Nicotine-induced and depolarisation-induced glutamate release from hippocampus mossy fibre synaptosomes: two distinct mechanisms.

abstract：:Malignant gliomas are common and aggressive brain tumours associated with significant morbidity and mortality. We showed in this report that substratum adherence and migration by human U87MG glioma cells in culture were significantly attenuated by the extracellular domains of Nogo-A (Nogo-66) and the myelin-associated...

journal_title：Journal of neurochemistry

authors： Liao H,Duka T,Teng FY,Sun L,Bu WY,Ahmed S,Tang BL,Xiao ZC

更新日期：2004-09-01 00:00:00

abstract：:Recent studies have indicated that various growth factors are involved in synaptic functions; however, the precise mechanisms remain unclear. In order to elucidate the molecular mechanisms of the growth factor-mediated regulation of presynaptic functions, the effects of epidermal growth factor (EGF) and insulin-like g...

journal_title：Journal of neurochemistry

authors： Itakura M,Yamamori S,Kuwahara R,Sekiguchi M,Takahashi M

更新日期：2005-07-01 00:00:00

abstract：:The role of the glutamate dehydrogenase reaction as a pathway of glutamate synthesis was studied by incubating synaptosomes with 5 mM 15NH4Cl and then utilizing gas chromatography-mass spectrometry to measure isotopic enrichment in glutamate and aspartate. The rate of formation of [15N]glutamate and [15N]aspartate fro...

journal_title：Journal of neurochemistry

authors： Yudkoff M,Nissim I,Nelson D,Lin ZP,Erecińska M

更新日期：1991-07-01 00:00:00

abstract：:Nicotinic acetylcholine receptors play important roles in numerous cognitive processes as well as in several debilitating central nervous system (CNS) disorders. In order to fully elucidate the diverse roles of nicotinic acetylcholine receptors in CNS function and dysfunction, a detailed knowledge of their cellular an...

journal_title：Journal of neurochemistry

authors： Moser N,Mechawar N,Jones I,Gochberg-Sarver A,Orr-Urtreger A,Plomann M,Salas R,Molles B,Marubio L,Roth U,Maskos U,Winzer-Serhan U,Bourgeois JP,Le Sourd AM,De Biasi M,Schröder H,Lindstrom J,Maelicke A,Changeux JP,Weve

更新日期：2007-07-01 00:00:00

abstract：:We examined the effect of phenylalanine (50-400 microM) on the electrically stimulated release of endogenous 3,4-dihydroxyphenylethylamine (dopamine or DA) from superfused rat striatal slices. In the absence of tyrosine, phenylalanine (25 microM) partially sustained DA release, but less well than an equimolar concentr...

journal_title：Journal of neurochemistry

authors： Milner JD,Irie K,Wurtman RJ

更新日期：1986-11-01 00:00:00

abstract：:Microsomal fractions isolated from rat corpus striatum catalyze the oxidation of thiobenzamide to the sulfoxide. The rate of thiobenzamide sulfoxidation is 6.9 +/- 4.8 nmol(min)-1 (mg microsomal protein)-1. The reaction is inhibited by an excess of sulfur- and nitrogen-containing substrates for the microsomal flavin-c...

journal_title：Journal of neurochemistry

authors： Duffel MW,Gillespie SG

更新日期：1984-05-01 00:00:00

abstract：:Because of the relative impermeability of the blood-brain barrier (BBB), many drugs are unable to reach the CNS in therapeutically relevant concentration. One method to deliver drugs to the CNS is the osmotic opening of the BBB using mannitol. Hyperosmotic mannitol induces a strong phosphorylation on tyrosine residues...

journal_title：Journal of neurochemistry

authors： Wilhelm I,Nagyoszi P,Farkas AE,Couraud PO,Romero IA,Weksler B,Fazakas C,Dung NT,Bottka S,Bauer H,Bauer HC,Krizbai IA

更新日期：2008-10-01 00:00:00

abstract：:Previous pharmacological studies have indicated that impairment of GABAergic transmission may be involved in the pathophysiology of dystonia in the mutant dtsz hamster, i.e., a genetic animal model for idiopathic dystonia. In the present experiments, the kinetic constants of [3H]flumazenil binding to the benzodiazepin...

journal_title：Journal of neurochemistry

authors： Pratt GD,Richter A,Möhler H,Löscher W

更新日期：1995-05-01 00:00:00

abstract：:This article is a critique of the paper by Khairnar et al. in the current issue of the Journal of Neurochemistry which describes the use of a sophisticated magnetic resonance imaging technique, diffusion kurtosis imaging, to investigate microstructural changes in the brain of TNWT-61 mice that are over-expressing α-sy...

journal_title：Journal of neurochemistry

authors： Williams S

更新日期：2016-03-01 00:00:00

abstract：:Muscarinic receptors mediate metabotropic actions of acetylcholine in the CNS and PNS and autocrine functions of acetylcholine in non-neuronal systems. Because of the lack of highly selective muscarinic ligands, the precise location, functional role, and roles in various diseases of the five muscarinic receptor subtyp...

