Synaptic and extrasynaptic GABA transporters as targets for anti-epileptic drugs.

abstract：:Phospholipids are asymmetrically distributed across the mammalian plasma membrane, with phosphatidylserine (PS) and phosphatidylethanolamine concentrated in the cytoplasmic leaflet of the membrane bilayer and phosphatidylcholine in the exoplasmic leaflet. This asymmetric distribution is dependent on a group of P4 ATPa...

journal_title：Journal of neurochemistry

authors： Yang Y,Liu W,Sun K,Jiang L,Zhu X

更新日期：2019-02-01 00:00:00

abstract：:We have previously shown that Regulator of Calcineurin 1 (RCAN1) regulates multiple stages of vesicle exocytosis. However, the mechanisms by which RCAN1 affects secretory vesicle exocytosis and quantal release kinetics remain unknown. Here, we use carbon fibre amperometry to detect exocytosis from chromaffin cells and...

journal_title：Journal of neurochemistry

authors： Zanin MP,Mackenzie KD,Peiris H,Pritchard MA,Keating DJ

更新日期：2013-02-01 00:00:00

abstract：:Substrate-induced endocytic trafficking of dopamine transporter (DAT) has been observed, but little is known about the regulation of DAT oligomerization by substrate. The present study investigates the effect on substrates on DAT oligomerization and explores a potential link with the presence of DAT at the cell surfac...

journal_title：Journal of neurochemistry

authors： Chen N,Reith ME

更新日期：2008-05-01 00:00:00

abstract：:Activation of extracellular signal-regulated protein kinase 1/2 (ERK1/2) are implicated in the pathophysiology of spinal cord injury (SCI). However, the specific functions of individual ERK isoforms in neurodegeneration are largely unknown. We investigated the hypothesis that ERK2 activation may contribute to patholog...

journal_title：Journal of neurochemistry

authors： Yu CG,Yezierski RP,Joshi A,Raza K,Li Y,Geddes JW

更新日期：2010-04-01 00:00:00

abstract：:Metipranolol is a β-adrenergic receptor antagonist that is given orally for the treatment of hypertension and also applied topically to the cornea for treating glaucoma. It also inhibits nitrosative stress which has previously been shown to be the cause of cone photoreceptor death in retinitis pigmentosa. In this stud...

journal_title：Journal of neurochemistry

authors： Kanan Y,Khan M,Lorenc VE,Long D,Chadha R,Sciamanna J,Green K,Campochiaro PA

更新日期：2019-01-01 00:00:00

abstract：:The protein anosmin-1, coded by the KAL1 gene responsible for the X-linked form of Kallmann syndrome (KS), exerts its biological effects mainly through the interaction with and signal modulation of fibroblast growth factor receptor 1 (FGFR1). We have previously shown the interaction of the third fibronectin-like type ...

journal_title：Journal of neurochemistry

authors： Esteban PF,Murcia-Belmonte V,García-González D,de Castro F

更新日期：2013-03-01 00:00:00

abstract：:In Alzheimer's disease, the neuritic or senile amyloid plaques in hippocampus and association cortex, the diffuse plaques in brain areas such as the cerebellum and sensorimotor cortex, and the amyloid deposits in the walls of pial and parenchymal blood vessels are mainly composed of amyloid beta-peptides. In the prese...

journal_title：Journal of neurochemistry

authors： Ghersi-Egea JF,Gorevic PD,Ghiso J,Frangione B,Patlak CS,Fenstermacher JD

更新日期：1996-08-01 00:00:00

abstract：:We have shown previously that the plecomacrolide antibiotics bafilomycin A1 and B1 significantly attenuate cerebellar granule neuron death resulting from agents that disrupt lysosome function. To further characterize bafilomycin-mediated cytoprotection, we examined its ability to attenuate the death of naïve and diffe...

journal_title：Journal of neurochemistry

authors： Pivtoraiko VN,Harrington AJ,Mader BJ,Luker AM,Caldwell GA,Caldwell KA,Roth KA,Shacka JJ

更新日期：2010-08-01 00:00:00

abstract：:Seven monoclonal antibodies (MAbs) directed to tetrasialoganglioside (GQ1b) were established, purified GQ1b being used for immunization and hybridoma screening. All of the MAbs reacted strongly with GQ1b, although they also reacted with other gangliosides, with different specificities and reactivities. Some MAbs (1H10...

journal_title：Journal of neurochemistry

authors： Yamamoto H,Tsuji S,Nagai Y

更新日期：1990-02-01 00:00:00

abstract：:Parkinson's disease (PD) motor symptoms are caused by degeneration of nigrostriatal dopaminergic (DAergic) neurons. The most common causes of hereditary PD are mutations in the PARKIN gene. The ubiquitin ligase parkin has been shown to mediate neuroprotection in cell culture and in vivo, but the molecular mechanisms a...

