,Kishida S,Kikuchi A,Tanaka N,Hata Y

更新日期：2004-07-01 00:00:00

abstract：:'Metabolism' refers to the vast collection of chemical processes that occur within a living organism. Within this broad designation, one can identify metabolism events that relate specifically to energy homeostasis, whether they occur at the subcellular, cellular, organ, or whole organism level. This review operationa...

journal_title：Journal of neurochemistry

authors： Swerdlow RH

更新日期：2016-10-01 00:00:00

abstract：:Previous studies have indicated that the brains of DBA/2J (D2) mice have a more heavily myelinated CNS than those of C57BL/6J (B6) at postnatal days 17-21. However, the amount of myelin in the brains of F1 (B6 X D2) hybrids is even higher than in their parental strains. To investigate further factors involved in regul...

journal_title：Journal of neurochemistry

authors： Sato C,Yu RK

更新日期：1987-10-01 00:00:00

abstract：:We have introduced a series of point mutations into the human opioid receptor-like (ORL1) receptor and characterized them for their ability to constitutively activate G protein-coupled receptor signalling pathways. Among the 12 mutants generated, mutation at Asn133 (N133W) gave increased basal signalling through three...

journal_title：Journal of neurochemistry

authors： Kam KW,New DC,Wong YH

更新日期：2002-12-01 00:00:00

abstract：:Parkinson's disease (PD) motor symptoms are caused by degeneration of nigrostriatal dopaminergic (DAergic) neurons. The most common causes of hereditary PD are mutations in the PARKIN gene. The ubiquitin ligase parkin has been shown to mediate neuroprotection in cell culture and in vivo, but the molecular mechanisms a...

journal_title：Journal of neurochemistry

authors： Hasegawa T,Treis A,Patenge N,Fiesel FC,Springer W,Kahle PJ

更新日期：2008-06-01 00:00:00

abstract：:Myelin proteolipid protein (PLP) is known to contain long-chain, covalently bound fatty acids. Previous studies, including our own, have suggested the occurrence of an oxyester type of linkage between fatty acids and PLP. However, we found that protein-SH groups are required in the acylation reaction, suggesting the p...

journal_title：Journal of neurochemistry

authors： Bizzozero OA,Good LK

更新日期：1990-12-01 00:00:00

abstract：:Cavernous angiomas are vascular malformations that cause neurodegeneration and symptoms including epileptiform seizures, headache, and motor deficits. Following neurosurgical removal of the angiomas, patients mostly recover well and become seizure-free. This study reports on the levels of certain amino acids in angiom...

journal_title：Journal of neurochemistry

authors： von Essen C,Rydenhag B,Nyström B,Mozzi R,van Gelder N,Hamberger A

更新日期：1996-07-01 00:00:00

abstract：:The conversion of protease-sensitive prion protein (PrP-sen) to a high beta-sheet, protease-resistant and often fibrillar form (PrP-res) is a central event in transmissible spongiform encephalopathies (TSE) or prion diseases. This conversion can be induced by PrP-res itself in cell-free conversion reactions. The deter...

journal_title：Journal of neurochemistry

authors： Xiong LW,Raymond LD,Hayes SF,Raymond GJ,Caughey B

更新日期：2001-11-01 00:00:00

abstract：:The effects of heat stress on protein synthesis and fast axonal transport were examined in an in vitro bullfrog primary afferent neuron preparation. The magnitude of effect was determined for individual [35S]methionine-labelled protein species separated via two-dimensional gel electrophoresis. Elevation of temperature...

journal_title：Journal of neurochemistry

authors： Stone GC,Dougher MM

更新日期：1988-09-01 00:00:00

abstract：:The presence of a [3H]muscimol binding site on the purified benzodiazepine receptor was demonstrated. The purified protein was apparently homogeneous as shown by sodium dodecyl sulfate polyacrylamide gel electrophoresis (stained with silver), with a molecular weight of 60,000 +/- 3000. The benzodiazepine binding sites...