journal_title：Journal of neurochemistry

authors： Servent D,Fruchart-Gaillard C

更新日期：2009-06-01 00:00:00

abstract：:Exposure to cocaine-associated conditioned stimuli elicits craving and increases the probability of cocaine relapse in cocaine users even after extended periods of abstinence. Recent evidence indicates that cocaine seeking can be inhibited by disrupting the reconsolidation of the cocaine cue memories and that basolate...

journal_title：Journal of neurochemistry

authors： Wu P,Xue YX,Ding ZB,Xue LF,Xu CM,Lu L

更新日期：2011-07-01 00:00:00

abstract：:Alzheimer's disease (AD) is marked by the presence of neurofibrillary tangles and amyloid plaques in the brain of patients. To study plaque formation, we report on further quantitative and qualitative analysis of human and mouse amyloid beta peptides (Abeta) from brain extracts of transgenic mice overexpressing the Lo...

journal_title：Journal of neurochemistry

authors： Pype S,Moechars D,Dillen L,Mercken M

更新日期：2003-02-01 00:00:00

abstract：:Rats were administered [3H]fucose by intracranial injection and synaptic membranes (SMs) isolated 18 h later. Oligosaccharides associated with SM glycoproteins were prepared by hydrazinolysis and analyzed by a combination of affinity chromatography on concanavalin A (Con A)-agarose, ion-exchange chromatography on DEAE...

journal_title：Journal of neurochemistry

authors： Stanojev D,Gurd JW

更新日期：1987-05-01 00:00:00

abstract：:Substantial amounts of phospholipase A2 activity were detected in bovine brain cytosol. The major phospholipase A2 activity was present in the precipitate at 40% saturation with solid ammonium sulfate. After the desaltate of the precipitate was loaded onto an Ultrogel AcA 54 gel filtration column, almost all the activ...

journal_title：Journal of neurochemistry

authors： Hirashima Y,Farooqui AA,Mills JS,Horrocks LA

更新日期：1992-08-01 00:00:00

abstract：:Neuropathic pain is a debilitating chronic pain condition occurring after damage in the nervous system and is refractory to the currently available treatments. Major challenges include elucidating its mechanisms and developing new medications to treat it. Nerve injury-induced pain hypersensitivity involves aberrant ex...

journal_title：Journal of neurochemistry

authors： Tsuda M,Koga K,Chen T,Zhuo M

更新日期：2017-05-01 00:00:00

abstract：:CNS myelin was isolated from the spinal cord of the African lungfish Protopterus dolloi. Its proteins consisted of (1) two basic proteins (16,000 and 18,500 apparent Mr) that reacted with anti-human CNS myelin basic protein antibodies and (2) a major protein (29,000 apparent Mr) that stained with concanavalin A-horser...

journal_title：Journal of neurochemistry

authors： Waehneldt TV,Matthieu JM,Jeserich G

更新日期：1986-05-01 00:00:00

abstract：:Parkinson's disease (PD) motor symptoms are caused by degeneration of nigrostriatal dopaminergic (DAergic) neurons. The most common causes of hereditary PD are mutations in the PARKIN gene. The ubiquitin ligase parkin has been shown to mediate neuroprotection in cell culture and in vivo, but the molecular mechanisms a...

journal_title：Journal of neurochemistry

authors： Hasegawa T,Treis A,Patenge N,Fiesel FC,Springer W,Kahle PJ

更新日期：2008-06-01 00:00:00

abstract：:The in vitro and in vivo performance of three different semipermeable microdialysis membranes was compared: a proprietary polycarbonate-ether membrane made by Carnegie Medecin; cuprophan, a regenerated cellulose membrane; and polyacrylonitrile. When microdialysis probes were tested in a stirred in vitro solution, larg...

journal_title：Journal of neurochemistry

authors： Hsiao JK,Ball BA,Morrison PF,Mefford IN,Bungay PM

更新日期：1990-04-01 00:00:00

abstract：:Nuclear factor (NF)-κB-mediated neuroinflammation is an important mechanism of intracerebral hemorrhage (ICH)-induced neurotoxicity. Silent information regulator 1 (SIRT1) plays a multi-protective effect in a variety of diseases by deacetylating and inhibiting NF-κB/p65. However, the role of SIRT1 in brain damage foll...

journal_title：Journal of neurochemistry

authors： Deng HJ,Zhou CH,Huang LT,Wen LB,Zhou ML,Wang CX

更新日期：2020-12-02 00:00:00

abstract：:We are very sad that the ISN lost its President Kazuhiro Ikenaka, Professor and Chairman at National Institute for Physiological Sciences (NIPS), Director of Okazaki Institute of Integrative Biology. JNeurochem published an Obituary to value his outstanding achievements: Akio Wanaka et al. (2019) OBITUARY Kazuhiro Ike...

