[3H]muscimol binding site on purified benzodiazepine receptor.

abstract：:Spatial solute concentration profiles resulting from in vivo microdialysis were measured in rat caudate-putamen by quantitative autoradiography. Radiolabeled sucrose was included in the dialysate, and the tissue concentration profile measured after infusions of 14 min and 61.5 min in an acute preparation. In addition,...

journal_title：Journal of neurochemistry

authors： Dykstra KH,Hsiao JK,Morrison PF,Bungay PM,Mefford IN,Scully MM,Dedrick RL

更新日期：1992-03-01 00:00:00

abstract：:The concentration of dopamine (DA) in the synaptic cleft in the mouse striatum in vivo was estimated from the competition between the synaptic DA and the 3H-labelled DA D2 receptor agonists N-n-propylnorapomorphine (NPA) or N,N-diethyl-N'-[(3 alpha, 4a alpha, 10 beta)-1,2,3,4,4a,5,10,10a-octahydro- 7-hydroxyl-1-propyl...

journal_title：Journal of neurochemistry

authors： Ross SB

更新日期：1991-01-01 00:00:00

abstract：:Differential assembly of N-methyl-D-aspartate (NMDA) receptor subunits determines their functional characteristics. Using in situ hybridization, we found a selective increase of the subunits NR1 and NR2A mRNA at 24 h in ventral motor neurons (VMN) caudal to a standardized spinal cord contusion injury (SCI). Other neur...

journal_title：Journal of neurochemistry

authors： Grossman SD,Wolfe BB,Yasuda RP,Wrathall JR

更新日期：2000-07-01 00:00:00

abstract：:We previously reported that annexin V promoted the survival of cultured rat neocortical neurons. In an effort to elucidate the mechanism underlying this neurotrophic activity of annexin V, we have attempted to identify the target or binding proteins of annexin V in neuronal cells. Herein, we screened an embryonic day ...

journal_title：Journal of neurochemistry

authors： Ohsawa K,Imai Y,Ito D,Kohsaka S

更新日期：1996-07-01 00:00:00

abstract：:Chick pineal glands in organ culture showed a circadian rhythm in the rate of thymidine incorporation. Thymidine incorporation was very markedly inhibited when 3-isobutyl-l-methylxanthine (IBMX) was continuously present. When IBMX was added to cultures in control medium during the photoperiod of the second day in cult...

journal_title：Journal of neurochemistry

authors： Wainwright SD,Wainwright LK

更新日期：1991-05-01 00:00:00

abstract：:Angiotensin (Ang)-converting enzyme (ACE) 2 cleaves Ang-II into the vasodilator peptide Ang-(1-7), thus acting as a pivotal element in balancing the local effects of these peptides. ACE2 has been identified in various tissues and is supposed to be a modulator of cardiovascular function. Decreases in ACE2 expression an...

journal_title：Journal of neurochemistry

authors： Xia H,Lazartigues E

更新日期：2008-12-01 00:00:00

abstract：:We describe here two types of apoptotic cell death observed in the rat CNS-derived neuroblastoma B50 and B104 cells. One type was induced by dibutyryl cyclic AMP (DBcAMP) after differentiation, and the other was induced by treatment of proliferating cells with cycloheximide. When B50 and B104 cells were treated with 1...

journal_title：Journal of neurochemistry

authors： Honma N,Uchida A,Hirose H,Srsen V,Kishimoto T,Hisanaga S

更新日期：1996-11-01 00:00:00

abstract：:Voltage-gated sodium channels (VGSC) are involved in the generation of action potentials in neurons. Brevetoxins (PbTx) are potent allosteric enhancers of VGSC function and are associated with the periodic 'red tide' blooms. Using PbTx-2 as a probe, we have characterized the effects of activation of VGSC on Ca(2+) dyn...

journal_title：Journal of neurochemistry

authors： Dravid SM,Baden DG,Murray TF

更新日期：2004-05-01 00:00:00

abstract：:Microglia are known to be a primary inflammatory cell type in the brain. However, microglial inflammatory responses are attenuated in the injured brain compared to those in cultured pure microglia. In the present study, we found that astrocytes challenged by oxygen-glucose deprivation (OGD) or H(2) O(2) released solub...

journal_title：Journal of neurochemistry

authors： Kim JH,Min KJ,Seol W,Jou I,Joe EH

更新日期：2010-12-01 00:00:00

abstract：:Studies performed over the past several years have provided evidence that phosphorylation of proteins is important in the regulation of neurotransmitter release. In this study, it is shown that rabphilin-3A is present in cerebellar granule cells as a phosphoprotein, by using 32P-labeling of cerebellar granule cells, i...