journal_title：Journal of neurochemistry

authors： Martini C,Rigacci T,Lucacchini A

更新日期：1983-10-01 00:00:00

abstract：:Myelinogenesis in developing rats was studied following chronic dosing with triethyl tin (TET), at a level of 1.0 mg TET/kg body wt/day. Experiments included starved controls with body weights depressed by 17 to 40% to equal those of the TET-treated groups. Rats at ages of 16, 21, and 30 days showed decreases relative...

journal_title：Journal of neurochemistry

authors： Blaker WD,Krigman MR,Thomas DJ,Mushak P,Morell P

更新日期：1981-01-01 00:00:00

abstract：:Transmitter release at high probability phasic synapses of crayfish neuromuscular junctions depresses by over 50% in 60 min when stimulated at 0.2 Hz. Inhibition of the protein phosphatase calcineurin by intracellular pre-synaptic injection of autoinhibitory peptide inhibited low-frequency depression (LFD) and resulte...

journal_title：Journal of neurochemistry

authors： Silverman-Gavrila LB,Charlton MP

更新日期：2009-05-01 00:00:00

abstract：:For nearly 100 years following the first description of this neurological disorder by Dr Alois Alzheimer, amyloid plaques and neurofibrillary tangles have been hypothesized to cause neuronal loss. With evidence that the extent of insoluble, deposited amyloid poorly correlated with cognitive impairment, research effort...

journal_title：Journal of neurochemistry

authors： Larson ME,Lesné SE

更新日期：2012-01-01 00:00:00

abstract：:Sequences in the transcribed region of the c-fos gene have been suggested to control c-fos induction following exposure of cells to mitogens or stimuli that increase intracellular calcium concentrations. Using a mutational analysis we show that putative regulatory elements present in the first intron of the human c-fo...

journal_title：Journal of neurochemistry

authors： Lange CM,Bading H

更新日期：2001-06-01 00:00:00

abstract：:Although isoelectric focusing has been used to demonstrate the presence of oligoclonal IgG in the CSF, the technique has not allowed detection of oligoclonal IgG in unconcentrated CSF. A new technique is reported, by which unconcentrated CSF is separated by isoelectric focusing, and the IgG bands are then detected by ...

journal_title：Journal of neurochemistry

authors： Lasne Y,Benzerara O,Chazot G,Creyssel R

更新日期：1981-05-01 00:00:00

abstract：:The amyloid precursor protein (APP) is an ubiquitous receptor-like molecule involved in the pathogenesis of Alzheimer's disease (AD). APP and some of its C-terminal proteolytic fragments (CTFs) have been shown to be phosphorylated and to interact with cytosolic phosphotyrosine binding (PTB) domain containing proteins ...

journal_title：Journal of neurochemistry

authors： Venezia V,Russo C,Repetto E,Salis S,Dolcini V,Genova F,Nizzari M,Mueller U,Schettini G

更新日期：2004-09-01 00:00:00

abstract：:As a result of the identification, pharmacological characterization, and localization of the cannabinoid receptor in the CNS, the existence of an endogenous ligand for this receptor can be hypothesized. Following the premise that such a substance could have the properties of a neuromodulator being stored in intracellu...

journal_title：Journal of neurochemistry

authors： Evans DM,Johnson MR,Howlett AC

更新日期：1992-02-01 00:00:00

abstract：:A neurochemical evaluation of beagle dogs with naturally occurring spontaneous generalized convulsive seizures was performed. Amino acid profiles of serum, cerebrospinal fluid (CSF), and biopsied cerebral cortex from epileptic dogs were compared with those from seizure-free siblings. No differences in absolute levels ...

journal_title：Journal of neurochemistry

authors： van Gelder NM,Edmonds HL Jr,Hegreberg GA,Chatburn CC,Clemmons RM,Sylvester DM

