Enhanced hippocampal F2-isoprostane formation following kainate-induced seizures.

abstract：:Nitric oxide (NO) has been implicated in both the pathogenesis of and protection from NMDA receptor-mediated neuronal injury. This apparent paradox has been attributed to alternate redox states of nitrogen monoxide, whereby, depending on the redox milieu, nitrogen monoxide can be neuroprotective via nitrosation chemis...

journal_title：Journal of neurochemistry

authors： Vidwans AS,Kim S,Coffin DO,Wink DA,Hewett SJ

更新日期：1999-05-01 00:00:00

abstract：:Recent evidence supports the emerging hypothesis that the amyloid-β precursor protein C-terminal fragments (APP-CTFs) and dysregulations in both their qualitative and quantitative productions may actively and directly contribute to the neuronal toxicity in early phases of Alzheimer's disease (AD). These new findings r...

journal_title：Journal of neurochemistry

authors： Mosser S,Gerber H,Fraering PC

更新日期：2020-08-05 00:00:00

abstract：:Extracellular amino acid levels in the rat piriform cortex, an area highly susceptible to seizure-induced neuropathology, were determined by means of intracranial microdialysis. Seizures were induced by systemic administration of either soman (O-1,2,2-trimethylpropyl methylphosphonofluoridate), a potent inhibitor of a...

journal_title：Journal of neurochemistry

authors： Wade JV,Samson FE,Nelson SR,Pazdernik TL

更新日期：1987-08-01 00:00:00

abstract：:Cytokines have been suggested to be involved in the cross talk between the immune and the nervous systems, under normal and pathological conditions. For example, the cytokine interleukin-2 was suggested to be involved in response to CNS trauma and spontaneous regeneration. Here, we examined whether mammalian CNS has a...

journal_title：Journal of neurochemistry

authors： Eizenberg O,Faber-Elman A,Lotan M,Schwartz M

更新日期：1995-05-01 00:00:00

abstract：:Parkinson's disease is the second most common neurodegenerative disorder after Alzheimer's disease and is estimated to affect approximately 1-4% of individuals aged over 60 years old. Although considerable efforts have been invested into developing disease-modifying therapies for Parkinson's disease, such efforts have...

journal_title：Journal of neurochemistry

authors： Fayyad M,Salim S,Majbour N,Erskine D,Stoops E,Mollenhauer B,El-Agnaf OMA

更新日期：2019-09-01 00:00:00

abstract：:Slices of rabbit caudate and hypothalamus take up and accumulate [3H]imipramine. In superfused slices of both structures electrical stimulation or exposure to tyramine failed to release recently taken up [3H]imipramine. Depolarization by exposure to 30--60 mM-potassium caused only a small release of [3H]imipramine tha...

journal_title：Journal of neurochemistry

authors： Langer SZ,Galzin AM,Kamal LA

更新日期：1982-02-01 00:00:00

abstract：:Because ATP is degraded to adenosine, its effect could be mediated by both P1 and P2 receptors. Hence, the actions of an ATP analogue, resistant to enzymatic breakdown (alpha, beta-methylene ATP), were studied on the resting and electrically evoked release of radioactivity from longitudinal muscle strips of guinea pig...

journal_title：Journal of neurochemistry

authors： Sperlagh B,Vizi ES

更新日期：1991-05-01 00:00:00

abstract：:The FE65 adaptor protein family was identified in two-hybrid screens as proteins that bind the cytoplasmic domain of the amyloid precursor protein (APP). Studies have shown that FE65 binding to APP modulates APP processing. Increased levels of alpha-secretase derived secreted APP (APPsalpha) and beta-amyloid (Abeta) w...

journal_title：Journal of neurochemistry

authors： Guénette SY,Chang Y,Hyman BT,Tanzi RE,Rebeck GW

更新日期：2002-08-01 00:00:00

abstract：:Post-traumatic immune suppression renders individuals with spinal cord injury (SCI) susceptible to infection. Normally, proper immune function is regulated by collaboration between the sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenal (HPA) axis and involves the controlled release of glucocorticoids ...

journal_title：Journal of neurochemistry

authors： Lucin KM,Sanders VM,Popovich PG

更新日期：2009-09-01 00:00:00

abstract：:Male copulatory behavior in the snail Lymnaea stagnalis is controlled by several types of peptidergic neurons, including a cluster of neurons in the ventral lobe of the right cerebral ganglion that show immunoreactivity to myomodulin-A of Aplysia and innervate the penis complex. We identified structurally myomodulin-A...