journal_title：Journal of neurochemistry

authors： Fykse EM

更新日期：1998-10-01 00:00:00

abstract：:The dopamine (DA) transporter (DAT) regulates DA neurotransmission by recycling DA back into neurons. Drugs that interfere with DAT function, e.g., cocaine and amphetamine, can have profound behavioral effects. The kinetics of DA transport by DAT in isolated synaptosomal or single cell preparations have been previousl...

journal_title：Journal of neurochemistry

authors： Jones SR,Joseph JD,Barak LS,Caron MG,Wightman RM

更新日期：1999-12-01 00:00:00

abstract：:Cyclic AMP phosphodiesterase activity in bovine brain coated vesicles displayed a Km of approximately 22 microM for cyclic AMP, a Vmax of 3.2 nmol/min/mg protein, and a Hill coefficient of 1.5, suggesting positive cooperativity. The enzyme activity was stimulated by cyclic GMP with maximal indexes of stimulation rangi...

journal_title：Journal of neurochemistry

authors： Silva WI,Schook W,Mittag TW,Puszkin S

更新日期：1986-04-01 00:00:00

abstract：:Previous studies examining age differences in membrane fluidity and cholesterol content have reported on the average or total change in membrane structure, respectively. However, a membrane consists of an exofacial leaflet and a cytofacial leaflet that differ in fluidity and cholesterol distribution. The purpose of th...

journal_title：Journal of neurochemistry

authors： Igbavboa U,Avdulov NA,Schroeder F,Wood WG

更新日期：1996-04-01 00:00:00

abstract：:N-Methyl-D-aspartate (NMDA) receptors mediate increases in intracellular calcium that can be modulated by protein kinase C (PKC). As PKC modulation of NMDA receptors in neurons is complex, we studied the effects of PKC activation on recombinant NMDA receptor-mediated calcium rises in a nonneuronal mammalian cell line,...

journal_title：Journal of neurochemistry

authors： Grant ER,Bacskai BJ,Anegawa NJ,Pleasure DE,Lynch DR

更新日期：1998-10-01 00:00:00

abstract：:The effect of phorbol esters was investigated on the down-regulation of protein kinase C (PKC) and on the release of [3H]norepinephrine (NE) in synaptosomes from the rat cerebrum. Treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) promoted the translocation of PKC activity in a P2 fraction from the cytosol to t...

journal_title：Journal of neurochemistry

authors： Oda T,Shearman MS,Nishizuka Y

更新日期：1991-04-01 00:00:00

abstract：:Following cellular stress or tissue injury, the proteasome plays a critical role in protein degradation and signal transduction. The present study examined the beta-subunit expression of constitutive proteasomes (beta1, beta2, and beta5), immunoproteasomes (beta1i, beta2i, and beta5i) and the 11S proteasome activator,...

journal_title：Journal of neurochemistry

authors： Yao X,Liu J,McCabe JT

更新日期：2008-01-01 00:00:00

abstract：:Ependymins are thought to be implicated in fundamental processes involved in plasticity of the goldfish CNS. Gas-phase sequencing of purified ependymins beta and gamma revealed that they share the same N-terminal sequence. Each sequence displays microheterogeneities at several positions. Based on the protein sequences...

journal_title：Journal of neurochemistry

authors： Königstorfer A,Sterrer S,Eckerskorn C,Lottspeich F,Schmidt R,Hoffmann W

更新日期：1989-01-01 00:00:00

abstract：:Endocannabinoids (eCBs) play key roles in short-term and long-term synaptic plasticity in the corticostriatal circuit. By activating cannabinoid receptors expressed in the central nervous system, eCBs regulate several neural functions and behaviors. The major eCB 2-arachidonoyl-glycerol (2-AG) is particularly importan...

journal_title：Journal of neurochemistry

authors： Socodato R

更新日期：2020-05-01 00:00:00

abstract：:The mammalian telencephalon, which comprises the cerebral cortex, olfactory bulb, hippocampus, basal ganglia, and amygdala, is the most complex and intricate region of the CNS. It is the seat of all higher brain functions including the storage and retrieval of memories, the integration and processing of sensory and mo...

journal_title：Journal of neurochemistry

authors： Corbin JG,Gaiano N,Juliano SL,Poluch S,Stancik E,Haydar TF

更新日期：2008-09-01 00:00:00

abstract：:A protein has been purified from human brain that appears to be the human equivalent of bovine 14-3-3 protein. On polyacrylamide gel electrophoresis the protein migrates as a faster major component, termed 14-3-3-2 protein, and a slower minor component, termed 14-3-3-1 protein, which consists of approximately 12% of t...