journal_title：Journal of neurochemistry

authors： Hasegawa T,Treis A,Patenge N,Fiesel FC,Springer W,Kahle PJ

更新日期：2008-06-01 00:00:00

abstract：:Incubation of rat pheochromocytoma PC12 cells with 4 beta-phorbol-12 beta-myristate-13 alpha-acetate (PMA), an activator of Ca2+/phospholipid-dependent protein kinase (protein kinase C), or forskolin, an activator of adenylate cyclase, is associated with increased activity and enhanced phosphorylation of tyrosine hydr...

journal_title：Journal of neurochemistry

authors： Tachikawa E,Tank AW,Weiner DH,Mosimann WF,Yanagihara N,Weiner N

更新日期：1987-05-01 00:00:00

abstract：:The presynaptic terminals of skate (Raja montagui) electric organ were tested for their sensitivity to calcium channel antagonists. Acetylcholine (ACh) release and the elevation of intraterminal Ca2+ concentrations triggered by K+ depolarisation were studied. ACh release was measured as 3H efflux from slices of organ ...

journal_title：Journal of neurochemistry

authors： Richardson CM,Dowdall MJ,Green AC,Bowman D

更新日期：1995-02-01 00:00:00

abstract：:Exposure to excessive levels of light induces photoreceptor apoptosis and can be a causative factor in age-related macular degeneration (AMD). However, the cellular events that mediate this apoptotic response are poorly understood. Here, we investigated the roles of endoplasmic reticulum (ER) stress in light-induced c...

journal_title：Journal of neurochemistry

authors： Nakanishi T,Shimazawa M,Sugitani S,Kudo T,Imai S,Inokuchi Y,Tsuruma K,Hara H

更新日期：2013-04-01 00:00:00

abstract：:Voltage-gated sodium channels (VGSC) are involved in the generation of action potentials in neurons. Brevetoxins (PbTx) are potent allosteric enhancers of VGSC function and are associated with the periodic 'red tide' blooms. Using PbTx-2 as a probe, we have characterized the effects of activation of VGSC on Ca(2+) dyn...

journal_title：Journal of neurochemistry

authors： Dravid SM,Baden DG,Murray TF

更新日期：2004-05-01 00:00:00

abstract：:A ganglioside antigen was detected in infant human brains by the monoclonal antibody C-50. Structural analysis of the isolated ganglioside antigen showed it to be 3'-isoLM1, sialosyllactotetraosylceramide. The concentration of this ganglioside in human infant brain was 0.5 nmol/g. ...

journal_title：Journal of neurochemistry

authors： Molin K,Månsson JE,Fredman P,Svennerholm L

更新日期：1987-07-01 00:00:00

abstract：:The mechanism(s) underlying neurodegeneration-associated activation of ERK1/2 remain poorly understood. We report that in cultured rat cortical neurons, whose basal ERK1/2 phosphorylation required NMDA receptors (NMDAR), the neurotoxic DNA intercalating drug cisplatin increased ERK1/2 phosphorylation via NMDAR despite...

journal_title：Journal of neurochemistry

authors： Gozdz A,Vashishta A,Kalita K,Szatmari E,Zheng JJ,Tamiya S,Delamere NA,Hetman M

更新日期：2008-09-01 00:00:00

abstract：:A method for rapid, automated (less than 5 min), and sensitive (detection limit 50 fmol/10 microliter) determination of gamma-aminobutyric acid (GABA) is described. The method is based on precolumn derivatization with o-phthaldialdehyde/t-butylthiol reagent and separation by reverse-phase HPLC with electrochemical det...

journal_title：Journal of neurochemistry

authors： Kehr J,Ungerstedt U

更新日期：1988-10-01 00:00:00

abstract：:The effects of excitatory amino acid agonists and alpha-amino-omega-phosphonocarboxylic acid antagonists on phosphoinositide hydrolysis in hippocampal slices of the 7-day neonatal rat were examined. Significant stimulation of [3H]inositol monophosphate formation was observed with ibotenate, quisqualate, L-glutamate, L...

journal_title：Journal of neurochemistry

authors： Schoepp DD,Johnson BG

更新日期：1989-12-01 00:00:00

abstract：:Hairy/Enhancer of split (Hes) 6 is a basic helix-loop-helix protein that interacts with the transcriptional co-repressor, Groucho, and antagonizes the neural functions of the Notch pathway. More specifically, mouse Hes6 regulates cerebral corticogenesis by promoting neurogenesis and suppressing astrocyte differentiati...

journal_title：Journal of neurochemistry

authors： Belanger-Jasmin S,Llamosas E,Tang Y,Joachim K,Osiceanu AM,Jhas S,Stifani S

更新日期：2007-12-01 00:00:00

abstract：:Quinolinic acid is an excitatory, neurotoxic tryptophan metabolite proposed to play a role in the pathogenesis of hepatic encephalopathy. This involvement was investigated in rat and rabbit models of fulminant hepatic failure at different stages of hepatic encephalopathy. Although plasma and brain tryptophan levels we...