更新日期：1980-11-01 00:00:00

abstract：:Agonist activation of the delta-opioid receptor leads to internalization via G betagamma recruitment of G protein coupled receptor kinase-2, which phosphorylates the receptor at several sites, including Ser363, allowing beta-arrestin binding and localization to clathrin coated pits. Using human embryonic kidney cells ...

journal_title：Journal of neurochemistry

authors： Bradbury FA,Zelnik JC,Traynor JR

更新日期：2009-06-01 00:00:00

abstract：:Neural progenitor cells isolated from the embryonic cerebral cortex are well known to differentiate into neurons and glial cells, but recent reports have demonstrated differentiation into smooth muscle cells (SMCs) under the influence of fetal bovine serum. In this study, we report that agonists for G protein-coupled ...

journal_title：Journal of neurochemistry

authors： Morishita R,Nagata K,Ito H,Ueda H,Asano M,Shinohara H,Kato K,Asano T

更新日期：2007-05-01 00:00:00

abstract：:For clarification of the beneficial effects of the extract of Ginkgo biloba (EGB) on triethyltin (TET) toxicity in rats, the phosphodiesterase (PDE) activities of the cerebral tissue were measured under in vitro and ex vivo conditions. Under in vitro conditions, low concentrations of EGB (0.25-4.0 mg/L) activated the ...

journal_title：Journal of neurochemistry

authors： Macovschi O,Prigent AF,Nemoz G,Pacheco H

更新日期：1987-07-01 00:00:00

abstract：:Cathepsin D (CTSD) deficiencies are fatal neurological diseases that in human infants and in sheep are characterized by extreme loss of neurons and myelin. To date, similar morphological evidence for myelin disruption in CTSD knockout mice has not been reported. Here, we show that CTSD deficiency leads to pronounced m...

journal_title：Journal of neurochemistry

authors： Mutka AL,Haapanen A,Käkelä R,Lindfors M,Wright AK,Inkinen T,Hermansson M,Rokka A,Corthals G,Jauhiainen M,Gillingwater TH,Ikonen E,Tyynelä J

更新日期：2010-01-01 00:00:00

abstract：:Published evidence has linked glutamate with the pathogenesis of Alzheimer's disease (AD) and the up-regulation of a variety of chemokines, including monocyte chemotactic protein-1 (MCP-1)/chemokine ligand 2, with AD-associated pathological changes. In this study, we assessed the potential molecular basis for the role...

journal_title：Journal of neurochemistry

authors： Lee EO,Park HJ,Kang JL,Kim HS,Chong YH

更新日期：2010-03-01 00:00:00

abstract：:Sphingosine-1-phosphate (S1P) is a potent biomediator that can act as either an intracellular or an intercellular messenger. In the nervous system it exerts a wide range of actions, and specific membrane receptors for it have been identified in various regions. However, the physiological origin of extracellular S1P in...

journal_title：Journal of neurochemistry

authors： Anelli V,Bassi R,Tettamanti G,Viani P,Riboni L

更新日期：2005-03-01 00:00:00

abstract：:The proteasome is a multiprotein complex that is involved in the intracellular protein degradation in eukaryotes. Here, we show that human malignant glioma cells are susceptible to apoptotic cell death induced by the proteasome inhibitors, MG132 and lactacystin. The execution of the apoptotic death program involves th...

journal_title：Journal of neurochemistry

authors： Wagenknecht B,Hermisson M,Groscurth P,Liston P,Krammer PH,Weller M

更新日期：2000-12-01 00:00:00

abstract：:Postischemic recovery from brain edema and of protein synthesis was examined following 1 h of middle cerebral artery (MCA) occlusion in rats. Recovery from brain edema and of protein synthesis showed a good correlation until 7 days after reperfusion in each area (cerebral cortex or lateral caudate) in the occluded MCA...

journal_title：Journal of neurochemistry

authors： Abe K,Araki T,Kogure K

更新日期：1988-11-01 00:00:00