journal_title：Journal of neurochemistry

authors：

更新日期：2019-06-01 00:00:00

abstract：:The effects of treatment with the anti-convulsant agents, lamotrigine and riluzole were compared with gabapentin in a rat experimental model of neuropathic pain. Rats were treated intraperitoneally, with gabapentin (30, 100 and 300 mg/kg), lamotrigine (2, 10 and 50 mg/kg) or riluzole (6 and 12 mg/kg) prior to, and eve...

journal_title：Journal of neurochemistry

authors： Coderre TJ,Kumar N,Lefebvre CD,Yu JS

更新日期：2007-03-01 00:00:00

abstract：:It is well established that ischemia-induced release of glutamate and the subsequent activation of post-synaptic glutamate receptors are important processes involved in the development of ischemic neuronal damage. Moderate intraischemic hypothermia attenuates glutamate release and confers protection from ischemic dama...

journal_title：Journal of neurochemistry

authors： Busto R,Globus MY,Neary JT,Ginsberg MD

更新日期：1994-09-01 00:00:00

abstract：:Vanishing white matter disease (VWM) is an autosomal recessive neurological disorder caused by mutation(s) in any subunit of eukaryotic translation initiation factor 2B (eIF2B), an activator of translation initiation factor eIF2. VWM occurs with mutation of the genes encoding eIF2B subunits (EIF2B1, EIF2B2, EIF2B3, EI...

journal_title：Journal of neurochemistry

authors： Terumitsu-Tsujita M,Kitaura H,Miura I,Kiyama Y,Goto F,Muraki Y,Ominato S,Hara N,Simankova A,Bizen N,Kashiwagi K,Ito T,Toyoshima Y,Kakita A,Manabe T,Wakana S,Takebayashi H,Igarashi H

更新日期：2020-07-01 00:00:00

abstract：:Antisera raised to the 68,000, 145,000 and 200,000 molecular weight subunits of rat neurofilaments were used for immunochemical staining of polypeptides separated by one- and two-dimensional gel electrophoresis. It was found that each antiserum reacts intensely with its corresponding neurofilament subunit and weakly w...

journal_title：Journal of neurochemistry

authors： Autilio-Gambetti L,Velasco ME,Sipple J,Gambetti P

更新日期：1981-11-01 00:00:00

abstract：:We recently reported that prostaglandin E2 (PGE2) stimulated phosphoinositide metabolism in cultured bovine adrenal chromaffin cells and that PGE2 and ouabain, an inhibitor of Na+,K+-ATPase, synergistically induced a gradual secretion of catecholamines from the cells. The effect on catecholamine release was specific f...

journal_title：Journal of neurochemistry

authors： Tanaka T,Yokohama H,Negishi M,Hayashi H,Ito S,Hayaishi O

更新日期：1990-01-01 00:00:00

abstract：:The effects of short- and long-chain fatty acids on the cerebromicrovascular (Na+ + K+)-ATPase were investigated using specific [3H]ouabain binding to the enzyme. Specific binding increased linearly with total microvessel protein (37-110 micrograms) and was time-dependent with maximum binding obtained by 10 min. Arach...

journal_title：Journal of neurochemistry

authors： Caspers ML,Grammas P

更新日期：1988-04-01 00:00:00

abstract：:The role of gamma-aminobutyric acid (GABA) modulation of septohippocampal cholinergic neurons in kindling was investigated. Hippocampal acetylcholine release was evaluated with the microdialysis technique in freely moving rats either after acute administration of isoniazid (an inhibitor of GABA synthesis) or pentylene...

journal_title：Journal of neurochemistry

authors： Serra M,Dazzi L,Cagetti E,Chessa MF,Pisu MG,Sanna A,Biggio G

更新日期：1997-01-01 00:00:00

abstract：:Oligodendrocytes are glial cells responsible for the synthesis and maintenance of myelin in the central nervous system (CNS). Oligodendrocytes are vulnerable to damage occurring in a variety of neurological diseases. Understanding oligodendrocyte biology is crucial for the dissemination of de- and remyelination mechan...

journal_title：Journal of neurochemistry

authors： Dumont D,Noben JP,Moreels M,Vanderlocht J,Hellings N,Vandenabeele F,Lambrichts I,Stinissen P,Robben J

更新日期：2007-07-01 00:00:00

abstract：:In the preceding report we demonstrated a dose-dependent increase in 32P-phosphoprotein labeling after 24-h exposure of cultured cerebellar granule neurons to methyl mercury (MeHg), a response that was not observed in glial cultures. In the present study we have examined 32P-labeled phosphoproteins by two-dimensional ...

journal_title：Journal of neurochemistry

authors： Sarafian T,Verity MA

更新日期：1990-09-01 00:00:00

abstract：:In the adult mammalian brain, neural stem cells (NSCs) reside in two neurogenic regions, the walls of the lateral ventricles, and the subgranular zone of the hippocampus, which generate new neurons for the olfactory bulb and dentate gyrus, respectively. These adult NSCs retain their self-renewal ability and capacity t...

journal_title：Journal of neurochemistry

authors： Hayashi Y,Jinnou H,Sawamoto K,Hitoshi S

更新日期：2018-12-01 00:00:00