journal_title：Journal of neurochemistry

authors： Boston PF,Jackson P,Kynoch PA,Thompson RJ

更新日期：1982-05-01 00:00:00

abstract：:The endogenous cannabinoid anandamide has been reported to produce well-defined behavioral tolerance, but studies on the possible mechanisms underlying this process are few and often contradictory. The present study was designed to survey the cellular events involved in anandamide tolerance, in terms of the effects on...

journal_title：Journal of neurochemistry

authors： Rubino T,Viganò D,Costa B,Colleoni M,Parolaro D

更新日期：2000-12-01 00:00:00

abstract：:Neural progenitor cells isolated from the embryonic cerebral cortex are well known to differentiate into neurons and glial cells, but recent reports have demonstrated differentiation into smooth muscle cells (SMCs) under the influence of fetal bovine serum. In this study, we report that agonists for G protein-coupled ...

journal_title：Journal of neurochemistry

authors： Morishita R,Nagata K,Ito H,Ueda H,Asano M,Shinohara H,Kato K,Asano T

更新日期：2007-05-01 00:00:00

abstract：:We recently demonstrated that the presenilin-dependent gamma-secretase complex regulates the expression and activity of neprilysin, one of the main enzymes that degrade the amyloid beta-peptide (Abeta) which accumulates in Alzheimer's disease. Here, we examined the influence of endogenous nicastrin (NCT), a member of ...

journal_title：Journal of neurochemistry

authors： Pardossi-Piquard R,Dunys J,Yu G,St George-Hyslop P,Alves da Costa C,Checler F

更新日期：2006-05-01 00:00:00

abstract：:One-week treatment with the benzodiazepine (BZ) flurazepam (FZP), results in anticonvulsant tolerance, associated with reduced GABAA receptor (GABAR) subunit protein and miniature inhibitory post-synaptic current (mIPSC) amplitude in CA1 neurons of rat hippocampus. Because protein kinase A (PKA) has been shown to modu...

journal_title：Journal of neurochemistry

authors： Lilly SM,Zeng XJ,Tietz EI

更新日期：2003-05-01 00:00:00

abstract：:The uptake of radioactive biotin has been studied in glial cell cultures from dissociated cerebral hemispheres of newborn rats. We describe saturable kinetics for the biotin uptake at biotin concentrations of less than 60 nM and linear at greater than 60 nM. The uptake appeared temperature sensitive, Na+ independent, ...

journal_title：Journal of neurochemistry

authors： Rodriguez-Pombo P,Ugarte M

更新日期：1992-04-01 00:00:00

abstract：:Current evidence indicates that glutamate acting via the N-methyl-D-aspartate (NMDA) receptor/ion channel complex plays a major role in the neuronal degeneration associated with a variety of neurological disorders. In this report the role of glycine in NMDA neurotoxicity was examined. We demonstrate that NMDA-mediated...

journal_title：Journal of neurochemistry

authors： Patel J,Zinkand WC,Thompson C,Keith R,Salama A

更新日期：1990-03-01 00:00:00

abstract：:Recent etiological study in twins (Tanner et al. 1999) strongly suggests that environmental factors play an important role in typical, non-familial Parkinson's disease (PD), beginning after age 50. Epidemiological risk factor analyses of typical PD cases have identified several neurotoxicants, including MPP(+) (the ac...

journal_title：Journal of neurochemistry

authors： Chun HS,Gibson GE,DeGiorgio LA,Zhang H,Kidd VJ,Son JH

更新日期：2001-02-01 00:00:00

abstract：:The brain-specific protein p42IP4, also called centaurin-alpha1, specifically binds phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P3] and inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P4]. Here, we investigate the interaction of p42IP4/centaurin-alpha1 with nardilysin (NRDc), a member of the M16 family of z...

journal_title：Journal of neurochemistry

authors： Stricker R,Chow KM,Walther D,Hanck T,Hersh LB,Reiser G

更新日期：2006-07-01 00:00:00

abstract：:Calcium-activated neutral proteases (calpains) are regulated by specific endogenous protein inhibitors, the calpastatins, which are widely distributed in mammalian tissues. Calpastatins from different species or in various tissues from the same species exhibit considerable size heterogeneity on sodium dodecyl sulfate ...

journal_title：Journal of neurochemistry

authors： Mohan PS,Nixon RA

更新日期：1995-02-01 00:00:00

abstract：:L-Aspartate N-acetyltransferase, a nervous system enzyme that mediates the synthesis of N-acetyl-L-aspartic acid, has been characterized. In the presence of acetyl-CoA, L-aspartate was acetylated 10-fold more efficiently than L-glutamate, and the acetylation of aspartylglutamate was not detectable. Within the nervous ...

journal_title：Journal of neurochemistry

authors： Truckenmiller ME,Namboodiri MA,Brownstein MJ,Neale JH

更新日期：1985-11-01 00:00:00