Synaptic scaffolding molecule interacts with axin.

abstract：:Hyperglycemia is known to induce microvascular complications, thereby altering blood-brain barrier (BBB) permeability. This study investigated the role of matrix metalloproteinases (MMPs) and their endogenous inhibitors in increased BBB permeability and evaluated the protective effect of S-nitrosoglutathione (GSNO) in...

journal_title：Journal of neurochemistry

authors： Aggarwal A,Khera A,Singh I,Sandhir R

更新日期：2015-03-01 00:00:00

abstract：:De novo heterozygous mutations in the STX1B gene, encoding syntaxin 1B, cause a familial, fever-associated epilepsy syndrome. Syntaxin 1B is an essential component of the pre-synaptic neurotransmitter release machinery as a soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein that regulates th...

journal_title：Journal of neurochemistry

authors： Mishima T,Fujiwara T,Kofuji T,Saito A,Terao Y,Akagawa K

更新日期：2020-08-28 00:00:00

abstract：:Conversion of the cellular prion protein (PrP(C)) into the abnormal scrapie isoform (PrP(Sc)) is the hallmark of prion diseases, which are fatal and transmissible neurodegenerative disorders. ER-retained anti-prion recombinant single-chain Fv fragments have been proved to be an effective tool for inhibition of PrP(C) ...

journal_title：Journal of neurochemistry

authors： Filesi I,Cardinale A,Mattei S,Biocca S

更新日期：2007-06-01 00:00:00

abstract：:Molecular mechanisms underlying tauopathy remain undetermined. In the current study, single cell gene expression profiling was coupled with custom-designed cDNA array analysis to evaluate tau expression and other cytoskeletal elements within individual neuronal populations in patients with no cognitive impairment (NCI...

journal_title：Journal of neurochemistry

authors： Ginsberg SD,Che S,Counts SE,Mufson EJ

更新日期：2006-03-01 00:00:00

abstract：:The subunit compositions of the NR1 C2 exon-containing N-methyl-D-aspartate (NMDA) receptors of adult mammalian forebrain were determined by using a combination of immunoaffinity chromatography and immunoprecipitation studies with NMDA receptor subunit-specific antibodies. NMDA receptors were solubilised by sodium deo...

journal_title：Journal of neurochemistry

authors： Chazot PL,Stephenson FA

更新日期：1997-11-01 00:00:00

abstract：:Myelin-associated glycoprotein (MAG) and Schwann cell myelin protein (SMP) are highly glycosylated members of a newly defined family of cell adhesion molecules belonging to the immunoglobulin superfamily that recognize terminal sialic acid residues on N- and O-linked oligosaccharides. The importance of the N-linked ol...

journal_title：Journal of neurochemistry

authors： Tropak MB,Roder JC

更新日期：1997-04-01 00:00:00

abstract：:The effects of the protein kinase inhibitor H-7 on early and delayed responses to nerve growth factor (NGF) were investigated in PC12 cells. H-7 reduced the NGF-induced expression of c-Fos in a dose-dependent manner without affecting the time course of c-Fos appearance. Conversely, H-7 potentiated delayed NGF effects,...

journal_title：Journal of neurochemistry

authors： Kahle P,Mangold M,Kuwahara T,Schubenel R,Hertel C

更新日期：1994-02-01 00:00:00

abstract：:The effect of selective inhibition of monoamine oxidase (MAO) subtypes A and B on striatal metabolism of DOPA to dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), and 4-hydroxy-3-methoxyphenylacetic acid (homovanillic acid; HVA) was studied in halothane-anesthetized rats 3 weeks after unilateral 6-hydroxydopamine...

journal_title：Journal of neurochemistry

authors： Finberg JP,Wang J,Goldstein DS,Kopin IJ,Bankiewicz KS

更新日期：1995-09-01 00:00:00

abstract：:An alteration in signal transduction systems in Alzheimer's disease (AD) would likely be of pathophysiological significance, because these processes control normal brain functions. Previously, a diminished beta-adrenergic-mediated cyclic AMP response was found in cultured fibroblasts from AD patients. Because cross-ta...

journal_title：Journal of neurochemistry

authors： Huang HM,Lin TA,Sun GY,Gibson GE

更新日期：1995-02-01 00:00:00

abstract：:Three serine residues (Ser193, Ser194, Ser197) in the fifth transmembrane-spanning region of the D2 dopamine receptor have been mutated separately to alanine and the effects of the mutations determined in ligand-binding experiments with [3H] spiperone. For many antagonists the mutations had little effect, showing that...

journal_title：Journal of neurochemistry

authors： Woodward R,Coley C,Daniell S,Naylor LH,Strange PG

更新日期：1996-01-01 00:00:00

abstract：:We have shown that following heat shock (42.5 degree C for 30 min), mouse-derived C1300 N2A neuroblastoma cells contain increased levels of mRNA coding for the inducible form of heat shock protein 70 and for ubiquitin. Incubation of C1300 cells with iron also induces an elevation in content of mRNAs coding for the sam...