journal_title：Journal of neurochemistry

authors： Basile AS,Saito K,Li Y,Heyes MP

更新日期：1995-06-01 00:00:00

abstract：:We recently reported an abnormal production of interleukin-1 (IL-1) in peripheral macrophages of several neurological mutant mice that exhibit patterns of neuronal degeneration, especially in the cerebellum. After in vitro activation by lipopolysaccharide acid (LPS), these macrophages hyperexpress IL-1 beta mRNA and h...

journal_title：Journal of neurochemistry

authors： Kopmels B,Mariani J,Delhaye-Bouchaud N,Audibert F,Fradelizi D,Wollman EE

更新日期：1992-01-01 00:00:00

abstract：:Genomic and cDNA clones encoding the rat D1 receptor were isolated and sequenced. Comparison of the D1 receptor cDNA and genomic sequences revealed that the rat D1 receptor gene is organized into two exons separated by a small intron in the 5' untranslated region of its mRNA. The transcription start site is located 86...

journal_title：Journal of neurochemistry

authors： Zhou QY,Li C,Civelli O

更新日期：1992-11-01 00:00:00

abstract：:The thermodynamic parameters associated with the interactions of agonists and antagonists with glycine receptors in rat spinal cord membranes were determined. The binding of the antagonist [3H]strychnine and the inhibition of strychnine binding by 11 different glycinergic ligands were examined at temperatures between ...

journal_title：Journal of neurochemistry

authors： Ruiz-Gómez A,García-Calvo M,Vázquez J,Marvizón JC,Valdivieso F,Mayor F Jr

更新日期：1989-06-01 00:00:00

abstract：:The consequences of H(2)O(2)/Fe(2+)-induced oxidative stress on translocation of ethanolamine phosphoglyceride (EPG) and serine phosphoglyceride (SPG) were studied in an oligodendroglia-like cell line (OLN 93) following 3 days of supplementation with 0.1 mM docosahexaenoic acid (DHA) and a series of polar head group p...

journal_title：Journal of neurochemistry

authors： Brand A,Yavin E

更新日期：2001-09-01 00:00:00

abstract：:Increased cerebrovascular permeability is an important factor for the development of cerebral edema. To investigate the effect of hypoxia on the transport of blood-borne proteins to the brain, we used a cell culture model of the blood-brain barrier (BBB) consisting of a coculture of brain capillary endothelial cells a...

journal_title：Journal of neurochemistry

authors： Plateel M,Teissier E,Cecchelli R

更新日期：1997-02-01 00:00:00

abstract：:Niemann-Pick type C disease (NPCD) was first described in 1914 and affects approximately 1 in 150 000 live births. It is characterized clinically by diverse symptoms affecting liver, spleen, motor control, and brain; premature death invariably results. Its molecular origins were traced, as late as 1997, to a protein o...

journal_title：Journal of neurochemistry

authors： Wheeler S,Sillence DJ

更新日期：2020-06-01 00:00:00

abstract：:Tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of the catecholamines dopamine, noradrenaline and adrenaline, is regulated acutely by feedback inhibition by the catecholamines and relief of this inhibition by phosphorylation of serine 40 (Ser40). Phosphorylation of serine 40 abolishes the bindi...

journal_title：Journal of neurochemistry

authors： Gordon SL,Quinsey NS,Dunkley PR,Dickson PW

更新日期：2008-08-01 00:00:00

abstract：:The effects of acute and chronic administration of buspirone, a serotonin 5-HT1A agonist, on the 5-HT synthesis rates in various rat brain structures were investigated using alpha-[14C]methyl-L-tryptophan (alpha-[14C]MTrp) and an autoradiographic method. In the acute treatment study, buspirone (10 mg/kg) was injected ...

journal_title：Journal of neurochemistry

authors： Okazawa H,Yamane F,Blier P,Diksic M

更新日期：1999-05-01 00:00:00

abstract：:Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain scaffolding protein with kinase and GTPase activities involved in synaptic vesicle (SV) dynamics. While its role in Parkinson's disease has been largely investigated, little is known about LRRK2 physiological role and until now few proteins have been describe...

journal_title：Journal of neurochemistry

authors： Marte A,Russo I,Rebosio C,Valente P,Belluzzi E,Pischedda F,Montani C,Lavarello C,Petretto A,Fedele E,Baldelli P,Benfenati F,Piccoli G,Greggio E,Onofri F

更新日期：2019-08-01 00:00:00

abstract：:In the preceding report we demonstrated a dose-dependent increase in 32P-phosphoprotein labeling after 24-h exposure of cultured cerebellar granule neurons to methyl mercury (MeHg), a response that was not observed in glial cultures. In the present study we have examined 32P-labeled phosphoproteins by two-dimensional ...

journal_title：Journal of neurochemistry

authors： Sarafian T,Verity MA

更新日期：1990-09-01 00:00:00