journal_title：Journal of neurochemistry

authors： van Golen FA,Li KW,Chen S,Jiménez CR,Geraerts WP

更新日期：1996-01-01 00:00:00

abstract：:Incubation of beta-endorphin with cytosolic and particulate fractions of rat brain resulted in the formation of several peptides, including gamma-endorphin [beta-endorphin-(1-17)] and beta-endorphin-(18-31), indicating the presence of enzyme activity cleaving the Leu17-Phe18 bond of beta-endorphin. An assay for this L...

journal_title：Journal of neurochemistry

authors： Lebouille JL,Hendriks RW,Soeter NM,Burbach JP

更新日期：1989-06-01 00:00:00

abstract：:Glycogen synthase kinase 3 (GSK3) plays important roles in Wnt and insulin signaling, cell fate determination, and Alzheimer-like tau phosphorylation. We discovered an isoform of tau protein kinase I (TPKI)/GSK3beta with a 13 amino acid insert in the catalytic domain owing to alternative splicing. The alternative tran...

journal_title：Journal of neurochemistry

authors： Mukai F,Ishiguro K,Sano Y,Fujita SC

更新日期：2002-06-01 00:00:00

abstract：:RGS (regulators of G-protein signaling) proteins comprise a large family that modulates heterotrimeric G-protein signaling. This protein family has a common RGS domain and functions as GTPase-activating proteins for the alpha-subunits of heterotrimeric G-proteins located at the plasma membrane. RGS8 was identified as ...

journal_title：Journal of neurochemistry

authors： Masuho I,Itoh M,Itoh H,Saitoh O

更新日期：2004-01-01 00:00:00

abstract：:This study evaluated the developmental gene and protein expression of proton-coupled oligopeptide transporters (POTs: peptide transporter, PepT1 and PepT2; peptide-histidine transporter, PhT1 and PhT2) in different regions of rodent brain, and the age-dependent uptake of a POT substrate, glycylsarcosine (GlySar), in b...

journal_title：Journal of neurochemistry

authors： Hu Y,Xie Y,Keep RF,Smith DE

更新日期：2014-06-01 00:00:00

abstract：:Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominantly inherited neurodegenerative disorder for which no curative therapy is available. The cause of this disease is the expansion of a CAG repeat in the so-called ATXN3 gene leading to an expanded polyglutamine stretch in the ataxin-3 protein. Although the func...

journal_title：Journal of neurochemistry

authors： Schmidt J,Schmidt T,Golla M,Lehmann L,Weber JJ,Hübener-Schmid J,Riess O

更新日期：2016-07-01 00:00:00

abstract：:We have found NAD to be rapidly degraded by extracellular enzymes present on intact rat brain synaptosomes. The enzyme involved had the specificity of an NADase cleaving the molecule at the nicotinamide-glycoside linkage and was inhibited by nicotinamide mononucleotide (NMN). This inhibitor did not displace specific b...

journal_title：Journal of neurochemistry

authors： Snell CR,Snell PH,Richards CD

更新日期：1984-12-01 00:00:00

abstract：:Glycine and GABA are likely co-transmitters in the spinal cord. Their possible interactions in presynaptic terminals have, however, not been investigated. We studied the effects of glycine on GABA release using superfused mouse spinal cord synaptosomes. Glycine concentration dependently elicited [(3)H]GABA release whi...

journal_title：Journal of neurochemistry

authors： Raiteri L,Raiteri M,Bonanno G

更新日期：2001-03-01 00:00:00

abstract：:The natural vitamin E tocotrienols possess properties not shared by tocopherols. Nanomolar alpha-tocotrienol, not alpha-tocopherol, is potently neuroprotective. On a concentration basis, this finding represents the most potent of all biological functions exhibited by any natural vitamin E molecule. We sought to dissec...

journal_title：Journal of neurochemistry

authors： Khanna S,Roy S,Parinandi NL,Maurer M,Sen CK

更新日期：2006-09-01 00:00:00

abstract：:We have previously shown that prolonged exposure to neurotrophins induces oxidative neuronal death. In the present study, we further examined the cascades involved in neurotrophin-4/5 (NT-4/5)-induced neuronal death. Exposure of mature cortical cultures for 48 h to NT-4/5 induced neuronal death through TrkB activation...

journal_title：Journal of neurochemistry

authors： Choi SY,Hwang JJ,Koh JY

更新日期：2004-02-01 00:00:00

abstract：:Hippocampus mossy fibre terminals activate CA3 pyramidal neurons via two distinct mechanisms, both quantal and glutamatergic: (i) rapid excitatory transmission in response to afferent action potentials and (ii) delayed and prolonged release following nicotinic receptor activation. These processes were analysed here us...

journal_title：Journal of neurochemistry

authors： Bancila V,Cordeiro JM,Bloc A,Dunant Y

更新日期：2009-07-01 00:00:00

abstract：:It is well established that ischemia-induced release of glutamate and the subsequent activation of post-synaptic glutamate receptors are important processes involved in the development of ischemic neuronal damage. Moderate intraischemic hypothermia attenuates glutamate release and confers protection from ischemic dama...