journal_title：Journal of neurochemistry

authors： Uney JB,Anderton BH,Thomas SM

更新日期：1993-02-01 00:00:00

abstract：:In this study, we describe a novel form of anti-homeostatic plasticity produced after culturing spinal neurons with strychnine, but not bicuculline or 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX). Strychnine caused a large increase in network excitability, detected as spontaneous synaptic currents and calcium transient...

journal_title：Journal of neurochemistry

authors： Carrasco MA,Castro PA,Sepulveda FJ,Cuevas M,Tapia JC,Izaurieta P,van Zundert B,Aguayo LG

更新日期：2007-03-01 00:00:00

abstract：:We examined the effects of orally administered 5'-cytidinediphosphocholine (CDP-choline) on arterial plasma choline and cytidine levels and on brain phospholipid composition in rats. Animals receiving a single oral dose of 100, 250, or 500 mg/kg showed peak plasma choline levels 6-8 h after drug administration (from 1...

journal_title：Journal of neurochemistry

authors： López-Coviella I,Agut J,Savci V,Ortiz JA,Wurtman RJ

更新日期：1995-08-01 00:00:00

abstract：:Morphine is a key drug for the treatment of pain but its side effects limit its clinical application. MEL-0614, an endomorphin-1 analog, has fewer side effects than morphine in addition to its powerful analgesic effect. In this study, we measured the effect of morphine and MEL-0614 on hyperalgesia (7 days) and neuropa...

journal_title：Journal of neurochemistry

authors： Ma M,Wang Z,Wang J,Wei S,Cui J,Wang Y,Luo K,Zhao L,Liu X,Wang R

更新日期：2020-07-15 00:00:00

abstract：:Therapy of malignant glioma relies on treatment with the O6 -methylating agent temozolomide (TMZ) concomitant with ionizing radiation followed by adjuvant TMZ. For the treatment of recurrences, DNA chloroethylating drugs are also used. The main killing lesion induced by these drugs is O6 -alkylguanine. Since this dama...

journal_title：Journal of neurochemistry

authors： Aasland D,Reich TR,Tomicic MT,Switzeny OJ,Kaina B,Christmann M

更新日期：2018-01-01 00:00:00

abstract：:Kallikrein 6 is a serine protease expressed abundantly in normal adult human and rodent CNS, and therein is regulated by injury. In the case of CNS demyelinating disease, K6 expression in CNS occurs additionally in perivascular and parenchymal inflammatory cells suggesting a role in pathogenesis. Herein we describe tw...

journal_title：Journal of neurochemistry

authors： Christophi GP,Isackson PJ,Blaber S,Blaber M,Rodriguez M,Scarisbrick IA

更新日期：2004-12-01 00:00:00

abstract：:Autophosphorylation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) at Thr286 generates Ca2+-independent activity. As an initial step toward understanding CaMKII inactivation, protein phosphatase classes (PP1, PP2A, PP2B, or PP2C) responsible for dephosphorylation of Thr286 in rat forebrain subcellular fractio...

journal_title：Journal of neurochemistry

authors： Strack S,Barban MA,Wadzinski BE,Colbran RJ

更新日期：1997-05-01 00:00:00

abstract：:Acute seizures and other stimuli that increase neuronal activity cause a rapid induction of the immediate-early genes c-fos and c-jun, also referred to as nuclear proto-oncogenes, in the nervous system. In the present study, rats were administered one or more electroconvulsive seizures (ECS) and the responsiveness of ...

journal_title：Journal of neurochemistry

authors： Winston SM,Hayward MD,Nestler EJ,Duman RS

更新日期：1990-06-01 00:00:00

abstract：:Neuropeptide Y (NPY) is an important regulator of energy balance in mammals through its orexigenic, antithermogenic, and insulin secretagogue actions. We investigated the regulation of endogenous NPY release from rat hypothalamic slices by NPY receptor ligands and calcium channel antagonists. High-potassium stimulatio...

journal_title：Journal of neurochemistry

authors： King PJ,Widdowson PS,Doods HN,Williams G

更新日期：1999-08-01 00:00:00

abstract：:Currently, the underlying mechanisms and the specific cell types associated with Japanese encephalitis-associated leukocyte trafficking are not understood. Brain microvascular endothelial cells represent a functional barrier and could play key roles in leukocyte central nervous system trafficking. We found that cultur...

journal_title：Journal of neurochemistry

authors： Lai CY,Ou YC,Chang CY,Pan HC,Chang CJ,Liao SL,Su HL,Chen CJ

更新日期：2012-10-01 00:00:00

abstract：:At the premyelinating stage, the Schwann cells of peripheral nerves are able to recognize the axon, to arrange themselves along it in a nonoverlapping manner, and finally to establish a one-to-one cell-axon relationship. The mechanism that regulates these processes is not known in detail. We found the existence of a s...

journal_title：Journal of neurochemistry

authors： Nakao J,Shinoda J,Nakai Y,Murase S,Uyemura K

更新日期：1997-05-01 00:00:00

abstract：:Neuropeptide S (NPS) is known to produce anxiolytic-like effects and facilitate extinction of conditioned fear. Catecholaminergic neurotransmission in the medial prefrontal cortex (mPFC) has been suggested to be crucially involved in these brain functions. In the current study, we investigated the effect of NPS on the...

journal_title：Journal of neurochemistry

authors： Si W,Aluisio L,Okamura N,Clark SD,Fraser I,Sutton SW,Bonaventure P,Reinscheid RK

更新日期：2010-10-01 00:00:00

abstract：:Purified tribulin, an endogenous monoamine oxidase (MAO) inhibitor, has been identified by direct probe insertion mass spectrometry as the indole-2,3-dione, isatin. A gas chromatographic-mass spectrometric assay for isatin has been developed and used to measure its relatively high concentrations in unpurified human ur...

journal_title：Journal of neurochemistry

authors： Glover V,Halket JM,Watkins PJ,Clow A,Goodwin BL,Sandler M

更新日期：1988-08-01 00:00:00

abstract：:Nicotinic cholinergic receptor binding sites labeled by [3H]acetylcholine were measured in the cerebral cortices, thalami, striata, and hypothalami of rats lesioned by intraventricular injection of either 6-hydroxydopamine or 5, 7-dihydroxytryptamine. In addition, [3H]acetylcholine binding sites were measured in the c...

journal_title：Journal of neurochemistry

authors： Schwartz RD,Lehmann J,Kellar KJ

更新日期：1984-05-01 00:00:00

abstract：:cDNAs encoding four isoforms of the human NMDA receptor (NMDAR) NMDAR2C (hNR2C-1, -2, -3, and -4) have been isolated and characterized. The overall identity of the deduced amino acid sequences of human and rat NR2C-1 is 89.0%. The sequences of the rat and human carboxyl termini (Gly925-Val1,236) are encoded by differe...

journal_title：Journal of neurochemistry

authors： Daggett LP,Johnson EC,Varney MA,Lin FF,Hess SD,Deal CR,Jachec C,Lu CC,Kerner JA,Landwehrmeyer GB,Standaert DG,Young AB,Harpold MM,Veliçelebi G

更新日期：1998-11-01 00:00:00

abstract：:In the preceding report we demonstrated a dose-dependent increase in 32P-phosphoprotein labeling after 24-h exposure of cultured cerebellar granule neurons to methyl mercury (MeHg), a response that was not observed in glial cultures. In the present study we have examined 32P-labeled phosphoproteins by two-dimensional ...

journal_title：Journal of neurochemistry

authors： Sarafian T,Verity MA

更新日期：1990-09-01 00:00:00

abstract：:The role of protein kinase C (PKC) in modulating the release of the octapeptide cholecystokinin (CCK-8) was investigated in rat hippocampal nerve terminals (synaptosomes). The PKC-activating phorbol ester 4beta-phorbol 12,13-dibutyrate (beta-PDBu) dose dependently (5-5,000 nM) increased CCK-8 release in a strictly Ca2...

journal_title：Journal of neurochemistry

authors： Breukel AI,Wiegant VM,Lopes da Silva FH,Ghijsen WE

更新日期：1998-01-01 00:00:00

abstract：:Accumulating evidence indicates that increased intracellular Na(+) concentration ([Na(+) ]i ) in astroglial cells is associated with the development of brain edema under ischemic conditions, but the underlying mechanisms are still elusive. Here, we report that in primary cultured rat cortical astrocytes, elevations of...

journal_title：Journal of neurochemistry

authors： Minieri L,Pivonkova H,Harantova L,Anderova M,Ferroni S

更新日期：2015-02-01 00:00:00

abstract：:An oligodendroglial specific property, glucocorticoid regulation of glycerol-3-phosphate dehydrogenase (GPDH) levels, was inhibited in C6 rat glioma cells when 4 beta-phorbol 12-myristate 13-acetate (PMA) was added to the cultures. PMA inhibited GPDH induction in both logarithmic- and stationary-phase cells. These eve...

journal_title：Journal of neurochemistry

authors： Bressler JP,Weingarten D,Kornblith PL

更新日期：1985-10-01 00:00:00

abstract：:A ganglioside antigen was detected in infant human brains by the monoclonal antibody C-50. Structural analysis of the isolated ganglioside antigen showed it to be 3'-isoLM1, sialosyllactotetraosylceramide. The concentration of this ganglioside in human infant brain was 0.5 nmol/g. ...

journal_title：Journal of neurochemistry

authors： Molin K,Månsson JE,Fredman P,Svennerholm L

更新日期：1987-07-01 00:00:00