journal_title：Journal of neurochemistry

authors： Busto R,Globus MY,Neary JT,Ginsberg MD

更新日期：1994-09-01 00:00:00

abstract：:Neolactoglycolipids are derived from neolactotetraosylceramide (nLcOse4Cer). They are found during the embryonic and neonatal developmental periods in the rat cerebral cortex and disappear shortly after birth. These glycolipids are, however, abundant in the adult cerebellum. Lactotriosylceramide (LcOse3Cer):galactosyl...

journal_title：Journal of neurochemistry

authors： Chou DK,Jungalwala FB

更新日期：1994-01-01 00:00:00

abstract：:Action mechanism of lipopolysaccharide (LPS), interleukin-1β (IL-1β), and lysophosphatidic acid (LPA) to regulate motility, an important process of astrogliosis, was investigated in rat astrocytes. While LPA exerted no significant effect on the cell migration, the prior treatment of the cells with LPS or IL-1β resulte...

journal_title：Journal of neurochemistry

authors： Sato K,Horiuchi Y,Jin Y,Malchinkhuu E,Komachi M,Kondo T,Okajima F

更新日期：2011-04-01 00:00:00

abstract：:Prospective studies in humans and experimental investigations in animals have correlated elevated perinatal blood lead levels with enduring behavioural and cognitive perturbations. Although deficits in neuroplastic events necessary for long-term memory consolidation have been observed during the postnatal period, ther...

journal_title：Journal of neurochemistry

authors： Murphy KJ,Regan CM

更新日期：1999-05-01 00:00:00

abstract：:PRMT1, a major arginine methyltransferase, plays critical roles in transcription, DNA damage response, and cell proliferation. Although we have previously discovered the crucial roles of PRMT1 for oligodendrocyte lineage progression in the central nervous system of neural stem cell-specific PRMT1 conditional knockout ...

journal_title：Journal of neurochemistry

authors： Hashimoto M,Kumabe A,Kim JD,Murata K,Sekizar S,Williams A,Lu W,Ishida J,Nakagawa T,Endo M,Minami Y,Fukamizu A

更新日期：2020-08-16 00:00:00

abstract：:The effect of ascorbic acid on Ca2+ uptake in cultured rat astrocytes was examined in the presence of ouabain and monensin, which are considered to drive the Na(+)-Ca2+ exchanger in the reverse mode. Ascorbic acid at 0.1-1 mM inhibited Na(+)-dependent Ca2+ uptake significantly but not Na(+)-dependent glutamate uptake ...

journal_title：Journal of neurochemistry

authors： Takuma K,Matsuda T,Asano S,Baba A

更新日期：1995-04-01 00:00:00

abstract：:[3H]Spiroperidol binding to homogenates of rat striatum is saturable and shows either monophasic or biphasic saturation isotherms under specified conditions. In poorly washed membrane fragment preparations, saturation isotherms of [3H]spiroperidol binding are monophasic, revealing an apparently homogeneous set of site...

journal_title：Journal of neurochemistry

authors： Andorn AC,Maguire ME

更新日期：1980-11-01 00:00:00

abstract：:In NG 108-15 clonal cells, extracellular application of micromolar concentrations of serotonin [5-hydroxytryptamine (5-HT)] and substance P induces the opening of a cation permeability monitored by the influx of [14C]-guanidinium. The serotoninergic component of this cation permeability is linked to 5-HT3 receptor act...

journal_title：Journal of neurochemistry

authors： Riad M,Hamon M,Emerit MB

更新日期：1994-06-01 00:00:00

abstract：:The levels and conformers of alpha-synuclein are critical in the pathogenesis of Parkinson's Disease and related synucleinopathies. Homeostatic mechanisms in protein degradation and secretion have been identified as regulators of alpha-synuclein at different stages of its intracellular trafficking and transcellular pr...

journal_title：Journal of neurochemistry

authors： Stefanis L,Emmanouilidou E,Pantazopoulou M,Kirik D,Vekrellis K,Tofaris GK

更新日期：2019-09-01 00:00:00

abstract：:Transient exposure to ethanol (EtOH) results in a massive neurodegeneration in the developing brain leading to behavioral and cognitive deficits observed in fetal alcohol syndrome. There is now compelling evidence that K+ channels play an important role in the control of programmed cell death. The aim of the present w...

journal_title：Journal of neurochemistry

authors： Lefebvre T,Gonzalez BJ,Vaudry D,Desrues L,Falluel-Morel A,Aubert N,Fournier A,Tonon MC,Vaudry H,Castel H

更新日期：2009-08-01 00:00:00